The Relationship between Glycemic Load, Fiber, Magnesium, Zinc, Stress, Physical Activity and Fasting Blood Glucose Level of Woman Patients with Type 2 Diabetes Mellitus in Cibinong Hospital 2018

BackgroundPrevious studies showed altered angiopoietin-like protein-8 (ANGPTL-8) and resistin circulating levels in type 2 diabetes mellitus (T2DM). Whether or not the alteration in ANGPTL-8 and resistin level can be a predictive maker for increased diabetic nephropathy risk remains unclear.AimTo Investigate the possible association of ANGPTL-8 and resistin with DN, and whether this association is affected by NAFLD status.MethodsA total of 278 T2DM patients were enrolled. Serum levels of ANGPTL8, resistin, BMI, blood pressure, duration of diabetes, glycosylated hemoglobin (HbA1c), fasting blood glucose (FPG), hypersensitive C-reactive protein (hs-CRP), lipid profile, liver, and kidney function tests were assessed. The relationship between DN with ANGPTL8 and resistin was analyzed in the unadjusted and multiple-adjusted regression models.ResultsSerum levels of ANGPTL8 and resistin were significantly higher in DN compared with T2DM subjects without DN (respectively; P <0.001), especially in non-NAFLD populations. ANGPTL8 and resistin showed positive correlation with hs-CRP (respectively; P<0.01), and negative correlation with estimated GFR (eGFR) (respectively; P=<0.001) but no significant correlation to HOMA-IR(respectively; P>0.05). Analysis showed ANGPTL8 levels were positively associated with resistin but only in T2DM patients with DN(r=0.1867; P<0.05), and this significant correlation disappeared in T2DM patients without DN. After adjusting for confounding factors, both ANGPTL8(OR=2.095, 95%CI 1.253-3.502 P=0.005) and resistin (OR=2.499, 95%CI 1.484-4.208 P=0.001) were risk factors for DN. Data in non-NAFLD population increased the relationship between ANGPTL8 (OR=2.713, 95% CI 1.494-4.926 P=0.001), resistin (OR=4.248, 95% CI 2.260-7.987 P<0.001)and DN. The area under the curve (AUC) on receiver operating characteristic (ROC) analysis of the combination of ANGPTL8 and resistin was 0.703, and the specificity was 70.4%. These data were also increased in non-NAFLD population, as the AUC (95%CI) was 0.756, and the specificity was 91.2%.ConclusionThis study highlights a close association between ANGPTL8, resistin and DN, especially in non-NAFLD populations. These results suggest that ANGPTL-8 and resistin may be risk predictors of DN.

Download Full-text

The Relationship between Smartphone-Based Physical Activity and BMI in Type 2 Diabetes Mellitus Patients

Journal of the Korean society for Wellness ◽

10.21097/ksw.2020.02.15.1.389 ◽

2020 ◽

Vol 15 (1) ◽

pp. 389-398

Author(s):

Reum Jung Ah ◽

Ae Kim Shin ◽

Tae Kim Kun ◽

Taek Lee Dae ◽

Kun Ho Yoon ◽

...

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

The Relationship

Download Full-text

Pola Makan Dan Aktivitas Fisik Pada Pasien Diabetes Mellitus Tipe 2 Di Rumah Sakit Pancaran Kasih Manado

Jurnal GIZIDO ◽

10.47718/gizi.v11i2.765 ◽

2019 ◽

Vol 11 (2) ◽

pp. 57-62

Author(s):

I Made Djendra ◽

Muksin Made Pasambuna ◽

Siani Pintan

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Blood Sugar ◽

Eating Patterns ◽

Diet And Physical Activity ◽

Sugar Levels ◽

The Relationship

The purpose of this study was to determine the relationship between diet and physical activity on blood sugar levels of Type 2 Diabetes Mellitus patients at Pancaran Kasih Hospital in Manado City and the results of this study can be used as input material for patients to be able to maintain their diet and regulate physical activity to control blood sugar levels remain at normal limits. Diabetes mellitus is a chronic condition where the body cannot or does not produce insulin optimally. The study design used was a type of observational study with a cross sectional approach to determine the relationship between risk factors and disease. In this study used 2 independent variables, namely diet and physical activity and the dependent variable Diabetes Mellitus. The method of taking samples is using purposive sampling in accordance with the proposed inclusion and exclusion criteria. The samples needed in this study were 41 people determined by the Slovin formula. From the results of this study note that eating patterns have a value of p = 0.00, p <0.05 which means there is a significant relationship with eating patterns with blood sugar levels of Type 2 Diabetes Mellitus patients. Results of physical activity p = 0.03, p < 0.05 which means there is a significant relationship between physical activity and blood sugar levels in Type 2 Diabetes Mellitus patients at Pancaran Kasih Hospital in Manado City.

