Phytochemical and biological investigation of Indian medicinal plant of givotia rottlerifromis griff

A study on givotia rottlerifomis griff shows that studies on a tremendous of pharmacological and physiological activities and other applications. Moreover, givotia rottlerifomis griff has diverse physiological effects. This tempted us to use the bark of givotia rottlerifomis griff for extraction of new compound from the extract. Attempt is made to develop an efficient method for isolation of compounds from the barks of givotia rottlerifomis griff. Our scheme of work is to separate a portion by treatment with pure methanol (CH3OH) using soxhlet apparatus at boiling temperature and the sample is crystallized to separate to the pure compound. The compound was identified further by chromatographic studies, melting point determination, and spectral analysis (IR, 1D and 2D NMR) etc. Furthermore, antimicrobial studies are tested various antibacterial and antifungal species and also molecular docking studies are checked with HIV protease with Schrodinger 9.5 software.

Synthesis of 3-Ferrocenyl Isocoumarins

The derivatives of 3-ferrocenyl isocoumarin were synthesized by the condensation of substituted homothphalic anhydride with ferrocene using phosphoric acid or anhydrous aluminium chloride as cyclising agent. Substituted homophthalic acid did not condense with ferrocene so homophthalic acids were converted into their anhydride and then allowed to react with ferrocene in the presence of polyphosphoric acid or in the presence of anhydrous aluminium chloride using dichloromethane as the solvent to give 3-ferrocenyl isocoumarins. 7-Methoxy, 6-methyl, 5,7-dihydroxy, 6,7-dimethoxy and 5,7-dimethoxy derivatives of 3-ferrocenyl isocoumarin were synthesized. All the compounds were characterised by melting point determination, elemental and spectral analysis.

Bis-(3,5-dimethyl salicylidine)-ethylenediamine as a Gravimetric Reagent for Cu(II)

Complex of Cu(II) with bis-(3,5-dimethyl salicylidine)-ethylenediamine was synthesized and characterized by elemental analysis, melting point determination, conductivity measurement, magnetic and spectroscopic studies. Molecular formula of the newly prepared complex was determined as C20H22N2O2Cu and the probable geometry has been suggested as square planar. Gravimetric estimation of Cu(II) was made with bis-(3,5-dimethyl salicylidine)-ethylenediamine and the result was compared with the known method of estimation of Cu(II) iodometrically. It was found that the result of estimation with newly prepared reagent was as good as the reported result of estimation of Cu(II) iodometrically.

Sintesis Senyawa Turunan Amoksilin Dan Uji Aktivitas Antibakterinya Terhadap Bakteri Salmonella typhi

The synthesis of amoxicillin derivate has been done by reacting amoxicillin with 4-t-butylbenzoil chloride. The product was characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, and FTIR Spectrophotometry. Antibacterial activity of amoxicillin derivative against Salmonella typhi were tested using dilution method. Result showed that the product has characteristic as follow: light yellow powder, bitter bite, melting point of 132 °C, Rf value of 0.86, pH value of 7.7, maximum wavelength (uv) of 286 nm. Moreover, FTIR spectra of amoxicillin derivate exhibited peaks at 3271 cm-1 (-NH amine), 2962 cm-1 (-CH aromatic), 1633 cm-1 (-C=O ketone), and other. Antibacterial test showed that amoxicillin derivate was unable to form a clear zone around the disc paper. Amoxicillin derivate cannot be used for the treatment of Salmonella typhi.

Synthesis Analgetic-Antiiflammation N-(4t-Buthylbenzoil)-p-Aminophenol by Using MgF2 Catalist

Synthesis of N-(4t-buthylbenzoyl)-p-aminophenol has been done by reacting p-aminophenol and 4-tert- buthylbenzoyl chloride compounds with 1% MgF2 catalyst. N-(4t-buthylbenzoyl)-p- aminophenol as an antiinflamatory analgesic. Products were characterized by organoleptic test, melting point determination, TLC, UV/Vis Spectrophotometry, and infrared spectrophotometry. The results of the organoleptic test showed that N- (4t-butylbenzoyl) -p- aminophenol is powdered, gray and tasteless. Melting point of N-(4t- buthylbenzoyl)-p- aminophenol was 193 – 194 °C. TLC results showed that N-(4t-buthylbenzoyl)-p- aminophenol had two Rf values of 0.73 – 0.76 and 0.89 – 0.91. The results of UV wavelength scanning showed that N- (4t-butylbenzoyl) -p-aminophenol had two peaks at 290 and 294 wavelengths. Yield of N-4t- butylbenzoyl-p-aminophenol was 24.35%. Keywords: N-(4t-buthylbenzoyl)-p-aminophenol, MgF2, catalyst, an antiinflamatory analgesic

Synthesis, Characterization and Antimicrobial Studies of Schiff Base Ligand-Derived from Amoxicillin and Benzaldehyde

Advanced research into synthetic chemistry has pointed out several organic compounds with antimicrobial potential. Schiff bases are one of such compounds. This research aims at the synthesis of a Schiff base out of a fairly common antibiotic amoxicillin and benzaldehyde. The synthesized compound was characterized by different spectroscopic techniques. It was also subjected to melting point determination, TLC and solubility tests. The Schiff base was screened for antibacterial and antifungal activities in-vitro by disc diffusion method.Bangladesh Pharmaceutical Journal 19(2): 211-214, 2016

Synthesis, Characterization And Electrolytic Behavior Of Cadmium(II) Complexes Of 5,7,7,12,14,14- Hexamethyl-1,4,8,11-Tetraazacyclotetradeca-4,11- Diene And Isomers Of Its Saturated Analogue

Condensation of ethylendiamine with acetone in the presence of quantitative amount of perchloric acid, yielded the ligand 5,7,7,12,14,14- hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene dihydroperchlorate (denoted by L.2HClO4). The ligand L.2HClO4 on reduction with NaBH4, yielded an isomeric mixture of saturated macrocycles, the Me6[14]anes, which were resolved into two distinct C-chiral isomers (denoted by ‘tet-a’ and ‘tet-b’). Interaction of ligands L.2HClO4, ‘tet-a’ and ‘tet-b’ with salts CdI2, Cd(NO3)2.4H2O, CdCl2.2H2O and Cd(ClO4)2.6H2O produced different five coordinated square pyramidal and six coordinated octahedral cdmium(II) complexes. Among them the complexes, cis-[Cd(teta)( NO3)](NO3) and cis-[Cd(tet-b)(NO3)](NO3) underwent axial ligand substitution reaction with KCNS; whereas complex [Cd(tet-a)I2] underwent axial ligand substitution reaction and complex [CdLI](ClO4) underwent simultaneous ligand substitution and addition reaction with NaNO2. Characterization of all the complexes were carried out on the basis of elemental analysis; FT-IR, UV-Vis. and 1H-NMR spectroscopy; melting point determination as well as by magnetic moment and conductivity measurements. Molar conductivity measurment of the complexes reavealed that they show different electrolytic behavior in different solvents.

Solvent-Free Green Synthesis of 4-amino-5-substituted-1,2,4-triazole-3-thione by Grinding

A novel efficient method for the synthesis of 4-amino-5- substituted-1,2,4- triazole -3-thione was developed in which substituted aromatic/aliphatic acids with symmetrical dithiocarbohydrazones were used as starting materials and phosphorus pentachloride was used as catalyst.The structures of these products were confirmed by melting point determination, IR, 1H NMR and elemental analysis. This is a novel and cost-effective synthetic method. In addition, the synthetic method avoids the use of organic solvents and significantly improves reaction yields.