scholarly journals Influence of Selected Biomarkers on Stress and Alexithymia in Patients under Hemodialysis Treatment

2019 ◽  
Author(s):  
Esra Tayaz ◽  
Ayşegül Koç
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Demographic Data ◽  
High Stress ◽  
Chronic Kidney Failure ◽  
C Reactive Protein ◽  
Protein Biomarkers ◽  
Reactive Protein ◽  
Hemodialysis Treatment ◽  
Data Form

Abstract Background: Chronic renal failure causes a number of physical problems in patients. Hemodialysis treatment and the stress brought along by the treatment are high and this circumstance sets the ground for alexithymia. Alexithymic feelings basically emerge as restriction in the world of emotion and thought, and inability to recognize physiological changes. Biomarkers that are indicators of physical change are influential in the stress lives of individuals. They lead to negative changes in the physical and mental lives of patients who have chronic kidney failure and individuals who receive hemodialysis treatment. This research was carried out as a relationship seeker in order to determine the influence of urea, creatinin, sodium, potassium, hemoglobin, hematocrit, albumin, calcium, phosphorus and C-reactive protein biomarkers on stress and alexithymia in individuals, who are diagnosed with chronic renal failure and receive hemodialysis treatment. Methods: The research environment was formed of patients who underwent hemodialysis treatment in a hospital in Turkey. The subject group was completed of 72 individuals. Demographic data form, biochemical data form, Hemodialysis Stressor Scale and Toronto Alexithymia Scale were used in the research. Results: It was found that the levels of perceived stress of individuals who participated in the research were high at all dimensions, and 59.7% were alexithymic. The means of the total scale scores of all patients were calculated as 87.81±13.59 for HSS and 62.46±9.84 for TAS. The relationship between TAS-20 and HSS and selected biomarkers were determined (p<0.05). Conclusion: It was concluded that stress and alexithymic feelings were high in patients who received hemodialysis treatment. It was concluded that there is a relationship between C-reactive protein, creatinin, sodium, hemoglobin, hematocrit, potassium from the biomarkers and the scales and scale sub-dimensions. It is necessary to increase the awareness of nurses on the importance of the skills to communicate with individuals who have to cope with stress, manage emotions, and have high stress and emotional deprivation.

scholarly journals Mental Health Effects Of Biomarkers In Chronic Renal Failure: Stress And Alexithymia Dimention

2019 ◽  
Author(s):  
Esra Tayaz ◽  
Ayşegül Koç
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Demographic Data ◽  
Physical Symptoms ◽  
Coping With Stress ◽  
Hemodialysis Treatment ◽  
Data Form ◽  
Study Results ◽  
Stress Levels ◽  
Stressor Scale

Abstract Background: Chronic renal failure causes many physical problems in patients. Hemodialysis treatment and the stress that accompanies the treatment are high and this constitutes a basis for alexithymia. Changes in biomarkers cause physical symptoms and increase individuals’ stress levels. Methods: The sample for the researcher was completed with 72 individuals. Demographic data form, biochemical data form, Hemodialysis Stressor Scale, and Toronto Alexithymia Scale were used in this study. Results: Individuals participating in the study found that the perceived stress levels were high in all dimensions and 59.7% were alexithymic. The relationship between Toronto alexithmia scale and hemodialysis stressor scale and the selected biomarkers was determined (p<0.05). Conclusion: It was concluded that stress and alexithymic feelings were high among hemodialysis patients and it was suggested the awareness of health professionals and patients should be increased in areas of coping with stress and emotional management in hemodialysis treatment patients.

scholarly journals ROLE OF CARDIAC MARKERS IN CHRONIC RENAL FAILURE PATIENTS.

2020 ◽  
pp. 81-82
Author(s):  
Ramesh Chandra Thanna ◽  
B K Agarwal ◽  
Rakesh Romday ◽  
Neha Sharma
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Positive Association ◽  
Morbidity And Mortality ◽  
Control Group ◽  
High Morbidity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