Download Full-text

Comparative Hypoglycaemic Activity of Fixed Dose Combination Anti-Diabetic Formulations Versus Respective Monotherapies in Diabetic Rabbits

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.11.3.17 ◽

2020 ◽

Vol 11 (03) ◽

pp. 409-416

Author(s):

Rajarao Chinta ◽

Rohini Pilli

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Fasting Blood Glucose ◽

Fixed Dose Combination ◽

Fixed Dose ◽

Fasting Blood Glucose Level ◽

Hypoglycaemic Activity ◽

Dose Combination

Type 2 diabetes mellitus is a disease of impaired glucose homeostasis and chronic hyperglycemia. Current approaches for the treatment frequently involving the use of combination therapy. The aim of the present study was to evaluate and compare the hypoglycaemic activity of fixed-dose combination anti-diabetic formulations and respective individual agents using rabbits as an animal model. Experimental diabetes was induced by a single intravenous injection of alloxan monohydrate at a dose of 150 mg/kg. Individual drugs and combination tablets were administered to experimental groups. Fasting blood glucose level was estimated at 0, 1, 2, 4, 6, 8, 10, 12, 24, 36, 48, and 72 hours using glucometer. Data were statistically analyzed using student t-test and p less than 0.05 considered as statistically significant. The reduction in fasting blood glucose level in diabetes-induced rabbits was significantly higher with combination products compared to individual drugs. Fixed-dose combination products had shown improved glycaemic control than individual agents. Fixed-dose combination therapy can be used as a suitable option for selected patients requiring multiple glucose-lowering therapies for use as an adjunct to diet and exercise to improve glycaemic control in type 2 diabetes mellitus.

Download Full-text

Hubungan Asupan Makanan Berisiko Dan Aktivitas Fisik Dengan Kejadian Diabetes Melitus Tipe II Di Kota Kupang

JURNAL INFO KESEHATAN ◽

10.31965/infokes.vol16.iss1.168 ◽

2018 ◽

Vol 16 (1) ◽

pp. 44-58

Author(s):

Maria Sambriong

Keyword(s):

Physical Activity ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Food Intake ◽

Energy Intake ◽

Visceral Obesity ◽

P Value ◽

The Relationship

Diabetes mellitus (DM) is a serious threat to health development and ranked 6th as a cause of death. About 1.3 million people die from diabetes and 4% die before age 70 (Infodatin, 2014). In the province of East Nusa Tenggara, this disease ranks 19th has increased to 3 times compared to 2007. Cases of diabetes mellitus in the city of Kupang vary greatly in each age group wherein 2014 the proportion of the highest cases was at age 65-75 years totaling 780 people (Kupang City Health Profile, 2014). High energy intake from pure carbohydrates will stimulate insulin secretion by pancreatic beta cells as compensation to increase blood sugar levels. At a certain level, compensation efforts will not be able to compensate for insulin resistance so insulin insufficiency will arise with glucose intolerance (Waspadji et al., 2003). Polikandrioti and Dokoutsidou (2009), said obesity and lack of physical activity are also directly closely related to insulin resistance as is the characteristic of type 2 diabetes mellitus. This study was to analyze the relationship between risky food intake and physical activity with the incidence of type 2 diabetes mellitus. observational study with a case-control design. The population is 52,965 people living in the city of Kupang. The total number of samples was 234 people who met the inclusion criteria, consisting of 117 cases of type 2 diabetes and control group of 117 people who did not have type 2 diabetes mellitus taken in 2 stages: the first stage was to determine the cluster of research areas, and second consecutive sampling was taken. The measuring instrument used is the questionnaire International Physical Activity Activity Test (IPAQ), format Food Recall 24 hours and semi Quantitative Food Frequency Questioner (FFQ), Food Model, Waist ruler/tape measure. Data were analyzed using a Chi-Square test to see the relationship between; food intake is at risk with visceral obesity, visceral obesity with type 2 diabetes mellitus, food intake at risk with type 2 diabetes mellitus. To see the relationship between body activity with visceral obesity and body activity with the incidence of type 2 diabetes mellitus using Pearson Chi-Square. The results of an analysis of the bivariate energy intake test for the incidence of type 2 diabetes mellitus, had an OR of 2.543 with 95% CI = 1.4-4.3 and (p-value 0.001). Fat intake for type 2 diabetes mellitus has an OR of 1.530 with 95% CI = 0.9-2.5 and (p-value 0.142). Fiber intake for type 2 diabetes mellitus has OR 0.760 with 95% CI = 0.4-1.2 and (p-value 0.370). Visceral obesity in the incidence of type 2 diabetes mellitus has an OR 2.510 with 95% CI = 1.4-4.2 and (p-value 0.001). Energy intake for the incidence of visceral obesity has OR 28,292 with 95% CI = 13,3-59,8 and (p-value 0,000). Fat intake for the incidence of visceral obesity had OR 23.435 with 95% CI 11.4-47, 8 and (p-value 0.000). Fiber intake on the incidence of visceral obesity has OR 4.959 with 95% CI = 2.7-8.8) and (p-value 0,000). In the case group, the results of statistical tests of activity on visceral obesity found a p-value of 0.246 which means that physical activity was not associated with the incidence of visceral obesity. While the control group statistical test results obtained p-value 0.000 means that there is a relationship between physical activity and the incidence of type 2 diabetes mellitus.

Download Full-text