scholarly journals Quantitative CT parameters correlate with lung function in chronic obstructive pulmonary disease: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Yan Wang ◽  
Shan Lin ◽  
Jian-Ting Li ◽  
Jing Wu ◽  
Dong Han ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Pulmonary Function Tests ◽  
Airflow Obstruction ◽  
Forced Expiratory Volume ◽  
Airway Wall ◽  
Quantitative Ct ◽  
Ct Measurements

Abstract Abstract purpose : The aim of the study was to analyze the correlation between quantitative computed tomography (CT) parameters and airflow obstruction in patients with chronic obstruction pulmonary disease (COPD). Methods: PubMed, Embase, Cochrane and Web of Knowledge were searched by two investigators from inception to 2018, using a combination of pertinent items to discover articles that investigated the relationship between CT measurements and lung function parameters in patients with COPD. Five reviewers independently evaluated the quality, extracted data and evaluated bias. The correlation coefficient was calculated and heterogeneity was explored. The following CT measurements were extracted: percentage of lung attenuation area < -950 Hounsfield Units (HU), mean lung density, percentage of airway wall area, air trapping index, airway wall thickness. Two airflow obstruction parameters were extracted: forced expiratory volume in the first second as a percentage of prediction (FEV 1 % pred) and FEV 1 divided by forced expiratory volume lung capacity. Results: A total of 117 studies (19,942 participants) were identified, 36 of which (4,762 participants) were suitable for meta-analysis. Results from our analysis demonstrated that there was a significant correlation between quantitative CT parameters and lung function. The absolute pooled correlation coefficients ranged from 0.44 (95% CI, 0.36 to 0.53) to 0.71(95% CI,0.65 to 0.77) for inspiratory CT and 0.59 (95% CI, 0.53 to 0.65) to 0.66 (95% CI,0.61 to 0.72) for expiratory CT. Conclusions: Results from this analysis demonstrated that quantitative CT parameters are significantly correlated with lung function in patients with COPD. With recent advances in chest CT, we can evaluate morphological features in the lungs that cannot be obtained by other clinical indices, such as pulmonary function tests. Therefore, CT can provide a quantitative method to advance the development and testing of new interventions and therapies for patients with COPD. Keywords: Airway obstruction, Systematic review, Meta-analysis.

scholarly journals Quantitative CT parameters correlate with lung function in chronic obstructive pulmonary disease: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Yan Wang ◽  
Shan Lin ◽  
Jian-Ting Li ◽  
Jing Wu ◽  
Dong Han ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Pulmonary Function Tests ◽  
Quantitative Computed Tomography ◽  
Airflow Obstruction ◽  
Forced Expiratory Volume ◽  
Airway Wall ◽  
Quantitative Ct ◽  
Ct Measurements

Abstract Background The aim of the study was to analyze the correlation between quantitative computed tomography (CT) parameters and airflow obstruction in patients with chronic obstruction pulmonary disease (COPD). Methods PubMed, Embase, Cochrane and Web of Knowledge were searched by two investigators from inception to 2018, using a combination of pertinent items to discover articles that investigated the relationship between CT measurements and lung function parameters in patients with COPD. Five reviewers independently evaluated the quality, extracted data and evaluated bias. The correlation coefficient was calculated and heterogeneity was explored. The following CT measurements were extracted: percentage of lung attenuation area < -950 Hounsfield Units (HU), mean lung density, percentage of airway wall area, air trapping index, airway wall thickness. Two airflow obstruction parameters were extracted: forced expiratory volume in the first second as a percentage of prediction (FEV1% pred) and FEV1 divided by forced expiratory volume lung capacity. Results A total of 117 studies (19,942 participants) were identified, 36 of which (4,762 participants) were suitable for meta-analysis. Results from our analysis demonstrated that there was a significant correlation between quantitative CT parameters and lung function. The absolute pooled correlation coefficients ranged from 0.44 (95% CI, 0.36 to 0.53) to 0.71(95% CI,0.65 to 0.77) for inspiratory CT and 0.59 (95% CI, 0.53 to 0.65) to 0.66 (95% CI,0.61 to 0.72) for expiratory CT. Conclusions Results from this analysis demonstrated that quantitative CT parameters are significantly correlated with lung function in patients with COPD. With recent advances in chest CT, we can evaluate morphological features in the lungs that cannot be obtained by other clinical indices, such as pulmonary function tests. Therefore, CT can provide a quantitative method to advance the development and testing of new interventions and therapies for patients with COPD .

