Relationship Between Injured Cingulum and Impaired Consciousness in Patients with Hypoxic-Ischemic Brain Injury

Mapping Intimacies ◽

10.21203/rs.3.rs-1154550/v1 ◽

2021 ◽

Author(s):

SungHO Jang ◽

YOUSUNG SEO

Keyword(s):

Brain Injury ◽

Diffusion Tensor ◽

Control Group ◽

Ischemic Brain Injury ◽

Impaired Consciousness ◽

Ischemic Brain ◽

Group A ◽

Hypoxic Ischemic Brain Injury ◽

Group B ◽

The Relationship

Abstract Objectives We investigated the relationship between cingulum injury and impaired consciousness in patients with hypoxic-ischemic brain injury (HI-BI) by using diffusion tensor tractography (DTT). Methods We recruited 29 patients with HI-BI and 25 normal control subjects. The patients were classified as intact consciousness (group A, 13 patients) or impaired consciousness (group B, 16 patients). The DTT parameters of fractional anisotropy (FA) and tract volume (TV) were estimated for both cinguli. Glasgow Coma Scale (GCS) and Coma Recovery Scale-Revised (CRS-R) scores were also evaluated. Results The FA and TV values of the cinguli in groups A and B were lower than those of the control group (p < 0.05), and the FA and TV values of group B were lower than those of group A (p < 0.05). The FA and TV values of the cinguli in group A were not significantly correlated with GCS and CRS-R scores (p > 0.05); however, regarding the group B, the FA correlations with GCS (r = 0.457, p < 0.05) and CRS-R (r = 0.494, p < 0.05) and those of TV with GCS (r = 0.500, p < 0.05) and CRS-R (r = 0.491, p < 0.05) were moderately positive. Conclusions We found a significant relationship between injury of the cingulum and impaired consciousness in patients with HI-BI. Our results suggest that an injured cingulum could be an appropriate target for neurointervention or neurorehabilitation in patients with impaired consciousness following HI-BI.

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Neural tracts injuries in patients with hypoxic ischemic brain injury: Diffusion tensor imaging study

Neuroscience Letters ◽

10.1016/j.neulet.2012.08.053 ◽

2012 ◽

Vol 528 (1) ◽

pp. 16-21 ◽

Cited By ~ 22

Author(s):

Ah Young Lee ◽

Dong-Gu Shin ◽

Jong-Seon Park ◽

Geu Ru Hong ◽

Pyung-Hun Chang ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Brain Injury ◽

Diffusion Tensor ◽

Imaging Study ◽

Ischemic Brain Injury ◽

Ischemic Brain ◽

Hypoxic Ischemic Brain Injury ◽

Diffusion Tensor Imaging Study

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Injury of the lower ascending reticular activating system in patients with hypoxic–ischemic brain injury: diffusion tensor imaging study

Neuroradiology ◽

10.1007/s00234-014-1419-y ◽

2014 ◽

Vol 56 (11) ◽

pp. 965-970 ◽

Cited By ~ 20

Author(s):

Sung Ho Jang ◽

Seong Ho Kim ◽

Hyoung Won Lim ◽

Sang Seok Yeo

Keyword(s):

Diffusion Tensor Imaging ◽

Brain Injury ◽

Diffusion Tensor ◽

Imaging Study ◽

Ischemic Brain Injury ◽

Ischemic Brain ◽

Ascending Reticular Activating System ◽

Reticular Activating System ◽

Hypoxic Ischemic Brain Injury ◽

Diffusion Tensor Imaging Study

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Relationship between Dizziness and the Core Vestibular Projection Injury in Patients with Mild Traumatic Brain Injury

Diagnostics ◽

10.3390/diagnostics11112070 ◽

2021 ◽

Vol 11 (11) ◽

pp. 2070

Author(s):

Sung-Ho Jang ◽

Chang-Hoon Bae ◽

Jae-Woon Kim ◽

Hyeok-Gyu Kwon

Keyword(s):

