scholarly journals Viscosity-sensitive emission of anionic hydrogen-bonded urea-derivative–acetate-ion complexes and their aggregation-induced emission enhancement

2020 ◽  
Author(s):  
Masaki Takahashi ◽  
Nozomu Ito ◽  
Hayato Ninagawa ◽  
Kohei Yazaki ◽  
Yoshihisa Sei ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Fluorescent Dyes ◽  
High Sensitivity ◽  
Fluid Viscosity ◽  
Aggregation Induced Emission ◽  
Novel Approach ◽  
Emission Enhancement ◽  
Phenyl Rings ◽  
Ionic Hydrogen Bonding ◽  
Hydrogen Bonded

Abstract Anions often quench fluorescence (FL). However, strong ionic hydrogen bonding between fluorescent dyes and anion molecules has the potential to control the electronic state of FL dyes, creating new functions via non-covalent interactions. Here, we propose a novel approach, utilising ionic hydrogen bonding between urea groups and anions, to control the electronic states of fluorophores and develop an aggregation-induced emission enhancement (AIEE) system. The AIEE ionic hydrogen-bonded complex (IHBC) formed between 1,8-diphenylnaphthalene (p-2urea), with aryl urea groups at the para-positions on the peri-phenyl rings, and acetate ions exhibits a remarkably high sensitivity to fluid viscosity compared with most conventional viscosity-sensitive dyes, and the FL quantum yield (QY) in ion-pair assemblies of the IHBC and tetrabutylammonium cations is more than five times higher than that of the IHBC in solution. Our versatile and simple approach for the design of AIEE dye facilitates the future development of viscosity probes and solid-state emitting materials.

scholarly journals Environment-sensitive emission of anionic hydrogen-bonded urea-derivative–acetate-ion complexes and their aggregation-induced emission enhancement

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Masaki Takahashi ◽  
Nozomu Ito ◽  
Naoki Haruta ◽  
Hayato Ninagawa ◽  
Kohei Yazaki ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Fluorescent Dyes ◽  
Urea Derivative ◽  
Aggregation Induced Emission ◽  
Emission Enhancement ◽  
Phenyl Rings ◽  
Non Covalent Interactions ◽  
Ionic Hydrogen Bonding ◽  
Covalent Interactions ◽  
Hydrogen Bonded

AbstractAnions often quench fluorescence (FL). However, strong ionic hydrogen bonding between fluorescent dyes and anion molecules has the potential to control the electronic state of FL dyes, creating new functions via non-covalent interactions. Here, we propose an approach, utilising ionic hydrogen bonding between urea groups and anions, to control the electronic states of fluorophores and develop an aggregation-induced emission enhancement (AIEE) system. The AIEE ionic hydrogen-bonded complex (IHBC) formed between 1,8-diphenylnaphthalene (p-2Urea), with aryl urea groups at the para-positions on the peri-phenyl rings, and acetate ions exhibits high environmental sensitivities in solution phases, and the FL quantum yield (QY) in ion-pair assemblies of the IHBC and tetrabutylammonium cations is more than five times higher than that of the IHBC in solution. Our versatile and simple approach for the design of AIEE dye facilitates the future development of environment-sensitive probes and solid-state emitting materials.

Multi-responsive fluorescence switches and iodine capture of porous hydrogen-bonded self-assemblies

2021 ◽  
Author(s):  
Peng Chong Xue ◽  
Xinyu Chen ◽  
Tong Zhang ◽  
Qiao Chen ◽  
Yanning Han ◽  
...  
Keyword(s):  
Aggregation Induced Emission ◽  
Emission Enhancement ◽  
Supramolecular Gels ◽  
Hydrogen Bonded

A four-armed divinylanthracene derivative was designed and synthesized to construct multifunctional porous self-assemblies. It could form stable supramolecular gels, and the fluorescence gradually increased during gelation, exhibiting aggregation-induced emission enhancement....

scholarly journals Flavanone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics for Mitochondria-Imaging and Zebrafish-Imaging

Molecules ◽  
2020 ◽  
Vol 25 (14) ◽  
pp. 3298
Author(s):  
Na Li ◽  
Liyan Liu ◽  
Huiqing Luo ◽  
Huaqiao Wang ◽  
Depo Yang ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Fluorescence Quantum Yield ◽  
Fluorescent Dyes ◽  
Fluorescence Emission ◽  
In Vivo Studies ◽  
Aggregation Induced Emission ◽  
Emission Enhancement ◽  
High Fluorescence ◽  
Potential Use

Fluorophores with aggregation-induced emission enhancement (AIEE) characteristics applied in bioimaging have attracted more and more attention in recent years. In this work, a series of flavanone compounds with AIEE characteristics was developed and applied to fluorescence imaging of mitochondria and zebrafish. The compounds were readily prepared by the thermal dehydration of chalcone that was obtained by the reaction of o-hydroxyacetophenone and benzaldehyde. Two of these compounds showed significant AIEE characteristics by fluorescence performance experiments, including optical spectra, fluorescence spectra, fluorescence quantum yield (φF), fluorescence lifetime, and scanning electron microscopy (SEM). Compared with traditional organic fluorescent dyes, these compounds have high fluorescence emission and high fluorescence quantum yield in solid or aggregated state, which overcomes the shortcoming of aggregation-caused quenching (ACQ). More importantly, the two compounds exhibited low cytotoxicity and good cytocompatibility in A549 lung cells at the experimental concentration range and they specifically targeted mitochondria, which make it of great potential use in mitochondria labeling. In addition, they were embryonic membrane permeable and had different affinities for different tissues and organs of zebrafish, but mainly distributed in the digestive system, providing a basis for the application of such compounds in bioimaging. These AIEE compounds with superior properties could be of great potential use in mitochondria imaging and other in vivo studies.

