scholarly journals Various Application of Corneal Tattooing

2018 ◽  
Author(s):  
Jinho Jeong ◽  
Jonathan D Fay ◽  
Jimmy K Lee ◽  
Roy S Chuck ◽  
Ji-won Kwon
Keyword(s):  
Case Series ◽  
Corneal Opacity ◽  
Phthisis Bulbi ◽  
Common Causes ◽  
Corneal Opacities ◽  
Large Case Series ◽  
Cosmetic Outcomes ◽  
The Mean ◽  
Large Case

Abstract Background: To evaluate the efficacy of corneal tattooing in a large case series. Methods: The medical charts of 62 eyes of 62 patients who underwent corneal tattooing between March 2016 and August 2017 were retrospectively reviewed. The causes of opacity and various methods of corneal tattooing applied were analyzed. Results: Among our 62 patients, 38 were male and 24 female. Average age was 48.47±15.30 (range, 12-74)years old. The mean follow-up period was 23.19 ±2.34 (range, 19-27) months. The most common causes of corneal opacity were ocular trauma (33 eyes, 53.2%), prior retinal surgery (9 eyes, 14.5%), congenital etiologies (8 eyes, 12.9%) and measles (5 eyes, 8.0%). The most common associated ocular findings were strabismus (23eyes, 37.0%), phthisis bulbi (17 eyes, 27.4%) and band keratopathy (13 eyes, 20.9%). Cosmetic outcomes improved without serious complications in all cases. Conclusions: Corneal tattooing is a viable option with an expanding set of indications, such as discolored corneal tattoos, white pupil due to inoperable cataract with clear cornea, and dense corneal opacities in blind eyes. Elective corneal tattooing seems to be a viable and convenient method to improve cosmesis with minimal complications and high patient satisfaction.

Midterm results of radiocapitellar arthroplasty of the elbow

2019 ◽  
Vol 101-B (11) ◽  
pp. 1362-1369 ◽  
Author(s):  
Giuseppe Giannicola ◽  
Piergiorgio Calella ◽  
Prospero Bigazzi ◽  
Alberto Mantovani ◽  
Paolo Spinello ◽  
...  
Keyword(s):  
Radial Head ◽  
Case Series ◽  
Dash Score ◽  
Mayo Elbow Performance Score ◽  
Elbow Function ◽  
Large Case Series ◽  
Post Traumatic ◽  
The Mean ◽  
Large Case

Aims The aim of this study was to analyze the results of two radiocapitellar prostheses in a large case series followed prospectively, with medium-term follow-up. Patients and Methods A total of 31 patients with a mean age of 54 years (27 to 73) were analyzed; nine had primary osteoarthritis (OA) and 17 had post-traumatic OA, three had capitellar osteonecrosis, and two had a fracture. Overall, 17 Lateral Resurfacing Elbow (LRE) and 14 Uni-Elbow Radio-Capitellum Implant (UNI-E) arthroplasties were performed. Pre- and postoperative assessment involved the Mayo Elbow Performance Score (MEPS), the Quick Disabilities of the Arm, Shoulder and Hand (Q-DASH) score, and the modified American Shoulder Elbow Surgeons (m-ASES) score. Results The mean follow-up was 6.8 years (3.8 to 11.5). The mean MEPS, m-ASES, and Q-DASH scores improved significantly by 50 (p < 0.001), 55 (p < 0.001), and 54 points (p < 0.001), respectively, with no differences being detected between the implants. Preoperative pronation and supination were worse in patients in whom the UNI-E was used. Two patients with the UNI-E implant had asymptomatic evidence of gross loosening. Conclusion Radiocapitellar arthroplasty yielded a significant improvement in elbow function at a mean follow-up of 6.8 years, with a high implant survival rate when the LRE was used in patients with primary or post-traumatic OA, without radial head deformity, and when the UNI-E was used in patients in whom radial head excision was indicated. Cite this article: Bone Joint J 2019;101-B:1362–1369

scholarly journals Optimal Ki67 cut-off for luminal breast cancer prognostic evaluation: a large case series study with a long-term follow-up

