scholarly journals Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study

2020 ◽  
Author(s):  
Junping Li ◽  
Dongping Li ◽  
Na Zhou ◽  
Mengying Qi ◽  
Yanzhu Luo ◽  
...  
Keyword(s):  
Clinical Study ◽  
Conservative Treatment ◽  
Treatment Method ◽  
Meibomian Gland ◽  
Short Term ◽  
Acinar Structure ◽  
Significant Difference ◽  
Gland Function ◽  
Imagej Software ◽  
Slit Lamp Microscopy

Abstract Background: To observe the effects of chalazion and its treatments on meibomian gland function and morphology in the chalazion area. Methods: This nonrandomized, prospective observational clinical study included 58 patients (67 eyelids) who were cured of chalazion, including 23 patients (23 eyelids) treated with a conservative method and 35 patients (44 eyelids) treated with surgery. Infrared meibomian gland photography combined with image analysis by ImageJ software was used to measure the chalazion area proportion. Slit-lamp microscopy was employed to evaluate meibomian gland function, and a confocal microscope was used to observe meibomian gland acinar morphology before treatment and 1 month after complete chalazion resolution. Results: At 1 month after chalazion resolution, the original chalazion area showed meibomian gland loss according to infrared meibomian gland photography in both groups. In patients who received conservative treatment, the meibomian gland function parameters before treatment were 0.74±0.75, 0.48±0.67, and 1.22±0.60, respectively. One month after chalazion resolution, the parameters were 0.35±0.49, 0.17±0.49, and 0.91±0.60, respectively; there was significant difference (P<0.05). The proportion of the chalazion area before treatment was 14.90 (11.03, 25.3), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.64 (10.33, 25.77); there was no significant difference (P>0.05). In patients who underwent surgery, the meibomian gland function parameters before surgery were 0.93±0.87, 1.07±0.70, and 1.59±0.76, respectively, and at 1 month after chalazion resolution, they were 0.93±0.82, 0.95±0.75, and 1.52±0.70, respectively; there was no significant difference (P>0.05). The proportion of the chalazion area before surgery was 14.90 (12.04, 21.6), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.84 (11.31, 21.81); there was no significant difference (P>0.05). The acinar structure could not be observed clearly in the meibomian gland loss area in most patients. Conclusions: Chalazion causes meibomian gland loss, and the range of meibomian gland loss is not related to the treatment method but to the range of chalazion itself. A hot compress as part of conservative treatment can improve meibomian gland function at the site of chalazion in the short term.

scholarly journals Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study

2020 ◽  
Author(s):  
Junping Li ◽  
Dongping Li ◽  
Na Zhou ◽  
Mengying Qi ◽  
Yanzhu Luo ◽  
...  
Keyword(s):  
Clinical Study ◽  
Conservative Treatment ◽  
Treatment Method ◽  
Meibomian Gland ◽  
Short Term ◽  
Acinar Structure ◽  
Significant Difference ◽  
Gland Function ◽  
Imagej Software ◽  
Slit Lamp Microscopy

Abstract Background To observe the effects of chalazion and its treatments on meibomian gland function and morphology in the chalazion area.Methods This nonrandomized, prospective observational clinical study included 58 patients (67 eyelids) who were cured of chalazion, including 23 patients (23 eyelids) treated with a conservative method and 35 patients (44 eyelids) treated with surgery. Infrared meibomian gland photography combined with image analysis by ImageJ software was used to measure the chalazion area proportion. Slit-lamp microscopy was employed to evaluate meibomian gland function, and a confocal microscope was used to observe meibomian gland acinar morphology before treatment and 1 month after complete chalazion resolution.Results At 1 month after chalazion resolution, the original chalazion area showed meibomian gland loss according to infrared meibomian gland photography in both groups. In patients who received conservative treatment, the meibomian gland function parameters before treatment were 0.74±0.75, 0.48±0.67, and 1.22±0.60, respectively. One month after chalazion resolution, the parameters were 0.35±0.49, 0.17±0.49, and 0.91±0.60, respectively; there was significant difference (P<0.05). The proportion of the chalazion area before treatment was 14.90 (11.03, 25.3), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.64 (10.33, 25.77); there was no significant difference (P>0.05). In patients who underwent surgery, the meibomian gland function parameters before surgery were 0.93±0.87, 1.07±0.70, and 1.59±0.76, respectively, and at 1 month after chalazion resolution, they were 0.93±0.82, 0.95±0.75, and 1.52±0.70, respectively; there was no significant difference (P>0.05). The proportion of the chalazion area before surgery was 14.90 (12.04, 21.6), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.84 (11.31, 21.81); there was no significant difference (P>0.05). The acinar structure could not be observed clearly in the meibomian gland loss area in most patients.Conclusions Chalazion causes meibomian gland loss, and the range of meibomian gland loss is not related to the treatment method but to the range of chalazion itself. A hot compress as part of conservative treatment can improve meibomian gland function at the site of chalazion in the short term.

