scholarly journals Profil Gangguan Tidur Penderita Parkinson di Rumah Sakit Rujukan di Kota Denpasar Tahun 2018

2020 ◽  
Vol 3 (1) ◽  
pp. 12-16
Author(s):  
Winda Haeriyoko ◽  
Purwa Samatra ◽  
Sri Yenni Trisnawati ◽  
IGN Budiarsa ◽  
Anak Agung Ayu Suryapraba
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Latency ◽  
Demographic Data ◽  
Poor Sleep ◽  
Male Patients ◽  
Disease Experience ◽  
Observational Descriptive Study

Abstrak Latar Belakang : Jumlah kasus Penyakit Parkinson di Indonesia cukup tinggi dengan prevalensi per penduduk dan insiden per penduduk. Gangguan tidur ddapatkan pada penderita Penyakit Parkinson. Data demografi dapat digunakan sebagai pertimbangan klinisi dalam mendiagnosis serta menentukan penanganan lanjutan yang optimal. Tujuan : Mengetahui karakteristik klinis pasien Penyakit Parkinson dengan gangguan tidur di Poliklinik Saraf Rumah Sakit Umum Pusat Sanglah (RSUP) Sanglah dan Rumah Sakit Umum Daerah (RSUD) Wangaya periode bulan 2018. Metode Penelitian : Penelitian deskriptif observasional menggunakan kuesioner pasien Penyakit Parkinson yang berobat di Poliklinik Saraf RSUP Sanglah dan RSUD Wangaya bulan hingga 2018. Hasil : Sebanyak pasien dari 47 pasien Penyakit Parkinson dengan rerata usia 61 – 70 tahun sebanyak dengan laki – laki sebanyak 34 orang (72,3%). Pasien dominan berobat ke RSUP Sanglah sebanyak 30 orang (63,8%) dengan pekerjaan terbanyak adalah petani/buruh sebanyak 13 orang (27,7%). Awitan penyakit rata – rata 1 – 5 tahun (39%). Penderita Penyakit Parkinson mengalami gangguan tidur sebanyak 24 orang (51,1%). Profil gangguan tidur dengan rerata kualitas tidur buruk 55,3%; mengalami latensi tidur 1x seminggu 40,4%. Simpulan : Penyakit Parkinson didominasi oleh pasien laki – laki dengan rerata usia 61 – 70 tahun dengan awitan peyakit rata – rata 1 – 5 tahun yang mengalami gangguan tidur. Gangguan tidur yang banyak diemukan berupa terjadinya latensi tidur sebanyak  1 kali seminggu. Kata kunci : Penyakit Parkinson, gangguan tidur, karakteristik   Abstract Background: The number of cases of Parkinson's disease in Indonesia is quite high with prevalence per population and incidence per population. Sleep disorders can be found in people with Parkinson's Disease. Demographic data can be used as a clinician's consideration in diagnosing and determining optimal follow-up treatment. Objective: To determine the clinical characteristics of Parkinson's disease patients with sleep disorders in the Neurology Polyclinic at Sanglah Central Hospital (RSUP) and Sanglah Regional General Hospital (RSUD) Wangaya for the period of 2018. Research Methods: An observational descriptive study using a questionnaire for Parkinson's disease patients seeking treatment at the Neurology Polyclinic at Sanglah Hospital and Wangaya District Hospital until 2018. Results: A total of 47 patients from Parkinson's disease with a mean age of 61-70 years were 34 men (72.3%). Most of the patients went to Sanglah Hospital as many as 30 people (63.8%) with the most work being farmers as many as 13 people (27.7%). The average onset of disease is 1 - 5 years (39%). Patients with Parkinson's Disease experience sleep disorders as many as 24 people (51.1%). Profile of sleep disorders with an average of poor sleep quality 55.3%; sleep latency 1 time a week 40.4%. Conclusion: Parkinson's disease is dominated by male patients with an average age of 61 - 70 years with onset of disease on average 1-5 years who experience sleep disorders. Sleep disorders are often found in the form of sleep latency as much as 1 time a week. Keywords: Parkinson's disease, sleep disorders, characteristics

scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Previous History ◽  
Sub Saharan Africa ◽  
Poor Sleep ◽  
Motor Symptoms ◽  
Cross Sectional

