Effects of xipayi mouth rinse combined with minocycline on localized aggressive periodontitis’ therapeutic effect and the levels of CRP, TNF-α, IL-6 in serum

Purpose: To determine the therapeutic effect of Xuezhitong capsule in patients with microvascular angina (MVA), and its impact on vascular endothelial function.Methods: In total, 172 MVA patients treated in Beijing City Fengtai District Nanyuan Hospital from September 2017 to September 2019 were selected and randomized into control group which received conventional treatment, and treatment group which received Xuezhitong capsules plus. There were 86 patients in each group. Therapeutic effect, levels of inflammatory factors, i.e., high-sensitivity C- reactive protein (hs-CRP), interleukin-(IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial factors such as nitric oxide (NO), thromboxane B2 (TXB2) and endothelin (ET), were determined.Results: Markedly higher total treatment effectiveness was observed in the treatment group than in the control group (89.53 % vs. 72.94 %; p < 0.05). In both groups, treatment reduced the levels of hs-CRP, IL-6, TNF-α, TXB2 and ET, but elevated NO, with better results for treatment group than the control group (p < 0.05). Better optimizations of total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein (HDL) were observed in the treatment group, relative to the control group (p < 0.05). Patients in the treatment group experienced fewer (8.14%) adverse reactions than those in control group (21.18 %, p < 0.05).Conclusion: Xuezhitong capsule, when combined with conventional treatment, exerts high therapeutic effectiveness and safety in MVA patients by inhibiting inflammatory reactions, optimizing endothelialfunction, reducing blood lipid levels, and decreasing the incidence of cardiovascular adverse events. Thus, the combination therapy is a potentially superior therapeutic strategy to the conventional approach for the management of MVA patients.

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Comparative evaluation of amoxicillin plus metronidazole and doxycycline alone in the nonsurgical treatment of localized aggressive periodontitis

Indian Journal of Oral Sciences ◽

10.4103/0976-6944.144514 ◽

2014 ◽

Vol 5 (3) ◽

pp. 112

Author(s):

Rajasekhar Nutalapati ◽

SureshKumar Kasagani ◽

NarendraDev Jampani ◽

RameshBabu Mutthineni ◽

Srikanth Chintala ◽

...

Keyword(s):

Comparative Evaluation ◽

Aggressive Periodontitis ◽

Nonsurgical Treatment ◽

Localized Aggressive Periodontitis

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One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis

Cytokine ◽

10.1016/j.cyto.2018.12.019 ◽

2019 ◽

Vol 116 ◽

pp. 27-37 ◽

Cited By ~ 3

Author(s):

E.S. Martins ◽

J.B. César-Neto ◽

E. Albuquerque-Souza ◽

E.S. Rebeis ◽

M. Holzhausen ◽

...

Keyword(s):

Aggressive Periodontitis ◽

Immune Profile ◽

Localized Aggressive Periodontitis ◽

One Year

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Therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis

Journal of International Medical Research ◽

10.1177/0300060519873461 ◽

2019 ◽

Vol 48 (3) ◽

pp. 030006051987346 ◽

Cited By ~ 1

Author(s):

Jun Zhang ◽

Jing Yin ◽

Daohong Zhao ◽

Chaoran Wang ◽

Yuhao Zhang ◽

...

Keyword(s):

Therapeutic Effect ◽

Mechanism Of Action ◽

Rat Model ◽

Dependent Manner ◽

Nuclear Factor ◽

Toll Like Receptor ◽

Tnf Α ◽

Dose Dependent ◽

Light Chain Enhancer ◽

Necrosis Factor

Objective To study the therapeutic effect and mechanism of action of quercetin in a rat model of osteoarthritis (OA). Methods The OA rat model was established by intra-articular injection of papain. Changes in knee diameter, toe volume and histopathology were measured. Levels of interleukin (IL)-β and tumor necrosis factor (TNF)-α were assessed by ELISA. Relative expression of Toll-like receptor (TLR)-4 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) was evaluated by western blotting. Results Compared with rats treated with papain alone, changes in knee diameter, toe volume and Makin' s score were less apparent in OA rats treated with quercetin. Levels of serum IL-1β and TNF-α were also reduced in quercetin-treated OA rats. Expression of TLR-4 and NF-κB was significantly suppressed in a dose-dependent manner in quercetin-treated OA rats. Conclusion Quercetin exhibited a therapeutic effect in OA rats, which may be related to inhibition of IL-1β and TNF-α production via the TLR-4/NF-κB pathway.

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Clinical Evaluation of Intrabony Defects in Localized Aggressive Periodontitis Patients with and without Bioglass- An In-vivo Study

Kathmandu University Medical Journal ◽

10.3126/kumj.v10i1.6906 ◽

2012 ◽

Vol 10 (1) ◽

pp. 7-10

Author(s):

KV Satyanarayana ◽

BR Anuradha ◽

G Srikanth ◽

P Mohan Chandra ◽

T Anupama ◽

...

Keyword(s):

Bioactive Glass ◽

Test Group ◽

Gingival Recession ◽

Aggressive Periodontitis ◽

Control Group ◽

Defect Depth ◽

Clinical Attachment Level ◽

Probing Depth ◽

Localized Aggressive Periodontitis ◽

Attachment Level

Background Aggressive periodontitis is a specific type of periodontitis with clearly identifiable clinical characteristics such as “rapid attachment loss, bone destruction” and “familial aggregation”. Regeneration of mineralized tissues affected by aggressive periodontitis comprises a major scientific and clinical challenge. In recent years some evidence has been provided that bioactive glass is also capable of supporting the regenerative healing of periodontal lesions. Objective The aim of this clinical and radiological prospective study was to evaluate the efficacy of bioactive glass in the treatment of intra-bony defects in patients with localized aggressive periodontitis. Methods Twelve localized aggressive periodontitis patients with bilaterally located three-walled intra-bony defect depth ? 2 mm, preoperative probing depths ? 5 mm were randomly treated either with the bioactive glass or without the bioactive glass. The clinical parameters plaque index, gingival index, probing depth, gingival recession, clinical attachment level, and mobility were recorded prior to surgery as well as 12 months after surgery. Intraoral radiographs were digitized to evaluate the bone defect depth at baseline and 12 months after the surgery. Results After 12 months, a reduction in probing depth of 3.92 + 0.313 mm (P <0.001) and a gain in clinical attachment level of 4.42+0358mm (P <0.001) were registered in the test group. In the control group, a reduction in probing depth of 2.5 +0.230mm (P <0.001) and a gain in clinical attachment level of 2.58 + 0.149 mm (P<0.001) was recorded. Radiographically, the defects were found to be filled by 2.587 + 0.218 mm (P <0.001) in the test group and by 0.1792 + 0.031mm (P <0.001) in the control group. Changes in gingival recession showed no significant differences. . Conclusion Highly significant improvements in the parameters Probing depth, Clinical attachment level, and Bone defect depth were recorded after 12 months, with regenerative material. KATHMANDU UNIVERSITY MEDICAL JOURNAL VOL.10 | NO. 1 | ISSUE 37 | JAN - MAR 2012 | 11-15 DOI: http://dx.doi.org/10.3126/kumj.v10i1.6906

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