scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Previous History ◽  
Sub Saharan Africa ◽  
Poor Sleep ◽  
Motor Symptoms ◽  
Cross Sectional

Abstract Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms.Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 43.9% of patients had a PDSS score > 18. Presence of previous history of sleep disturbance before PD motor symptoms (OR 3.54; 95% CI 1.61-7.76, p=0.001) and unemployment (OR 2.27; 95% CI 1.07-4.79, p=0.023) associated with a high PDSS-2 score. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed.

scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Sub Saharan Africa ◽  
Symptom Duration ◽  
Poor Sleep ◽  
Motor Symptoms ◽  
Cross Sectional

Abstract ABSTRACT Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms. Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 23% of patients had a PDSS score > 30. Hoehn and Yahr score > 3 (OR 6.16; 95% CI 1.59-23.9, p=0.009) and PD symptom duration > 5 yrs (OR 5.11; 95% CI 1.41-18.5, p=.013) associated with a high PDSS-2 score. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed. Keywords: Parkinson’s disease, Sleep disorders, Africa, poverty

scholarly journals Prevalence of sleep disorders in Parkinson’s disease patients in two Neurology referral hospitals in Ethiopia

2019 ◽  
Author(s):  
Dereje Melka ◽  
Abenet Tafesse ◽  
James H. Bower ◽  
Demeke Assefa
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Addis Ababa ◽  
Demographic Data ◽  
Clinical History ◽  
Sub Saharan Africa ◽  
Poor Sleep ◽  
Cross Sectional ◽  
Sub Saharan

Abstract Background: Non motor symptoms (NMS) of Parkinson’s disease (PD) are common and can be more disabling than motor symptoms.Sleep disorders can be seen in up to 98% of patients with Parkinson disease. Poor sleep quality has been associated with poverty and race, and yet there has been no prior report on sleep disorders in those with PD living in sub Saharan Africa. We wished to document the prevalence of sleep disorders in PD patients in Ethiopia. Methods: We conducted a cross-sectional point prevalence study from July 1 to October 30, 2015 of all patients attending the neurology outpatient department in Tikur Anbessa and Zewuditu Memorial Hospitals, Addis Ababa, Ethiopia. Demographic data, clinical history and physical examination findings were collected from participants using a structured questionnaire. We used the Parkinson’s disease sleep scale version two (PDSS-2) and Epworth Sleepiness Scale (ESS) to assess the sleep symptoms. Results: Of the 155 patients surveyed, all patients reported some sleep problem. Over 43.9% of patients had a PDSS score > 18. The median score of ESS was 9 (IQR = 5-12), with 77/155 (49.7%) of the patients having possible or definite excessive daytime somnolence. A high EDSS score significantly associated with a Hoehn & Yahr score > 4 (p= 0.02). Conclusions: In Ethiopian PD patients, the prevalence of those with severe sleep disorders is the highest reported to date. The prevalence of possible/definite EDS is amongst the highest in the world. Further investigation into whether poverty or race explains this finding is needed.

scholarly journals Profil Gangguan Tidur Penderita Parkinson di Rumah Sakit Rujukan di Kota Denpasar Tahun 2018

2020 ◽  
Vol 3 (1) ◽  
pp. 12-16
Author(s):  
Winda Haeriyoko ◽  
Purwa Samatra ◽  
Sri Yenni Trisnawati ◽  
IGN Budiarsa ◽  
Anak Agung Ayu Suryapraba
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Latency ◽  
Demographic Data ◽  
Poor Sleep ◽  
Male Patients ◽  
Disease Experience ◽  
Observational Descriptive Study

