scholarly journals Extracellular vesicles in prostate cancer: a narrative review

2021 ◽  
Vol 10 (4) ◽  
pp. 1890-1907
Author(s):  
Koji Hatano ◽  
Kazutoshi Fujita
Keyword(s):  
Prostate Cancer ◽  
Extracellular Vesicles ◽  
Narrative Review

miRNA-expression in prostate cancer-associated fibroblasts and their extracellular vesicles

2021 ◽  
Vol 79 ◽  
pp. S584
Author(s):  
J. Linxweiler ◽  
H. Ayoubian ◽  
D. Himbert ◽  
M. Saar ◽  
M. Stöckle ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Vesicles ◽  
Mirna Expression ◽  
Cancer Associated Fibroblasts

scholarly journals Detection of Prostate Cancer via IR Spectroscopic Analysis of Urinary Extracellular Vesicles: A Pilot Study

Membranes ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 591
Author(s):  
Xin-Le Yap ◽  
Bayden Wood ◽  
Teng-Aik Ong ◽  
Jasmine Lim ◽  
Bey-Hing Goh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Extracellular Vesicles ◽  
Cancer Progression ◽  
Prostate Cancer Screening ◽  
Principal Component ◽  
Urine Samples ◽  
Cancer Type ◽  
Marker Proteins ◽  
Novel Strategy ◽  
Ir Spectroscopic

Extracellular vesicles (EVs) are membranous nanoparticles naturally released from living cells which can be found in all types of body fluids. Recent studies found that cancer cells secreted EVs containing the unique set of biomolecules, which give rise to a distinctive absorbance spectrum representing its cancer type. In this study, we aimed to detect the medium EVs (200–300 nm) from the urine of prostate cancer patients using Fourier transform infrared (FTIR) spectroscopy and determine their association with cancer progression. EVs extracted from 53 urine samples from patients suspected of prostate cancer were analyzed and their FTIR spectra were preprocessed for analysis. Characterization of morphology, particle size and marker proteins confirmed that EVs were successfully isolated from urine samples. Principal component analysis (PCA) of the EV’s spectra showed the model could discriminate prostate cancer with a sensitivity of 59% and a specificity of 81%. The area under curve (AUC) of FTIR PCA model for prostate cancer detection in the cases with 4–20 ng/mL PSA was 0.7, while the AUC for PSA alone was 0.437, suggesting the analysis of urinary EVs described in this study may offer a novel strategy for the development of a noninvasive additional test for prostate cancer screening.

scholarly journals Narrative review of Mediterranean diet in Cilento: longevity and potential prevention for prostate cancer

2021 ◽  
Vol 13 ◽  
pp. 175628722110264
Author(s):  
Matteo Ferro ◽  
Giuseppe Lucarelli ◽  
Carlo Buonerba ◽  
Daniela Terracciano ◽  
Giovanni Boccia ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mediterranean Diet ◽  
Narrative Review

Salvage local treatment for localized radio-recurrent prostate cancer: a narrative review and future perspectives

2021 ◽  
Author(s):  
David Büchser ◽  
Rafael Medina ◽  
Esther Mayrata ◽  
Alba González ◽  
Marina Marban ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Local Treatment ◽  
Focus Ultrasound ◽  
Disease Recurrence ◽  
High Dose Rate ◽  
Narrative Review ◽  
High Dose ◽  
Treatment Techniques ◽  
Frequent Site ◽  
New Treatment

Although dose escalation protocols have improved biochemical control in prostate cancer radiotherapy, 10–45% of patients will experience disease recurrence. The prostate and seminal vesicles are the most frequent site of the first relapse. Traditionally, these patients have been managed with hormonal therapy, which is not curative. Recent improvements in diagnostic tests (e.g., multiparametric magnetic resonance and molecular imaging, including PET/CT scan with choline or Ga-PSMA) and new treatment techniques (e.g., stereotactic body radiation therapy or other minimally invasive alternatives like high-intensity focus ultrasound, cryoablation or high-dose-rate brachytherapy) offer new therapeutic strategies with the potential to cure some patients with limited adverse effects. In this narrative review, the authors present the most recent evidence to help identify the most suitable candidates for salvage treatment.

scholarly journals Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles

2017 ◽  
Vol 6 (1) ◽  
pp. 1354645 ◽  
Author(s):  
Elisa Lázaro-Ibáñez ◽  
Maarit Neuvonen ◽  
Maarit Takatalo ◽  
Uma Thanigai Arasu ◽  
Cristian Capasso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cell ◽  
Extracellular Vesicles ◽  
Prostate Cancer Cell

scholarly journals Label-Free Prostate Cancer Detection by Characterization of Extracellular Vesicles Using Raman Spectroscopy

2018 ◽  
Vol 90 (19) ◽  
pp. 11290-11296 ◽  
Author(s):  
Wooje Lee ◽  
Afroditi Nanou ◽  
Linda Rikkert ◽  
Frank A. W. Coumans ◽  
Cees Otto ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Raman Spectroscopy ◽  
Extracellular Vesicles ◽  
Cancer Detection ◽  
Label Free ◽  
Prostate Cancer Detection

scholarly journals Does Physical Activity Regulate Prostate Carcinogenesis and Prostate Cancer Outcomes? A Narrative Review

2020 ◽  
Vol 17 (4) ◽  
pp. 1441 ◽  
Author(s):  
Marco Capece ◽  
Massimiliano Creta ◽  
Armando Calogero ◽  
Roberto La Rocca ◽  
Luigi Napolitano ◽  
...  
Keyword(s):  
Physical Activity ◽  
Prostate Cancer ◽  
Functional Outcomes ◽  
Narrative Review ◽  
Common Disease ◽  
Prostate Carcinogenesis ◽  
Patients At Risk ◽  
The Impact ◽  
Circulating Levels

Background: Prostate cancer (PCa) represents a common disease in men aged >65 years. The role of physical activity (PA) in patients at risk or diagnosed with PCa represents an evolving issue. We aimed to summarize available evidences about the impact of PA on the pathophysiology and clinical outcomes of PCa. Methods: We performed a narrative review. Evidences about the role of PA in elderly patients in terms of PCa biology, epidemiology, oncological and functional outcomes, as well as in terms of impact on the outcomes of androgen deprivation therapy (ADT) were summarized. Results: Potential pathophysiological pathways hypothesized to explain the benefits of PA in terms of prostate carcinogenesis include circulating levels of Insulin-like growth factor-1 (IGF-1), oxidative stress, systemic inflammation, sex hormones, and myokines. Clinically, emerging evidences support the hypothesis that PA is associated with decreased PCa risk, improved PCa-related survival, improved functional outcomes, and reduced ADT-related adverse events.

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