Objective: The study was carried out to comprehensively evaluate association between Vitamin D receptor gene polymorphism and susceptibility to TB, using meta-analysis.
Methods: Literature on controlled case studies on association between vitamin D receptor gene polymorphism and TB were collected through online database (Pubmed, Chinese CNKI, VIP database, Wanfang database and Google search). Odd ratio (OR) of all the studies were collected depending on the result of their heterogeneity tests. Publication bias was assessed by using a funnel plot and Egger’s test.
Results: Eight papers were selected based on study criteria. Meta analysis results showed that the combined OR values (95%CI) of dominant model and recessive model were 0.51(0.40,0.65) and0.72(0.61, 0.85), They were both statistically significant (P<0.001). Significant associations were observed for Fok? polymorphisms among Chinese.
Conclusion: The results suggest that Vitamin D receptor gene polymorphism was significantly associated with TB in China. Our findings support the hypothesis that vitamin D deficiency might play a role in TB infection and development of associated risk factors.
Meta-Analysis of the Association Between the rs228570 Vitamin D Receptor Gene Polymorphism and Arterial Hypertension Risk