Tunable Color of Aggregation-Induced Emission Enhancement in a Family of Hydrogen-Bonded Azines and Schiff Bases

2018 ◽  
Vol 24 (65) ◽  
pp. 17262-17267 ◽  
Author(s):  
Samuel Guieu ◽  
Francisco Cardona ◽  
João Rocha ◽  
Artur M. S. Silva
Keyword(s):  
Schiff Bases ◽  
Aggregation Induced Emission ◽  
Emission Enhancement ◽  
Hydrogen Bonded

Theoretical study of hydrogen bonding interactions in substituted nitroxide radicals

2021 ◽  
Author(s):  
Thufail M. Ismail ◽  
Neetha Mohan ◽  
P. K. Sajith
Keyword(s):  
Hydrogen Bonding ◽  
Interaction Energy ◽  
Electrostatic Potential ◽  
Molecular Electrostatic Potential ◽  
Theoretical Study ◽  
Nitroxide Radicals ◽  
Hydrogen Bonding Interactions ◽  
Bonded Complexes ◽  
Hydrogen Bonded

Interaction energy (Eint) of hydrogen bonded complexes of nitroxide radicals can be assessed in terms of the deepest minimum of molecular electrostatic potential (Vmin).

scholarly journals From Multiplex Serology to Serolomics—A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 749
Author(s):  
Julia Butt ◽  
Rajagopal Murugan ◽  
Theresa Hippchen ◽  
Sylvia Olberg ◽  
Monique van Straaten ◽  
...  
Keyword(s):  
Antibody Response ◽  
High Throughput ◽  
Large Population ◽  
High Sensitivity ◽  
Population Based ◽  
Antibody Responses ◽  
Hek293 Cells ◽  
Novel Approach ◽  
Assay Performance ◽  
Multiplex Serology

The emerging SARS-CoV-2 pandemic entails an urgent need for specific and sensitive high-throughput serological assays to assess SARS-CoV-2 epidemiology. We, therefore, aimed at developing a fluorescent-bead based SARS-CoV-2 multiplex serology assay for detection of antibody responses to the SARS-CoV-2 proteome. Proteins of the SARS-CoV-2 proteome and protein N of SARS-CoV-1 and common cold Coronaviruses (ccCoVs) were recombinantly expressed in E. coli or HEK293 cells. Assay performance was assessed in a COVID-19 case cohort (n = 48 hospitalized patients from Heidelberg) as well as n = 85 age- and sex-matched pre-pandemic controls from the ESTHER study. Assay validation included comparison with home-made immunofluorescence and commercial enzyme-linked immunosorbent (ELISA) assays. A sensitivity of 100% (95% CI: 86–100%) was achieved in COVID-19 patients 14 days post symptom onset with dual sero-positivity to SARS-CoV-2 N and the receptor-binding domain of the spike protein. The specificity obtained with this algorithm was 100% (95% CI: 96–100%). Antibody responses to ccCoVs N were abundantly high and did not correlate with those to SARS-CoV-2 N. Inclusion of additional SARS-CoV-2 proteins as well as separate assessment of immunoglobulin (Ig) classes M, A, and G allowed for explorative analyses regarding disease progression and course of antibody response. This newly developed SARS-CoV-2 multiplex serology assay achieved high sensitivity and specificity to determine SARS-CoV-2 sero-positivity. Its high throughput ability allows epidemiologic SARS-CoV-2 research in large population-based studies. Inclusion of additional pathogens into the panel as well as separate assessment of Ig isotypes will furthermore allow addressing research questions beyond SARS-CoV-2 sero-prevalence.

Efficient artificial light-harvesting systems based on aggregation-induced emission constructed in supramolecular gels

Soft Matter ◽  
2021 ◽  
Author(s):  
Xinxian Ma ◽  
bo qiao ◽  
Jinlong Yue ◽  
JingJing Yu ◽  
yutao geng ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Rhodamine B ◽  
Fluorescent Dyes ◽  
Light Harvesting ◽  
Artificial Light ◽  
Efficient Energy Transfer ◽  
Aggregation Induced Emission ◽  
Efficient Energy ◽  
Harvesting Systems ◽  
Acyl Hydrazone

Based on a new designed acyl hydrazone gelator (G2), we developed an efficient energy transfer supramolecular organogel in glycol with two different hydrophobic fluorescent dyes rhodamine B (RhB) and acridine...

Sign in / Sign up

Export Citation Format

Share Document