scholarly journals Prevention of the adverse effects of androgen deprivation therapy for prostate cancer using a 12-month home-based progressive resistance training program: a randomised controlled study

2019 ◽  
Author(s):  
Teresa Lam ◽  
Birinder Cheema ◽  
Amy Hayden ◽  
Stephen R. Lord ◽  
Howard Gurney ◽  
...  
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Prostate Cancer ◽  
Body Composition ◽  
Resistance Training ◽  
Adverse Effects ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Progressive Resistance Training ◽  
Home Based

Abstract Background In men with prostate cancer, androgen deprivation therapy (ADT) has detrimental effects on body composition and quality of life (QOL), which can be ameliorated with exercise interventions including progressive resistance training (PRT). Existing studies focus on reversing established changes using supervised programs. We investigated whether a home-based PRT program, instituted at the start of ADT, could prevent adverse effects over 12-months.Methods Twenty-five patients scheduled to receive at least 12 months of ADT were assigned to either usual care (UC) (n=12) or PRT (n=13) starting after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), insulin sensitivity, QOL and muscle function were measured at 6 weeks, 6- and 12 months. Data were analysed by a linear mixed model.Results Across the cohort, ADT had a negative impact on body composition, muscle strength, glucose metabolism and QOL. Compared to PRT patients at 12 months, UC patients had greater reductions in BCM by -1.9 ± 0.8% (p = 0.02) and higher gains in fat mass by 3.1 ± 1.0% (p = 0.002). There was a significant increase in physical activity levels (p = 0.02), and QOL in the mental health (p = 0.01) and vitality (p = 0.02) domains in the PRT compared to the UC group.Conclusion A home-based PRT program instituted at the start of ADT counteracts detrimental changes in body composition, improves physical activity and mental health over 12 months.

scholarly journals Androgen deprivation in prostate cancer: benefits of home-based resistance training

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Teresa Lam ◽  
Birinder Cheema ◽  
Amy Hayden ◽  
Stephen R. Lord ◽  
Howard Gurney ◽  
...  
Keyword(s):  
Mental Health ◽  
Physical Activity ◽  
Prostate Cancer ◽  
Body Composition ◽  
Resistance Training ◽  
Physical Function ◽  
Cell Mass ◽  
Androgen Deprivation ◽  
Mineral Density ◽  
Home Based

Abstract Introduction Androgen deprivation therapy (ADT) has detrimental effects on body composition, metabolic health, physical functioning, bone mineral density (BMD) and health-related quality of life (HRQOL) in men with prostate cancer. We investigated whether a 12-month home-based progressive resistance training (PRT) programme, instituted at the start of ADT, could prevent these adverse effects. Methods Twenty-five patients scheduled to receive at least 12 months of ADT were randomly assigned to either usual care (UC) (n = 12) or PRT (n = 13) starting immediately after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), BMD, physical function, insulin sensitivity and HRQOL were measured at 6 weeks and 6 and 12 months. Data were analysed by a linear mixed model. Results ADT had a negative impact on body composition, BMD, physical function, glucose metabolism and HRQOL. At 12 months, the PRT group had greater reductions in BCM by − 1.9 ± 0.8 % (p = 0.02) and higher gains in fat mass by 3.1 ± 1.0 % (p = 0.002), compared to the UC group. HRQOL domains were maintained or improved in the PRT versus UC group at 6 weeks (general health, p = 0.04), 6 months (vitality, p = 0.02; social functioning, p = 0.03) and 12 months (mental health, p = 0.01; vitality, p = 0.02). A significant increase in the Matsuda Index in the PRT versus UC group was noted at 6 weeks (p = 0.009) but this difference was not maintained at subsequent timepoints. Between-group differences favouring the PRT group were also noted for physical activity levels (step count) (p = 0.02). No differences in measures of BMD or physical function were detected at any time point. Conclusion A home-based PRT programme instituted at the start of ADT may counteract detrimental changes in body composition, improve physical activity and mental health over 12 months. Trial registration Australian and New Zealand Clinical Trials Registry, ACTRN12616001311448

scholarly journals Examining the effects of creatine supplementation in augmenting adaptations to resistance training in patients with prostate cancer undergoing androgen deprivation therapy: a randomised, double-blind, placebo-controlled trial

