scholarly journals Effect of ABO blood groups on response to warfarin

2019 ◽  
Author(s):  
Shan Zou ◽  
Lishan Wu ◽  
Zeliang Chen ◽  
Hongxiao Li ◽  
Hongjuan Chen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Venous Thromboembolism ◽  
Blood Group ◽  
Southern China ◽  
Warfarin Dose ◽  
Blood Groups ◽  
Chinese Han Population ◽  
Abo Blood Groups ◽  
Chinese Han ◽  
Han Population

Abstract Background: Numerous studies have demonstrated that patients with non-O blood groups have higher risk for venous thromboembolism than those with O blood group. However, it has remained unknown about the effect of ABO blood groups on warfarin dose requirements in patients receiving anticoagulation in Chinese Han population. The study aimed to investigate the influence of ABO blood groups on warfarin dose requirements in Chinese Han population. Methods: A retrospective study was conducted in the First Affiliated Hospital of Shantou University Medical College in Southern China. Three hundreds and 58 patients with confirmed diagnosis of deep venous thromboembolism and atrial fibrillation were included. Frequency of blood groups and warfarin dose requirements were determined. Results: Of 358 patients with deep venous thromboembolism and atrial fibrillation, 111 patients had blood group A (31.01%), 104 patinets had blood group B (29.05%), 20 patients had blood group AB (5.59%), and 123 patients had blood group O (34.36%). The patients with O blood group had a lower warfarin dose requirements compared with those with A, B and AB blood group. Conclusion: Our study showed that patients with non-O blood groups require higher doses of warfarin.

scholarly journals ABO blood groups and risk of deep venous thromboembolism in Chinese Han population from Chaoshan region in South China

2017 ◽  
Vol 38 (4) ◽  
pp. 396-399 ◽  
Author(s):  
Min Yu ◽  
Cantian Wang ◽  
Tingting Chen ◽  
Shuang Hu ◽  
Kaihong Yi ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
South China ◽  
Blood Groups ◽  
Chinese Han Population ◽  
Abo Blood Groups ◽  
Chinese Han ◽  
Han Population

Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population

2009 ◽  
Vol 126 (6) ◽  
pp. 843-849 ◽  
Author(s):  
Lisong Shi ◽  
Cong Li ◽  
Chuchu Wang ◽  
Yunlong Xia ◽  
Gang Wu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals The rs6771157 C/G polymorphism in SCN10A is associated with the risk of atrial fibrillation in a Chinese Han population

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhen Fang ◽  
Yue Jiang ◽  
Yifeng Wang ◽  
Yuan Lin ◽  
Yaowu Liu ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Oral Contraceptive Types in Relation to ABO Blood Groups Among Saudi Women of Different Reproductive Age Groups and Impact on Venous Thromboembolism

2020 ◽  
Vol 26 ◽  
pp. 107602962096605
Author(s):  
Abdulrahman B. O. Mohamed ◽  
Nabeel Al-Ama ◽  
Huda Al Kreathy ◽  
Khalid H. B. Ahmed ◽  
Turki Al Amri ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Blood Group ◽  
Protein C ◽  
Second Generation ◽  
Activated Protein C ◽  
Blood Groups ◽  
Fourth Generation ◽  
Third Generation ◽  
Abo Blood Groups ◽  
Saudi Women

Saudi women have recently started using oral contraceptives (OCs), which has led to risk of venous thromboembolism (VTE). The risk varies with the type of OC generations used, and with OC use the risk for VTE increases by 2- to 6-fold. This study evaluated the effect of OC types in relation to ABO blood group on the risk of VTE among Saudi women. Thrombin generation (TG) was measured in the plasma of the women in the presence and absence of platelet rich plasma, platelet poor plasma and thrombomodulin or activated protein C. OC usage increased TG parameters ETP and Peak height by 9.81% and 16.04%, respectively. An increased risk of VTE was seen among women on third generation OCs as compared to those on second generation products. Within OC generations, we found that for women using fourth generation OCs, their ETP increased by 36.18% as compared to those using second generation and by 6.07% in those using third generation compared to those using second generation. There was significant difference with respect to ABO blood groups and OC generation types, but larger sample size is required. Women who are 40 years and older and using third generation OC had a higher risk of having thrombosis (11.84%), as compared to those using second generation OC (8.79%) and to those using fourth generation OC (5.03%). An association between different OC groups and non-O blood group in thrombosis generation was noted. TG parameters were significantly increased in relation to BMI when comparing to OC users versus non-users. In addition, inhibition of TG parameters in the presence of recombinant human thrombomodulin (TM) and activated protein C (APC) were significantly increased.

