Association between Vitamin D receptor gene polymorphism and the risk of Multiple Sclerosis: Systematic review and meta-analysis

Abstract Background The association between the vitamin D receptor ( VDR ) gene polymorphism and the risk of Multiple sclerosis (MS) has been evaluated in several studiese. However, the findings were inconsistent and inconclusive.Methods All relevant studies reporting the association between the FokI (rs2228570) or/and TaqI (rs731236) or/and BsmI (rs1544410) or/and ApaI (rs7975232) polymorphisms of the VDR and susceptibility to multiple sclerosis published up to September 2019 were identified by comprehensive systematic database search in web of science, Scopus, and PubMed.Results A total of 30 case–control studies were included in this meta-analysis. The overall results suggested a significant association between TaqI gene polymorphism and MS risk under heterozygote contrast (OR = 1.27, 95%CI = 1.01–1.59, REM). Moreover, the pooled results of subgroup analysis decline presence of significant association under all defined genotype model. In subgroup analysis, BsmI gene polymorphism was associated with increased risk of MS under the recessive model in Asian population. In other hand, ApaI gene polymorphism was associated with decreased risk of MS under recessive and homozygote contrast (aa vs AA) models in Asian population.Conclusions This meta-analysis suggested a significant association between TaqI gene polymorphism and MS susceptibility. Furthermore, BsmI gene polymorphism was associated with an increased risk of MS in Asian population. In contrast, ApaI gene polymorphism was associated with a decreased risk of MS in Asian population. Future large scale studies on gene–environment and gene– gene interactions are required to estimate related risk factors and assist early diagnosis of patients at high risk for MS.

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Vitamin D Receptor Gene FokI Polymorphism Contributes to Increasing the Risk of Tuberculosis: Evidence from a Meta-Analysis

10.21203/rs.3.rs-774522/v1 ◽

2021 ◽

Author(s):

Bin Li ◽

Yunxia Li ◽

Fei Wen ◽

Zhaofen Wang

Keyword(s):

Vitamin D ◽

Confidence Interval ◽

Gene Polymorphism ◽

Vitamin D Receptor ◽

Odds Ratio ◽

Meta Analysis ◽

Receptor Gene ◽

Recessive Model ◽

Cochrane Library ◽

Increased Risk

Abstract Purpose In the present study, we explored the link between vitamin D receptor (VDR) FokI gene polymorphisms with tuberculosis(TB). Methods Based on a comprehensive search of PubMed, Embase, Web of Science, Elsevier Science Direct, Cochrane Library, CNKI, Wanfang, and Chongqing VIP databases, we searched case-control study on FokI gene polymor-phism and TB susceptivity. The Newcastle-Ottawa Scale(NOS) was used to evaluate the quality of the literature and extracted data, and R 4.0.5 software was used for the meta-analysis. Results: Among the 243 selected articles, 35 in the meta analysis. The meta-analysis showed that the FokI gene polymorphism allene gene model(f vs F, Odds ratio=1.22,95% confidence interval:1.11-1.36); dominant model (ff+fF vs F, Odds ratio=1.29,95% confidence interval:1.13-1.47); recessive model(ff vs fF+FF, Odds ratio=1.31,95% confidence interval:1.09-1.56); codominant (ff vs FF, Odds ra-tio=1.48,95% confidence interval:1.19-1.83); codominant(fF vs FF, Odds ratio=1.23,95% confidence interval:1.09-1.39). The meta-analysis indicates a high level of heterogeneity between the VDR FokI gene polymorphism and TB and the race is a source of heterogeneity in the results. Conclusion The present update meta-analysis suggest that FokI gene polymorphism is significantly associated with an increased risk of TB.

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FokI polymorphism of the vitamin D receptor (VDR) gene and susceptibility to tuberculosis: evidence through a meta-analysis

10.21203/rs.3.rs-266491/v1 ◽

2021 ◽

Author(s):

Upendra Yadav ◽

Pradeep Kumar ◽

Vandana Rai

Keyword(s):

