Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

Fasting Glucose Level ◽

Glucose Levels ◽

Mc4r Rs17782313 ◽

Abstract Background: Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels and cardiovascular disease are associated with MC4R. Methods: A total of 4,294 subjects participated in this study. There were 1810 subjects with cardiovascular disease among the 4294 subjects. We used multivariate linear regression models and multiple logistic regression analysis. Results: Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in women (OR, 1.99; 95% CI, 1.01-3.93). Men with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean men (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in overweight men.Conclusions: This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean men.

Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

10.21203/rs.2.21680/v3 ◽

2020 ◽

Author(s):

Jae Woong Sull ◽

Gitae Kim ◽

Sun Ha Jee

Keyword(s):

Cardiovascular Disease ◽

Regression Models ◽

Fasting Glucose ◽

Fasting Glucose Level ◽

Glucose Levels ◽

Mc4r Rs17782313 ◽

Abstract Background: Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels and cardiovascular disease are associated with MC4R. Methods: A total of 4,294 subjects participated in this study. There were 1810 subjects with cardiovascular disease among the 4294 subjects. We used multivariate linear regression models and multiple logistic regression analysis. Results: Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in women (OR, 1.99; 95% CI, 1.01-3.93). Men with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean men (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in overweight men.Conclusions: This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean men.

Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

10.21203/rs.2.21680/v4 ◽

2020 ◽

Author(s):

Jae Woong Sull ◽

Gitae Kim ◽

Sun Ha Jee

Keyword(s):

Cardiovascular Disease ◽

Regression Models ◽

Fasting Glucose ◽

Fasting Glucose Level ◽

Glucose Levels ◽

Mc4r Rs17782313 ◽

Abstract Background: Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels and cardiovascular disease are associated with MC4R. Methods: A total of 4,294 subjects participated in this study. There were 1810 subjects with cardiovascular disease among the 4294 subjects. We used multivariate linear regression models and multiple logistic regression analysis. Results: Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in women (OR, 1.99; 95% CI, 1.01-3.93). Men with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean men (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in overweight men.Conclusions: This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean men.

Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

10.21203/rs.2.21680/v5 ◽

2020 ◽

Author(s):

Jae Woong Sull ◽

Gitae Kim ◽

Sun Ha Jee

Keyword(s):

Cardiovascular Disease ◽

Regression Models ◽

Fasting Glucose ◽

Fasting Glucose Level ◽

Glucose Levels ◽

Mc4r Rs17782313 ◽

Abstract Background: Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels and cardiovascular disease are associated with MC4R. Methods: A total of 4,294 subjects participated in this study. There were 1810 subjects with cardiovascular disease among the 4294 subjects. We used multivariate linear regression models and multiple logistic regression analysis. Results: Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in women (OR, 1.99; 95% CI, 1.01-3.93). Men with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean men (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in overweight men.Conclusions: This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean men.

Association of MC4R (rs17782313) with diabetes and cardiovascular disease in Korean men and women

10.21203/rs.2.21680/v1 ◽

2020 ◽

Author(s):

Jae Woong Sull ◽

Gitae Kim ◽

Sun Ha Jee

Keyword(s):

Cardiovascular Disease ◽

Regression Models ◽

Fasting Glucose ◽

Glucose Levels ◽

Mc4r Rs17782313 ◽

The Relationship ◽

Male Subjects ◽

Obese Male

Abstract Background Diabetes is mostly assessed by the fasting glucose level. Several studies reported that serum fasting glucose levels are causally associated with MC4R. Methods A total of 4,294 subjects participated in this study. We used multivariate linear regression models and multiple logistic regression analysis. Results Individuals with the TC/CC genotype had a 1.29-fold higher risk of diabetes than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.29; 95% CI, 1.04-1.60). For healthy subjects, the association was significant in females (OR, 1.99; 95% CI, 1.01-3.93). Male participants with the TC/CC genotype had a 1.21-fold higher risk of cardiovascular disease than did those with the TT genotype when adjusting for age, sex, and BMI (OR, 1.21; 95% CI, 1.04-1.41). The relationship between MC4R and cardiovascular disease was stronger in lean male individuals (OR, 1.40; 95% CI, 1.12–1.74, p = 0.0028) than in obese male subjects. Conclusions This study suggests that the rs17782313 SNP in MC4R is related to diabetes and the SNP is also associated with cardiovascular disease in lean male individuals.

1400Central but not general obesity is positively associated with risk of hyperhomocysteinemia in middle-aged women

International Journal of Epidemiology ◽

10.1093/ije/dyab168.696 ◽

2021 ◽

Vol 50 (Supplement_1) ◽

Author(s):

Yingying Wang

Keyword(s):

Cardiovascular Disease ◽

Logistic Regression ◽

Regression Models ◽

Central Obesity ◽

Obese Women ◽

General Obesity ◽

Middle Aged ◽

Logistic Regression Models ◽

Abstract Background Obesity and homocysteine (Hcy) are two important risk factors for cardiovascular disease (CVD); however, there were conflicting results for the relationship between them. Our study is to explore the associations of general and central obesity with hyperhomocysteinemia (HHcy) in middle-aged women. Methods The current analysis was based on data from 11007 women aged 40-60 years. Height, weight, and waist circumference (WC) were measured and serum homocysteine was determined. Multiple logistic regression models were used to assess the associations of the risk of hyperhomocysteinemia (HHcy, Hcy>15μmol/L) with BMI and WC. Results 13.71% women had HHcy. The prevalences of BMI-based general obesity and WC-based central obesity were 11.17% and 22.88%, respectively. Compared with non-obese women, the mean serum Hcy concentration was significantly higher in WC-based central obese women (P = 0.002), but not in BMI-based general obese women (P > 0.05). In the multiple logistic regression models, central obesity was positively related to the risk of HHcy (OR = 1.30, 95%CI=1.10 to 1.52), while general obesity was inversely related to the risk of HHcy (OR = 0.82, 95%CI=0.72 to 0.93 and OR = 0.71,95% CI = 0.57 to 0.89). Conclusions Central obesity was positively, while general obesity was negatively related to the risk of HHcy. Menopause showed no effect modification on these associations. Key messages Homocysteine; Central obesity; Menopause; Cardiovascular Disease

