scholarly journals Time-sensitive Prefrontal Involvement in Associating Confidence With Task Performance Illustrates Metacognitive Introspection in Monkeys

2022 ◽  
Author(s):  
Yudian Cai ◽  
Zhiyong Jin ◽  
Chenxi Zhai ◽  
Huiming Wang ◽  
Jijun Wang ◽  
...  
Keyword(s):  
Task Performance ◽  
Magnetic Stimulation ◽  
Critical Role ◽  
Computational Modelling ◽  
Single Pulse ◽  
Neural Substrates ◽  
Ample Evidence ◽  
Domain Specific ◽  
Stimulation Technique ◽  
Human Primate

Abstract Metacognition refers to the ability to be aware of one’s own cognition. Ample evidence indicates that metacognition in the human primate is highly dissociable from cognition, specialized across domains, and subserved by distinct neural substrates. However, these aspects remain relatively understudied in macaque monkeys. In the present study, we investigated the functionality of macaque metacognition by combining a confidence proxy, hierarchical Bayesian meta-d′ computational modelling, and a single-pulse transcranial magnetic stimulation technique. We found that Brodmann area 46d (BA46d) played a critical role in supporting metacognition independent of task performance; we also found that the critical role in of this region in meta-calculation was time-sensitive. Additionally, we report that macaque metacognition is highly domain-specific with respect to memory and perception decisions. These findings carry implications for our understanding of metacognitive introspection within the primate lineage.

scholarly journals Temporal-sensitive prefrontal involvement in associating confidence with task performance illustrates metacognitive introspection in Old World monkeys (Macaca mulatta)

2021 ◽  
Author(s):  
Yudian Cai ◽  
Zhiyong Jin ◽  
Chenxi Zhai ◽  
Huimin Wang ◽  
Jijun Wang ◽  
...  
Keyword(s):  
Task Performance ◽  
Critical Role ◽  
Computational Modelling ◽  
Critical Time ◽  
Single Pulse ◽  
Neural Substrates ◽  
Ample Evidence ◽  
Domain Specific ◽  
Stimulation Technique

AbstractMetacognition refers to the ability to be aware of one’s own cognition. Ample evidence indicate that metacognition in the human primate is highly dissociable from cognition, specialized across domains, and subserved by distinct neural substrates. However, these aspects remain relatively understudied in the macaque monkeys. Here we investigated the functionality of macaques’ metacognition by combining a confidence proxy, hierarchical Bayesian meta-d’ computational modelling, and single-pulse transcranial magnetic stimulation technique. We found a critical role of Brodmann Area 46d (BA 46d) in supporting metacognition without implicating task performance and its critical time-sensitive role in meta-calculation. We additionally revealed that macaque metacognition is highly domain-specific with respect to memory and perception decisions. These findings carry implications for our understanding of metacognitive introspection within the primate lineage.

scholarly journals Repetitive Transcranial Magnetic Stimulation and Stroke Rehabilitation

2018 ◽  
Vol 1 (1) ◽  
pp. 01-02
Author(s):  
Berthold Kepplinger
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Wide Spectrum ◽  
Single Pulse ◽  
Brain Structures ◽  
Treatment Modalities ◽  
Neurologic Injury ◽  
Cortical Regions ◽  
Stimulation Technique

Neurorehabilitation involves a wide spectrum of different approaches of treatment modalities and is a notable period for patient after stabilization of patient’s neurologic injury. In 1985 Barker and co-authors introduced transcranial magnetic stimulation (TMS) as a noninvasive and safe brain stimulation technique. TMS can be delivered via single-pulse, double-pulse, paired-pulse and low or high frequency repetitive pulses (rTMS). Depending on stimulation parameters i.e. frequency, rate, and duration, application of repetitive stimuli to cortical regions can enhance or decrease the excitability of the affected brain structures. In the last years the development of stimulators significantly progressed, specially discharging at high frequencies up to 100 Hz and the application of TMS expanded into the areas of behavioral and cognitive functions assessment, as well.