Abstract Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms.Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 43.9% of patients had a PDSS score > 18. Presence of previous history of sleep disturbance before PD motor symptoms (OR 3.54; 95% CI 1.61-7.76, p=0.001) and unemployment (OR 2.27; 95% CI 1.07-4.79, p=0.023) associated with a high PDSS-2 score. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed.

scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Sub Saharan Africa ◽  
Symptom Duration ◽  
Poor Sleep ◽  
Motor Symptoms ◽  
Cross Sectional

Abstract ABSTRACT Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms. Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 23% of patients had a PDSS score > 30. Hoehn and Yahr score > 3 (OR 6.16; 95% CI 1.59-23.9, p=0.009) and PD symptom duration > 5 yrs (OR 5.11; 95% CI 1.41-18.5, p=.013) associated with a high PDSS-2 score. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed. Keywords: Parkinson’s disease, Sleep disorders, Africa, poverty

scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in two Neurology referral hospitals in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Clinical History ◽  
Sub Saharan Africa ◽  
Poor Sleep ◽  
Cross Sectional ◽  
Sub Saharan

Abstract Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms.Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 43.9% of patients had a PDSS score > 18. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. A high EDSS score significantly associated with a Hoehn & Yahr score > 4 (p= 0.02). Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed.

scholarly journals Insomnia and autonomic dysfunction may identify patients at risk for developing early Parkinson's disease dementia

2019 ◽  
Author(s):  
Anamaria Jurcau ◽  
Vharoon Sharma Nunkoo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Autonomic Dysfunction ◽  
Odds Ratio ◽  
Rating Scale ◽  
Demographic Data ◽  
Severity Index ◽  
Complex Evaluation ◽  
Patients At Risk

Abstract Background: The prospective study aims at identifying features predictive of early onset of dementia in patients with Parkinson's disease (PD). Methods: 89 non-demented PD patients underwent a complex evaluation (demographic data, UPDRS, Unified Multiple System Atrophy Rating Scale - UMSAR, Insomnia Severity Index - ISI, Neuro-Psychiatric Inventory - NPI, Hamilton Depression Rating Scale - HDRS, Mini Mental State Examination) at baseline and at 3-year follow-up. Results: At 3-year follow-up 43.8% of patients developed dementia. An ordinal regression of MMSE at follow-up showed that dementia developed in patients with autonomic dysfunctions (odds ratio 16.18, 95% CI 3.16 to 82.77, p = 0.001), old age (odds ratio 1.24, 95% CI 1.11 to 1.39, p < 0.001), and insomnia (odds ratio 1.23, 95% CI 1.09 to 1.38, p = 0.001). Conclusion: Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.

WED 106 Unilateral abnormal dat scan: early indicator of parkinson’s disease

2018 ◽  
Vol 89 (10) ◽  
pp. A11.3-A11
Author(s):  
Heng Nicholas ◽  
Chin Mei Ying ◽  
Monaghan Clare ◽  
Davidson John ◽  
Gilbertson Tom ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Predictive Factor ◽  
Demographic Data ◽  
Tertiary Institution ◽  
Parkinsonian Syndromes ◽  
Dat Scan ◽  
Diagnostic Changes ◽  
Degenerative Parkinsonism

IntroductionDopamine transporter (DaT) scans are used in the investigation of clinically uncertain Parkinsonian syndromes (CUPS). Presently, bilateral abnormal DaT scans are diagnostic of Parkinson’s disease and degenerative Parkinsonism, while normal scans suggest non-degenerative causes. However, the clinical significance of unilateral abnormal scans remains ambiguous. Therefore, we aimed to determine their relevance in CUPS, and hypothesised that they may presage Parkinson’s disease and degenerative Parkinsonism.MethodsA retrospective analysis was performed for patients with CUPS within a tertiary institution who had undergone DaT scans. Demographic data, clinical features, imaging and diagnoses were collected. In patients with unilateral scans, follow-up assessments, further imaging and diagnostic changes were also recorded.ResultsA total of 200 DaT scans were performed from 1 January 2008 to 1 January 2017. There were 100 (50.0%) with normal scans, 77 (38.5%) with bilateral scans, and 23 (11.5%) with unilateral scans. Of the latter group (n=23), 8 (34.8%) underwent follow-up DaT imaging in a mean period of 31.9±12.6 months from baseline, with 4 (17.4%) now reported as bilateral, although 2 (8.7%) remained unilateral and 2 (8.7%) were reported as normal.ConclusionUnilateral DaT scans can serve as a predictive factor for development of Parkinson’s disease and degenerative Parkinsonism.

