scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in two Neurology referral hospitals in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Clinical History ◽  
Sub Saharan Africa ◽  
Poor Sleep ◽  
Cross Sectional ◽  
Sub Saharan

Abstract Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms.Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 43.9% of patients had a PDSS score > 18. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. A high EDSS score significantly associated with a Hoehn & Yahr score > 4 (p= 0.02). Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed.

scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Previous History ◽  
Sub Saharan Africa ◽  
Poor Sleep ◽  
Motor Symptoms ◽  
Cross Sectional

Abstract Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms.Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 43.9% of patients had a PDSS score > 18. Presence of previous history of sleep disturbance before PD motor symptoms (OR 3.54; 95% CI 1.61-7.76, p=0.001) and unemployment (OR 2.27; 95% CI 1.07-4.79, p=0.023) associated with a high PDSS-2 score. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed.

scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Sub Saharan Africa ◽  
Symptom Duration ◽  
Poor Sleep ◽  
Motor Symptoms ◽  
Cross Sectional

Abstract ABSTRACT Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms. Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 23% of patients had a PDSS score > 30. Hoehn and Yahr score > 3 (OR 6.16; 95% CI 1.59-23.9, p=0.009) and PD symptom duration > 5 yrs (OR 5.11; 95% CI 1.41-18.5, p=.013) associated with a high PDSS-2 score. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed. Keywords: Parkinson’s disease, Sleep disorders, Africa, poverty

scholarly journals Profil Gangguan Tidur Penderita Parkinson di Rumah Sakit Rujukan di Kota Denpasar Tahun 2018

2020 ◽  
Vol 3 (1) ◽  
pp. 12-16
Author(s):  
Winda Haeriyoko ◽  
Purwa Samatra ◽  
Sri Yenni Trisnawati ◽  
IGN Budiarsa ◽  
Anak Agung Ayu Suryapraba
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Latency ◽  
Demographic Data ◽  
Poor Sleep ◽  
Male Patients ◽  
Disease Experience ◽  
Observational Descriptive Study

Abstrak Latar Belakang : Jumlah kasus Penyakit Parkinson di Indonesia cukup tinggi dengan prevalensi per penduduk dan insiden per penduduk. Gangguan tidur ddapatkan pada penderita Penyakit Parkinson. Data demografi dapat digunakan sebagai pertimbangan klinisi dalam mendiagnosis serta menentukan penanganan lanjutan yang optimal. Tujuan : Mengetahui karakteristik klinis pasien Penyakit Parkinson dengan gangguan tidur di Poliklinik Saraf Rumah Sakit Umum Pusat Sanglah (RSUP) Sanglah dan Rumah Sakit Umum Daerah (RSUD) Wangaya periode bulan 2018. Metode Penelitian : Penelitian deskriptif observasional menggunakan kuesioner pasien Penyakit Parkinson yang berobat di Poliklinik Saraf RSUP Sanglah dan RSUD Wangaya bulan hingga 2018. Hasil : Sebanyak pasien dari 47 pasien Penyakit Parkinson dengan rerata usia 61 – 70 tahun sebanyak dengan laki – laki sebanyak 34 orang (72,3%). Pasien dominan berobat ke RSUP Sanglah sebanyak 30 orang (63,8%) dengan pekerjaan terbanyak adalah petani/buruh sebanyak 13 orang (27,7%). Awitan penyakit rata – rata 1 – 5 tahun (39%). Penderita Penyakit Parkinson mengalami gangguan tidur sebanyak 24 orang (51,1%). Profil gangguan tidur dengan rerata kualitas tidur buruk 55,3%; mengalami latensi tidur 1x seminggu 40,4%. Simpulan : Penyakit Parkinson didominasi oleh pasien laki – laki dengan rerata usia 61 – 70 tahun dengan awitan peyakit rata – rata 1 – 5 tahun yang mengalami gangguan tidur. Gangguan tidur yang banyak diemukan berupa terjadinya latensi tidur sebanyak  1 kali seminggu. Kata kunci : Penyakit Parkinson, gangguan tidur, karakteristik   Abstract Background: The number of cases of Parkinson's disease in Indonesia is quite high with prevalence per population and incidence per population. Sleep disorders can be found in people with Parkinson's Disease. Demographic data can be used as a clinician's consideration in diagnosing and determining optimal follow-up treatment. Objective: To determine the clinical characteristics of Parkinson's disease patients with sleep disorders in the Neurology Polyclinic at Sanglah Central Hospital (RSUP) and Sanglah Regional General Hospital (RSUD) Wangaya for the period of 2018. Research Methods: An observational descriptive study using a questionnaire for Parkinson's disease patients seeking treatment at the Neurology Polyclinic at Sanglah Hospital and Wangaya District Hospital until 2018. Results: A total of 47 patients from Parkinson's disease with a mean age of 61-70 years were 34 men (72.3%). Most of the patients went to Sanglah Hospital as many as 30 people (63.8%) with the most work being farmers as many as 13 people (27.7%). The average onset of disease is 1 - 5 years (39%). Patients with Parkinson's Disease experience sleep disorders as many as 24 people (51.1%). Profile of sleep disorders with an average of poor sleep quality 55.3%; sleep latency 1 time a week 40.4%. Conclusion: Parkinson's disease is dominated by male patients with an average age of 61 - 70 years with onset of disease on average 1-5 years who experience sleep disorders. Sleep disorders are often found in the form of sleep latency as much as 1 time a week. Keywords: Parkinson's disease, sleep disorders, characteristics