scholarly journals Serum Albumin Concentrations in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (2) ◽  
pp. 269
Author(s):  
Elisabetta Zinellu ◽  
Alessandro G. Fois ◽  
Elisabetta Sotgiu ◽  
Sabrina Mellino ◽  
Arduino A. Mangoni ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Obstructive Pulmonary Disease ◽  
Serum Albumin ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Standard Mean Difference ◽  
Copd Patients

Background: Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by chronic airway inflammation and lung parenchyma damage. Systemic inflammation and oxidative stress also play a role in the pathogenesis of COPD. Serum albumin is a negative acute-phase protein with antioxidant effects and an important marker of malnutrition. The aim of this meta-analysis was to investigate differences in serum albumin concentrations between patients with stable COPD and non-COPD subjects. Methods: A systematic search was conducted, using the terms “albumin” and “chronic obstructive pulmonary disease” or “COPD”, in the electronic databases PubMed and Web of Science, from inception to May 2020. Results: Twenty-six studies were identified on a total of 2554 COPD patients and 2055 non-COPD controls. Pooled results showed that serum albumin concentrations were significantly lower in COPD patients (standard mean difference, SMD = −0.50, 95% CI −0.67 to −0.32; p < 0.001). No significant differences were observed in SMD of serum albumin concentrations between COPD patients with forced expiratory volume in the 1st second (FEV1) < 50% and those with FEV1 > 50%. Conclusions: Our systematic review and meta-analysis showed that serum albumin concentrations are significantly lower in patients with stable COPD compared to non-COPD controls. This supports the presence of a deficit in systemic anti-inflammatory and antioxidant defense mechanisms in COPD.

scholarly journals Radiographic pulmonary vessel volume, lung function and airways disease in the Framingham Heart Study

2019 ◽  
Vol 54 (3) ◽  
pp. 1900408 ◽  
Author(s):  
Andrew J. Synn ◽  
Wenyuan Li ◽  
Raúl San José Estépar ◽  
Chunyi Zhang ◽  
George R. Washko ◽  
...  
Keyword(s):  
Lung Function ◽  
Framingham Heart Study ◽  
Airflow Obstruction ◽  
Logistic Models ◽  
Forced Expiratory Volume ◽  
Small Vessel ◽  
Quantitative Ct ◽  
Pulmonary Vessel ◽  
Heart Study ◽  
Lung Health

Radiographic abnormalities of the pulmonary vessels, such as vascular pruning, are common in advanced airways disease, but it is unknown if pulmonary vascular volumes are related to measures of lung health and airways disease in healthier populations.In 2388 participants of the Framingham Heart Study computed tomography (CT) sub-study, we calculated total vessel volumes and the small vessel fraction using automated CT image analysis. We evaluated associations with measures of lung function, airflow obstruction on spirometry and emphysema on CT. We further tested if associations of vascular volumes with lung function were present among those with normal forced expiratory volume in 1 s and forced vital capacity.In fully adjusted linear and logistic models, we found that lower total and small vessel volumes were consistently associated with worse measures of lung health, including lower spirometric volumes, lower diffusing capacity and/or higher odds of airflow obstruction. For example, each standard deviation lower small vessel fraction (indicating more severe pruning) was associated with a 37% greater odds of obstruction (OR 1.37, 95% CI 1.11–1.71, p=0.004). A similar pattern was observed in the subset of participants with normal spirometry.Lower total and small vessel pulmonary vascular volumes were associated with poorer measures of lung health and/or greater odds of airflow obstruction in this cohort of generally healthy adults without high burdens of smoking or airways disease. Our findings suggest that quantitative CT assessment may detect subtle pulmonary vasculopathy that occurs in the setting of subclinical and early pulmonary and airways pathology.