Abstrak Latar Belakang : Jumlah kasus Penyakit Parkinson di Indonesia cukup tinggi dengan prevalensi per penduduk dan insiden per penduduk. Gangguan tidur ddapatkan pada penderita Penyakit Parkinson. Data demografi dapat digunakan sebagai pertimbangan klinisi dalam mendiagnosis serta menentukan penanganan lanjutan yang optimal. Tujuan : Mengetahui karakteristik klinis pasien Penyakit Parkinson dengan gangguan tidur di Poliklinik Saraf Rumah Sakit Umum Pusat Sanglah (RSUP) Sanglah dan Rumah Sakit Umum Daerah (RSUD) Wangaya periode bulan 2018. Metode Penelitian : Penelitian deskriptif observasional menggunakan kuesioner pasien Penyakit Parkinson yang berobat di Poliklinik Saraf RSUP Sanglah dan RSUD Wangaya bulan hingga 2018. Hasil : Sebanyak pasien dari 47 pasien Penyakit Parkinson dengan rerata usia 61 – 70 tahun sebanyak dengan laki – laki sebanyak 34 orang (72,3%). Pasien dominan berobat ke RSUP Sanglah sebanyak 30 orang (63,8%) dengan pekerjaan terbanyak adalah petani/buruh sebanyak 13 orang (27,7%). Awitan penyakit rata – rata 1 – 5 tahun (39%). Penderita Penyakit Parkinson mengalami gangguan tidur sebanyak 24 orang (51,1%). Profil gangguan tidur dengan rerata kualitas tidur buruk 55,3%; mengalami latensi tidur 1x seminggu 40,4%. Simpulan : Penyakit Parkinson didominasi oleh pasien laki – laki dengan rerata usia 61 – 70 tahun dengan awitan peyakit rata – rata 1 – 5 tahun yang mengalami gangguan tidur. Gangguan tidur yang banyak diemukan berupa terjadinya latensi tidur sebanyak  1 kali seminggu. Kata kunci : Penyakit Parkinson, gangguan tidur, karakteristik   Abstract Background: The number of cases of Parkinson's disease in Indonesia is quite high with prevalence per population and incidence per population. Sleep disorders can be found in people with Parkinson's Disease. Demographic data can be used as a clinician's consideration in diagnosing and determining optimal follow-up treatment. Objective: To determine the clinical characteristics of Parkinson's disease patients with sleep disorders in the Neurology Polyclinic at Sanglah Central Hospital (RSUP) and Sanglah Regional General Hospital (RSUD) Wangaya for the period of 2018. Research Methods: An observational descriptive study using a questionnaire for Parkinson's disease patients seeking treatment at the Neurology Polyclinic at Sanglah Hospital and Wangaya District Hospital until 2018. Results: A total of 47 patients from Parkinson's disease with a mean age of 61-70 years were 34 men (72.3%). Most of the patients went to Sanglah Hospital as many as 30 people (63.8%) with the most work being farmers as many as 13 people (27.7%). The average onset of disease is 1 - 5 years (39%). Patients with Parkinson's Disease experience sleep disorders as many as 24 people (51.1%). Profile of sleep disorders with an average of poor sleep quality 55.3%; sleep latency 1 time a week 40.4%. Conclusion: Parkinson's disease is dominated by male patients with an average age of 61 - 70 years with onset of disease on average 1-5 years who experience sleep disorders. Sleep disorders are often found in the form of sleep latency as much as 1 time a week. Keywords: Parkinson's disease, sleep disorders, characteristics

scholarly journals FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON

2020 ◽  
Vol 5 (1) ◽  
pp. 343
Author(s):  
Attiya Istarini ◽  
Yuliarni Syafrita ◽  
Restu Susanti
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Age At Onset ◽  
Motor Symptom ◽  
Disease Stage ◽  
Motor Symptoms ◽  
Research Subjects ◽  
Cross Sectional ◽  
Duration Of Disease ◽  
Cross Sectional Design

<p><strong><em>Background</em></strong><em>: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some  factors that influence motor symptoms in Parkinson's disease.</em><strong><em>Methods:</em></strong><em> This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values &lt;0.05 were considered statistically significant.</em><strong><em>Results:</em></strong><em> This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p &lt;0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.</em><strong><em>Conclusions:</em></strong><em> There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.</em></p>

scholarly journals Non-motor clinical manifestations of Parkinson’s disease and its relevance in early diagnosis

2021 ◽  
Author(s):  
Lucca Ferdinando Queiroz Fernandes ◽  
Raiana Carol de Medeiros Dantas ◽  
Maria Clara Medeiros Araújo ◽  
Lucas de Oliveira Araújo Andrade
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Complex Disease ◽  
Clinical Manifestations ◽  
Olfactory Dysfunction ◽  
Screening Tests ◽  
Motor Symptoms ◽  
Scientific Publications ◽  
Study Results

Introduction: Parkinson’s disease is a progressive neurodegenerative disease that affects millions of people worldwide. Although Parkinson’s disease has traditionally been described as a disorder of the motor system, it is now recognized as a complex disease with several clinical features that include neuropsychiatric and non-motor manifestations. Studies show that 97% of patients with Parkinson’s disease report non-motor symptoms, in addition to motor symptoms, and some non-motor characteristics may appear before classic motor signs. Objectives: To list the main non-motor clinical manifestations of Parkinson’s disease and analyze its importance in establishing an accurate and early clinical diagnosis. Methods: This is an integrative review, carried out based on the search of scientific publications indexed in the datebase MEDLINE via PubMed, Lilacs and SciELO. At the end of the searches, 66 publications met the eligibility criteria and were selected to compose the study. Results: Within the non-motor clinical manifestations, there may be present: cognitive dysfunction and dementia, psychosis and hallucinations, mood disorders, sleep disorders, fatigue, autonomic dysfunction, olfactory dysfunction, gastrointestinal dysfunction, pain, sensory disorders and dermatological manifestations. Of these, olfactory dysfunction, constipation, depression and sleep disorders stand out because they often precede the motor symptoms of Parkinson’s disease. Conclusion: In this perspective, it is up to the general practitioner and the neurologist or geriatrician to carry out, whenever possible, screening tests to identify early changes that may precede Parkinson’s disease, guaranteeing patients an early multiprofessional treatment and consequently a better prognosis in the course of the disease.