scholarly journals Motor disability in patients with multiple sclerosis: transcranial magnetic stimulation study

2020 ◽  
Vol 56 (1) ◽  
Author(s):  
Anssam Bassem Mohy ◽  
Aqeel Kareem Hatem ◽  
Hussein Ghani Kadoori ◽  
Farqad Bader Hamdan
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Lower Limb ◽  
Magnetic Stimulation ◽  
Motor Evoked Potential ◽  
Invasive Procedure ◽  
Single Pulse ◽  
Lower Limbs ◽  
Control Group ◽  
Conduction Time ◽  
Motor Disability

Abstract Background Transcranial magnetic stimulation (TMS) is a non-invasive procedure used in a small targeted region of the brain via electromagnetic induction and used diagnostically to measure the connection between the central nervous system (CNS) and skeletal muscle to evaluate the damage that occurs in MS. Objectives The study aims to investigate whether single-pulse TMS measures differ between patients with MS and healthy controls and to consider if these measures are associated with clinical disability. Patients and methods Single-pulse TMS was performed in 26 patients with MS who hand an Expanded Disability Status Scale (EDSS) score between 0 and 9.5 and in 26 normal subjects. Different TMS parameters from upper and lower limbs were investigated. Results TMS disclosed no difference in all MEP parameters between the right and left side of the upper and lower limbs in patients with MS and controls. In all patients, TMS parameters were different from the control group. Upper limb central motor conduction time (CMCT) was prolonged in MS patients with pyramidal signs. Upper and lower limb CMCT and CMCT-f wave (CMCT-f) were prolonged in patients with ataxia. Moreover, CMCT and CMCT-f were prolonged in MS patients with EDSS of 5–9.5 as compared to those with a score of 0–4.5. EDSS correlated with upper and lower limb cortical latency (CL), CMCT, and CMCT-f whereas motor evoked potential (MEP) amplitude not. Conclusion TMS yields objective data to evaluate clinical disability and its parameters correlated well with EDSS.

scholarly journals Top-down control of visual cortex by the frontal eye fields through oscillatory realignment

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Domenica Veniero ◽  
Joachim Gross ◽  
Stephanie Morand ◽  
Felix Duecker ◽  
Alexander T. Sack ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Visual Perception ◽  
Magnetic Stimulation ◽  
Single Pulse ◽  
Frontal Eye Fields ◽  
Phase Reset ◽  
Top Down ◽  
Visual Areas ◽  
Beta Frequency

AbstractVoluntary allocation of visual attention is controlled by top-down signals generated within the Frontal Eye Fields (FEFs) that can change the excitability of lower-level visual areas. However, the mechanism through which this control is achieved remains elusive. Here, we emulated the generation of an attentional signal using single-pulse transcranial magnetic stimulation to activate the FEFs and tracked its consequences over the visual cortex. First, we documented changes to brain oscillations using electroencephalography and found evidence for a phase reset over occipital sites at beta frequency. We then probed for perceptual consequences of this top-down triggered phase reset and assessed its anatomical specificity. We show that FEF activation leads to cyclic modulation of visual perception and extrastriate but not primary visual cortex excitability, again at beta frequency. We conclude that top-down signals originating in FEF causally shape visual cortex activity and perception through mechanisms of oscillatory realignment.

scholarly journals Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients

2021 ◽  
Vol 11 (1) ◽  
pp. 54
Author(s):  
Yoshihiro Noda ◽  
Mera S. Barr ◽  
Reza Zomorrodi ◽  
Robin F. H. Cash ◽  
Pantelis Lioumis ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Evoked Potential ◽  
Single Pulse ◽  
Signal Propagation ◽  
Lower Amplitude ◽  
Dorsolateral Prefrontal ◽  
The Right