scholarly journals A Variant of IL6R Is Associated with the Recurrence of Atrial Fibrillation after Catheter Ablation in a Chinese Han Population

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99623 ◽  
Author(s):  
Gang Wu ◽  
Mian Cheng ◽  
He Huang ◽  
Bo Yang ◽  
Hong Jiang ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Catheter Ablation ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population

scholarly journals Polymorphisms but Not Mutations of theKCNQ1Gene Are Associated with Lone Atrial Fibrillation in the Chinese Han Population

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Hui-min Chu ◽  
Ming-jun Feng ◽  
Yi-gang Li ◽  
Yi-xin Zhang ◽  
Ji-fang Ma ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Risk Factor ◽  
Chinese Han Population ◽  
Chinese Patients ◽  
Delayed Rectifier ◽  
Allelic Association ◽  
Healthy Controls ◽  
Chinese Han ◽  
Han Population ◽  
Common Genetic Variants

Background. Recent studies suggest that mutation of the slow delayed rectifier potassium channel (IKs) contributes to familial atrial fibrillation (FAF). In the current study, we identified common genetic variants ofKCNQ1and explored the potential association betweenKCNQ1polymorphism with lone AF (LAF).Methods. Clinical data and blood samples were collected from 190 Han Chinese patients with sporadic AF and matched healthy controls. Variants of theKCNQ1gene were identified using single-strand conformational polymorphism (SSCP) analysis. A case-control association study inKCNQ1identified six known single-nucleotide polymorphisms (SNPs) during SSCP screening of the 190 LAF patients and 190 healthy controls.Results. One of the SNPs inKCNQ1was strongly associated with LAF; significant allelic association was detected rs59233444 (P=0.013,OR=1.469, 95% confidence interval (CI): 1.083–1.993). A multiple regression analysis indicated that rs59233444 is an independent risk factor for LAF. Twelve new variants were identified inKCNQ1, including one in the 5′-UTR, two in the 3′-UTR, six in introns, two synonymous substitutions, and one missense substitution. Variants c.1009C>T, c.1860C>T, and c.+2285C>T were not present in the 190 controls, and the others were identified in controls at various frequencies.Conclusions. rs59233444, a common SNP but not mutation in the coding regions of theKCNQ1gene, is a risk factor for LAF in Chinese Han population.

scholarly journals Common Variants in the TBX5 Gene Associated with Atrial Fibrillation in a Chinese Han Population

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160467 ◽  
Author(s):  
Rongfeng Zhang ◽  
Xiaochen Tian ◽  
Lianjun Gao ◽  
Huihua Li ◽  
Xiaomeng Yin ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chinese Han Population ◽  
Common Variants ◽  
Chinese Han ◽  
Han Population ◽  
Tbx5 Gene

scholarly journals ABO Blood Groups and the Risk of Venous Thromboembolism (VTE) Among Saudi Patients at a Tertiary Care Hospital in Riyadh

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 4926-4926
Author(s):  
Ghaydaa Juma Kullab ◽  
Abdul Rehman Z. Zaidi ◽  
Sultan Albaqmi ◽  
Haya Alajlan ◽  
Mohammed Abdullah Alsheef
Keyword(s):  
Venous Thromboembolism ◽  
Blood Group ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Blood Groups ◽  
Blood Type ◽  
Care Hospital ◽  
Abo Blood Groups ◽  
Blood Types ◽  
Obesity Status

Background: ABO blood types are scientifically proved to be associated with the risk of venous thromboembolism (VTE), but data is lacking in the Saudi population. Aims: We aimed to investigate the association between ABO blood types and VTE, to explore potential interactions between ABO blood type with sex and obesity status. Methods: This was a retrospective study with a total of 998 patients, who were admitted with venous thromboembolism at our tertiary care hospital, between January 2010 and January 2018. Demographic and clinical data were collected. We used chi-square tests to assess the association between ABO blood group and the development of VTE. It was decided that the test will be considered significant if the p-value is <0.05. Results: Out of 998 VTE patients, 506 of patients were excluded, because their ABO blood group was not tested. Therefore, 492 patients were qualified as study subjects, of whom 66% of patients had DVT, 23% of patients had pulmonary embolism. Most of them had provoked VTE. Female patients constituted the majority of the study subjects (82.5%). Sample distribution appeared that O blood group was present in 34.1% of all VTE patients, while non-O-blood groups were present in 66% of them. Overall, there was a non-significant difference between VTE in patients with non-O blood type compared to O blood type (p=0.268). Conclusions: Non-O-blood groups (A, B, AB) are the most common blood types in Saudi patients with VTE. There is no statistically significant association between ABO blood groups, gender, and obesity status. Disclosures No relevant conflicts of interest to declare.

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