scholarly journals SYNTHESIS AND CHARACTERIZATION OF C-HEXYL CALIX[4]RESORCINARENA FROM RESORCINOL-HEPTANAL CONDENSATION

2016 ◽  
Vol 10 (1) ◽  
pp. 49
Author(s):  
Desi Suci Handayani ◽  
Zainal Arifin Almaqqomul Amin ◽  
Triana Kusumaningsih ◽  
Abu Masykur
Keyword(s):  
Melting Point ◽  
Nmr Spectroscopy ◽  
Structural Analysis ◽  
Chemical Shifts ◽  
Condensation Reaction ◽  
Wave Number ◽  
Synthesis And Characterization ◽  
H Nmr ◽  
Brown Powder

<p>Synthesis of  C-hexyl  calix[4]resorcinarene  through condensation reaction between resorcinol  and  heptanal  with  HCl  catalyst  has  been  investigated.  Synthesis  conducted  by the ratio of resorcinol: heptanal (1:1) using reflux for 6 hours in ethanol. Structural  analysis of  the  product  was  done  by  FTIR  and 1 H-NMR  spectroscopy,  while  the  characterization was  done  by  determining  melting  point.  The  product  was  golden  brown  powder  with  a yield 99.43%  and  melting point more than 300 °C.  Structural analysis with FTIR and 1 HNMR  known  vibration  and  signals  characteristic  of  calix[4]resorcinarena  group, the vibrations of the CH  bridge. Vibration of CH bridge appearance at wave number 1445 cm<sup>-1</sup> and 1456  cm<sup>-1</sup>, while signal of CH bridge appearance at chemical shifts from  4.17 to 4.21 ppm.</p>

SYNTHESIS AND CHARACTERIZATION OF C-HEXYL CALIX[4]RESORCINARENA FROM RESORCINOL-HEPTANAL CONDENSATION

2014 ◽  
Vol 10 (1) ◽  
pp. 49
Author(s):  
Desi Suci Handayani
Keyword(s):  
Melting Point ◽  
Nmr Spectroscopy ◽  
Structural Analysis ◽  
Chemical Shifts ◽  
Condensation Reaction ◽  
Wave Number ◽  
Synthesis And Characterization ◽  
H Nmr ◽  
Brown Powder

<p>Synthesis of C-hexyl calix[4]resorcinarene through condensation reaction between resorcinol and heptanal with HCl catalyst has been investigated. Synthesis conducted by the ratio of resorcinol: heptanal (1:1) using reflux for 6 hours in ethanol. Structural analysis of the product was done by FTIR and <sup>1</sup>H-NMR spectroscopy, while the characterization was done by determining melting point. The product was golden brown powder with a yield 99.43% and melting point more than 300 °C. Structural analysis with FTIR and <sup>1</sup>H-NMR known vibration and signals characteristic of calix[4]resorcinarena group,the vibrations of the CH bridge. Vibration of CH bridge appearance at wave number 1445 cm<sup>-1</sup> and 1456 cm<sup>-1</sup>, while signal of CH bridge appearance at chemical shifts from 4.17 to 4.21 ppm.</p>

Synthesis and characterization of several series of 4-acyl-1-[2-aryl-1-diazenyl]piperazines

2014 ◽  
Vol 92 (9) ◽  
pp. 838-848 ◽  
Author(s):  
Vanessa Renee Little ◽  
Keith Vaughan
Keyword(s):  
High Resolution ◽  
Ir Spectroscopy ◽  
Chemical Shifts ◽  
Synthesis And Characterization ◽  
Model Compounds ◽  
Primary Aromatic Amine ◽  
Piperazine Ring ◽  
H Nmr ◽  
C Nmr