scholarly journals Parkinson’s disease – a review of pathogenesis, recent advances in management, and challenges of care in sub-Saharan Africa

2021 ◽  
pp. e35
Author(s):  
Akintomiwa I. Makanjuola ◽  
Funmilola T. Taiwo ◽  
Joseph O. Yaria ◽  
Rufus O. Akinyemi ◽  
Adesola Ogunniyi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Treatment Options ◽  
Sub Saharan Africa ◽  
Treatment Modalities ◽  
Unequal Distribution ◽  
Low Resource Settings ◽  
Low Resource ◽  
Recent Advances ◽  
Sub Saharan

Parkinson’s disease (PD) remains a common neurodegenerative movement disorder with significant morbidity, which is expected to increase worldwide in the coming decades. Since its initial description, much has been elucidated about its etiology, pathogenesis, and the role of genetic and environmental risk factors. Effective treatments, including surgical therapies, have been discovered. Despite these strides, many questions remain unanswered; PD remains an active research area with ongoing efforts to discover newer treatment modalities and identify neuroprotective strategies. As with many neurological conditions, there is an unequal distribution of health resources, resulting in some management challenges in low resource settings, especially sub-Saharan Africa (SSA). In this communication, we provide an overview of PD etiopathogenesis, including genetics and management strategies, including some recent advances with respect to treatment options and disease modification approaches. Finally, we discuss some challenges of PD management in low-resource settings and highlight efforts to turn the tide.

scholarly journals The modern pre-levodopa era of Parkinson's disease: insights into motor complications from sub-Saharan Africa

Brain ◽  
2014 ◽  
Vol 137 (10) ◽  
pp. 2731-2742 ◽  
Author(s):  
R. Cilia ◽  
A. Akpalu ◽  
F. S. Sarfo ◽  
M. Cham ◽  
M. Amboni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sub Saharan Africa ◽  
Motor Complications ◽  
Sub Saharan

scholarly journals Burden of adult neurological diseases in Odeda Area, Southwest Nigeria

2020 ◽  
Vol 2 (2) ◽  
pp. e000062
Author(s):  
Folajimi Morenikeji Otubogun ◽  
Rufus Akinyemi ◽  
Sola Ogunniyi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Sub Saharan Africa ◽  
Morbidity Rate ◽  
Primary Headaches ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Southwest Nigeria

BackgroundFew population-based studies have been conducted to determine the burden of neurological diseases in sub-Saharan Africa. A better understanding of the magnitude and impact of these disorders is pivotal to effective planning and provision of neurological services.MethodsA cross-sectional survey of 2392 adults in Odeda Local Government Area, Ogun State, Southwest Nigeria was conducted between May and June 2015. Trained non-medical interviewers administered a screening instrument designed to measure the prevalence of neurological diseases and disability, while positive responders were subsequently examined by neurologists. Diagnoses were made clinically according to well-established criteria.ResultsThe mean age of respondents was 37.2±16.1 years. A total of 842 cases of neurological diseases/disability were diagnosed in 815 individuals (26 individuals with more than one disorder). The all-cause neurological morbidity rate was 352 per 1000, while the crude prevalence rates of common neurological disorders were 304.3 per 1000 for primary headaches, 16.3 per 1000 for tropical ataxic neuropathy, 7.11 per 1000 for stroke, 5.85 per 1000 for essential tremor and 4.18 per 1000 for Parkinson’s disease. Neurological years lost due to disability was 2806.18 per 100 000.ConclusionThis study provides evidence of a high neurological disease burden within the communities surveyed, which may be representative of Southwest Nigeria. In comparison with findings from previous studies within the same region, this report suggests a persistence of toxiconutritional disorders and postinfectious neurological sequelae on one hand and increased prevalence of non-communicable neurological disorders such as stroke and Parkinson’s disease.

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