Clinical characteristics and pathogens of pediatric pyogenic liver abscess in Beijing Children’s Hospital, China

Abstract Background: Data on pyogenic liver abscess (PLA) of children in China have been limited. Method: We retrospectively reviewed PLA cases from January 2017 to June 2019 at Beijing Children’s Hospital. Clinical features and pathogens were analyzed. Results: We diagnosed 15 PLA patients in our center. Median age of onset was 3.2 years and the median diagnostic time was 9 days. Four patients (26.7%) had underlying diseases and seven patients (46.7%) had multiple organ involvement. The sensitivity achieved 100% when ultrasound and contrast-enhanced CT scan were combined use to diagnose PLA. Two patients were defined pathogen through metagenomic next-generation sequencing (mNGS). Finally, eleven patients (73.3%) were cured during follow-up time and four patients (26.7%) dead. Compared to the survival group and the death group, the patients in death group were more likely to have multiple organ involved (100 vs. 27%, P < 0.05) and bilateral lobe occupied ( P < 0.05) . Conclusions: PLA often occurs in patients with underlying disease. Multiple organs involved may lead to poor prognosis. mNGS can be a new method to detect pathogen.

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The Value of Effective Lung Ventilation Area Ratio Based on CT Image Analysis Is a New Index to Predict the Shorter Outcome of Anti-melanoma Differentiation-Associated Protein 5 Positive Dermatomyositis Associated Interstitial Lung Disease: A Single-Center Retrospective Study

Frontiers in Medicine ◽

10.3389/fmed.2021.728487 ◽

2021 ◽

Vol 8 ◽

Author(s):

Changjian Wang ◽

Jinfeng Du ◽

Xilong Mei ◽

Lingchao Guo ◽

Fangzhao Li ◽

...

Keyword(s):

Image Analysis ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Age Of Onset ◽

Lung Ventilation ◽

Early Death ◽

Survival Group ◽

Early Survival ◽

Poor Outcomes ◽

Death Group

Background: Anti-melanoma differentiation-associated protein 5 (MDA5) positive dermatomyositis (MDA5+DM) patients have poor outcomes due to rapidly progressive interstitial lung disease (ILD). The accurate assessment of lung involvement is an urgent focus of research.Methods: A computer-aided lung interstitial image analysis technology has been developed, and a quantitative indicator named effective lung ventilation area ratio (ELVAR) that calculates the proportion of the area outside the lung interstitium in lung tissue has been established. 55 newly diagnosed MDA5+DM patients and 46 healthy individuals, matched for age and gender, were enrolled in this study. MDA5+DM patients were classified into early death group or early survival group according to their survival state within 3 months after diagnosis. Clinical characteristics, laboratory and immunological test results, lung involvement (including ELVAR value) and treatment were compared between early death group and early survival group to determine an index that can predict prognoses of patients with MDA5+DM.Results: There were significant differences between early death MDA5+DM patients and early survival MDA5+DM patients about 12 indices including age of onset, CRP, ferritin, albumin, and pulmonary involvement including severity of type I respiratory failure at diagnosis, P/F ratio, oxygen supplementation, values of ELVAR, FVC, and DLCO. The results of ROC analysis and correlation analysis showed the value of ELVAR had good diagnostic value and widely correlation with many clinical characteristics. Univariate analysis and Multivariate analysis showed four factors including age of onset, ferritin, value of ELVAR, and oxygen supplementation >4 L/min significantly value for poor prognosis in MDA5+DM patients. A cutoff value of 0.835 about ELVAR had good predictive power for mortality within 3 months in 54.2% of MDA5+DM patients.Conclusion: The value of ELVAR derived from computed tomography image analysis is a new index that can predict poor outcomes in MDA5+DM patients with rapidly progressive interstitial lung disease.

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Current Situation of Treatment and Follow-up Re-examination of Children with Epilepsy at Vietnam National Children’s Hospital

Tạp chí Nghiên Cứu Và Thực Hành Nhi Khoa ◽

10.25073/jprp.v4i5.232 ◽

2020 ◽

Vol 4 (5) ◽

Author(s):

Thi Huyen Tran ◽

Vu Hung Cao ◽

Van Hoc Tran ◽

Danh Ngon Nguyen

Keyword(s):

Treatment Time ◽

Age Of Onset ◽

Treatment Compliance ◽

Duration Of Treatment ◽

Cross Sectional ◽

Female Ratio ◽

Children's Hospital ◽

Male Female Ratio ◽

Children’S Hospital

Purpose: To assess treatment compliance and follow-up appointment of children with epilepsy at the Vietnam National Children’s Hospital in 2019. Method: A cross-sectional descriptive study was conducted on pediatric patients and primary caregivers came for examination and treatment at the Neurology Department, Vietnam National Children’s Hospital from January 2019 to December 2019. Results: Mean age was 74.3 ± 45.1 (month age). The most common age group was the 2-6 year old group (40.5%), the lower rate was the 6-12 year old group (30.0%), and rest groups was the low rate. The male: female ratio is 1.43:1. Most of the main caregivers are parents (92.5%). Average treatment time was 20.4 ± 15.7 months, the rate of good adherence to treatment 43.5%, 31.5% of children had moderated adhering to treatment and 25.0% had poor adhering to treatment. Within 6 months, 40.5% of children re-examined on time. The reasons for not complying with on-time re-examination were mainly due to the caregiver's busy work or the child was busy at school (37.8%) and the distance from home to hospital (26.1%). Conclusions: The percentage of patients who complied with treatment and re-examination was not high. Factors that were statistically significant for children's non-compliance were: health insurance level, age of onset, duration of treatment, and frequency of attacks following treatment.