High eosinophil counts predict decline in FEV1: Results from the CanCOLD study

2020 ◽  
pp. 2000838 ◽  
Author(s):  
Wan C. Tan ◽  
Jean Bourbeau ◽  
Gilbert Nadeau ◽  
Wendy Wang ◽  
Neil Barnes ◽  
...  
Keyword(s):  
Lung Function ◽  
Reference Group ◽  
Population Based ◽  
Forced Expiratory Volume ◽  
Blood Eosinophil ◽  
Lung Function Decline ◽  
Quantitative Ct ◽  
Ct Measurements ◽  
History Of ◽  
Airway Abnormalities

IntroductionThe aim of this study was to examine the association between blood eosinophil (EOS) levels and the decline in lung function in individuals over the age of 40 from the general population.MethodsThe study evaluated the EOS counts from thawed blood in 1120 participants (mean age 65 years) from the prospective population-based Canadian Cohort of Obstructive Lung Disease (CanCOLD) study. Participants answered interviewer-administered respiratory questionnaires and performed pre-/post-bronchodilator spirometric tests at 18-month intervals; computed tomography (CT) imaging was performed at baseline. Statistical analyses to describe the relationship between EOS levels and decline in forced expiratory volume in 1 s (FEV1) were performed using random mixed effects regression models with adjustments for demographics, smoking, baseline FEV1, ever-asthma and history of exacerbations in the previous 12 months. CT measurements were compared between EOS subgroups using an analysis of variance.ResultsParticipants who had a peripheral EOS count of ≥300 cells·µL−1 (n=273) had a greater decline in FEV1 compared with those with EOS counts of <150 cells·µL−1 (n=430) [p=0.003] (reference group) and 150 to <300 cells·µL−1 (n=417) [p=0.003]. The absolute change in FEV1 was −32.99 mL·year−1 for participants with EOS counts <150 cells·µL−1; −38.78 mL·year−1 for those with 150 to <300 cells·µL−1; and −67.30 mL·year−1 for participants with ≥300 cells·µL−1. In COPD, higher EOS count was associated with quantitative CT measurements reflecting both small and large airway abnormalities.ConclusionA blood EOS count of ≥300 cells·µL−1 is an independent risk factor for accelerated lung function decline in older adults and is related to undetected structural airway abnormalities.

Objectively Measured Steps/Day in Patients With Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 13 (11) ◽  
pp. 1275-1283 ◽  
Author(s):  
Travis Saunders ◽  
Nerissa Campbell ◽  
Timothy Jason ◽  
Gail Dechman ◽  
Paul Hernandez ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Pulmonary Rehabilitation ◽  
Meta Analysis ◽  
Airflow Obstruction ◽  
Forced Expiratory Volume ◽  
Activity Level ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Objectively Measured

Background:Although individual studies have reported on the number of steps/day taken by individuals with chronic obstructive pulmonary disease (COPD), this evidence has not been systematically reviewed or synthesized.Methods:MEDLINE and PsycINFO were searched for studies reporting objectively-measured steps/day and percent predicted forced expiratory volume in 1 second (FEV1%) in patients with COPD. Meta-analyses were used to estimate steps/day across studies, while metaregression was used to estimate between-study variance based on clinical and demographic factors (year and location of study, activity monitor brand, number of days wearing the monitor, whether participants were about to enter pulmonary rehabilitation, 6-minute walk distance (6MWD), FEV1%, age, and sex).Results:38 studies including 2621 participants met inclusion criteria. The pooled mean estimate was 4579 steps/day (95% CI:4310 to 5208) for individuals with COPD. Only 6MWD, FEV1% and whether patients were about to undergo pulmonary rehabilitation explained a significant portion of the variance (P < 0.1) in univariate meta-regression. In a multivariate model including the above risk factors, only FEV1% was associated with steps/day after adjustment for other covariates.Conclusions:These results indicate that patients with COPD achieve extremely low levels of physical activity as assessed by steps/day, and that severity of airflow obstruction is associated with activity level.

scholarly journals Comparative Effectiveness of Western and Eastern Manual Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis

