From Hair to Heart: Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Simultaneously Differentiate Into Mature Cardiomyocytes and Atrial Myocytes

Abstract Hair-follicle-associated pluripotent (HAP) stem cells express nestin, and are located in the bulge area of hair follicles and can differentiate to numerous types of cells. In the present study, we demonstrate that rat HAP stem cells simultaneously differentiated to mature cardiomyocytes and atrial myocytes. The addition of isoproterenol, activin A, bone morphogenetic protein 4 (BMP 4), basic fibroblast growth factor (bFGF), and cyclosporin A (CSA), induced simultaneously differentiation of HAP stem cells to c-kit-positive cardiomyocytes and MLC-2a-expressing atrial myocytes. The results of the present study suggest that HAP stem cells differentiating to cardiomyocytes and atrial myocytes have future clinical potential for heart regeneration.

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Effect of nitric oxide on fibroblast growth factor-10 and bone morphogenetic protein 4 expressions in the branching morphogenesis of fetal rat lung explants

Journal of Pediatric Surgery ◽

10.1016/j.jpedsurg.2005.03.022 ◽

2005 ◽

Vol 40 (6) ◽

pp. 1030-1033 ◽

Cited By ~ 3

Author(s):

Masato Shinkai ◽

Toko Shinkai ◽

Martina A. Pirker ◽

Sandra Montedonico ◽

Prem Puri

Keyword(s):

Nitric Oxide ◽

Growth Factor ◽

Branching Morphogenesis ◽

Bone Morphogenetic Protein 4 ◽

Fibroblast Growth ◽

Rat Lung ◽

Morphogenetic Protein ◽

Fetal Rat ◽

Fetal Rat Lung ◽

Fibroblast Growth Factor 10

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Cranial bone defect healing is accelerated by mesenchymal stem cells induced by coadministration of bone morphogenetic protein-2 and basic fibroblast growth factor

Wound Repair and Regeneration ◽

10.1111/j.1067-1927.2004.012118.x ◽

2004 ◽

Vol 12 (2) ◽

pp. 252-259 ◽

Cited By ~ 68

Author(s):

Sadanori Akita ◽

Masashi Fukui ◽

Hiroshi Nakagawa ◽

Tohru Fujii ◽

Kozo Akino

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Bone Morphogenetic Protein 2 ◽

Cranial Bone ◽

Fibroblast Growth ◽

Defect Healing ◽

Bone Defect Healing ◽

Morphogenetic Protein

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Stimulatory Effects of Basic Fibroblast Growth Factor and Bone Morphogenetic Protein-2 on Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells

Journal of Bone and Mineral Research ◽

10.1359/jbmr.1997.12.10.1606 ◽

1997 ◽

Vol 12 (10) ◽

pp. 1606-1614 ◽

Cited By ~ 278

Author(s):

Keigo Hanada ◽

James E. Dennis ◽

Arnold I. Caplan

Keyword(s):

Stem Cells ◽

Bone Marrow ◽

Mesenchymal Stem Cells ◽

Growth Factor ◽

Osteogenic Differentiation ◽

Fibroblast Growth Factor ◽

Bone Morphogenetic Protein 2 ◽

Fibroblast Growth ◽

Morphogenetic Protein ◽

Rat Bone

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Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick

Mechanisms of Development ◽

10.1016/0925-4773(95)00453-x ◽

1995 ◽

Vol 53 (3) ◽

pp. 383-392 ◽

Cited By ~ 91

Author(s):

Nancy A. Wall ◽

Brigid L.M. Hogan

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Bone Morphogenetic Protein ◽

Sonic Hedgehog ◽

Branchial Arch ◽

Bone Morphogenetic Protein 4 ◽

Fibroblast Growth ◽

Bone Morphogenetic Protein 7 ◽

Fibroblast Growth Factor 8 ◽

Morphogenetic Protein

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The Effects of Bone Morphogenetic Protein and Basic Fibroblast Growth Factor on Cultured Mesenchymal Stem Cells for Spine Fusion

Spine ◽

10.1097/01.brs.0000261626.32999.8a ◽

2007 ◽

Vol 32 (10) ◽

pp. 1067-1071 ◽

Cited By ~ 32

Author(s):

Akihito Minamide ◽

Munehito Yoshida ◽

Mamoru Kawakami ◽

Motohiro Okada ◽

Yoshio Enyo ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Bone Morphogenetic Protein ◽

Basic Fibroblast Growth Factor ◽

Spine Fusion ◽

Fibroblast Growth ◽

Morphogenetic Protein

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Osteogenic Differentiation of Human Mesenchymal Stem Cells Cultured with Dexamethasone, Vitamin D3, Basic Fibroblast Growth Factor, and Bone Morphogenetic Protein-2

Connective Tissue Research ◽

10.3109/03008207.2011.611601 ◽

2011 ◽

Vol 53 (2) ◽

pp. 117-131 ◽

Cited By ~ 35

Author(s):

Nesrine Z. Mostafa ◽

Ross Fitzsimmons ◽

Paul W. Major ◽

Adetola Adesida ◽

Nadr Jomha ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Vitamin D3 ◽

Human Mesenchymal Stem Cells ◽

Bone Morphogenetic Protein 2 ◽

Fibroblast Growth ◽

Morphogenetic Protein ◽

Cells Cultured

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Dual-stage growth factor release within 3D protein-engineered hydrogel niches promotes adipogenesis

Biomaterials Science ◽

10.1039/c4bm00142g ◽

2014 ◽

Vol 2 (11) ◽

pp. 1627-1639 ◽

Cited By ~ 13

Author(s):

Midori Greenwood-Goodwin ◽

Eric S. Teasley ◽

Sarah C. Heilshorn

Keyword(s):

Growth Factor ◽

Fibroblast Growth Factor ◽

Stromal Cells ◽

Bone Morphogenetic Protein 4 ◽

Fibroblast Growth ◽

Adipose Derived Stromal Cells ◽

Morphogenetic Protein ◽

Dual Stage ◽

Growth Factor Release ◽

Factor Release

We developed a strategy for dual-stage delivery of fibroblast growth factor 1 (FGF-1) and bone morphogenetic protein 4 (BMP-4) within 3D biomimetic hydrogels to promote adipogenesis of human adipose-derived stromal cells.

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