Association between periodontal disease and coronary heart disease risk in Chinese population: evidence from a meta-analysis

Abstract Aims More and more research is focused on studying the relationship of periodontal disease with susceptibility to coronary heart disease (CHD), among which discrepancies have risen. The current study aimed to evaluate the possible relationship about periodontal disease and CHD in certain Chinese population. Methods The PubMed, Embase, Web of Science, the Cochrane Library, the Chinese Biomedical Database, and the Chinese National Knowledge Infrastructure were searched up to December 2018. The overall and subgroup analyses were performed using fixed or random-effect model depending on heterogeneity. Results A total of 2241 CHD cases and 2160 in 15 studies were used in the current study. Overall, a significantly elevated relationship about periodontal disease on CHD risk was found in all included Chinese subjects (OR=3.04, 95% CI, 2.37-3.92). Subgroup analyses by geographic location and sources of control were also performed; all the results in subgroup analyses were consistent with the overall result. Meanwhile, the significant association was found among the measures of periodontal disease with attachment loss, periodontal index, two or more clinical indications, and gum recession as well as CHD assessment method with WHO criteria and coronary arteriongraphy. Conclusions Collectively, the meta-analysis indicated that periodontal disease was capable of causing CHD susceptibility among Chinese.

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Paraoxonase 1 -L55M polymorphism and coronary heart disease risk in the Chinese population: evidence from a meta-analysis

Food Science and Technology ◽

10.1590/fst.56721 ◽

2021 ◽

Author(s):

Kelian ZHANG ◽

Huilin ZHUO ◽

Jingyi GUO ◽

Delong LI ◽

Ruozhu DAI

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Heart Disease Risk ◽

Chinese Population ◽

Disease Risk ◽

Meta Analysis ◽

Paraoxonase 1 ◽

Heart Disease Risk

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Periodontal disease is associated with increased coronary heart disease risk: A meta-analysis based on 38 casecontrol studies

World Journal of Meta-Analysis ◽

10.13105/wjma.v1.i1.47 ◽

2013 ◽

Vol 1 (1) ◽

pp. 47 ◽

Cited By ~ 4

Author(s):

Wei-Dong Leng ◽

Xian-Tao Zeng ◽

Yong-Ji Chen ◽

Zhong-Qun Zhan ◽

Yong Yang

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Periodontal Disease ◽

Coronary Heart Disease Risk ◽

Disease Risk ◽

Meta Analysis ◽

Heart Disease Risk

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Abstract P127: Posttraumatic Stress Disorder and Risk for Coronary Heart Disease: A Meta-analytic Review

Circulation ◽

10.1161/circ.127.suppl_12.ap127 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Donald Edmondson ◽

Ian M Kronish ◽

Jonathan A Shaffer ◽

Louise Falzon ◽

Matthew M Burg

Keyword(s):

Posttraumatic Stress Disorder ◽

Coronary Heart Disease ◽

Heart Disease ◽

Posttraumatic Stress ◽

Stress Disorder ◽

Meta Analysis ◽

Cochrane Library ◽

Forest Plot ◽

Increased Risk ◽

Analytic Review

Context: Recent evidence suggests that posttraumatic stress disorder (PTSD) may be associated with increased risk for coronary heart disease (CHD). Objective: To determine the association of PTSD to incident CHD using systematic review and meta-analysis. Data Sources: Articles were identified by searching Ovid MEDLINE, PsycINFO, Scopus, Cochrane Library, PILOTS database, and through manual search of reference lists. Study Selection: Prospective cohort studies that assessed PTSD in participants free of CHD and assessed subsequent CHD or cardiac-specific mortality. Data Extraction: We extracted estimates of the association of PTSD to incident CHD, as well as study characteristics. Odds ratios were converted to hazard ratios (HR), and a random-effects model was used to pool results. Data Synthesis: Five studies met our inclusion criteria (N= 401,712); 4 of these included depression as a covariate. The pooled HR for the magnitude of the relationship between PTSD and CHD was 1.53 (95% CI, 1.27-1.84) before adjustment for depression. The pooled HR estimate for the 4 depression-adjusted estimates (N= 362,388) was 1.22 (95% CI, 1.05-1.42). Conclusion: PTSD is independently associated with increased risk for incident CHD, even after adjusting for depression and other covariates. Figure 1. Forest plot of association of PTSD to incident MI or cardiac mortality Note: The area of each square is proportional to the study’s weight in the meta-analysis, and each line represents the confidence interval around the estimate. The diamond represents the aggregate estimate, and its lateral points indicate confidence intervals for this estimate.

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