Association among fatigue, sleep disorders and other clinical parameters in Parkinson’s disease

2020 ◽  
Vol 30 (Supplement_2) ◽  
Author(s):  
A Asano ◽  
N Asano ◽  
D Mota ◽  
I Gondim ◽  
F Aroxa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Disorders ◽  
Sleep Disorder ◽  
Clinical Parameters ◽  
Motor Symptoms ◽  
Nocturnal Sleep ◽  
Advanced Stages

Abstract Introduction Fatigue and sleep disorders are common in Parkinson disease (PD) patients. Fatigue is not always clinically recognized because of its subjective character manifested by feelings of extreme tiredness. These non-motor symptoms can occur from the early stages of the disease and tend to persist. Objectives To evaluate fatigue in patients with PD and the possible association with sleep disorders and other clinical parameters of the PD; and to evaluate the impact of fatigue on quality of life Methodology A cross-sectional study with 123 patients with PD was implemented. The following instruments were used: Mini Mental State Examination, the Hoehn-Yarh Scale, Beck Depression Inventory, Parkinson’s Disease Quality of Life Questionnaire, Parkinson’s Disease Sleep Scale, Epworth Sleepiness Scale, and Parkinson’s Disease Fatigue Scale. Results Fatigue was found in 48% of patients. Patients with fatigue presented longer duration of illness, depressive symptoms, cognitive impairment, severity of motor symptoms, excessive daytime sleepiness and nocturnal sleep disorder. Fatigue combined with sleep disorder occurred in 21% of the total sample, being more frequent in females (32% vs 15%) and in patients at more advanced stages of the disease (52% in HY3). The multiple logistic regression analysis indicated that the significant independent variables for the presence of fatigue were: cognition (OR = 1.19 P = 0.02), nocturnal sleep disorder (OR = 1.03 P = 0.0001); among PDSS domains, nocturnal motor symptoms (OR = 1.09 P = 0.0005) and sleep refreshment (OR = 1.11 P = 0.02); among PDQ-39 domains, mobility (OR = 0.9323 P &lt; 0.0001) and body discomfort (OR = 0.9767 P = 0.0428). Conclusion Fatigue is common in PD, especially in the more advanced stages, and it seems to be associated with the female gender, nocturnal sleep disorder and cognition, having thus a negative impact on the quality of life.

Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson’s Disease

2020 ◽  
pp. 089198872096425
Author(s):  
Diego Santos-García ◽  
E. Suárez Castro ◽  
T. de Deus Fonticoba ◽  
M. J. Feal Panceiras ◽  
J. G. Muñoz Enriquez ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Problems ◽  
Cross Sectional Study ◽  
Motor Symptoms ◽  
Levodopa Dose ◽  
Cross Sectional ◽  
Non Motor Symptoms

Introduction: The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients. Methods: PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson’s disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems. Results: The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 ± 28.8 vs 132.8 ± 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 ± 14 vs 13 ± 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 ± 0.5 vs 3.9 ± 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015–1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009–1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments. Conclusion: Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.

scholarly journals Burden of adult neurological diseases in Odeda Area, Southwest Nigeria

2020 ◽  
Vol 2 (2) ◽  
pp. e000062
Author(s):  
Folajimi Morenikeji Otubogun ◽  
Rufus Akinyemi ◽  
Sola Ogunniyi
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Sub Saharan Africa ◽  
Morbidity Rate ◽  
Primary Headaches ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Southwest Nigeria

BackgroundFew population-based studies have been conducted to determine the burden of neurological diseases in sub-Saharan Africa. A better understanding of the magnitude and impact of these disorders is pivotal to effective planning and provision of neurological services.MethodsA cross-sectional survey of 2392 adults in Odeda Local Government Area, Ogun State, Southwest Nigeria was conducted between May and June 2015. Trained non-medical interviewers administered a screening instrument designed to measure the prevalence of neurological diseases and disability, while positive responders were subsequently examined by neurologists. Diagnoses were made clinically according to well-established criteria.ResultsThe mean age of respondents was 37.2±16.1 years. A total of 842 cases of neurological diseases/disability were diagnosed in 815 individuals (26 individuals with more than one disorder). The all-cause neurological morbidity rate was 352 per 1000, while the crude prevalence rates of common neurological disorders were 304.3 per 1000 for primary headaches, 16.3 per 1000 for tropical ataxic neuropathy, 7.11 per 1000 for stroke, 5.85 per 1000 for essential tremor and 4.18 per 1000 for Parkinson’s disease. Neurological years lost due to disability was 2806.18 per 100 000.ConclusionThis study provides evidence of a high neurological disease burden within the communities surveyed, which may be representative of Southwest Nigeria. In comparison with findings from previous studies within the same region, this report suggests a persistence of toxiconutritional disorders and postinfectious neurological sequelae on one hand and increased prevalence of non-communicable neurological disorders such as stroke and Parkinson’s disease.

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