scholarly journals Antidiabetic Properties and Possible Mechanism of the Traditional Chinese Medicine Yi Qi Yang Yin Recipe in Db/db Mice

2021 ◽  
Author(s):  
Hongmei Lin ◽  
Ziying Xu ◽  
Baosheng Zhao ◽  
Jingxuan Zhang ◽  
Zilan Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Serum Protein ◽  
Water Consumption ◽  
Liver Tissue ◽  
Fasting Blood Glucose ◽  
Tissue Morphology

Abstract Background Yi Qi Yang Yin Recipe (YQYY) is a well-known clinical prescription used in Traditional Chinese Medicine (TCM) that ameliorates type 2 diabetes. The aim of the present study was to comprehensively evaluate the efficacy of YQYY granules and explore their mechanism of action. Methods db/db mice were studied as an animal model of type 2 diabetes. After administered with YQYY for eight weeks, food and water consumption, levels of fasting blood glucose, glycosylated serum protein, and liver and pancreas tissue morphology were investigated. In addition, RT-PCR and Westernblot analysis were used to determine the expression of genes and proteins related to glycogen synthesis and gluconeogenesis pathways in the liver. Results YQYY resulted in significantly reduced food and water consumption, and lower fasting blood glucose and glycated serum protein levels. Furthermore, the proliferation of α-cells in db/db mouse pancreatic tissue decreased and liver tissue morphology was significantly ameliorated. YQYY upregulated the expression of phosphorylated GSK-3β and GS proteins in db/db mouse liver tissue, and promoted the synthesis of liver glycogen. Additionally, AMPK was activated, PEPCK and G6Pase gene expression levels decreased, and consequently, gluconeogenesis in the liver was inhibited. Therefore, YQYY improves diabetic phenotyp, suggesting that YQYY could be a prospective agent for preventing and treatment diabetes .

scholarly journals Clinical Study on Treatment of Vascular Aging in Patients with Type 2 Diabetes Complicated by Hypertension with Combination of Traditional Chinese Medicine and Western Medicine

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Bin Ju
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Western Medicine ◽  
Blood Lipids ◽  
Control Group ◽  
Observational Group

Objective: To explore the clinical effect of combination of traditional Chinese medicine and western medicine in treatment of vascular aging in patients with type 2 diabetes complicated by hypertension. Methods: Ninety patients with type 2 diabetes complicated by hypertension admitted to our hospital from May 2016 to August 2019 were selected as research objects. They were randomly divided into control group and observational group, with 45 cases each. Control group was given amlodipine besylate combined with metformin hydrochloride. On the basis of control group, observational group was given combination of TCM syndrome differentiation. Blood glucose, blood pressure and blood lipids before and after 14 days of treatment were compared between two groups. Results: Blood glucose, blood pressure and lipid indexes after treatment were lower than before treatment in both groups; observational group was lower than control group and the difference was statistically significant (P<0.05). Conclusion: Combination of traditional Chinese medicine and Western medicine could lower blood glucose and blood pressure indexes, control blood lipids and delay blood vessel aging in patients with type 2 diabetes complicated by hypertension, it is worthy of clinical popularization.

scholarly journals Hantangping-a traditional Chinese medicine compound versus metformin for treating early type 2 diabetes mellitus:study protocol for a non-inferiority randomized controlled trial

2021 ◽  
Author(s):  
Xiao Jiang ◽  
Baohua Wang ◽  
Xinlin Chen ◽  
Zebiao Cao ◽  
Kexin Li ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Blood Glucose ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Model Assessment ◽  
Early Type ◽  
Homeostasis Model Assessment ◽  
Randomized Controlled

