scholarly journals Integrated analysis of immunocyte infiltration and differential gene expression in tricuspid aortic valve-associated thoracic aortic aneurysms

2020 ◽  
Vol 8 (6) ◽  
pp. 285-285
Author(s):  
Xiaoping Fan ◽  
Jihai Peng ◽  
Liming Lei ◽  
Jie He ◽  
Jinsong Huang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Aortic Valve ◽  
Differential Gene Expression ◽  
Aortic Aneurysms ◽  
Integrated Analysis ◽  
Thoracic Aortic Aneurysms ◽  
Tricuspid Aortic Valve ◽  
Differential Gene

scholarly journals Wall stress on ascending thoracic aortic aneurysms with bicuspid compared with tricuspid aortic valve

2018 ◽  
Vol 156 (2) ◽  
pp. 492-500 ◽  
Author(s):  
Yue Xuan ◽  
Zhongjie Wang ◽  
Raymond Liu ◽  
Henrik Haraldsson ◽  
Michael D. Hope ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Wall Stress ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
Tricuspid Aortic Valve

scholarly journals Altered Pattern of Gene Expression in Thoracic Aortic Aneurysms in Patients with Trileaflet and Bileaflet Aortic Valve: A Pilot Study Using Affymetrix Gene Chips

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Ramanath Majumdar ◽  
Takieddine Sami ◽  
Marineh Yagubyan ◽  
Gobinda Sarkar ◽  
Mark Bolander ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pilot Study ◽  
Aortic Valve ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
Gene Chips

scholarly journals Difference in hemodynamic and wall stress of ascending thoracic aortic aneurysms with bicuspid and tricuspid aortic valve

2013 ◽  
Vol 46 (10) ◽  
pp. 1729-1738 ◽  
Author(s):  
Salvatore Pasta ◽  
Antonino Rinaudo ◽  
Angelo Luca ◽  
Michele Pilato ◽  
Cesare Scardulla ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Wall Stress ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
Tricuspid Aortic Valve

The Relationship Between Diameter and Wall Stress in Ascending Thoracic Aortic Aneurysms With a Tricuspid Aortic Valve

2021 ◽  
Vol 5 (sup1) ◽  
pp. 14-14
Author(s):  
Axel O. Gomez ◽  
Zhongjie Wang ◽  
Yue Xuan ◽  
Liang Ge ◽  
Elaine E. Tseng
Keyword(s):  
Aortic Valve ◽  
Wall Stress ◽  
Aortic Aneurysms ◽  
Thoracic Aortic Aneurysms ◽  
Tricuspid Aortic Valve ◽  
The Relationship

Abstract 16886: Wall Stress Profiles in Tricuspid Aortic Valve Associated Ascending Thoracic Aortic Aneurysms: The Effect of Surgical Threshold Diameter ≥5.5cm

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Axel Gomez ◽  
Zhongjie Wang ◽  
Yue XUAN ◽  
Liang Ge ◽  
Elaine E Tseng
Keyword(s):  
Aortic Valve ◽  
Systolic Pressure ◽  
Peak Stress ◽  
Wall Stress ◽  
Aortic Aneurysms ◽  
Patient Specific ◽  
Thoracic Aortic Aneurysms ◽  
Tricuspid Aortic Valve ◽  
Elective Repair ◽  
Longitudinal Wall

Introduction: Ascending thoracic aortic aneurysms (aTAAs) carry a risk of dissection. Elective repair guidelines are designed around size thresholds, but the one-dimensional parameter is insufficient to predict acute events in small aneurysms. Biomechanically, aortic events can occur when wall stress exceeds wall strength. Patient-specific aTAA wall stresses may be a better predictor of complications. Our aim was to compare wall stresses in aTAAs associated with a tricuspid aortic valve (TAV) based on diameter. Methods: Patients with TAV-aTAA and diameter >4.0cm (n=448) were divided into groups by 0.5 cm diameter increments. Pre-stress three-dimensional aneurysm geometries were reconstructed from ECG-gated computer tomography images. A fiber-embedded hyperelastic material model was applied to obtain longitudinal and circumferential wall stress distributions under systolic pressure. Medians with interquartile ranges are reported. The Kruskal-Wallis test is used for comparisons between size groups. Results: Peak longitudinal wall stresses for TAV-aTAA were 308[282-338] kPa for size 4.0-4.4cm vs 341[309-362] kPa for 4.5-4.9cm vs 339[289-370] kPa for 5.0-5.4cm vs 319[297-355] kPa for 5.5-5.9cm vs 373[364-449] for 6.0cm (p=0.003). Peak circumferential wall stresses were 487[448-579] kPa for size 4.0-4.4cm vs 516[473-619] kPa for 4.5-4.9cm vs 506[422-580] kPa for 5.0-5.4cm vs 540[468-591] kPa for 5.5-5.9cm vs 565[506-634] for >6.0cm (p=0.19) (figure). 95th-percentile longitudinal peak stress for TAV-aTAA <5.5cm vs ≥5.5cm is 408 vs 465 kPa. Conclusions: Longitudinal wall stresses are higher as diameter increases. The 95% percentile longitudinal peak stress for diameter ≥5.5cm is ~450 kPa, which correlates with established ~5% dissection risk for size ≥5.5cm. Wall stress thresholds may be a better predictor of patient-specific risk of dissection than diameter and require testing in clinical trials.

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