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Etiology, Presentation and Management of Liver Abscesses at the Children’s Hospital Lahore

Annals of King Edward Medical University ◽

10.21649/akemu.v14i4.7 ◽

2010 ◽

Vol 14 (4) ◽

Cited By ~ 1

Author(s):

Huma Arshad Cheema ◽

Anjum Saeed

Keyword(s):

Liver Abscess ◽

Pediatric Population ◽

Management Strategies ◽

Positive Culture ◽

Diagnostic Tools ◽

Key Words Liver ◽

Children's Hospital ◽

Liver Abscesses ◽

Satisfactory Outcome ◽

Children’S Hospital

Background: Liver abscess is a common problem among children. The purpose of this study is to describe the etiology, different management strategies and outcome of children with liver abscess in Children’s Hospital Lahore. Patients and Methods: This study included 38 children with liver abscess seen during two-year period, from September 2004 to September 2006 at the Children’s Hospital and Institute of Child Health, Lahore. Diagnosis was made on history, examination and investigations. Ultrasound and CT scan were the main diagnostic tools. Results: Out of 38 patients, 33 children underwent aspiration and remaining 5 were managed conservatively. Eight aspirates yielded positive culture for various organisms. Three patients were positive for E.Coli, 2 for Staph Aureus, and 1 each case of Klebsiella and Pseudomonas. One patient had multiple micro-abscesses and was also positive for typhidot IgM. Another patient was positive for acid fast mycobacterium tuberculosis. All patients recovered from their abscesses. There was no mortality reported. Conclusions: In our pediatric population, liver abscess are mostly caused by pyogenic organisms. Amebic etiology was not proven in any case. Majority of liver abscesses can be satisfactorily treated by aspiration and /or percutaneous image guided drainage with satisfactory outcome. Key Words: Liver abscess, children.

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Case series of skin symptoms possibly related to SARS-CoV-2 infection admitted to Heim Pál Children’s Hospital and review of the literature

Bőrgyógyászati és Venerológiai Szemle ◽

10.7188/bvsz.2021.97.1.5 ◽

2021 ◽

Vol 97 (1) ◽

pp. 36-44

Author(s):

Klára Veres ◽

◽

Andrea Izabella Gál ◽

András Szabó ◽

Borbála Pataky ◽

...

Keyword(s):

Kawasaki Disease ◽

Multiple Organ Failure ◽

Organ Failure ◽

Young Patients ◽

Case Series ◽

Multiple Organ ◽

High Antibody ◽

Children's Hospital ◽

Skin Symptoms ◽

Children’S Hospital

The COVID-19 pandemic, which started in China in December2019, is caused by the SARS-CoV-2 virus. In addition to severe, even life-threatening respiratory symptoms caused by the SARS-CoV-2 virus, a number of systemic and atypical skin symptoms have developed in young patients. This article presents cases of skin symptoms possibly provoked by SARS-CoV-2 virus attended to Pál Heim Children’s Hospital from 15 November to 31 December 2020. Four chilblain-like acral lesions and one case of multiple organ failure similar to Kawasaki disease are presented. The SARS-COV-2 PCR test was negative in all cases, however, high antibody titer was found by serologic testing for antibodies in two cases. In another case, the frst antibody test found doubtful positivity, however, high antibody levels were confrmed one month later. Based on our fndings, it is presumed, that pernio-like symptoms and multiple organ failure similar to Kawasaki disease could be late symptoms of COVID-19. The authors also summarize the most common skin symptoms associated with SARS-CoV-2 infection in children, highlighting the diferent pediatric aspects from adult cases.

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Passy-Muir Speaking Valve Use in a Children's Hospital: An Interdisciplinary Approach

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd18.2.76 ◽

2008 ◽

Vol 18 (2) ◽

pp. 76-86 ◽

Cited By ~ 2

Author(s):

Lauren Hofmann ◽

Joseph Bolton ◽

Susan Ferry

Keyword(s):

Tracheostomy Tube ◽

Pediatric Population ◽

Interdisciplinary Approach ◽

Extended Period ◽

Speech Development ◽

Tube Placement ◽

Background Information ◽

Speaking Valve ◽

Children's Hospital ◽

Children’S Hospital

Abstract At The Children's Hospital of Philadelphia (CHOP) we treat many children requiring tracheostomy tube placement. With potential for a tracheostomy tube to be in place for an extended period of time, these children may be at risk for long-term disruption to normal speech development. As such, speaking valves that restore more normal phonation are often key tools in the effort to restore speech and promote more typical language development in this population. However, successful use of speaking valves is frequently more challenging with infant and pediatric patients than with adult patients. The purpose of this article is to review background information related to speaking valves, the indications for one-way valve use, criteria for candidacy, and the benefits of using speaking valves in the pediatric population. This review will emphasize the importance of interdisciplinary collaboration from the perspectives of speech-language pathology and respiratory therapy. Along with the background information, we will present current practices and a case study to illustrate a safe and systematic approach to speaking valve implementation based upon our experiences.

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