scholarly journals Association Between Triglyceride Glucose Index and Carotid Artery Plaque in Different Glucose Metabolic States in Patients with Coronary Heart Disease — A RCSCD-TCM Study in China

Author(s):  
Zhu Li ◽  
Yuanyuan He ◽  
Shuo Wang ◽  
Lin Li ◽  
Rongrong Yang ◽  
...  

Abstract BackgroundThe triglyceride glucose (TyG) index serves as a surrogate indicator of insulin resistance. However, there are limited data on the association between TyG index and carotid artery plaque (CAP) in patients with coronary heart disease (CHD).MethodsA total of 10,535 CHD patients were included in this study. TyG index was divided into quartiles, Q1: TyG index < 8.52, Q2: 8.52 ≤ TyG index < 8.93, Q3: 8.93 ≤ TyG index ≤ 9.40, Q4: TyG index >9.40. Logistic regression was used to analyze the relationship between TyG index and CAP in CHD patients, and further analyzed the relationship between TyG index and CAP in different genders, different age groups and different glucose metabolism states. ResultsA baseline analysis of CHD patients divided into four groups according to the quartile of the TyG index showed that there were significant differences in related parameters between the groups. As the TyG index increases, the incidence of CAP increases significantly. After adjustment for multivariate, TyG index levels for Q3 and Q4 correlated with increased OR in CAP, which Q4 has the highest correlation (OR: 1.42; 95% CI: 1.33 -1.53). The correlation between the Tyg index of female (OR:1.38; 95% CI: 1.31-1.45) and CAP was higher than that of male (OR:1.23; 95% CI: 1.16, 1.30). The OR value of middle-aged (≤ 60 years old) patients (OR:1.14; 95% CI: 1.07-1.22) is higher than that of elderly (>dayu 60 years old) patients (OR:1.07; 95% CI: 1.02-1.13). Under different glucose metabolism states, the TyG index of CHD patients was significantly related to the risk of CAP, and the OR value of diabetes (DM) was the highest (OR: 1.35; 95% CI: 1.26-1.45).ConclusionsThere is a significant correlation between the TyG index and CAP in CHD patients. In addition, the correlation between TyG index and CAP in CHD patients is higher in female than in male, and the correlation in middle-aged and elderly patients is higher than that in elderly patients. Under the condition of DM, the correlation between TyG index and carotid artery plaque in CHD patients is higher.

2001 ◽  
Vol 28 (12) ◽  
pp. 197-204
Author(s):  
Eriko SEKI ◽  
Yoshiro WATANABE ◽  
Satoshi SUNAYAMA ◽  
Yoshitaka IWAMA ◽  
Kazunori SHIMADA ◽  
...  

2021 ◽  
Author(s):  
Shengmei Qin ◽  
Hengjing Wu ◽  
Hao Wang ◽  
Qi Li ◽  
Jie Zhou ◽  
...  

Abstract Objective: To investigate the prevalence and related risk factors associated with coronary heart disease(CHD) among middle aged and elderly patients with vision impairment (VI). Study design: cross-sectional research. Methods: The study was conducted with 1,355 visually impaired adults over 45 years old, recruited from a Rehabilitation Hospital in China. Visual impairment is diagnosed by a doctor according to guidelines. Data was analyzed using multiple correspondence and logistic regression analysis. This research represents an important step towards the development of empirically based practical suggestions for decision-makers and health professionals that support visually impaired middle-aged and elderly people to participate in physical exercise and weight management when needed. Results: Of the 1335 middle aged and elderly adults with VI, a total of 154 (11.5%) developed CHD. Statistical analysis based on age grouping indicated that hypertension, diabetes, blindness, gentle and moderate activity were shown to have a strong association with development of CHD. In addition, fasting plasma glucose, heart rate (<60), and BMI were important risk factors for CHD in the middle-aged group and the elderly group respectively.Conclusion: Suggestions for related policy changes should focus on the social and environmental aspects. This includes developing a more accessible and inclusive environments and providing meaningful information about physical activity and weight management to middle-aged and elderly people with visually impaired.


2015 ◽  
Vol 12 (11) ◽  
pp. 14275-14284 ◽  
Author(s):  
Huiping Zhang ◽  
Mengxue Liu ◽  
Tiantian Ren ◽  
Xiangqian Wang ◽  
Dandan Liu ◽  
...  

Stroke ◽  
2019 ◽  
Vol 50 (2) ◽  
pp. 491-494 ◽  
Author(s):  
Pablo Catalan-Serra ◽  
Francisco Campos-Rodriguez ◽  
Nuria Reyes-Nuñez ◽  
Maria Jose Selma-Ferrer ◽  
Cristina Navarro-Soriano ◽  
...  

Background and Purpose— The influence of age on the relationship between obstructive sleep apnea (OSA) and the incidence of hard cardiovascular events remains controversial. We sought to analyze the relationship between OSA and the incidence of stroke and coronary heart disease in a large cohort of elderly patients, as well as to investigate the role of continuous positive airway pressure (CPAP) treatment in these associations. Methods— Post hoc analysis of a prospective observational study of consecutive patients ≥65 years studied for OSA suspicion at 2 Spanish University Hospitals. Patients with an apnea-hypopnea index (AHI) <15 were the reference group. OSA was defined by an AHI ≥15 and classified as untreated (CPAP not prescribed or compliance <4 hours/day), mild-moderate (AHI 15–29), untreated severe (AHI ≥30), and CPAP-treated (AHI ≥15 and CPAP compliance ≥4 hours/day). Results— 859 and 794 elderly patients were included in the stroke and coronary heart disease analyses, respectively. The median (interquartile range) follow-up was 72 (50–88.5) and 71 (51.5–89) months, respectively. Compared with the reference group, the fully adjusted hazard ratios for the incidence of stroke were 3.42 (95% CI, 1.37–8.52), 1.02 (95% CI, 0.41–2.56), and 1.76 (95% CI, 0.62–4.97) for the untreated severe OSA group, CPAP-treated group, and untreated mild-moderate OSA group, respectively. No associations were shown between any of the different OSA groups and coronary heart disease incidence. Conclusions— The incidence of stroke, but not coronary heart disease, is increased in elderly patients with untreated severe OSA. Adequate CPAP treatment may reduce this risk.


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