scholarly journals Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study

2020 ◽  
Author(s):  
Junping Li ◽  
Dongping Li ◽  
Na Zhou ◽  
Mengying Qi ◽  
Yanzhu Luo ◽  
...  
Keyword(s):  
Clinical Study ◽  
Conservative Treatment ◽  
Treatment Method ◽  
Meibomian Gland ◽  
Short Term ◽  
Acinar Structure ◽  
Significant Difference ◽  
Gland Function ◽  
Imagej Software ◽  
Slit Lamp Microscopy

Abstract Background To observe the effects of chalazion and its treatments on meibomian gland function and morphology in the chalazion area. Methods This nonrandomized, prospective observational clinical study included 58 patients (67 eyelids) who were cured of chalazion, including 23 patients (23 eyelids) treated with a conservative method and 35 patients (44 eyelids) treated with surgery. Infrared meibomian gland photography combined with image analysis by ImageJ software was used to measure the chalazion area proportion. Slit-lamp microscopy was employed to evaluate meibomian gland function, and a confocal microscope was used to observe meibomian gland acinar morphology before treatment and 1 month after complete chalazion resolution. Results At 1 month after chalazion resolution, the original chalazion area showed meibomian gland loss according to infrared meibomian gland photography in both groups. In patients who received conservative treatment, the meibomian gland function parameters before treatment were 0.74±0.75, 0.48±0.67, and 1.22±0.60, respectively. One month after chalazion resolution, the parameters were 0.35±0.49, 0.17±0.49, and 0.91±0.60, respectively; there was significant difference (P<0.05). The proportion of the chalazion area before treatment was 14.90 (11.03, 25.3), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.64 (10.33, 25.77); there was no significant difference (P>0.05). In patients who underwent surgery, the meibomian gland function parameters before surgery were 0.93±0.87, 1.07±0.70, and 1.59±0.76, respectively, and at 1 month after chalazion resolution, they were 0.93±0.82, 0.95±0.75, and 1.52±0.70, respectively; there was no significant difference (P>0.05). The proportion of the chalazion area before surgery was 14.90 (12.04, 21.6), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.84 (11.31, 21.81); there was no significant difference (P>0.05). The acinar structure could not be observed clearly in the meibomian gland loss area in most patients. Conclusions Chalazion causes meibomian gland loss, and the range of meibomian gland loss is not related to the treatment method but to the range of chalazion itself. A hot compress as part of conservative treatment can improve meibomian gland function at the site of chalazion in the short term.

scholarly journals Effects of chalazion and its treatments on the meibomian glands: a nonrandomized, prospective observation clinical study

2020 ◽  
Author(s):  
Junping Li ◽  
Dongping Li ◽  
Na Zhou ◽  
Mengying Qi ◽  
Yanzhu Luo ◽  
...  
Keyword(s):  
Clinical Study ◽  
Conservative Treatment ◽  
Treatment Method ◽  
Meibomian Gland ◽  
Short Term ◽  
Acinar Structure ◽  
Significant Difference ◽  
Gland Function ◽  
Imagej Software ◽  
Slit Lamp Microscopy