2016 ◽  
Vol 157 (2) ◽  
pp. 363-371 ◽  
Author(s):  
Sara Bustreo ◽  
Simona Osella-Abate ◽  
Paola Cassoni ◽  
Michela Donadio ◽  
Mario Airoldi ◽  
...  
Keyword(s):  
Case Series ◽  
Luminal Breast Cancer ◽  
Prognostic Evaluation ◽  
Case Series Study ◽  
Long Term Follow Up ◽  
Large Case Series ◽  
Series Study ◽  
Large Case

Hemangiopericytomas in the Spine

Neurosurgery ◽  
2012 ◽  
Vol 72 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Huan-guang Liu ◽  
An-chao Yang ◽  
Ning Chen ◽  
Jun Yang ◽  
Xiao-guang Qiu ◽  
...  
Keyword(s):  
Survival Time ◽  
Postoperative Radiotherapy ◽  
Case Series ◽  
Good Alternative ◽  
Surgical Removal ◽  
Low Grade ◽  
Kaplan Meier ◽  
Large Case Series ◽  
Large Case

Abstract BACKGROUND: Intraspinal hemangiopericytoma (HPC) is a rare and malignant extra-axial tumor with a strong tendency to recur and metastasize. There is a paucity in the literature of large case series of patients with intraspinal HPCs. OBJECTIVE: We retrospectively analyzed the clinical radiological and histological features, classification, and treatment of 26 patients with HPCs in the spine. METHODS: Twenty-six patients with HPCs in the spine were treated at our institution between 1987 and 2010. Medical records were reviewed retrospectively to collect data on the clinical features, tumor morphology, surgical resection, recurrence, and follow-up. RESULTS: The 26 patients were predominantly male, and the mean age at diagnosis was 33.8 years. The intraspinal HPCs were divided into 3 types and 5 subtypes. Most of them involved the neighboring segments and/or caused bony erosion. All tumors were immunohistochemically positive for vimentin and negative for epithelial membrane antigen. All patients underwent at least 1 surgery, and most of them received postsurgical radiotherapy. The 5-year Kaplan-Meier rate of survival was 76%. The 5-year recurrence-free rate of survival was 29.4%. Only the tumor pathological grade was significantly associated with survival time and recurrence. CONCLUSION: High-grade tumors had a shorter survival time and recurred earlier than low-grade tumors. Surgical removal and postoperative radiotherapy are critical for the treatment of intraspinal HPCs. However, total resection may not necessary for these tumors. Stereotactic radiosurgery may be a good alternative to control the recurrent lesions.

scholarly journals Repository corticotropin injection in patients with advanced symptomatic sarcoidosis: retrospective analysis of medical records

2019 ◽  
Vol 13 ◽  
pp. 175346661988812 ◽  
Author(s):  
Ishveen Chopra ◽  
Yimin Qin ◽  
John Kranyak ◽  
Jack R. Gallagher ◽  
Kylee Heap ◽  
...  
Keyword(s):  
Case Series ◽  
Patient Characteristics ◽  
Starting Dose ◽  
Daily Dose ◽  
Individualized Approach ◽  
Utilization Patterns ◽  
Large Case Series ◽  
The Mean ◽  
Large Case ◽  
Viable Treatment

