scholarly journals Analysis plan for primary cohort GWAS for blood lipid levels for the Global Lipids Genetics Consortium

2021 ◽  
Author(s):  
Cristen Willer
Keyword(s):  
Meta Analysis ◽  
Blood Lipid ◽  
Summary Statistics ◽  
Lipid Levels ◽  
Exact Time ◽  
Blood Lipid Levels

Abstract This protocol describes the guidelines for generating GWAS summary statistics that were provided to all participating cohorts in the Global Lipids Genetics Consortium HRC + 1KGP3 imputation meta-analysis collected jointly with the GIANT consortium. It is applicable for generating the input phenotype and genotype files for use with the rvtests software. Key stages include imputation, generating phenotype files, and running the analysis to generate summary statistics. The exact time needed to carry out this protocol varies depending on the existing genotype files and size of the cohort. The latest version of rvtests is available at: http://zhanxw.github.io/rvtests/

scholarly journals Effects of guar gum on blood lipid levels: A systematic review and meta-analysis on randomized clinical trials

2021 ◽  
Vol 85 ◽  
pp. 104605
Author(s):  
Niannian Wang ◽  
Da Pan ◽  
Ziqi Guo ◽  
Xuesong Xiang ◽  
Shaokang Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Guar Gum ◽  
Meta Analysis ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Blood Lipid Levels

scholarly journals Effects of probiotic supplementation on the regulation of blood lipid levels in overweight or obese subjects: a meta-analysis

2019 ◽  
Vol 10 (3) ◽  
pp. 1747-1759 ◽  
Author(s):  
Shoumeng Yan ◽  
Zhenwei Tian ◽  
Meng Li ◽  
Bo Li ◽  
Weiwei Cui
Keyword(s):  
Risk Factor ◽  
Meta Analysis ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Probiotic Supplementation ◽  
Obese Subjects ◽  
Blood Lipid Levels

Obesity is a risk factor for many deadly diseases.

scholarly journals The effects of almond consumption on fasting blood lipid levels: a systematic review and meta-analysis of randomised controlled trials

2016 ◽  
Vol 5 ◽  
Author(s):  
Kathy Musa-Veloso ◽  
Lina Paulionis ◽  
Theresa Poon ◽  
Han Youl Lee
Keyword(s):  
Systematic Review ◽  
Heart Disease ◽  
Randomised Controlled Trials ◽  
Large Scale ◽  
Meta Analysis ◽  
Blood Lipid ◽  
Controlled Trials ◽  
Lipid Levels ◽  
Randomised Controlled ◽  
Blood Lipid Levels

AbstractA systematic review and meta-analysis of randomised controlled trials was undertaken to determine the effects of almond consumption on blood lipid levels, namely total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), TAG and the ratios of TC:HDL-C and LDL-C:HDL-C. Following a comprehensive search of the scientific literature, a total of eighteen relevant publications and twenty-seven almond-control datasets were identified. Across the studies, the mean differences in the effect for each blood lipid parameter (i.e. the control-adjusted values) were pooled in a meta-analysis using a random-effects model. It was determined that TC, LDL-C and TAG were significantly reduced by −0·153 mmol/l (P < 0·001), −0·124 mmol/l (P = 0·001) and −0·067 mmol/l (P = 0·042), respectively, and that HDL-C was not affected (−0·017 mmol/l; P = 0·207). These results are aligned with data from prospective observational studies and a recent large-scale intervention study in which it was demonstrated that the consumption of nuts reduces the risk of heart disease. The consumption of nuts as part of a healthy diet should be encouraged to help in the maintenance of healthy blood lipid levels and to reduce the risk of heart disease.

scholarly journals Blood Lipid Levels in Patients with Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Hang Zhao ◽  
An Song ◽  
Yong Li ◽  
Licui Qi ◽  
Chong Zheng ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Relevant Information ◽  
Lipid Lowering ◽  
Cochrane Library ◽  
Lipid Levels ◽  
Lipid Lowering Drugs ◽  
Blood Lipid Levels

Abstract Background: Considering the controversial relationship between blood lipid levels and osteopenia and osteoporosis (OP), we performed this meta-analysis.Methods: Using specific keywords and related words, we searched PubMed, Embase, and Cochrane Library databases. The Newcastle-Ottawa Scale form was used to evaluate the quality of the literature. According to the inclusion and exclusion criteria, we systematically screened the literature to extract relevant information and data. Revman 5.3 and Stata 13.0 software were used for statistical analysis. Results were expressed as the mean difference and 95% confidence interval. The heterogeneity test was conducted according to I2 and Q tests. Egger’s test was used to quantitatively evaluate publication bias.Results: This analysis involved 12 studies and included 12,395 subjects. The quality of the literature was acceptable. Among subjects who were not taking lipid-lowering drugs, total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) in the osteopenia were not significantly increased/decreased. There were no significant differences in LDL-C in postmenopausal women in osteopenia. TG was unchanged in the OP group in subjects without taking lipid-lowering drugs. HDL-C was elevated in OP group but not in osteopenia group in all subjectsConclusions: HDL-C was elevated in patients with OP.

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