Relationship Between Fasting and Postprandial Glucose Levels and the Gut Microbiota

10.21203/rs.3.rs-917351/v1 ◽

2021 ◽

Author(s):

Yui Mineshita ◽

Hiroyuki Sasaki ◽

Hyeon-ki Kim ◽

Shigenobu Shibata

Keyword(s):

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Blood Glucose ◽

Fasting Glucose ◽

Postprandial Glucose ◽

Free Living ◽

Glucose Levels ◽

The Relationship ◽

Free Living Conditions

Abstract Postprandial hyperglycemia increases the risk of mortality among patients with type 2 diabetes and cardiovascular diseases. Additionally, the gut microbiota and type 2 diabetes and cardiovascular disease are known to be correlated. Currently, fasting blood glucose is the primary index for the clinical diagnosis of diabetes; however, postprandial blood glucose is associated with the risk of developing type 2 diabetes and cardiovascular disease and mortality. Therefore, the dynamic change in blood glucose levels under free-living conditions is considered an important and better marker than fasting glucose levels, to study the relationship between glucose levels and microbiota. Here, we investigated the relationship between fasting and postprandial glucose levels and microbiota under free-living conditions, for one week in the older adults. The results revealed a significant correlation between peak glucose levels after dinner and the gut bacteria, particularly, Bacteroides, Clostridiales Clostridiaceae group, Anaerostipes, Clostridiales [Mogibacteriaceae] group, Holdemania, and Bilophila. Together, these findings suggest that the glucose levels after dinner are a better predictor of microbiota conditions than fasting glucose levels.

Association of fasting glucose levels with incident atherosclerotic cardiovascular disease: An 8-year follow-up study in a Chinese population

Journal of Diabetes ◽

10.1111/1753-0407.12380 ◽

2016 ◽

Vol 9 (1) ◽

pp. 14-23 ◽

Cited By ~ 1

Author(s):

Fangchao Liu ◽

Xueli Yang ◽

Jianxin Li ◽

Jie Cao ◽

Jichun Chen ◽

...

Keyword(s):

Cardiovascular Disease ◽

Chinese Population ◽

Fasting Glucose ◽

Atherosclerotic Cardiovascular Disease ◽

Glucose Levels ◽

Follow Up Study

Long-term Absolute Risk for Cardiovascular Disease Stratified by Fasting Glucose Level

Diabetes Care ◽

10.2337/dc18-1773 ◽

2019 ◽

Vol 42 (3) ◽

pp. 457-465 ◽

Cited By ~ 12

Author(s):

Michael P. Bancks ◽

Hongyan Ning ◽

Norrina B. Allen ◽

Alain G. Bertoni ◽

Mercedes R. Carnethon ◽

...

Keyword(s):

Cardiovascular Disease ◽

Glucose Level ◽

Fasting Glucose ◽

Absolute Risk ◽

Fasting Glucose Level

Abstract P295: Association Between Remained Number of Teeth and Cardiovascular Disease Among Korean Adults

Circulation ◽

10.1161/circ.137.suppl_1.p295 ◽

2018 ◽

Vol 137 (suppl_1) ◽

Author(s):

Hong Seok Lee ◽

Yong-Moon Park ◽

Kyungdo Han

Keyword(s):

Cardiovascular Disease ◽

Total Cholesterol Level ◽

Drinking Alcohol ◽

Limited Evidence ◽

Health And Nutrition ◽

Income Status ◽

Number Of Teeth ◽

Increased Risk ◽

Background: It has been reported that people with teeth loss have an increased risk of cardiovascular disease. However, there is limited evidence for the specific relationship between remained teeth and cardiovascular disease (CVD). Method: Among subjects who participated in Korea National Health and Nutrition Examination Survey conducted in 2008-2013, a total of 12,612 adults with mean age of 60.2±1.2 years old were analyzed. Number of teeth was classified as number less than 20, from 20 to 27 and more than 27. Multiple logistic regression analysis was performed to determine the relationship between cardiovascular disease and remained teeth number after adjusting for potential confounders. Result: The prevalence of cardiovascular disease was 6.5%, 3.3% and 1.4% respectively in groups having number less than 20, 20 to 27 and more than 27 ( P < 0.001). Total number of cardiovascular disease was 666. Diabetes, hypertension, total cholesterol level, waist circumference, metabolic syndrome had large proportion in a group having less than 20 teeth ( P < 0.001). People having less than 20 remained teeth had statistically significant cardiovascular disease after adjusting for age, sex, body mass index, smoking, drinking alcohol, exercise, education, income status, stress, diabetes, and hypertension. A group having less 20 teeth was likely to have statistically significant relationship with cardiovascular disease. (Odds ratio [OR]: 1.41, 95 % confidence interval [CI]: 1.06-1.89) and stroke (OR:1.90, CI:1.03-3.48). Conclusion: Our findings suggest that the number of remained teeth could be a useful additional indicator for assessing cardiovascular disease and stroke