Abstract Background To observe the effects of chalazion and its treatments on meibomian gland function and morphology in the chalazion area. Methods This nonrandomized, prospective observational clinical study included 58 patients (67 eyelids) who were cured of chalazion, including 23 patients (23 eyelids) treated with a conservative method and 35 patients (44 eyelids) treated with surgery. Infrared meibomian gland photography combined with image analysis by ImageJ software was used to measure the chalazion area proportion. Slit-lamp microscopy was employed to evaluate meibomian gland function, and a confocal microscope was used to observe meibomian gland acinar morphology before treatment and 1 month after complete chalazion resolution. Results At 1 month after chalazion resolution, the original chalazion area showed meibomian gland loss according to infrared meibomian gland photography in both groups. In patients who received conservative treatment, the meibomian gland function parameters before treatment were 0.74±0.75, 0.48±0.67, and 1.22±0.60, respectively. One month after chalazion resolution, the parameters were 0.35±0.49, 0.17±0.49, and 0.91±0.60, respectively; there was significant difference (P<0.05). The proportion of the chalazion area before treatment was 14.90 (11.03, 25.3), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.64 (10.33, 25.77); there was no significant difference (P>0.05). In patients who underwent surgery, the meibomian gland function parameters before surgery were 0.93±0.87, 1.07±0.70, and 1.59±0.76, respectively, and at 1 month after chalazion resolution, they were 0.93±0.82, 0.95±0.75, and 1.52±0.70, respectively; there was no significant difference (P>0.05). The proportion of the chalazion area before surgery was 14.90 (12.04, 21.6), and the proportion of meibomian gland loss at 1 month after chalazion resolution was 14.84 (11.31, 21.81); there was no significant difference (P>0.05). The acinar structure could not be observed clearly in the meibomian gland loss area in most patients. Conclusions Chalazion causes meibomian gland loss, and the range of meibomian gland loss is not related to the treatment method but to the range of chalazion itself. A hot compress as part of conservative treatment can improve meibomian gland function at the site of chalazion in the short term.

scholarly journals Effects of chalazion and its treatments on the meibomian glands: non-randomized, prospective observation clinical study

2019 ◽  
Author(s):  
Junping Li ◽  
Dongping Li ◽  
Na Zhou ◽  
Mengying Qi ◽  
Yanzhu Luo ◽  
...  
Keyword(s):  
Clinical Study ◽  
Conservative Treatment ◽  
Complete Resolution ◽  
Laser Scanning ◽  
Statistical Difference ◽  
Meibomian Gland ◽  
Significant Statistical Difference ◽  
Acinar Structure ◽  
Gland Function

Abstract Background To observe the effects of chalazion and its treatments on the meibomian gland function and morphology in chalazion area. Methods This non-randomized, prospective observation clinical study included 58 patients (67 eyelids) cured of chalazion, including 23 patients (23 eyelids) treated with conservative method, and 35 patients (44 eyelids) with surgery. Slit lamp microscopy, infrared meibomian gland photography and in vivo laser scanning confocal microscopy (LSCM) were performed before treatment and 1 month after the chalazion complete resolution. The meibomian gland function, the area proportion and acinar structure in the chalazion area were analyzed before and 1 month after the chalazion resolution.Results In patients with conservative treatment, the meibomian gland function parameters improved at 1 month after chalazion resolution compared to those before treatment (P<0.05). There was no significant statistical difference in meibomian gland functional parameters before and after surgery (P>0.05). According to infrared meibomian gland photography, after chalazion resolution, the area presented meibomian gland loss, there was no significant statistical difference between the proportion of meibomian gland loss at 1 month after chalazion resolution and the proportion of the initial chalazion area (P>0.05) regardless of the treatment strategy. The acinar structure could not be observed clearly after the chalazion complete resolution. Conclusions Chalazion will cause meibomian gland loss, and the range of meibomian gland loss is not related to the treatment method, but the range of the chalazion itself. Hot compress in conservative treatment can improve the meibomian gland function that chalazion located in short term.

scholarly journals Clinical efficacy of plasma exchange therapy for treatment of autoimmune bullous skin disease