Background: Repository corticotropin injection (RCI) has regulatory approval for many indications, including symptomatic sarcoidosis. This large case series of patients with advanced symptomatic sarcoidosis treated with RCI describes patient characteristics, RCI utilization patterns, concomitant therapies, and physicians’ assessments of treatment response. Methods: Patients ⩾18 years with symptomatic sarcoidosis, treated with RCI in the previous 36 months, who had completed a course of RCI or received RCI for ⩾6 months at the time of data collection were included. Results: The study included 302 patients (mean age, 51 years; 52%, women) with a mean 4.8 years since initial diagnosis of sarcoidosis. Most patients (76%) had extrapulmonary involvement, primarily in the skin (28%), joints (25%), heart (22%), and eyes (22%); 34% had multiple (⩾2) organ involvement. The mean duration of RCI treatment was 32.5 weeks, with 61.6% of patients continuing RCI therapy for ⩾6 months. The RCI utilization pattern indicated an individualized approach to therapy, with a higher starting dose associated with a shorter duration of therapy compared with a lower starting dose. The percentage of patients who used corticosteroids decreased from 61.3% during the 3 months before initiation of RCI to 12.9% 3 months after RCI therapy; the mean daily dose of corticosteroid decreased from 18.2 mg to 9.9 mg. The proportion of patients given <10 mg/day of prednisone increased from 21% before RCI use to 47% 3 months after RCI use. According to physicians’ assessments of change in patients’ health status after RCI therapy, overall status improved in 95% of patients, overall symptoms in 73%, lung function in 38%, and inflammation in 33%. Conclusions: The findings suggest that RCI is a viable treatment option for patients with advanced symptomatic sarcoidosis and provide insights on patient characteristics and practice patterns to help clinicians determine appropriate use. The reviews of this paper are available via the supplemental material section.

scholarly journals Non-contrast computed tomography characteristics in a large cohort of cystinuria patients

2020 ◽  
Author(s):  
Hannah Warren ◽  
Daniel Poon ◽  
Rohit Srinivasan ◽  
Kerushan Thomas ◽  
Giles Rottenberg ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Case Series ◽  
Specialist Centre ◽  
Large Case Series ◽  
Prospective Case Series ◽  
Cystine Stones ◽  
Stone Type ◽  
Large Case

Abstract Purpose Cystine stones are widely considered hard and difficult to treat. Hounsfield Units (HU) are used in other stone types to estimate ‘hardness’ and treatments based on that finding. Our objective was to report mean HU of cystine stones in vivo in a large case series of cystinuria patients and assess for differences in genotype. Methods A prospective case series of cystinuria patients referred to a specialist centre was analysed. CT imaging was assessed by two independent radiologists to determine in vivo attenuation of cystine calculi. Mean HU was compared for both cystinuria genes (SLC3A1 and SLC7A9) using an independent t-test. Results 164 adult cystinuric patients were identified (55% male), median age 43 years (range 18–80). Median follow up was 31 months (IQR 10–62). Genetic data available for 153/164 (93%) demonstrated 97 SLC3A1 (63%) and 55 (36%) SLC7A9 mutations (39 homozygous, 16 heterozygous) and one heterozygous for both SLC3A1/SLC7A9. 107 patients had CT images available demonstrating calculi. Median HU across the cohort was 633 (5th to 95th centile 328–780). There was no difference in mean HU between SLC3A1 and SLC7A9 genotypes (p = 0.68) or homo and heterozygous SLC7A9 (p = 0.70). Mean HU correlated with stone size (Pearson correlation coefficient = 0.51, p < 0.001). Conclusion In this large single centre cystinuria cohort, mean HU was low for stones that are difficult to treat. Calculi of < 800 HU should prompt consideration of a cystinuria diagnosis. Attenuation was not associated with genotype, and distinct ‘smooth’ and ‘rough’ stones were not observed. Calculi with HU > 1000 are unlikely pure cystine, and in a known cystinuric would suggest conversion to another stone type.

scholarly journals Detailed Clinical and Electrophysiological Illustration of a Patient with Sturge–Weber Syndrome Presenting with Prolonged Transient Neurological Symptoms

2018 ◽  
Vol 09 (04) ◽  
pp. 608-612
Author(s):  
Halil Onder
Keyword(s):  
Right Hemisphere ◽  
Background Activity ◽  
Recovery Period ◽  
Case Series ◽  
Neurological Deficits ◽  
Weber Syndrome ◽  
Sturge Weber Syndrome ◽  
Large Case Series ◽  
Large Case