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e030080 ◽  
Author(s):  
Ciaran M Fairman ◽  
Krissy L Kendall ◽  
Robert U Newton ◽  
Nicolas H Hart ◽  
Dennis R Taaffe ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Composition ◽  
Resistance Training ◽  
Physical Function ◽  
Androgen Deprivation Therapy ◽  
Controlled Trial ◽  
Creatine Supplementation ◽  
Androgen Deprivation ◽  
Double Blind ◽  
Double Blind Placebo

IntroductionCreatine supplementation has consistently been demonstrated to augment adaptations in body composition, muscle strength and physical function in a variety of apparently healthy older adults and clinical populations. The effects of creatine supplementation and resistance training in individuals with cancer have yet to be investigated. This study aims to examine the effects of creatine supplementation in conjunction with resistance training on body composition, muscle strength and physical function in prostate cancer patients undergoing androgen deprivation therapy.Methods and analysisThis is a randomised, double-blind, placebo-controlled trial designed to examine the effects of creatine supplementation in addition to resistance training in patients with prostate cancer receiving androgen deprivation therapy. Both supplement and placebo groups will receive a 12-week supervised exercise programme comprising resistance training undertaken three times per week. The primary endpoint (fat-free mass) and secondary endpoints (fat mass, per cent body fat, physical fitness, quality of life and blood biomarkers) will be assessed at baseline and immediately following the intervention.Ethics and disseminationThe Human Research Ethics Committee of Edith Cowan University approved this study (ID: 22243 FAIRMAN). If the results of this trial demonstrate that creatine supplementation can augment beneficial adaptations of body composition, physical function and/or psychosocial outcomes to resistance training, this study will provide effect sizes that will inform the design of subsequent definitive randomised controlled trials. The results of this study will be published in peer-reviewed journals and presented at various national and international conferences.Trial registration numberACTRN12619000099123

scholarly journals Clinical Utility of miRNA-1, miRNA-29g and miRNA-133s Plasma Levels in Prostate Cancer Patients With High-Intensity Training After Androgen-Deprivation Therapy

2019 ◽  
pp. S139-S147
Author(s):  
A. GAZOVA ◽  
A. SAMAKOVA ◽  
E. LACZO ◽  
D. HAMAR ◽  
M. POLAKOVICOVA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Body Composition ◽  
Exercise Training ◽  
Androgen Deprivation Therapy ◽  
Plasma Levels ◽  
Exercise Intervention ◽  
Free Testosterone ◽  
Androgen Deprivation ◽  
Control Group ◽  
The Impact

The randomized trials showed that the addition of training resistance program to androgen-deprivation therapy (ADT) had many beneficial effects for prostate cancer (PC) patients (significant protective effect on the volume of muscle mass) and the studies have revealed a panel of miRNAs, which are deregulate in PC and may serve as promising biomarkers of PC risk. The primary aim of our present study was to investigate the effect of exercise training to changes in body composition (muscle strength) and the secondary endpoint was to investigate the impact of an exercise training program on plasma levels of selected myogenic microRNAs (miRNAs) (miRNA-1, miRNA-29b, and miRNA-133) in PC patients undergoing the ADT. Effect of ADT and exercise intervention showed significant increase (experimental group vs. control group) the changes in body composition, free testosterone levels, IL-6 and plasma levels of myogenic miRNAs and significant reduced insulin serum levels. In conclusion, resistance training with ADT in the treatment of PC significantly changed the physical and metabolic function and the plasma levels of specific myogenic miRNAs. Our data support with the other publicized results.

scholarly journals Review of major adverse effects of androgen-deprivation therapy in men with prostate cancer

Cancer ◽  
2009 ◽  
Vol 115 (11) ◽  
pp. 2388-2399 ◽  
Author(s):  
Lockwood G. Taylor ◽  
Steven E. Canfield ◽  
Xianglin L. Du
Keyword(s):  
Prostate Cancer ◽  
Adverse Effects ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation
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