Abstract Background: Hantangping is a traditional Chinese medicine compound, founded by Professor Saimei Li of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, and has been used to treat type 2 diabetes mellitus for more than 10 years. Clinical practice has shown that for early stage type 2 diabetes patients with acceptable islet secretion function, Hantangping can reduce blood glucose and improve islet function while correcting lipid metabolism disorders, preventing diabetes complications, and reducing adverse reactions..However, there is currently a lack of randomized controlled clinical trials that can confirm the efficacy of Hantangping in the treatment of early type 2 diabetes. We designed this study to objectively evaluate the effectiveness and safety of Hantangping in the treatment of early type 2 diabetes.Methods/Design: A randomized, open, parallel controlled and non-inferiority clinical trial was designed. Participants were randomly divided into Hantangping group(experimental group) and metformin group(positive control group) at a ratio of 1:1, and were intervened with Chinese medicine Hantangping and Western medicine metformin respectively.The participants will receive 12 weeks of drug intervention and 8 weeks of follow-up.The primary outcome measure is glycosylated hemoglobin a1c. The secondary outcome measures are fasting blood glucose， index of β-cell function in Homeostasis Model Assessment,and index of Insulin resistance in Homeostasis Model Assessment, etc.Discussion:This study can provide scientific and rigorous evidence-based medical evidence for the effectiveness and safety of Hantangping in the treatment of early type 2 diabetes, and may also provide new ideas and methods for the treatment of type 2 diabetes.Trial registration : Chinese Clinical Trial Registry, ChiCTR1900023378. Registered on 25 May 2019, http://www.chictr.org.cn/listbycreater.aspx .

Epigenetic modulation of autophagy genes linked to diabetic nephropathy by administration of isorhamnetin in Type 2 diabetes mellitus rats

Epigenomics ◽  
2021 ◽  
Author(s):  
Marwa Matboli ◽  
Doaa Ibrahim ◽  
Amany H Hasanin ◽  
Mohamed Kamel Hassan ◽  
Eman K Habib ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Light And Electron Microscopy ◽  
Lipid Profiles ◽  
Mirna Regulation ◽  
Protein Levels

Aim: To assess isorhamnetin efficacy for diabetic kidney disease in a Type 2 diabetes mellitus rat model, through investigating its effect at the epigenetic, mRNA and protein levels. Materials & methods: Type 2 diabetes mellitus was induced in rats by streptozotocin and high-fat diet. Rats were treated with isorhamnetin (50 mg/kg/d) for 4 or 8 weeks. Fasting blood glucose, renal and lipid profiles were evaluated. Renal tissues were examined by light and electron microscopy. Autophagy genes ( FYCO1, ULK, TECPR1 and  WIPI2) and miR-15b, miR-34a and miR-633 were assessed by qRT-PCR, and LC3A/B by immunoblotting. Results: Isorhamnetin improved fasting blood glucose, renal and lipid profiles with increased autophagosomes in renal tissues. It suppressed miRNA regulation of autophagy genes Conclusion: We propose a molecular mechanism for the isorhamnetin renoprotective effect by modulation of autophagy epigenetic regulators.

scholarly journals An anxiolytic drug buspirone ameliorates hyperglycemia and endothelial dysfunction in type 2 diabetic rat model

2020 ◽  
Vol 45 (4) ◽  
pp. 397-404
Author(s):  
Tugba Gurpinar Çavuşoğlu ◽  
Ertan Darıverenli ◽  
Kamil Vural ◽  
Nuran Ekerbicer ◽  
Cevval Ulman ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Endothelial Dysfunction ◽  
Vascular Function ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Diabetic Rat ◽  
Insulin Levels ◽  
Type 2 Diabetic

AbstractObjectivesType 2 diabetes is a common metabolic disease and anxiety disorders are very common among diabetics. Buspirone is used in the treatment of anxiety, also having blood glucose-lowering effects. The aim of the study was to investigate the effects of buspirone on the glucose and lipid metabolism as well as vascular function in type 2 diabetic rats.MethodsA type 2-diabetic model was induced through a high-fat diet for eight weeks followed by the administration of low-dose streptozotocin (35 mg/kg, intraperitoneal) in rats. Buspirone was given at two different doses (1.5 mg/kg/d and 5 mg/kg/d) and combined with metformin (300 mg/kg/d). The fasting glucose and insulin levels, lipid profile were analyzed, and vascular response measured from the thoracic aorta was also evaluated.ResultsBoth doses of buspirone caused a significant improvement in fasting blood glucose levels. In particular, the buspirone treatment, combined with metformin, improved endothelial dysfunction and was found to be correlated with decreased nitrate/nitrite levels.ConclusionsBuspirone may be effective in the treatment of type 2 diabetes, either alone or in combination with other treatments, particularly in terms of endothelial dysfunction, inflammation and impaired blood glucose, and insulin levels.

scholarly journals Testing the phenotypic decanalization hypothesis: social determinants of hyperglycemia and type 2 diabetes in adult urban Argentinian population