ABSTRACTAlthough transient neurological deficits in Sturge–Weber syndrome (SWS) have been acknowledged for many years, the underlying pathogenesis still constitutes a major topic of discussion. Here, we present the case of a 10-year-old boy with SWS presenting with a progressive clinically mimicking right middle cerebral artery syndrome. Cranial magnetic resonance imaging showed unremarkable findings except extensive right hemisphere leptomeningeal angiomas. Antiepileptic drug (AED) treatments provided recovery of the patient, and concurrently recorded electroencephalography (EEG) revealed delta slowing of the lesional hemisphere in the acute period. However, slowing of the background activity extended to the contralateral hemisphere in subacute period, while ipsilateral background activity started to recover. In the 3rd week of follow-up on intensive AED treatments, the patient totally recovered as well as nearly the normalization of EEG was achieved. In this report, we focus on the dramatic revolution of EEG activity in both hemispheres during the recovery period. Based on this rare illustration and limited literature data, the author suggests some hypotheses regarding the pathophysiology of this mysterious manifestation (transient neurological deficit) in SWS. Future studies of large case series, including detailed paraclinical parameters and remarkably electrophysiological data, are warranted to clarify these arguments.

Objective assessment of lymphatic and blood vascular invasion in lymph node-negative breast carcinoma: findings from a large case series with long-term follow-up

2010 ◽  
Vol 223 (3) ◽  
pp. 358-365 ◽  
Author(s):  
Rabab AA Mohammed ◽  
Stewart G Martin ◽  
Ali M Mahmmod ◽  
R. Douglas Macmillan ◽  
Andrew R Green ◽  
...  
Keyword(s):  
Lymph Node ◽  
Vascular Invasion ◽  
Objective Assessment ◽  
Case Series ◽  
Node Negative ◽  
Long Term Follow Up ◽  
Large Case Series ◽  
Large Case

Long-term outcomes of lumbar microdiscectomy in the pediatric population: a large single-institution case series

2019 ◽  
Vol 24 (5) ◽  
pp. 549-557
Author(s):  
Malia McAvoy ◽  
Heather J. McCrea ◽  
Vamsidhar Chavakula ◽  
Hoon Choi ◽  
Wenya Linda Bi ◽  
...  
Keyword(s):  
Conservative Management ◽  
Functional Outcomes ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Case Series ◽  
Csf Leak ◽  
Single Institution ◽  
The Mean

OBJECTIVEFew studies describe long-term functional outcomes of pediatric patients who have undergone lumbar microdiscectomy (LMD) because of the rarity of pediatric disc herniation and the short follow-up periods. The authors analyzed risk factors, clinical presentation, complications, and functional outcomes of a single-institution series of LMD patients over a 19-year period.METHODSA retrospective case series was conducted of pediatric LMD patients at a large pediatric academic hospital from 1998 to 2017. The authors examined premorbid risk factors, clinical presentation, physical examination findings, type and duration of conservative management, indications for surgical intervention, complications, and postoperative outcomes.RESULTSOver the 19-year study period, 199 patients underwent LMD at the authors’ institution. The mean age at presentation was 16.0 years (range 12–18 years), and 55.8% were female. Of these patients, 70.9% participated in competitive sports, and among those who did not play sports, 65.0% had a body mass index greater than 25 kg/m2. Prior to surgery, conservative management had failed in 98.0% of the patients. Only 3 patients (1.5%) presented with cauda equina syndrome requiring emergent microdiscectomy. Complications included 4 cases of postoperative CSF leak (2.0%), 1 case of a noted intraoperative CSF leak, and 3 cases of wound infection (1.5%). At the first postoperative follow-up appointment, minimal or no pain was reported by 93.3% of patients. The mean time to return to sports was 9.8 weeks. During a mean follow-up duration of 8.2 years, 72.9% of patients did not present again after routine postoperative appointments. The total risk of reoperation was a rate of 7.5% (3.5% of patients underwent reoperation for the same level; 4.5% underwent adjacent-level decompression, and one patient [0.5%] ultimately underwent a fusion).CONCLUSIONSMicrodiscectomy is a safe and effective treatment for long-term relief of pain and return to daily activities among pediatric patients with symptomatic lumbar disc disease in whom conservative management has failed.

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