Biomarkers of Vascular Injury and Type 2 Diabetes: A Prospective Study, Systematic Review and Meta-Analysis

Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC–Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC–Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding.

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Skipping breakfast and risk of type 2 diabetes: A systematic review and meta-analysis of prospective studies

Revue d Épidémiologie et de Santé Publique ◽

10.1016/j.respe.2018.05.314 ◽

2018 ◽

Vol 66 ◽

pp. S352

Author(s):

S. Schlesinger ◽

A. Ballon ◽

M. Neuenschwander

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Prospective Studies ◽

Meta Analysis ◽

Skipping Breakfast

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Fish Consumption, Dietary Long-Chain n-3 Fatty Acids, and Risk of Type 2 Diabetes: Systematic review and meta-analysis of prospective studies

Diabetes Care ◽

10.2337/dc11-1631 ◽

2012 ◽

Vol 35 (4) ◽

pp. 918-929 ◽

Cited By ~ 127

Author(s):

A. Wallin ◽

D. Di Giuseppe ◽

N. Orsini ◽

P. S. Patel ◽

N. G. Forouhi ◽

...

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Fatty Acids ◽

Prospective Studies ◽

Fish Consumption ◽

Meta Analysis ◽

Long Chain

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Prevention of Type 2 Diabetes by Dietary Patterns: A Systematic Review of Prospective Studies and Meta-Analysis

Metabolic Syndrome and Related Disorders ◽

10.1089/met.2010.0009 ◽

2010 ◽

Vol 8 (6) ◽

pp. 471-476 ◽

Cited By ~ 79

Author(s):

Katherine Esposito ◽

Christina-Maria Kastorini ◽

Demosthenes B. Panagiotakos ◽

Dario Giugliano

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Dietary Patterns ◽

Prospective Studies ◽

Meta Analysis

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Vitamin D, type 2 diabetes and other metabolic outcomes: a systematic review and meta-analysis of prospective studies

Proceedings of The Nutrition Society ◽

10.1017/s0029665112002765 ◽

2012 ◽

Vol 72 (1) ◽

pp. 89-97 ◽

Cited By ~ 100

Author(s):

Hassan Khan ◽

Setor Kunutsor ◽

Oscar H. Franco ◽

Rajiv Chowdhury

Keyword(s):

Systematic Review ◽

Type 2 Diabetes ◽

Vitamin D ◽

Prospective Studies ◽

Metabolic Diseases ◽

Meta Analysis ◽

Dietary Vitamin ◽

Vitamin D Status ◽

Metabolic Outcomes

Vitamin D status may influence the risk of developing metabolic diseases such as Type 2 diabetes (T2D), metabolic syndrome (MetS) and insulin resistance (IR). Several studies have assessed vitamin D in relationship with metabolic outcomes; however, results remain inconsistent. A systematic review and meta-analysis using multiple databases (MEDLINE, Web of Science and EMBASE), was performed up to 10 August 2012. Prospective studies reporting association of circulating or dietary vitamin D with incident T2D, MetS and IR outcomes were included. Relative risks (RR) were pooled using random effects and subgroup analysis by pertinent study-level characteristics was performed. A total of seventeen articles based on eighteen unique prospective studies, and comprising 210 107 participants with 15 899 metabolic events, collected during a median follow up of 10 years (range 3–22 years), were included. RR for individuals in top v. bottom thirds of baseline vitamin D were 0·81 (95% CI 0·71, 0·92); 0·86 (95% CI 0·80, 0·92); and 0·84 (95% CI 0·64, 1·12) for T2D, MetS and IR outcomes, respectively. Moderate heterogeneity was found between fourteen studies (I2 = 67%, P < 0·001) reporting on T2D. Findings were generally consistent across various study-level characteristics. In conclusion, vitamin D status at baseline in apparently healthy adults is inversely associated with future risks of T2D and MetS. Interventions aimed at maintaining adequate levels of vitamin D in addition to preventing deficiency may be a useful preventive measure for metabolic diseases. However, reliable evidence from carefully designed intervention studies, particularly those based on healthy populations, is needed to confirm observational findings.

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