2021 ◽  
Author(s):  
Maria Alejandra Petino Zappala ◽  
Guillermo Folguera ◽  
Santiago Benitez Vieyra
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Alcohol Consumption ◽  
Adult Population ◽  
Fasting Blood Glucose ◽  
Human Populations ◽  
Phenotypic Variance ◽  
Fasting Glycemia ◽  
Individual Behaviors

Type 2 diabetes, one of the major causes of death and disability worldwide, is characterized by problems in the homeostasis of blood glucose. Current preventive policies focus mainly on individual behaviors (diet, exercise, salt and alcohol consumption). Recent hypotheses state that the higher incidence of metabolic disease in some human populations may be related to phenotypic decanalization causing a heightened phenotypic variance in response to unusual or stressful environmental conditions, although the nature of these conditions is under debate. Our aim was to explore variability patterns of fasting blood glucose to test phenotypic decanalization as a possible explanation of heightened prevalence for type 2 diabetes in some groups and to detect variables associated with its variance using a nation-wide survey of Argentinian adult population. We found patterns of higher local variance for fasting glycemia associated with lower income and educational attainment. We detected no meaningful association of glycemia or its variability with covariates related to individual behaviors (diet, physical activity, salt or alcohol consumption). Our results were consistent with the decanalization hypothesis for fasting glycemia, which appears associated to socioeconomic disadvantage. We therefore propose changes in public policy and discuss the implications for data gathering and further analyses.

scholarly journals The Effects of Almonds on Gut Microbiota, Glycometabolism, and Inflammatory Markers in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3377
Author(s):  
Omorogieva Ojo ◽  
Xiao-Hua Wang ◽  
Osarhumwese Osaretin Ojo ◽  
Amanda Rodrigues Amorim Adegboye
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Gut Microbiota ◽  
Inflammatory Markers ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Glycated Haemoglobin ◽  
Postprandial Blood Glucose

The use of nutritional interventions for managing diabetes is one of the effective strategies aimed at reducing the global prevalence of the condition, which is on the rise. Almonds are the most consumed tree nut and they are known to be rich sources of protein, monounsaturated fatty acids, essential minerals, and dietary fibre. Therefore, the aim of this review was to evaluate the effects of almonds on gut microbiota, glycometabolism, and inflammatory parameters in patients with type 2 diabetes. Methods: This systematic review and meta-analysis was carried out according to the preferred reporting items for systematic review and meta-analysis (PRISMA). EBSCOhost, which encompasses the Health Sciences Research Databases; Google Scholar; EMBASE; and the reference lists of articles were searched based on population, intervention, control, outcome, and study (PICOS) framework. Searches were carried out from database inception until 1 August 2021 based on medical subject headings (MesH) and synonyms. The meta-analysis was carried out with the Review Manager (RevMan) 5.3 software. Results: Nine randomised studies were included in the systematic review and eight were used for the meta-analysis. The results would suggest that almond-based diets have significant effects in promoting the growth of short-chain fatty acid (SCFA)-producing gut microbiota. Furthermore, the meta-analysis showed that almond-based diets were effective in significantly lowering (p < 0.05) glycated haemoglobin (HbA1c) levels and body mass index (BMI) in patients with type 2 diabetes. However, it was also found that the effects of almonds were not significant (p > 0.05) in relation to fasting blood glucose, 2 h postprandial blood glucose, inflammatory markers (C-reactive protein and Tumour necrosis factor α, TNF-α), glucagon-like peptide-1 (GLP-1), homeostatic model assessment of insulin resistance (HOMA–IR), and fasting insulin. The biological mechanisms responsible for the outcomes observed in this review in relation to reduction in HbA1c and BMI may be based on the nutrient composition of almonds and the biological effects, including the high fibre content and the low glycaemic index profile. Conclusion: The findings of this systematic review and meta-analysis have shown that almond-based diets may be effective in promoting short-chain fatty acid-producing bacteria and lowering glycated haemoglobin and body mass index in patients with type 2 diabetes compared with control. However, the effects of almonds were not significant (p > 0.05) with respect to fasting blood glucose, 2 h postprandial blood glucose, inflammatory markers (C-reactive protein and TNF-α), GLP-1, HOMA–IR, and fasting insulin.

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