scholarly journals Drugs via enteral feeding tubes in inpatients: dispersion analysis and safe use of dispensers

2017 ◽  
Vol 34 (2) ◽  
pp. 257 ◽  
Author(s):  
Milena Pontes Portela Beserra ◽  
Cristiani Lopes Capistrano Gonçalves De Oliveira ◽  
Mileyde Ponte Portela ◽  
Marcos Venícios de Oliveira Lopes ◽  
Marta Maria de França Fonteles
Keyword(s):  
Drug Administration ◽  
Enteral Feeding ◽  
Dispersion Analysis ◽  
Care Hospital ◽  
Solid Dosage Forms ◽  
Feeding Tubes ◽  
Solid Dosage ◽  
Level Ii ◽  
Eastern Brazil ◽  
North Eastern

This study aimed to improve knowledge about drug administration through enteral feeding tubes (EFTs) in order to minimize efficacy and safety problems. The study was conducted in a public secondary care hospital accredited with level II accreditation by the National Accreditation Organization (Organização Nacional de Acreditação – ONA), in Fortaleza, Ceará, north-eastern Brazil. 108 oral solid medications that could be administered through EFTs and were not available in liquid forms were evaluated via transformation of their solid dosage forms into liquid forms. Dispersion times and conditions were assessed to determine which medications should be crushed. We compared the use of dispensers and syringes and their connections to enteral feeding tubes and intravenous devices. Medications whose dispersion occurred within 20 minutes and could be visually perceived and whose content could be expelled without occluding the oral syringe were considered “satisfactory”. The dispersion was “satisfactory” in 82 (75.9%) of the medications; they were classified as capable of being dispersed in water in the oral syringe for further administration via EFTs without the need for crushing. Use the dispenser instead of the syringe for drug administration was safer because the dispenser apparatus did not fit into equipment for intravenous drug administration. 

scholarly journals PHARMACIST INTERVENTION AND PREPARATION OF MANUAL IN THE ADMINISTRATION OF DRUGS THROUGH ENTERAL FEEDING TUBE

2018 ◽  
Vol 10 (12) ◽  
pp. 21
Author(s):  
L. Induja ◽  
Aslam T. A. ◽  
G. Andhuvan
Keyword(s):  
Drug Administration ◽  
Enteral Feeding ◽  
Feeding Tube ◽  
Pharmacist Intervention ◽  
Solid Dosage Forms ◽  
Solid Dosage ◽  
Enteral Feeding Tube ◽  
Incorrect Solution ◽  
Enteric Coated

Objective: To monitor errors in current practice and prepare a manual for proper drug administration through the enteral feeding tube.Methods: It is a prospective observational study conducted for a period of 6 mo in eight departments. The current drug administrations were monitored and checked for the errors which include crushed non crushable solid dosage forms, each drug is not prepared separately, incorrect solution used for dilution, drugs mixed with feeding formula, each drug is not administered separately, not flushed before administration of each drug, not flushed after administration of each drug and others (tablets are not crushed with proper device, motors and pestles are not cleaned frequently, spillage during crushing). Using the data, a manual was prepared and submitted to the physicians of each department.Results: The most prominent error was found to be that the drugs were not prepared and administered separately, tube not flushed before drug administration. Uses of noncrushable tablets were high in neurology. Pantoprazole (enteric coated) and prazosin (modified release) tablets were the most commonly used noncrushable drugs.Conclusion: The study observed the need for developing a standard protocol for drug administration through enteral feeding tube by the pharmacist along with the physician, nursing team to improve the quality of enteral therapy.

PROCESSO DE PADRONIZACAO DE MEDICAMENTOS ORAIS PARA ADMINISTRACAO VIA SONDA ENTERAL PARA HOSPITAL UNIVERSITÁRIO MATERNO‑INFANTIL

2020 ◽  
Vol 32 (1) ◽  
pp. 30-40
Author(s):  
Isadora Dávila Da Silva ◽  
Michelle Silva Nunes ◽  
Almária Mariz Batista
Keyword(s):  
Drug Administration ◽  
Enteral Feeding ◽  
Feeding Tubes

A adaptação de formas farmacêuticas orais para uso via sonda enteral é necessária diante da escassez de formulações, especialmente para pacientes pediátricos, pacientes com transtornos de deglutição e pacientes  críticos internados em UTI. É necessária a avaliação do farmacêutico quando há necessidade de adaptar forma farmacêutica, para constatar se realmente é permitido fazê‑lo, se não há alternativa terapêutica disponível e, em caso de viabilidade de adaptação, realizar o procedimento. O estudo teve como objetivo a avaliação do processo de padronização de medicamentos administrados via oral que podem ser adaptados para administração via sonda enteral. Para isso, foi utilizada como base a lista de padronização de medicamentos da Maternidade Escola Januário Cicco e a consulta foi realizada nas fontes Micromedex, Dynamed, Handbook of Drug Administration via Enteral Feeding Tubes e Drugs.com. Das 68 formas farmacêuticas orais (63 princípios ativos), 76,47% podiam ser adaptadas e administradas por sonda enteral e para 13,23% não foram encontrados dados na literatura acerca da viabilidade da adaptação destas formas farmacêuticas. Além disso, 23,80% dos medicamentos possuíam vias alternativas de administração. Foram encontradas 46 interações medicamento‑alimento, sendo 15,22% da categoria Importante, 63,04% Moderada e 21,74% Menor/Secundária. As informações sobre adaptações de formas farmacêuticas para administração via sonda enteral ainda são escassas na literatura, sendo, portanto, imprescindível a compilação das informações disponíveis acerca do tema, uma vez que a não observância destas pode comprometer a segurança do paciente.

