Spurious Elevation of Ca-125 in Benign Ovarian Tumour

2017 ◽  
Vol 6 (2(Part-1)) ◽  
pp. 327-329
Author(s):  
Vincy T.M. ◽  
◽  
Kanchana M.P. ◽  
Keyword(s):  
Ovarian Tumour ◽  
Ca 125 ◽  
Benign Ovarian Tumour

Serous cystadenoma of ovary with xanthogranulomatous oophoritis: combination of benign ovarian tumour with chronic inflammatory non-neoplastic pseudo-tumour-a rarity

2017 ◽  
Vol 6 (4) ◽  
pp. 1682
Author(s):  
Monika Anant ◽  
Kajal Sinha ◽  
Mukta Agarwal ◽  
Hemali H. Sinha ◽  
Punam Bhadani
Keyword(s):  
Chronic Inflammation ◽  
Female Genital Tract ◽  
Benign Neoplasm ◽  
Ovarian Tumour ◽  
Serous Cystadenoma ◽  
Rare Type ◽  
Macroscopic Appearance ◽  
Xanthogranulomatous Inflammation ◽  
Benign Ovarian Tumour ◽  
Female Genital

Xanthogranulomatous inflammation is a rare type of chronic inflammation. It destroys the tissue of the affected organ, mostly affecting the kidney and gall bladder. Xanthogranulomatous inflammation of female genital tract being a rare entity, only few numbered cases involving the ovary have been reported in literature. This chronic inflammation of fallopian tubes and ovaries, usually present with pelvic masses, and on imaging and macroscopic appearance, are mostly misdiagnosed as ovarian neoplasm or tuberculosis. We are presenting a case of 14-year-old girl, who presented with an abdominal lump and on clinical and radiological investigations was suspected as ovarian malignancy but histo-pathology reported it as serous cystadenoma with xanthogranulomaotus oophoritis. The rarity of this case lies in the fact that rare destructive inflammatory features was present in a benign neoplasm of the ovary (serous cystadenoma) and that too in a youngest age reported till now.

scholarly journals A rare benign ovarian tumour

2016 ◽  
pp. bcr2015214101 ◽  
Author(s):  
Marta Morna Palmeiro ◽  
Teresa Margarida Cunha ◽  
Ana Luisa Loureiro ◽  
Gonçalo Esteves
Keyword(s):  
Ovarian Tumour ◽  
Benign Ovarian Tumour

Role of laparoscopy in benign ovarian tumour

2019 ◽  
Vol 11 (1) ◽  
pp. 01-03
Author(s):  
Suvarna Samir Bhopale ◽  
◽  
Shyam Shirsam ◽  
Keyword(s):  
Ovarian Tumour ◽  
Benign Ovarian Tumour

scholarly journals A case of broad ligament leiomyoma presenting as an ovarian mass

2017 ◽  
Vol 6 (6) ◽  
pp. 2635
Author(s):  
Rajesh Kumari ◽  
Vandana Vaishya ◽  
Vidushi Kulshrestha ◽  
Jai Bhagwan Sharma ◽  
Alka Kriplani
Keyword(s):  
Histopathological Examination ◽  
Abdominal Cavity ◽  
Broad Ligament ◽  
Lower Abdominal Pain ◽  
Abdominal Distension ◽  
Ovarian Tumour ◽  
Ca 125 ◽  
Cystic Degeneration ◽  
Limited Mobility ◽  
Computer Tomography Scan

The broad ligament is the commonest extra uterine site for the occurrence of leiomyoma but with a very low incidence rate. It poses both clinical and radiological challenge in differentiating from an ovarian tumour. A 25-year-old unmarried female presented with history of lower abdominal pain associated with rapidly increasing abdominal distension for last 3 months. General physical examination was unremarkable. Examination of the abdomen revealed a firm, non-tender mass, with limited mobility arising from the pelvis corresponding to a uterine size of 32 weeks. Ultrasonography of abdomen revealed a 20×17×11cm right adnexal multi-loculated cyst. Contrast enhanced computer tomography scan of abdomen and pelvis showed a 12×17×17 cm well defined cystic lesion arising from the pelvis and ascending in to the abdominal cavity. The lesion also showed internal septa and peripheral rim enhancement. Right ovary was not seen separately. Tumor markers including CA-125 (22.4 IU/ ml), CEA (1.83/ml), CA-19.9 (22U/ml), Beta HCG (1.20IU/ ml), LDH (1.17IU/ml), and alpha feto-protein (0.8 ng/ml) were within normal limit. Laparotomy revealed a cystic mass arising from the right broad ligament. Histopathological examination revealed a broad ligament leiomyoma with extensive cystic degeneration. Broad ligament leiomyoma is uncommon tumour of pelvis and its differentiation from ovarian masses may be challenging for the clinicians. 