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Xiaoxu Shi ◽  
Lanying Qin ◽  
Jun Peng ◽  
Zishen Zhao ◽  
Haixiang Zhang
Keyword(s):  
Plasma Exchange ◽  
Clinical Efficacy ◽  
Skin Disease ◽  
Treatment Method ◽  
Control Group ◽  
Short Term ◽  
Plasma Exchange Therapy ◽  
Significant Difference ◽  
The Difference ◽  
Experimental Group

Objective: To investigate the clinical efficacy of plasma exchange therapy for autoimmune bullous skin disease. METHODS: Fifty patients with autoimmune bullous skin disease enrolled in our hospital from January 2018 to January 2019 were selected. The patients were grouped by treatment method: 25 control group patients were given conventional hormone therapy, while 25 experimental group patients were treated with plasma exchange therapy; efficacy of treatment was compared between two groups of patients. RESULTS: Initial dose, maximum dose, and cumulative dose of glucocorticoids were lower in experimental group patients than those in control group (P<0.05). Incidence of complication was lower in experimental group patients than those in control group (P<0.05); the difference was significant. There was no significant difference in short-term efficacy between the two groups (P>0.05). Conclusion: The application of plasma exchange therapy was effective for treatment of autoimmune bullous skin disease. It could reduce dosage amount of glucocorticoids and incidence of complications; its application can be promoted.

Is arthroscopic decompression better than conservative management for shoulder impingement? A systematic review and meta-analysis

2019 ◽  
Author(s):  
Shujing Liu ◽  
Yingying Yu ◽  
Guangxu Lu ◽  
Hui Dong ◽  
Wenliang Wang
Keyword(s):  
Conservative Treatment ◽  
Conservative Management ◽  
Meta Analysis ◽  
Arthroscopic Surgery ◽  
Shoulder Function ◽  
Controlled Trials ◽  
Short Term ◽  
Shoulder Impingement ◽  
Significant Difference

Abstract Background Arthroscopic decompression is commonly used to treat shoulder impingement, while the role of conservative treatment in these patients remains unclear. The objective of this paper is to synthesise available evidence regarding the effectiveness of subacromial decompression for shoulder impingement compared with conservative treatment to verify whether arthroscopic surgery is superior to conservative treatment. Methods We systematicly retrieved the Cochrane databases, Embase as well as Pubmed (from inception to July. 02, 2019) for randomized controlled trials. Cochrane risk-of-bias tool was used to assess all referred studies’ quality and we pooled outcomes with a random-effects model. We divided the outcomes into short-term subgroup(<2 years) and long-term subgroup (≥2 years). Results 7 randomised controlled trials (RCTs) were included, involving a total of 607 patients, 297 patients operated arthroscopic decompression, compared to 310 patients treated with conservative management. We found no significant differences either in shoulder pain scores or shoulder function scores between arthroscopic decompression and conservative management wether in long-term or short-term follow-up subgroups. Conclusion No significant difference was demonstrated on the treatment outcomes of shoulder impingement between arthroscopic decompression and conservative management in our meta-analysis. Thus, we suggested that conservative management should be chosen firstly for patients with shoulder impingement, when patients’ symptom cannot be relieved from the conservative treatment, arthroscopic decompression should be taken into consideration.Levels of Evidence Level-I study

scholarly journals AB0896 EFFECTIVENESS OF SACROPLASTY IN THE MANAGEMENT OF OSTEOPOROTIC SACRAL FRACTURE IN ELDERLY PATIENTS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1751.1-1752
Author(s):  
S. Hecquet ◽  
F. Verhoeven ◽  
S. Aubry ◽  
C. Prati ◽  
D. Wendling
Keyword(s):  
Treatment Group ◽  
Conservative Treatment ◽  
Elderly Patients ◽  
Sacral Fracture ◽  
Control Group ◽  
Medical Procedure ◽  
Short Term ◽  
Sacral Fractures ◽  
Significant Difference ◽  
Loss Of Autonomy