Five series of a novel class of 4-acyl-1-[2-aryl-1-diazenyl]piperazines have been synthesized and characterized: the 4-acetyl-1-[2-aryl-1-diazenyl]piperazines [series 1]; the 4-cyclohexylcarbonyl-1-[2-aryl-1-diazenyl]piperazines [series 2]; the 4-benzoyl-1-[2-aryl-1-diazenyl]piperazines [series 3]; the benzyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates [series 4]; and the t-butyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates [series 5]. The compounds were synthesized by diazotization of a primary aromatic amine and subsequent coupling to an appropriate secondary amine: 1-acetylpiperazine [series 1]; 1-(cyclohexylcarbonyl)-piperaizine [series 2]; 1-benzoylpiperazine [series 3]; benzyl 1-piperazinecarboxylate [series 4]; and t-butyl piperazine-1-carboxylate (1-BOC-piperazine) [series 5]. The compounds of series 1–5 were characterized by 1H NMR, 13C NMR, high-resolution MS and IR spectroscopy. The model compounds 1,4-di[2-aryl-1-diazenyl]piperazines, and ethyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates were used to facilitate the assignment of the chemical shifts specific to the piperazine ring carbons. HSQC spectra of select compounds established the correlation between proton and carbon resonance signals.

scholarly journals Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro)

2012 ◽  
Vol 9 (2) ◽  
pp. 962-969 ◽  
Author(s):  
Zahraa Salim M. Al-Garawi ◽  
Ivan Hameed R. Tomi ◽  
Ali Hussein R. Al-Daraji
Keyword(s):  
Schiff Base ◽  
Condensation Reaction ◽  
Synthesis And Characterization ◽  
Activation Effect ◽  
Inhibition Effect ◽  
H Nmr ◽  
Ft Ir ◽  
High Concentrations

In this study, two new Schiff base compounds derived from the condensation reaction ofL-glycine andL-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and1H NMR spectroscopy. Their effects on the activity of total (ACP), prostatic (PAP) and non prostatic (NPA) acid phosphatase enzymes were studied. The Schiff base derived fromL-glycine (A) demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived fromL-tryptophan (B) demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10-2, 5.5×10-3and 5.5×10-4M) and activator effect at low concentration (5.5×10-5M) while it was exhibits as activator on PAP activity.

scholarly journals Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters

2013 ◽  
Vol 2013 ◽  
pp. 1-8
Author(s):  
Kuan-Han Lee ◽  
Yu-Sheng Lin ◽  
Po-Jui Huang
Keyword(s):  
Nmr Spectroscopy ◽  
Gold Clusters ◽  
Hydroxyl Group ◽  
Synthesis And Characterization ◽  
Nmr Spectrum ◽  
Design Synthesis ◽  
H Nmr

A series of new thiol-derivatized ibuprofen monolayer protected gold clusters have been prepared by amidation of ibuprofen with alkyl alcohol or aminophenol affording the carboxamides, N-hydroxyalkyl amide2, and N-hydroxyphenyl amide6, which were then tosylated withp-toluenesulfonyl chloride at hydroxyl group to give3and7. Reactions of3and7with NaSH afforded the mercapto derivatives4and8. Conducting Brust’s reaction with a 3 : 1 mole ratio of thiolate ibuprofen/AuCl4-yielded polydisperse thiol-derivatized ibuprofen-MPCs5and9. All compounds have been identified by NMR, MS, UV, and IR spectroscopies. Compounds4and8and the MPCs5and9have been investigated by using the method of1H NMR spectroscopy. The broadening of the signals from 0.8 to 2.0 ppm in1H NMR spectrum of MPCs5and9confirmed the success of the conjugation of thiol-containing derivatives with nanogold cluster.

scholarly journals Synthesis and Characterization of some Thiazolidinone Derivatives Possessing Benzimidazole Nucleus

2014 ◽  
Vol 30 ◽  
pp. 1-8
Author(s):  
Prakash Mehta ◽  
Prakash Dawedra ◽  
Vaishali Goswami ◽  
Hitendra S. Joshi
Keyword(s):  
Schiff Bases ◽  
Mass Spectroscopy ◽  
Condensation Reaction ◽  
Synthesis And Characterization ◽  
Benzimidazole Derivatives ◽  
H Nmr ◽  
Anhydrous Zncl

