Milk and dairy products consumption and the risk of oral or oropharyngeal cancer: A meta-analysis
Abstract Background Previous studies have been conducted to assess the association of milk and dairy products consumption and oral or oropharyngeal cancer risk, with inconsistent results. We therefore conducted a meta-analysis to explore the role of milk and dairy products consumption on oral or oropharyngeal cancer risk.Methods Databases of PubMed, Embase and Chinese Wanfang database were investigated until June 30th, 2019. The overall and subgroup associations were pooled with odds ratios (OR) and 95% confidence intervals (CI).Results This study involving 4635 cases and 50777 participants from 12 publications suggested that an inverse association was found between milk and dairy products consumption and oral or oropharyngeal cancer risk (OR= 0.74, 95%CI= 0.59-0.92; I2= 65.9%, Pfor heterogeneity = 0.001). Four studies reported milk consumption on oral cancer risk, but no significant association was found (OR= 0.91, 95%CI= 0.61-1.37). Six studies about milk consumption and oropharyngeal cancer risk found that there was a positive association between them (OR= 0.63, 95%CI= 0.44-0.90).Conclusion Findings from our meta-analysis indicated that milk and dairy products consumption may be associated with decreased risk of oral or oropharyngeal cancer.