Background:Sacral fractures are a source of pain leading to loss of autonomy in elderly patients. Sacroplasty may be an effective alternative of conservative medical treatment.Objectives:To evaluate the short-term analgesic effect of sacroplasty compared to conservative treatment in patients with osteoporotic sacral fracturesMethods:This is a retrospective study of cases of osteoporotic sacral fractures treated with sacroplasty, compared with cases treated with conservative medical procedure over the same period. Outcome was evaluated by pain (Visual analogic scale) short-term (one month) evolution and side effects occurrence.Results:From January 2009 to June 2019, eleven patients were treated with sacroplasty for osteoporotic fractures at the Besançon University Hospital Centre. These were compared to 12 patients with osteoporotic sacral fracture with exclusive medical management, as a control group. The two groups were similar in age, gender and pain level at baseline. The median VAS was 7/10 in both groups at baseline, In the sacroplasty group, a significant decrease of pain was observed over the two first weeks, with a tendency remaining at day 30. There were no significant differences in the conservative treatment group at one week (p=0.2), fourteen days (p=0.6) and thirty days (p=0.7) compared to basal assessment.When comparing the sacroplasty group and the conservative treatment group, no differences were noted at baseline between the two groups, there was a significant difference between the two groups the following day (p=0.001), one week (p=0.003) and day 15 (p=0.01) after the intervention. However, there was no significant difference between the two groups at day 30, but only a trend (p=0.08).Regarding analgesic treatments, 30% of patients in the sacroplasty group could reduce their analgesics between the time they entered and left hospital. None of the patients in the control group were able to reduce their analgesic treatment over this period. In addition, half of the patients in the sacroplasty group were successful in returning home compared to only one-third of the patients in the conservative treatment group.Conclusion:In this study, sacroplasty was associated with an early and significant pain relief compared to conservative management in patients with osteoporotic sacral fracture. The procedure is well tolerated and may prevent loss of autonomy in these patients.Disclosure of Interests:None declared

scholarly journals Retrospective Clinical Study of a Freely Removable Implant-Supported Fixed Dental Prosthesis by a Microlocking System

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Eun-Bin Bae ◽  
Won-Tak Cho ◽  
Hyun-Young Bae ◽  
So-Hyoun Lee ◽  
Tae-Hyung Kim ◽  
...  
Keyword(s):  
Clinical Study ◽  
Survival Rate ◽  
Bone Resorption ◽  
Treatment Method ◽  
Fixed Dental Prosthesis ◽  
Probing Depth ◽  
Retrospective Clinical Study ◽  
Significant Difference ◽  
Implant Prosthesis ◽  
Observation Period

This retrospective clinical study was conducted to evaluate the clinical usefulness of a freely removable microlocking implant prosthesis (MLP) that was developed to overcome the problems with conventional implant prostheses. A total of 54 patients (male: 31, female: 23) and 100 implant prostheses were included. Patients were divided into three groups such as 6-12 months, 12-18 months, and 18-24 months according to the used period after implant prosthesis delivery, and the patients in each group were recalled for examinations of survival rate, marginal bone resorption, peri-implant soft tissue indices, and complications. The prosthetic complications were analysed by combining the recorded chart data during the periodic checks including the last call for this study. During a 2-year observation period, all the implants showed a 100% survival rate without clinical mobility and functional problems. There was no significant difference in marginal bone resorption, plaque index, and bleeding index over the observation period after implant prosthesis delivery. Probing depth of the 18-24 months group ( 1.5 ± 0.19   mm ) was significantly lower than that of the 6-12 months group ( p < 0.05 ). The main complication was abutment loosening (4%), followed by implant prosthesis fracture (2%) and food impaction (2%) which were recorded. Within the limits of the present study, the implant prostheses with MLP are considered to be an applicable and predictable treatment method.

scholarly journals Rational Pharmacotherapy in Case of Exacerbation of the Primary Low Back Pain

2021 ◽  
pp. 51-58
Author(s):  
Oleksandr Burianov ◽  
Taras Omelchenko ◽  
Volodymyr Volodymyr ◽  
Myroslav Myroslav ◽  
Volodymyr Lianskorunskyi
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Clinical Study ◽  
Side Effects ◽  
Conservative Treatment ◽  
Diclofenac Sodium ◽  
Main Group ◽  
Low Back ◽  
Significant Difference ◽  
Daily Dose