scholarly journals Pharmaco-technological researches for development of sachet composition

2018 ◽  
pp. 32-41
Author(s):  
O. V. Tryhubchak ◽  
S. N. Gureyeva ◽  
O. A. Yuryeva ◽  
А. М. Goy
Keyword(s):  
Dispersion Analysis ◽  
Technological Parameters ◽  
Solid Dosage Forms ◽  
Pharmaceutical Ingredients ◽  
Solid Dosage ◽  
Organoleptic Characteristics ◽  
Anti Inflammatory ◽  
Sugar Powder ◽  
Selection Of

In the article it is presented data on the relevance of drugs from the group of analgesics-antipyretics in the form of fast dissolving solid dosage forms and excipients for its manufacture are described. The advantages of a sachet as a solid dosage form are described. For developing a sachet with anti-inflammatory properties, the features of active pharmaceutical ingredients interrelation and their physicochemical properties, which determine the technology, are shown. The purpose of this work was to select the excipients for improvement the pharmaco-technological and organoleptic characteristics of the sachet. We studied 27 excipients 5 functional groups. The experiment is based on the Latin cube of the second order. Technology was the mixing of components. The obtained mass was tested twice on pharmaco-technological parameters and the characteristics of the solution. Experimental data were subjected to statistical analysis by the method of dispersion analysis. The results were expressed using ranked rows of benefits and bar charts. The results of the study present the effect of excipients from groups of alkaline and acid fractions, dyes, flavors, fillers on the quality of the sachets. The results of the study show that the different tested excipients show the greatest influence on appearance of the mass, bulk density, density after shrinkage, Carr`s index, fluidity, angle of the slope, mass loss in drying, solution appearance, solution smell, solution taste and pH of the solution. Generalized results of dispersion analysis showed that calcium phosphate, citric anhydrous acid, maleic acid, curcumin, lemon-lime flavor and sugar powder improve the pharmacological-technological and organoleptic characteristics of the studied sachet. In the result of the work, the selection of excipients in the development of a sachet is scientifically substantiated. The influence of the exipiences nature on the pharmaco-technological indicators sachets and organoleptic properties was studied. It was selected the excipients for the optimal sachet composition with anti-inflammatory properties.

scholarly journals LIQUISOLID COMPACT TECHNIQUES: A REVIEW

2018 ◽  
Vol 10 (4) ◽  
pp. 1
Author(s):  
Manisha Rokade ◽  
Pradnya Khandagale ◽  
Dipti Phadtare
Keyword(s):  
Drug Administration ◽  
Water Soluble ◽  
Oral Drug ◽  
Solid Dosage Forms ◽  
Coating Materials ◽  
Solid Dosage ◽  
Substantial Problem ◽  
Water Soluble Drugs ◽  
Insoluble Drugs ◽  
Routes Of Drug Administration

The poor dissolution rate of water-insoluble drugs is still a substantial problem confronting the pharmaceutical industry. There are several methods used to increase the solubility of drugs, of those liquid-solid compact technique is a new and promising addition towards such a novel aim, that the solubility of the insoluble drug moiety is increased by the aid of non-volatile solvents and hence increasing the dissolution and bioavailability. Oral drug administration has been one of the most convenient and widely accepted routes of delivery for most of the therapeutic agents. It is one of the most extensively used routes of drug administration because of its obvious advantages of ease of administration, improved patient compliance, and convenience. The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. A more recent technique, “powdered solution technology” or “Liquisolid technology”, has been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. The limited solubility of drugs is a challenging issue for the industry, during the development of the ideal solid dosage form unit. The technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders.

scholarly journals Assessment of oral solid dosage forms administration manner and acceptability

Pharmacia ◽  
2021 ◽  
Vol 68 (2) ◽  
pp. 393-400
Author(s):  
May Almukainzi
Keyword(s):  
Drug Administration ◽  
Dosage Forms ◽  
Regulatory Agencies ◽  
Simple Random Sample ◽  
Solid Dosage Forms ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Solid Dosage ◽  
Pharmaceutical Manufacturers ◽  
Medicine Administration

Taking oral solid dosage forms (OSDFs) safely and effectively is particularly important. This study aimed to determine the pattern and knowledge about the proper criteria of OSDF administration and the consumers’ preferences toward OSDF characteristics. The aims of this study were achieved by cross-sectional survey through open and closed-ended questionnaires, and the presence of the main OSDF administration recommendations of a sample of 32 OSDF drug leaflets was assessed. Based on a simple random sample of 250 volunteers, we found inadequate compliance with the OSDF medicine administration criteria. We also found an absence of the main recommendations of OSDF drug administration on most of the investigated OSDF drug leaflets. Conventional white, round tablets were found to be the most preferred type of OSDF drug. These findings can be valuable to pharmaceutical manufacturers, regulatory agencies, and pharmacists to enhancing patient awareness and compliance with OSDF administration for safe and effective drug administration.

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