Synthesis of new thiazolidinone derivatives possessing benzimidazole nucleus by condensation reaction of various substituted mercapto acids in presence of anhydrous ZnCl2. In our present study we have also synthesized Schiff bases of benzimidazole derivatives. All synthesized compounds were characterized by IR, 1H NMR and Mass spectroscopy.

scholarly journals Synthesis and characterization of novel substituted spiro[isobenzofuran-1(3H), 9’-xanthene]-3-ones

2005 ◽  
Vol 70 (7) ◽  
pp. 931-936 ◽  
Author(s):  
Sachin.V. Patel ◽  
Manish Patel ◽  
Rangan Patel
Keyword(s):  
Melting Point ◽  
Nmr Spectroscopy ◽  
Benzoic Acid ◽  
Synthesis And Characterization ◽  
Acidic Media ◽  
Melting Point Determination ◽  
Infra Red ◽  
Point Determination ◽  
Uv Visible

The ketoacid, 2-(4-diethylamino-2-hydroxybenzoyl)benzoic acid, prepared from N,N-diethyl-m-aminophenol and phthalic anhydride, was reacted with various substituted 3-[6-methoxybenzothiazol-2-yl]-4(3H)-quinazolinones in the presence of a dehydration condensing agent to afford novel spiro[isobenzofuran-1(3H),9?-xanthene]-3-ones. The benzothiazolyl quinazolinones were synthesized by reacting 2-amino-6-methoxybenzothiazole with various substituted benzoxazinones. All compounds were characterized by melting point determination, elemental analysis, infra- red spectroscopy NMR-spectroscopy and UV-visible sprectroscopy. All the fluoran compounds are colourless or nearly colourless and produce colour in the presence of acidic media.

scholarly journals Synthesis and Characterization of Aza-Trimetalla Tetrahedranes

1996 ◽  
Vol 51 (11) ◽  
pp. 1621-1626 ◽  
Author(s):  
Max Herberhold ◽  
Uwe Bertholdt ◽  
Bernd Wrackmeyer
Keyword(s):  
Nitrogen Atom ◽  
Nmr Spectra ◽  
Chemical Shifts ◽  
Double Resonance ◽  
Synthesis And Characterization ◽  
Exchange Reactions ◽  
H Nmr ◽  
A Minor

The sulfimide complex Fe2(CO)6(μ-SNH) (1) reacts with Co2(CO)8 to form a 1:1 mixture of the known clusters FeCo2(CO)9(μ3-S) (2) and FeCo2(CO)9(μ3-NH) (3). The azatetrahedrane 3 may be used as a precursor for the synthesis of the new aza-trimetalla tetrahedranes Fe2Co(CO)9(μ-H)(μ3-NH) (5), CpMoFeCo(CO)8(μ3-NH) (6), CpNiFeCo(CO)6(μ3-NH) (7) and (CpNi)2Fe(CO)3(μ3-NH) (8) which were obtained from exchange reactions of 3 with Na2[Fe(CO)4], Na[CpMo(CO)3] and [CpNi(CO)]2. However, the reactions of 3 with Na2[Fe(CO)4] and Fe3(CO)12 gave Fe3(CO)9(μ-H)2(μ3-NH) (9) only as a minor product in addition to large amounts of Fe3(CO)9(μ-H)2(μ3-S) (10). The 1H NMR spectra of 3 and 5 - 9 show a broadened triplet for the NH proton between δ(1H) 8.21 and 9.53. Chemical shifts δ(14N) were determined most efficiently by heteronuclear 1H {14N} double resonance experiments. The δ(14N) values for aza-trimetalla tetrahedranes (-180 to -202) indicate delocalized bonding between the μ3-bridging nitrogen atom and the metal triangle.