Low back pain (LBP) is one of the most common causes of orthopedic disability in people under 45 years of age. Primary LBP accounts for more than 90 % of all cases. The main objectives of treatment are to slow the progression of the degenerative process, reduce the intensity of inflammation and pain, increase functional activity and quality of life of patients. The solution of the set tasks is impossible without effective complex influence on numerous links of pathogenesis of degenerative-dystrophic and inflammatory process and ensuring safety at treatment. The objective: to evaluate the clinical effectiveness of complex conservative treatment of primary LBP with the use of the drug Alsokam (meloxicam) in patients with uncomplicated forms of degenerative-dystrophic lesions of the spine in the period of exacerbation. Materials and methods. A non-randomized, prospective comparative clinical study in two parallel groups involved 30 patients with exacerbation of LBP on the background of uncomplicated forms of degenerative-dystrophic lesions of the spine (osteochondrosis, spondyloarthritis). The mean age of patients was 40±7,2 years. There were 12 (40 %) female patients and 18 (60 %) male patients. The main group consisted of 15 patients who were prescribed the drug Alsokam (meloxicam) at a dose of 15 mg 1 time per day intramuscularly for 7 days. The control group consisted of 15 patients who received diclofenac sodium at a traditional daily dose of 75 mg intramuscularly once daily for 7 days during the same treatment period. In both groups, tolperisone 150 mg 3 times a day and B vitamins were also used for 10 15 days. Outcome evaluation parameters included: Visual analog pain scale (VAS), Huskisson; assessment of the patient’s functional status on the Roland-Morris scale (RDQ-24); accounting for side effects and adverse events in the observation groups. Results. In both groups, a significant decrease in the intensity of the pain syndrome was observed in the assessment of pain by VAS, but no statistically significant difference was observed between the observation groups (p=0,312). The analysis of the results of the evaluation of RDQ-24 also showed an increase in functional capacity in both groups, but without a significant difference between the groups of clinical observation (p=0,302). Analysis of the number of undesirable side effects in the observation groups showed a significantly lower frequency in patients of the main group with a high statistical probability (p<0,01). Conclusions. The results of a clinical study showed the effectiveness of meloxicam (Alsokam) in the complex conservative treatment of patients with primary LBP in the period of exacerbation, which correlates with the effect of diclofenac sodium in the average daily dose. The nature and frequency of adverse reactions in the main and comparator groups showed that meloxicam in Alsocam has a significantly higher safety profile compared to diclofenac sodium, and its use in complex treatment regimens for patients with primary LBP syndrome reduces the risk of NSAIDs gastropathies.

scholarly journals The role of antimicrobial drops Okomistin® in combined chronic blepharoconjunctivitis treatment

2015 ◽  
Vol 8 (4) ◽  
pp. 55-60 ◽  
Author(s):  
Igor Anatilevich Makarov
Keyword(s):  
Combined Therapy ◽  
Combined Treatment ◽  
Treatment Method ◽  
Meibomian Gland ◽  
Eye Drops ◽  
Prevention Measures ◽  
Artificial Tears ◽  
Eyelid Margin ◽  
Treatment And Prevention ◽  
Gland Function

Purpose. The evaluation of antimicrobial drops Okomistin® efficacy in combined treatment of chronic blepharoconjunctivitis. Material and methods. 80 patients (160 eyes) with chronic blepharoconjunctivitis were monitored. Demodex acne was found in eyelids of 72 eyes, the growth of saprophytic microflora in 28 cases. The complex of treatment and prevention measures consisted of daily compresses of Сalendula aqueous solution, instillations of Okomistin® eye drops, artificial tears. In the research group, the ultrasound eyelid margin micromassage was performed, and eyelid D’Arsonval therapy in demodex acne cases. Results. More rapid acute illness relief was observed in the eyes of patients in whom physiotherapy treatment was performed. Okomistin® instillations allow achieving sterile conjunctival culture in 3-5 days. Combined therapy helps to restore meibomian gland function, to achieve long-term disease remission. Conclusions. Combined use of the Okomistin®, physiotherapy, hygiene procedures, artificial tears is an effective and safe treatment method for chronic blepharoconjunctivitis combined treatment.

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