Introduction: Cardiovascular diseases (CVD) are known as important reasons of the increased morbidity and mortality observed in patients with chronic renal failure (CRF). The association of serum Interlukin-6 , homocysteine as well as other cardiovascular risk factors in relation to existence and cause of CVD were investigated. Method: In this study 200 CRF patients were recruited and further stratified into group with Male and Female as case groups. Those without renal failure were assigned as control group (n=200). Results: The patients with CRF showed a significant increase in plasma levels of Cpk-MB homocysteine and C-reactive protein (CRP) compared to control. The positive association were observed between homocysteine, Urea and Hs-CRP, IL_6 . It shows a significant Association of parameters in CRF . Conclusion: The results demonstrated elevation in plasma values IL-6 , homocysteine and HS-CRP in patients with CRF . However, these modifications may be lead to atherosclerosis and consequence CVD event. These parameters may be important with respect to the high morbidity and mortality of CVD found in patients with CRF.

scholarly journals Hepatocyte nuclear factors as possible C-reactive protein transcriptional inducer in the liver and white adipose tissue of rats with experimental chronic renal failure

2018 ◽  
Vol 446 (1-2) ◽  
pp. 11-23 ◽  
Author(s):  
Elzbieta Sucajtys-Szulc ◽  
Alicja Debska-Slizien ◽  
Boleslaw Rutkowski ◽  
Ryszard Milczarek ◽  
Iwona Pelikant-Malecka ◽  
...  
Keyword(s):  
Renal Failure ◽  
Adipose Tissue ◽  
Chronic Renal Failure ◽  
White Adipose Tissue ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Nuclear Factors ◽  
Hepatocyte Nuclear Factors

C-Reactive Protein and Interleukin-6 Levels Are Related to Renal Function in Predialytic Chronic Renal Failure

Nephron ◽  
2002 ◽  
Vol 91 (4) ◽  
pp. 594-600 ◽  
Author(s):  
Vincenzo Panichi ◽  
Massimiliano Migliori ◽  
Stefano De Pietro ◽  
Daniele Taccola ◽  
Anna Maria Bianchi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Chronic Renal Failure ◽  
Interleukin 6 ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Study of Levels of Serum Malondialdehyde and Serum High Sensitivity C-Reactive Protein in Chronic Renal Failure Patients - A Hospital-Based Study

2020 ◽  
Vol 7 (49) ◽  
pp. 2913-2917
Author(s):  
Sreenivasulu Uppara ◽  
Rama Kishore Akula Venkata ◽  
Bhagya Shree K. Bhuyar ◽  
Jayaprakash Kumar ◽  
Shyam Prasad B.R
Keyword(s):  
Oxidative Stress ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Oxidative Damage ◽  
Serum Creatinine ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Group 1

BACKGROUND Kidneys are vital organs for excretory and many other biochemical functions in the human body. Most chronic diseases end up damaging the kidneys, acute to chronic, based on the cause and duration. Chronic kidney disease is a sequence of damages to the renal cells and parenchyma leading to progressive deterioration of kidney function, which eventually develops into terminal stage of chronic kidney failure. Chronic renal failure leads to a pro-oxidant state, which leads to damage to the renal cells and parenchyma and the amount of intracellular oxidative stress or extracellular oxidative stress has a relation to the severity of renal failure either directly or indirectly. The study aimed to find the correlation between high sensitivity c-reactive protein (hs-CRP) to lipid peroxidation product, malondialdehyde (MDA). METHODS This prospective study was designed and conducted from January 2018 to December 2019 in the Department of Biochemistry, Government Medical College, Ananthapuramu. The study comprised a total of 70 subjects in the age group of 35 - 65 years. The subjects of the approved study plan were divided into two groups; 35 subjects were healthy controls (group-1), and 35 subjects were chronic renal failure (CRF) patients. A blood sample was collected in Government General Hospital, Anantapuramu. RESULTS The sample was analysed for estimation of blood urea, plasma glucose, serum creatinine, Malondialdehyde (MDA) and C-reactive protein (CRP). The mean value of blood urea, serum creatinine, serum hs-CRP, serum MDA was higher in CRF (group-2) patients when compared to healthy controls (group-1) (p < 0.0001). We observed a positive correlation between serum MDA and serum creatinine (r = 0.46832), hs-CRP (r = 0.0234). CONCLUSIONS In CRF, oxidative stress is obviously evident, but the inflammation induced oxidative stress which can be corrected if detected early will reduce oxidative damage. Our study shows that there is an elevation in hs-CRP and MDA which confirms the presence of oxidative damage, inflammation and probably inflammation induced oxidative damage. KEYWORDS CRF, Oxidative Stress, MDA, Serum Creatinine, hs-CRP

Sign in / Sign up

Export Citation Format

Share Document