Healthcare ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1127
Author(s):  
Chan-Young Kwon ◽  
Boram Lee ◽  
Beom-Joon Lee ◽  
Kwan-Il Kim ◽  
Hee-Jae Jung
Keyword(s):  
Systematic Review ◽  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Exercise Capacity ◽  
Comparative Effectiveness ◽  
Meta Analysis ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Background: Manual therapy (MT) is considered a promising adjuvant therapy for chronic obstructive pulmonary disease (COPD). Comparing the effectiveness among different Western and Eastern MTs being used for the management of COPD could potentially facilitate individualized management of COPD. This systematic review attempted to estimate the comparative effectiveness of Western and Eastern MTs for COPD patients using a network meta-analysis (NMA) methodology. Methods: Nine electronic databases were comprehensively searched for relevant randomized controlled trials (RCTs) published up to February 2021. Pair-wise meta-analysis and NMA were conducted on the outcomes of COPD, which included lung function and exercise capacity. Results: The NMA results from 30 included RCTs indicated that the optimal treatment for each outcome according to the surface under the cumulative ranking curve was massage, acupressure, massage, and tuina for forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and 6 min walking distance, respectively. Conclusions: MTs such as massage, acupressure, and tuina have shown comparative benefits for lung function and exercise capacity in COPD. However, the methodological quality of the included studies was poor, and the head-to-head trial comparing the effects of different types of MTs for COPD patients was insufficient. Therefore, further high-quality RCTs are essential.

scholarly journals Meta-analysis of exome array data identifies six novel genetic loci for lung function

2018 ◽  
Vol 3 ◽  
pp. 4 ◽  
Author(s):  
Victoria E. Jackson ◽  
Jeanne C. Latourelle ◽  
Louise V. Wain ◽  
Albert V. Smith ◽  
Megan L. Grove ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Disease ◽  
Meta Analysis ◽  
African Ancestry ◽  
Regulation Of Gene Expression ◽  
Forced Expiratory Volume ◽  
European Ancestry ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Array Data

Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and the ratio of FEV1 to FVC (FEV1/FVC). These analyses by the SpiroMeta and CHARGE consortia included 60,749 individuals of European ancestry from 23 studies, and 7,721 individuals of African Ancestry from 5 studies in the discovery stage, with follow-up in up to 111,556 independent individuals. Results: We identified significant (P<2·8x10-7) associations with six SNPs: a nonsynonymous variant in RPAP1, which is predicted to be damaging, three intronic SNPs (SEC24C, CASC17 and UQCC1) and two intergenic SNPs near to LY86 and FGF10. Expression quantitative trait loci analyses found evidence for regulation of gene expression at three signals and implicated several genes, including TYRO3 and PLAU. Conclusions: Further interrogation of these loci could provide greater understanding of the determinants of lung function and pulmonary disease.

Pesticide exposure and lung function: a systematic review and meta-analysis

2019 ◽  
Vol 70 (1) ◽  
pp. 14-23 ◽  
Author(s):  
J Ratanachina ◽  
S De Matteis ◽  
P Cullinan ◽  
P Burney
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Exposure Assessment ◽  
Pesticide Exposure ◽  
Respiratory Health ◽  
Meta Analysis ◽  
Epidemiological Studies ◽  
Forced Expiratory Volume ◽  
Free Text ◽  
Mesh Terms

Abstract Background Epidemiological studies have reported associations between pesticide exposure and respiratory health effects, but the quantitative impact on lung function is unclear. To fill this gap, we undertook a systematic review of the available literature on the association between pesticide exposure and pulmonary function. Aims To examine all available literature regarding the relationship between occupational and environmental exposure to pesticides and lung function. Methods We searched MEDLINE, EMBASE and Web of Science databases to 1 October 2017 without any date or language restrictions using a combination of MeSH terms and free text for ‘pesticide exposure’ and ‘lung function’. We included studies that met the criteria of our research protocol registered in PROSPERO, and we assessed their quality using a modified Newcastle-Ottawa scale. Results Of 2356 articles retrieved, 56 articles were included in the systematic review and pooled in meta-analyses for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC), FVC and FEV1. There was tentative evidence that exposure to cholinesterase (ChE) inhibiting pesticides reduced FEV1/FVC and no evidence that paraquat exposure affected lung function in farmers. Conclusions Respiratory surveillance should be enhanced in those exposed to ChE-inhibiting pesticides which reduced FEV1/FVC according to the meta-analysis. Our study is limited by heterogeneity between studies due to different types of exposure assessment to pesticides and potential confounders. Further studies with a more accurate exposure assessment are suggested.

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