A Study of Clinical Profile and Associated Factors in the Patients of Polycystic Ovarian Syndrome

2017 ◽  
Vol 5 (3) ◽  
pp. 405-407
Author(s):  
Kranti V. Kendre ◽  
◽  
Shalini S. Gadale ◽  
Author(s):  
Tripti Nagaria ◽  
Arpita Mohapatra ◽  
Jyoti Jaiswal

Background: Polycystic ovarian syndrome (PCOS) also known as hyperandrogenic anovulation syndrome or Stein – Leventhal syndrome is an endocrine disorder, characterized by anovulation, oligomenorrhea, amenorrhea, features of androgenic hormone excess (hirsutism, acne, alopecia, seborrhea) and insulin resistance. The global prevalence ranges from 2.2% to 26%. Methods: A prospective observational study was conducted from December 2015 to December 2016 in Department of Obstetrics and Gynecology at Pt. Jawahar Lal Nehru Memorial medical college and associated Dr. Bhim Rao Ambedkar memorial hospital, Raipur (C.G.) after obtaining permission of ethical committee of the institute to evaluate the effect of myoinositol and metformin on clinical profile in patients of polycystic ovarian syndrome. 70 women were included in the study who received a combination of myoinositol 600mg and metformin 500mg (twice a day) for 3 months for the management of PCOS. Prior to the start of the therapy, a detailed history and baseline investigations were recorded. Cases were reassessed at the end of three months of therapy for evaluation of change in clinical and hormonal profile.Results: 90.09% (63/70) cases showed improvement in the menstrual complaints. Spontaneous onset of menses occurred in all the cases presented with amenorrhea, in nearly 90% within 2 months of start of treatment. Regularization of cycles was observed in nearly 50% of patients with infrequent menses. Amongst all the cases with cutaneous manifestations, maximum improvement was seen in cases of acne (4/6) i.e. 66.66%. 25% (5/20) patients with infertility conceived during the study period.Conclusions: Myoinositol with metformin in combination has resulted in significant improvement in the clinical profile with reduction in individual drug dosage in cases with PCOS.


2016 ◽  
Vol 9 (1) ◽  
pp. 1-6
Author(s):  
Hifsa Mobeen ◽  
Hamdan Hamid ◽  
Almina Shafiq ◽  
Muhammad Adil ◽  
Muhammad Kashif ◽  
...  

2014 ◽  
Vol 31 (3) ◽  
pp. 140-143
Author(s):  
SA Anwary ◽  
S Chowdhury ◽  
P Fatima ◽  
M Alfazzaman ◽  
N Begum ◽  
...  

Objective: This study tried to evaluate association of other factors of subfertility in women suffering from polycystic ovarian syndrome (PCOS). Methods: Fifty subfertile women suffering from PCOS attending infertility unit of the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, during July 2010 and June 2011, were evaluated. Results: In out study, Age, BMI and duration of marriage range was 20 38 years, 17.70 33.20 kg/m2 and 1 16 years, respectively. Serum FSH was normal (1.0 10.0 mIU/ml) in all 50 (100%) women. Hyperprolactinaemia (serum prolactin >25 ng/ml) was seen in 60%. Hypothyroidism (serum TSH >4 ìIU/ml) was seen in 74% women. Serum LH (>10 mIU/ml) was raised in 74%. USG finding of lower abdomen was abnormal in 75% cases. Conclusion: This study concludes that hyperprolactinaemia and subclinical hypothyroidism were associated causes of subfertility other than PCOS. DOI: http://dx.doi.org/10.3329/jbcps.v31i3.20980 J Bangladesh Coll Phys Surg 2013; 31: 140-143


2019 ◽  
Vol 56 (3) ◽  
pp. 289
Author(s):  
Rita Singh Raghuvanshi ◽  
Shweta Suri ◽  
Priyanka Tangariya ◽  
Himani Joshi ◽  
Nalini Trivedi ◽  
...  

The cross sectional community based study was conducted to assess the prevalence of Polycystic Ovarian Syndrome (PCOS) and its associated factors among college going girls (20-30 years) residing in hostels of U.S. Nagar district of Northern India. The data on 250 subjects was obtained using self-designed pre-tested questionnaires during March to June 2018. Information was collected on menstrual and clinical history, dietary history, physical activity parameters and general information of subjects. The data was presented in percentages; chi square analysis, correlation analysis and rate ratio was also used to analyze the association between dependent and independent variables. The results showed that the prevalence of PCOS was 6% as evaluated by clinical diagnostic tool used in the questionnaire. A total of 18.4% subjects reported variable or long menstrual cycles, 6% subjects reported less than 9 menses annually and 7.2% subjects reported irregular menses with weight gain. A significant association was found between PCOS and high body mass index values and sedentary physical activity level. It was found that overweight and obese subjects have seven times higher risk of developing PCOS as compared to underweight and normal individuals. Also subjects with sedentary physical activity level have eight times higher risk of developing PCOS as compared to their counterparts with moderate physical activity. No strong association was found between PCOS and fast food consumption. The study concluded that body mass index and physical activity level of subjects were associated with poly cystic ovary syndrome (PCOS) using rate ratio as a tool. The study results indicate the need to conduct large study on PCOS in India.


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