scholarly journals Prevention of the adverse effects of androgen deprivation therapy for prostate cancer using a 12-month home-based progressive resistance training program: a randomised controlled study

2020 ◽  
Author(s):  
Teresa Lam ◽  
Birinder Cheema ◽  
Amy Hayden ◽  
Stephen R. Lord ◽  
Howard Gurney ◽  
...  

Abstract The authors have withdrawn this preprint from Research Square

Author(s):  
Jacopo Antonino Vitale ◽  
Matteo Bonato ◽  
Stefano Borghi ◽  
Carmelo Messina ◽  
Domenico Albano ◽  
...  

Background. The aim of this study was to evaluate the effect of a six-month home-based resistance-training program on muscle health and physical performance in healthy older subjects during the unique condition of home confinement caused by the COVID-19 pandemic. Methods. This was a randomized-controlled study that enrolled older participants that were allocated to either an experimental group performing the six-months exercise prescription (EXE) or a control group (CON). At the beginning (PRE), and after 6 months (POST), participants were assessed for muscle strength, balance, gait assessment and body composition by dual energy X-ray absorptiometry and magnetic resonance imaging. Normality distribution of data was checked with the D’Agostino and Pearson test and changes between PRE and POST were assessed by paired Student’s t-test while percentage and absolute changes between groups at POST were tested by unpaired t-test. Results. Nine participants were included for the final analysis: EXE, n = 5 (age: 66 ± 4; BMI: 27.5 ± 3.7) and CON, n = 4 (age: 71 ± 9; BMI: 24.2 ± 4.1). Significant PRE-to-POST changes were observed in the EXE group only in the chair-stand test (+19.8%, p = 0.048 and ES:1.0, moderate) and in total fat mass (+5.0%, p = 0.035 and ES:1.4, large) with no between-group differences. Moreover, EXE had significantly higher absolute thigh CSA values than CON at POST (14.138 ± 2977 vs. 9039 ± 1015, p = 0.0178, ES = 1.7). No other within- and between-group differences were detected. Conclusions. The home-based resistance-training program during the lockdown period, caused by the COVID-19 outbreak, determined only within-group improvement in lower limb muscle strength but not in muscle mass and composition in older subjects. Home confinement may partially explain the increase in total body fat due to a reduced daily PA regime and altered diet pattern.


2019 ◽  
Vol 58 (5) ◽  
pp. 650-657 ◽  
Author(s):  
Linnea Waldorff Lund ◽  
Gunn Ammitzbøll ◽  
Dorte Gilså Hansen ◽  
Elisabeth Anne Wreford Andersen ◽  
Susanne Oksbjerg Dalton

2019 ◽  
Author(s):  
Teresa Lam ◽  
Birinder Cheema ◽  
Amy Hayden ◽  
Stephen R. Lord ◽  
Howard Gurney ◽  
...  

Abstract Background In men with prostate cancer, androgen deprivation therapy (ADT) has detrimental effects on body composition and quality of life (QOL), which can be ameliorated with exercise interventions including progressive resistance training (PRT). Existing studies focus on reversing established changes using supervised programs. We investigated whether a home-based PRT program, instituted at the start of ADT, could prevent adverse effects over 12-months.Methods Twenty-five patients scheduled to receive at least 12 months of ADT were assigned to either usual care (UC) (n=12) or PRT (n=13) starting after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), insulin sensitivity, QOL and muscle function were measured at 6 weeks, 6- and 12 months. Data were analysed by a linear mixed model.Results Across the cohort, ADT had a negative impact on body composition, muscle strength, glucose metabolism and QOL. Compared to PRT patients at 12 months, UC patients had greater reductions in BCM by -1.9 ± 0.8% (p = 0.02) and higher gains in fat mass by 3.1 ± 1.0% (p = 0.002). There was a significant increase in physical activity levels (p = 0.02), and QOL in the mental health (p = 0.01) and vitality (p = 0.02) domains in the PRT compared to the UC group.Conclusion A home-based PRT program instituted at the start of ADT counteracts detrimental changes in body composition, improves physical activity and mental health over 12 months.


1993 ◽  
Vol 163 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Tom Burns ◽  
Alan Beadsmoore ◽  
Ashok V. Bhat ◽  
Andrew Oliver ◽  
Carola Mathers

While research has shown community-based psychiatric care to be as good as, or better than, hospital-based care, generalisation to clinical practice has been difficult. This prospective, randomised controlled study examined a community-based approach feasible within NHS conditions. Ninety-four patients were randomly allocated to experimental and 78 to control treatments and followed for one year. The groups were well matched apart from an excess of psychotic control patients. No differences in clinical or social functioning outcome were found. Both groups improved substantially on clinical measures in the first six weeks, with some slow consolidation thereafter. There were three suicides in the control group and one in the experimental group. Access to care was better in the experimental group (93% attended assessment) than in the control group (75% attended assessment).


2008 ◽  
Vol 23 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Elizabeth V. Cyarto ◽  
Wendy J. Brown ◽  
Alison L. Marshall ◽  
Stewart G. Trost

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