Vitamin D ◽

Vitamin D Receptor ◽

Meta Analysis ◽

Receptor Gene ◽

Asian Population ◽

Recessive Model ◽

Dominant Model ◽

Vdr Gene ◽

Exact Relation ◽

Significance Level

Abstract Background: Tuberculosis is one of the top ten causes of deaths worldwide. The deficiency of vitamin D was reported to be associated with the increased susceptibility of tuberculosis. Various previous reports were published to check the association of FokI polymorphism of the vitamin D receptor gene with tuberculosis risk. But their results were inconsistent so, we performed a meta-analysis to know the exact relation of the two.Methods: Different databases were screened up to November, 2020 with the keywords “Vitamin D receptor”, “VDR”, and “FokI”, along with “Tuberculosis” and “TB” to find the suitable articles. All the statistical analyses were performed by the Open Meta-Analyst program and all p-values were two-tailed with a significance level of 0.05.Results: No statistically significant association was observed in the allele contrast model (ORfvs.F= 1.11, 95%CI= 0.99-1.24, p= 0.05, I2= 73.46%), in the dominant model (ORff+Ffvs.FF= 1.11, 95%CI= 0.96-1.28, p= 0.14, I2= 71.39%), and in the co-dominant model (ORFfvs.FF= 1.05, 95%CI= 0.92-1.21, p= 0.41, I2= 65.97%). However, a significant association was found in the homozygote model (ORffvs.FF= 1.32, 95%CI= 1.03-1.69, p= 0.02, I2= 67.02%) and in the recessive model (ORFF+Ff vs.ff= 1.26, 95%CI= 1.03-1.54, p= 0.02, I2= 58.01%). Further analysis was performed on the bases of the ethnicity. In Asian population a significant association was found in the homozygote model (ORffvs.FF= 1.57, 95%CI= 1.12-2.21, p= 0.008, I2= 70.37%) and in the recessive model (ORFF+Ff vs.ff= 1.43, 95%CI= 1.08-1.89, p= 0.01, I2= 63.13%).Conclusion: In conclusion, a significant association of FokI with tuberculosis susceptibility was found in the overall analysis and in the Asian population.

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Vitamin D receptor gene polymorphism in multiple sclerosis and the association with HLA class II alleles

Journal of the Neurological Sciences ◽

10.1016/s0022-510x(00)00336-1 ◽

2000 ◽

Vol 177 (1) ◽

pp. 65-71 ◽

Cited By ~ 92

Author(s):

Masaaki Niino ◽

Toshiyuki Fukazawa ◽

Ichiro Yabe ◽

Seiji Kikuchi ◽

Hidenao Sasaki ◽

...

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Gene Polymorphism ◽

Vitamin D Receptor ◽

Receptor Gene ◽

Class Ii ◽

Hla Class Ii ◽

Vitamin D Receptor Gene ◽

Receptor Gene Polymorphism ◽

Hla Class Ii Alleles

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Impact of vitamin D receptor gene polymorphism on Systemic Lupus Erythematosus susceptibility: A pooled analysis

10.21203/rs.2.15551/v1 ◽

2019 ◽

Author(s):

Shi-kun Yang ◽

Na Liu ◽

Ying-qiu Zhu ◽

Wei-juan Zhang ◽

Na Song ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Vitamin D ◽

Gene Polymorphism ◽

Vitamin D Receptor ◽

Lupus Erythematosus ◽

Meta Analysis ◽

Receptor Gene ◽

Systemic Lupus ◽

Vdr Gene ◽

Apai Polymorphism

Abstract It is still unclear whether there was an association between vitamin D receptor (VDR) gene polymorphism and systemic lupus erythematosus (SLE). This meta analysis including 19 studies were performed using Stata software. In our analysis, VDR ApaI polymorphism was correlated with SLE susceptibility in general populations (AA vs aa: P=0.003; AA+Aa vs aa: P=0.000). VDR gene ApaI and BsmI polymorphism were correlated with SLE susceptibility in Caucasian populations (BB vs Bb+bb: p=0.005; B vs b: P=0.026; AA vs aa: P =0.038). VDR BsmI and FokI polymorphism were correlated with SLE in African populations (BB+Bb vs bb: P=0.000; FF vs Ff +ff: P=0.000; F vs f: P=0.000; FF vs ff: P=0.000; FF+Ff vs ff: P=0.000). VDR ApaI polymorphism was correlated with SLE in Asian populations (AA+Aa vs aa) when stratified by race. Additionly, ApaI polymorphism was correlated with SLE in female subjects (AA vs aa: P =0.022) when stratified by gender. But there was no association between VDR TaqI polymorphism and SLE susceptibility in our analysis.

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Vitamin D receptor gene polymorphisms and the risk of the type 1 diabetes: a meta-analysis based on 40 case–control studies

10.21203/rs.2.20545/v4 ◽

2020 ◽

Author(s):

Na Zhai ◽

Ramtin Bidares ◽

Masoud Hassanzadeh Makoui ◽

Saeed Aslani ◽

Payam Mohammadi ◽

...

Keyword(s):

Vitamin D ◽

Type 1 Diabetes ◽

Vitamin D Receptor ◽

Subgroup Analysis ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Receptor Gene ◽

Case Control ◽

Case Control Studies

Abstract Background: The association between the polymorphisms in the vitamin D receptor (VDR) gene and the risk of type 1 diabetes mellitus (T1DM) has been evaluated in several studies. However, the findings were inconclusive. Thus, we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms on the risk of T1DM.Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T1DM published up to May 2020 were identified by comprehensive systematic database search in ISI Web of Science, Scopus, and PubMed/MEDLINE. Strength of association were assessed by calculating of pooled odds ratios (ORs) and 95% confidence intervals (CIs). The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. To find the potential sources of heterogeneity, meta-regression and subgroup analysis were also performed. Results: A total of 40 case–control studies were included in this meta-analysis. The results of overall population rejected any significant association between VDR gene polymorphisms and T1DM risk. However, the pooled results of subgroup analysis revealed significant negative and positive associations between FokI and BsmI polymorphisms and T1DM in Africans and Americans, respectively. Conclusions: This meta-analysis suggested a significant association between VDR gene polymorphism and T1DM susceptibility in ethnic-specific analysis.

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