scholarly journals Metastatic Renal Cell Carcinoma in an Ovarian Benign Mixed Mucinous Cystadenoma and Brenner Tumour: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Amar Ibrahim ◽  
Mohammad Salih Al-Jafari
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Abdominal Mass ◽  
Mucinous Cystadenoma ◽  
Ovarian Tumour ◽  
Therapeutic Implications ◽  
Benign Ovarian Tumour ◽  
Rule Out

This is a case of a 71-year-old woman, who presented with a large abdominal mass. Microscopic examination revealed metastatic renal cell carcinoma in an otherwise massively enlarged benign ovarian tumour of mixed mucinous cystadenoma and Brenner tumour. Clinicopathological and radiological assessment together with a thorough evaluation of gross and histological features, including the use of immunohistochemical stains, is essential to confirm the diagnosis and rule out the possibility of primary clear cell carcinoma of ovary, as this has important prognostic and therapeutic implications.

scholarly journals A Benign Ovarian Tumour developing an Endometrial Cancer? Sertoliform Ovarian Cystoadenoma getting together with an Endometrioid Adenocarcinoma

10.3823/1818 ◽  
2015 ◽  
Author(s):  
J. Martinez-Mas ◽  
A. Bueno-Crespo ◽  
P. J. Garcia-Laencina ◽  
J.P. Martinez-Cendan ◽  
A. Isaac-Montero ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Ovarian Tumour ◽  
Endometrioid Adenocarcinoma ◽  
Benign Ovarian Tumour

scholarly journals T-cadherin in epithelial ovarian cancer: relationship with cancer progression and drug resistanceT-cadherin in epithelial ovarian cancer: relationship with cancer progression and drug resistance

2020 ◽  
Author(s):  
Yutao Guan ◽  
Yi Lin ◽  
Fubin Zhang ◽  
Ling-ling Zhou ◽  
Yang-ping Chen ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Resistance ◽  
Ovarian Carcinoma ◽  
Epithelial Ovarian Cancer ◽  
Cancer Progression ◽  
Carcinoma Cell ◽  
Ovarian Tumour ◽  
Epithelial Ovarian Carcinoma ◽  
Migration And Invasion ◽  
Benign Ovarian Tumour

Abstract Background: T-cadherin plays a crucial role in maintaining normal tissue structure by regulating specific cell adhesion, cellular recognition and signal transduction. The purpose of this study was to evaluate whether T-cadherin influences epithelial ovarian cancer (EOC) progression, differentiation and drug resistance and its possible mechanisms.Methods: Epithelial ovarian carcinoma (EOC, n=63) and relevant contralateral normal ovarian (CNO, n=41) fresh tissues were collected from epithelial ovarian carcinoma patients, and benign ovarian tumour fresh tissues were collected from 55 patients with benign ovarian tumours. The human epithelial ovarian carcinoma cell line A2780 was cultured. T-cadherin expression was assessed by real-time RT-PCR and Western blotting, and the expression of matrix metalloproteinase-2 (MMP-2) was detected by Western blotting. pcDNA‑T‑cad plasmid technology was used to upregulate T-cadherin expression. In addition, A2780 cell migration and invasion ability, viability, colony formation, proliferation, apoptosis and sensitivity to paclitaxel were measured.Results: T‑cadherin mRNA and protein expression in EOC tissues from EOC patients was significantly downregulated, and there was no significant difference between the matched contralateral normal ovarian fresh tissue from the same patient and the benign ovarian tumour tissues from other patients. The migration and invasion abilities, viability, colony formation, and proliferation were attenuated by restoration of T‑cadherin expression in A2780 cells via pcDNA‑T‑cad transfection; apoptosis, MMP-2 expression and sensitivity to Taxol were also enhanced by restored T‑cadherin expression. The T‑cadherin expression level was well correlated with the clinical characteristics and symptoms of EOC patients, including tumour stage, histology, lymph node metastasis, tumour size, distant metastasis and cisplatin resistance.Conclusions: T‑cadherin participates in the processes of epithelial ovarian carcinoma cell migration, invasion, proliferation, apoptosis and sensitivity to paclitaxel and can regulate the expression of MMP-2. Downregulation of T‑cadherin expression may contribute to epithelial ovarian cancer progression, differentiation and drug resistance.

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