Traumatic Brain Injury ◽

Brain Injury ◽

Mild Traumatic Brain Injury ◽

Injury Severity ◽

Diffusion Tensor ◽

Control Group ◽

Item Score ◽

Mild Tbi ◽

Group A ◽

Group B

Some studies have reported that a core vestibular projection (CVP) injury is associated with dizziness following a brain injury using diffusion tensor tractography (DTT). On the other hand, there has been no DTT study on dizziness caused by a CVP injury in patients with mild traumatic brain injury (TBI). In this study, DTT was used to examine the relationship between dizziness and CVP injury in patients with mild TBI. Forty-three patients with mild TBI and twenty-nine normal subjects were recruited. The patients were classified into two groups based on the dizziness score: group A, patients with a dizziness score less than 2 on the sub-item score for dizziness in the Rivermead Post-concussion Symptoms Questionnaire; group B, patients with a dizziness score above 2. The tract volume (TV) in group B was significantly lower than group A and the control group (p < 0.05). By contrast, the TV in group A was similar to the control group (p > 0.05). Regarding the correlation, the dizziness score of all patients showed a strong negative correlation with the TV of the CVP (r = −0.711, p < 0.05). DTT revealed the CVP injury in patients with dizziness after mild TBI. In addition, the severity of dizziness of these patients was closely related to the injury severity of the CVP.

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Neuroplasticity for spontaneous functional recovery after neonatal hypoxic ischemic brain injury in rats observed by functional MRI and diffusion tensor imaging

NeuroImage ◽

10.1016/j.neuroimage.2015.11.032 ◽

2016 ◽

Vol 126 ◽

pp. 140-150 ◽

Cited By ~ 6

Author(s):

Won-Beom Jung ◽

Geun Ho Im ◽

Julius Juhyun Chung ◽

So-Yoon Ahn ◽

Tae Yeon Jeon ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Brain Injury ◽

Functional Mri ◽

Functional Recovery ◽

Diffusion Tensor ◽

Ischemic Brain Injury ◽

Ischemic Brain ◽

Hypoxic Ischemic Brain Injury ◽

And Diffusion

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Sevoflurane Post-Conditioning Alleviated Hypoxic-Ischemic Brain Injury in Neonatal Rats by Inhibiting Endoplasmic Reticulum Stress-Mediated Autophagy via IRE1 Signalings

10.21203/rs.3.rs-274276/v1 ◽

2021 ◽

Author(s):

Jiayuan Niu ◽

Ziyi Wu ◽

Hang Xue ◽

Yahan Zhang ◽

Qiushi Gao ◽

...

Keyword(s):

Endoplasmic Reticulum ◽

Brain Injury ◽

Er Stress ◽

Signaling Pathway ◽

Ischemic Brain Injury ◽

Neonatal Rats ◽

Artery Ligation ◽

Ischemic Brain ◽

Hypoxic Ischemic Brain Injury ◽

The Relationship

Abstract Post-conditioning with sevoflurane, a volatile anesthetic, has been proved to be neuroprotective against hypoxic-ischemic brain injury (HIBI). Our previous research showed that autophagy is over-activated in a rat model of neonatal HIBI, and inhibition of autophagy confers neuroprotection. There is increasing recognition that autophagy can be triggered by activating endoplasmic reticulum (ER) stress. This study aimed to explore: i) the relationship between ER stress and autophagy in the setting of neonatal HIBI; and ii) the possible roles of ER stress-mediated autophagy and IRE1 signalings in the neuroprotection of sevoflurane post-conditioning against neonatal HIBI. Seven-day-old rats underwent left common artery ligation followed by 2 h hypoxia (8% O2 / 92% N2). The relationship between ER stress and autophagy was examined by ER stress inducer (tunicamycin), ER stress inhibitor (4-PBA), or autophagy inhibitor (3-MA). Rats in the sevoflurane post-conditioning groups were treated with 2.4% sevoflurane for 30 min after HIBI induction. The roles of ER stress-mediated autophagy and the IRE1/JNK/beclin1 signaling pathway in the neuroprotection afforded by sevoflurane were examined by ER stress inducer (tunicamycin) and the IRE1 inhibitor (STF-083010). HIBI over‑activated ER stress and autophagy in neonatal rats. HIBI-induced autophagy was significantly aggravated by tunicamycin but blocked by 4-PBA; however, HIBI-induced ER stress was not affected by 3-MA. Sevoflurane post-conditioning significantly alleviated ER stress, autophagy, cell apoptosis, and cognitive impairments, which were remarkably abolished by tunicamycin. Also, tunicamycin blocked sevoflurane-induced downregulation of IRE1/JNK/beclin1 signaling pathway. Whereas, IRE1 inhibitor could reverse the effects of tunicamycin. ER stress contributes to autophagy induced by HIBI. Furthermore, sevoflurane post-conditioning significantly protects against HIBI in neonatal rats by inhibiting ER stress-mediated autophagy via IRE1/JNK/beclin1 signaling pathway.

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