Synthesis and Characterization of Polythiophenes Having Phosphonate Ester Groups

2011 ◽  
Vol 409 ◽  
pp. 502-507 ◽  
Author(s):  
Maki Katagiri ◽  
Masahiro Yoshizawa-Fujita ◽  
Yuko Takeoka ◽  
Masahiro Rikukawa
Keyword(s):  
Nmr Spectroscopy ◽  
Band Gap ◽  
Layered Structure ◽  
Oxidative Polymerization ◽  
Ester Group ◽  
Synthesis And Characterization ◽  
H Nmr ◽  
Self Organized ◽  
Polar Organic Solvents

Polythiophene derivatives containing a phosphonate ester group, poly [3-(3-diethyl-phosphonate) propoxythiophene] (PEPPT), were synthesized by Rieke and oxidative polymerization methods. These PEPPTs were soluble in polar organic solvents such as methanol, DMF, and chloroform. Thehead-to-tailratio of PEPPT (Rieke) was estimated to be 98 % by1H NMR spectroscopy, while that of PEPPT (Oxidative) was estimated to be 53 %. The maximum absorption peak of PEPPT (Rieke) was observed at 596 nm, which was 46 nm longer than that of PEPPT (Oxidative) in CHCl3solutions. This result suggests that the planarity of PEPPT (Rieke) is higher than that of PEPPT (Oxidative) due to the high regioregularity of the side chains. The estimated band gap of PEPPT was 1.60 eV for Rieke-synthesized derivatives. The XRD peak of PEPPT(Rieke) was observed at 5.14º (17.2 Å) and that of PEPPT (Oxidative) was not clearly observed, suggesting that PEPPT(Rieke) has self-organized properties to form a layered structure.

scholarly journals Synthesis and characterization of azetidin-2-one and 1,3-oxazepine derivatives using Schiff bases derived from 1,1’-biphenyl-4,4’-diamine

2021 ◽  
Vol 2063 (1) ◽  
pp. 012010
Author(s):  
H D Hanoon ◽  
H A Abd Al Hussain ◽  
S K Abass
Keyword(s):  
Schiff Bases ◽  
Heterocyclic Compounds ◽  
Nmr Spectra ◽  
Condensation Reaction ◽  
Synthesis And Characterization ◽  
Chloroacetyl Chloride ◽  
H Nmr ◽  
Ft Ir ◽  
Benzaldehyde Derivatives

Abstract The present study included the synthesis of two series of heterocyclic compounds, azetidin-2-one and 1,3-oxazepine derivatives. All synthesized compounds were characterized using FT-IR and 1H NMR spectra. The study was divided into two parts. The first synthesis Schiff bases derivatives (1-4) via the condensation reaction of 1,1′-biphenyl-4,4′-diamine (A) with benzaldehyde derivatives (2,5-dimethoxybenzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, furan-2-carbaldehyde and 3-hydroxybenzaldehyde). The second synthesis azetidine-2-one derivatives (5-8) from the reaction of Schiff bases with chloroacetyl chloride. Schiff bases also reacted with maleic anhydride to yield 1,3-oxazepine derivatives (9-12).

scholarly journals Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives

2014 ◽  
Vol 30 ◽  
pp. 185-192 ◽  
Author(s):  
Hasmukh R. Khunt ◽  
Jayesh S. Babariya ◽  
Chandni D. Dedakiya ◽  
Charmi A. Maniar ◽  
Yogesh T. Naliapara
Keyword(s):  
Nmr Spectroscopy ◽  
Synthesis And Characterization ◽  
H Nmr

We have described simple facile method for the synthesis of Novel (E)-1-(aylideneamino)-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile derivatives by using 1,3-diketone as synthon. All the synthesized compounds were characterized by IR, Mass and 1H NMR spectroscopy.

Sign in / Sign up

Export Citation Format

Share Document