Background: The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ). Methods: We compared the spatiotemporal characteristics of TEPs induced by spTMS among the groups. Results: Compared to YNG, M1-spTMS induced lower amplitudes of N45 and P180 in OLD and a lower amplitude of P180 in SCZ, whereas the DLPFC-spTMS induced a lower N45 in OLD. Further, OLD demonstrated latency delays in P60 after M1-spTMS and in N45-P60 over the right central region after left DLPFC-spTMS, whereas SCZ demonstrated latency delays in N45-P60 over the midline and right central regions after DLPFC-spTMS. Conclusions: These findings suggest that inhibitory and excitatory mechanisms mediating TEPs may be altered in OLD and SCZ. The amplitude and latency changes of TEPs with spTMS may reflect underlying neurophysiological changes in OLD and SCZ, respectively. The spTMS administered to M1 and the DLPFC can probe cortical functions by examining TEPs. Thus, TMS-EEG can be used to study changes in cortical connectivity and signal propagation from healthy to pathological brains.

Motion on Numbers: Transcranial Magnetic Stimulation on the Ventral Intraparietal Sulcus Alters Both Numerical and Motion Processes

2009 ◽  
Vol 21 (11) ◽  
pp. 2129-2138 ◽  
Author(s):  
Elena Salillas ◽  
Demis Basso ◽  
Maurizia Baldi ◽  
Carlo Semenza ◽  
Tomaso Vecchi
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Motion Detection ◽  
Magnetic Stimulation ◽  
Reaction Times ◽  
Single Pulse ◽  
Coherent Motion ◽  
Intraparietal Sulcus ◽  
Close Link ◽  
Number Comparison ◽  
Neural Substrate

It has often been proposed that there is a close link between representation of number and space. In the present work, single-pulse transcranial magnetic stimulation (TMS) was applied to the ventral intraparietal sulcus (VIPS) to determine effects on performance in motion detection and number comparison tasks. Participants' reaction times and thresholds for perception of laterally presented coherent motion in random dot kinematograms increased significantly when the contralateral VIPS was stimulated in contrast to the interhemispheric sulcus (Experiment 1) and to the ipsilateral VIPS (Experiment 2). In number comparison tasks, participants compared the magnitude of the laterally presented numbers 1–9 with the number 5. Again, reaction times significantly increased when TMS was applied to the contralateral VIPS in contrast to control sites. The finding that VIPS-directed TMS results in impaired efficiency in both motion perception and number comparison suggests that these processes share a common neural substrate.

Causal evidence for a domain-specific role of left superior frontal sulcus in human perceptual decision-making

2021 ◽  
Author(s):  
Miguel Barretto Garcia ◽  
Marcus Grueschow ◽  
Marius Moisa ◽  
Rafael Polania ◽  
Christian Carl Ruff
Keyword(s):  
Decision Making ◽  
Sequential Sampling ◽  
Computational Modelling ◽  
Perceptual Decision Making ◽  
Domain Specific ◽  
Neural Processes ◽  
Sequential Sampling Model ◽  
Evidence Integration ◽  
Superior Frontal Sulcus

Humans and animals can flexibly choose their actions based on different information, ranging from objective states of the environment (e.g., apples are bigger than cherries) to subjective preferences (e.g., cherries are tastier than apples). Whether the brain instantiates these different choices by recruiting either specialized or shared neural circuitry remains debated. Specifically, domain-general theories of prefrontal cortex (PFC) function propose that prefrontal areas flexibly process either perceptual or value-based evidence depending on what is required for the present choice, whereas domain-specific theories posit that PFC sub- areas, such as the left superior frontal sulcus (SFS), selectively integrate evidence relevant for perceptual decisions. Here we comprehensively test the functional role of the left SFS for choices based on perceptual and value-based evidence, by combining fMRI with a behavioural paradigm, computational modelling, and transcranial magnetic stimulation. Confirming predictions by a sequential sampling model, we show that TMS-induced excitability reduction of the left SFS selectively changes the processing of decision-relevant perceptual information and associated neural processes. In contrast, value-based decision making and associated neural processes remain unaffected. This specificity of SFS function is evident at all levels of analysis (behavioural, computational, and neural, including functional connectivity), demonstrating that the left SFS causally contributes to evidence integration for  perceptual but not value-based decisions.

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