Coexistent Osteoarthritis and Parkinson’s Disease: Data from the Parkinson’s Foundation Outcomes Project

2020 ◽  
Vol 10 (4) ◽  
pp. 1601-1610
Author(s):  
Jaimie A. Roper ◽  
Abigail C. Schmitt ◽  
Hanzhi Gao ◽  
Ying He ◽  
Samuel Wu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Study Data ◽  
Functional Mobility ◽  
Quality Improvement Initiative ◽  
Timed Up And Go ◽  
Mobility Performance ◽  
Risk Of Mortality ◽  
The Impact

Background: The impact of concurrent osteoarthritis on mobility and mortality in individuals with Parkinson’s disease is unknown. Objective: We sought to understand to what extent osteoarthritis severity influenced mobility across time and how osteoarthritis severity could affect mortality in individuals with Parkinson’s disease. Methods: In a retrospective observational longitudinal study, data from the Parkinson’s Foundation Quality Improvement Initiative was analyzed. We included 2,274 persons with Parkinson’s disease. The main outcomes were the effects of osteoarthritis severity on functional mobility and mortality. The Timed Up and Go test measured functional mobility performance. Mortality was measured as the osteoarthritis group effect on survival time in years. Results: More individuals with symptomatic osteoarthritis reported at least monthly falls compared to the other groups (14.5% vs. 7.2% without reported osteoarthritis and 8.4% asymptomatic/minimal osteoarthritis, p = 0.0004). The symptomatic group contained significantly more individuals with low functional mobility (TUG≥12 seconds) at baseline (51.5% vs. 29.0% and 36.1%, p < 0.0001). The odds of having low functional mobility for individuals with symptomatic osteoarthritis was 1.63 times compared to those without reported osteoarthritis (p < 0.0004); and was 1.57 times compared to those with asymptomatic/minimal osteoarthritis (p = 0.0026) after controlling pre-specified covariates. Similar results hold at the time of follow-up while changes in functional mobility were not significant across groups, suggesting that osteoarthritis likely does not accelerate the changes in functional mobility across time. Coexisting symptomatic osteoarthritis and Parkinson’s disease seem to additively increase the risk of mortality (p = 0.007). Conclusion: Our results highlight the impact and potential additive effects of symptomatic osteoarthritis in persons with Parkinson’s disease.

scholarly journals Present and Future of Parkinson’s Disease in Spain: PARKINSON-2030 Delphi Project

2021 ◽  
Vol 11 (8) ◽  
pp. 1027
Author(s):  
Diego Santos García ◽  
Marta Blázquez-Estrada ◽  
Matilde Calopa ◽  
Francisco Escamilla-Sevilla ◽  
Eric Freire ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
New Technologies ◽  
Management Strategies ◽  
Multidisciplinary Teams ◽  
Modified Delphi ◽  
Advanced Stages ◽  
Diagnostic Capacity ◽  
Socio Economic Impact

Parkinson’s disease (PD) is a chronic progressive and irreversible disease and the second most common neurodegenerative disease worldwide. In Spain, it affects around 120.000–150.000 individuals, and its prevalence is estimated to increase in the future. PD has a great impact on patients’ and caregivers’ lives and also entails a substantial socioeconomic burden. The aim of the present study was to examine the current situation and the 10-year PD forecast for Spain in order to optimize and design future management strategies. This study was performed using the modified Delphi method to try to obtain a consensus among a panel of movement disorders experts. According to the panel, future PD management will improve diagnostic capacity and follow-up, it will include multidisciplinary teams, and innovative treatments will be developed. The expansion of new technologies and studies on biomarkers will have an impact on future PD management, leading to more accurate diagnoses, prognoses, and individualized therapies. However, the socio-economic impact of the disease will continue to be significant by 2030, especially for patients in advanced stages. This study highlighted the unmet needs in diagnosis and treatment and how crucial it is to establish recommendations for future diagnostic and therapeutic management of PD.

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