Association of Empirically Derived Food-based Inflammatory Potential of the Diet and Breast Cancer: A Hospital Based Case-control Study

Abstract Background: Diet may be a modifiable factor in the prevention of breast cancer (BC) by modulating inflammation. We used a food-based empirical dietary inflammatory index (FDII) to evaluate the association between FDII and odds of breast cancer in Iranian women.Methods: The present case-control study carried out on 150 age-matched women with newly diagnosed breast cancer and controls. Data for dietary intake and anthropometric measures were collected. FDII score was developed according to participants dietary intakes of 21 pre-defined food groups. Multivariate odds ratios (OR) with 95% confidence intervals (CI) were used to investigate the association of empirically derived food-based inflammatory potential of the diet and breast cancer. Results: Our finding indicated that participants in the top tertile of FDII score had a higher odds of breast cancer (OR: 1.73; 95% CI: 1.14 - 2.53, P=0.01) compared with those in the first tertile. . After controlling confounders, multivariate logistic regressions showed in those at the third tertile of FDII chance of breast cancer was 1.7 times higher than those in the first terile (OR: 1.72; 95% CI: 1.12- 2.58, P=0.01). Conclusions: The results of our study suggested that more pro-inflammatory diets (higher FDII scores) are associated with increased breast cancer risk. These findings suggest that developing an effective dietary modification based on FDII may reduce risk of breast cancer.

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Dietary Food Groups and Nutrient Intake in Association with Multiple Sclerosis: A Case-Control Study

Journal of Environmental Health and Sustainable Development ◽

10.18502/jehsd.v6i1.5762 ◽

2021 ◽

Author(s):

Monire Fallah Yakhdani ◽

Mohammad Mohammadi ◽

Amin Salehi Abargouei ◽

Masuod Mirzaei ◽

Abolghasem Rahimdel ◽

...

Keyword(s):

Multiple Sclerosis ◽

Case Control Study ◽

Economic Status ◽

Sun Exposure ◽

Case Control ◽

Dietary Intakes ◽

Food Groups ◽

Yazd City ◽

The Relationship ◽

Control Study

Introduction: It has been proposed that dietary intake is associated with multiple sclerosis (MS). The present case-control study was conducted to investigate the relationship between intake of different food groups and occurrence of MS among the recently diagnosed adult patients in Yazd City, Iran. Materials and Methods: In the current study, a group of 45 patients who have recently been diagnosed with MS and 100 healthy controls were investigated in this research. Participants were matched regarding their gender. Dietary intakes were assessed using a self-administered semi-quantitative food frequency questionnaire (FFQ). Participants also completed a demographic questionnaire including information such as age, gender, marital status, job, education, sun exposure, smoking, sunscreen, body mass index (BMI), economic status, as well as their spouses' occupations and education. Logistic regressions in crude and multivariable-adjusted models were used to investigate the relationship between food groups and the odds of developing MS. Results: The findings showed that participants with high consumption of fruits, potatoes, refined grains, pickles, and fibers had a significantly lower chance for developing MS after adjustment for the maximum possible confounding variables (P < 0.05). Conclusion: The present study revealed that several food groups or nutrients are associated with the development of MS. Further multi-central prospective studies including more participants are needed to confirm these results

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Association Between Dietary Phytochemical Index and Breast Cancer: a Case-control Study

10.21203/rs.3.rs-136491/v1 ◽

2020 ◽

Author(s):

Seyed Mojtaba Ghoreishy ◽

Azadeh Aminianfar ◽

Sanaz Benisi-Kohansal ◽

Leila Azadbakht ◽

Ahmad Esmaillzadeh

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Case Control ◽

Cluster Method ◽

Inverse Association ◽

Dietary Intakes ◽

Crude Model ◽

Disease Associations ◽

History Of ◽

Control Study

Abstract Background: Dietary intake of isoflavones has been positively associated with risk of breast cancer (BC) in some earlier studies. In addition, most studies on diet-disease associations came from western countries and limited data are available in the Middle-East. Methods: This case-control study was performed on 350 women with breast cancer aged over 30 years old who were recruited from hospitals or private clinics in Isfahan, Iran. All patients were diagnosed with BC during the maximum of the last 6 months using physical examination and mammography findings. Using cluster method sampling, 700 apparently healthy age- and socioeconomic status-matched controls were randomly selected from healthy women who had no relationship with BC patients and had no familial history of BC. Data on dietary intakes were collected using a validated food frequency questionnaire. The DPI was calculated based on dietary energy derived from foods rich in phytochemicals (kcal) divided by total daily energy intake (kcal) of each participant. Results: Mean ± SD age and BMI in the study participants were 62.4±10.8 y and 24.3±5.2 kg/m2, respectively. In the crude model, participants in the highest quartile of DPI had 63% lower odds of breast cancer compared to those in the lowest quartile (95% CI: 0.26, 0.54; P-trend <0.001). After adjustment for potential confounders, this inverse association became strengthened (95% CI: 0.22, 0.49; P-trend <0.001). Further adjustment for BMI did not change the association (OR for the highest quartile vs. the lowest quartile = 0.40, 95% CI: 0.26, 0.60; P-trend <0.001). Conclusion: In conclusion, a protective association was observed between DPI and BC in this case-control study. Therefore, high consumption of foods rich in phytochemicals such as fruits, vegetables and whole grains might help reducing the odds of BC among women.

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A higher Dietary Inflammatory Index score is associated with a higher risk of breast cancer among Chinese women: a case–control study

British Journal Of Nutrition ◽

10.1017/s0007114517001192 ◽

2017 ◽

Vol 117 (10) ◽

pp. 1358-1367 ◽

Cited By ~ 19

Author(s):

Wu-Qing Huang ◽

Xiong-Fei Mo ◽

Yan-Bin Ye ◽

Nitin Shivappa ◽

Fang-Yu Lin ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Chinese Women ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Increased Risk ◽

Control Study

AbstractPrevious studies have investigated the association between dietary inflammatory potential and the development of cancer. For breast cancer the results have been equivocal. The present study aimed to investigate whether higher Dietary Inflammatory IndexTM (DII) scores were associated with increased risk of breast cancer among Chinese women. A total of 867 cases and 824 controls were recruited into the present case–control study from September 2011 to February 2016. DII scores were computed based on baseline dietary intake assessed by a validated 81-item FFQ. The OR and 95 % CI were assessed by multivariable logistic regression after adjusting for various potential confounders. DII scores in this study ranged from −5·87 (most anti-inflammatory score) to +5·71 (most proinflammatory score). A higher DII score was associated with a higher breast cancer risk (adjusted ORquartile 4 v. 1 2·28; 95 % CI 1·71, 3·03; adjusted ORcontinuous 1·40; 95 %CI 1·25, 1·39). In stratified analyses, positive associations also were observed except for underweight women or women with either oestrogen receptor+ or progesterone receptor+ status (but not both). Results from this study indicated that higher DII scores, corresponding to more proinflammatory diets, were positively associated with breast cancer risk among Chinese women.

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Association between the dietary inflammatory index and breast cancer in a large Italian case-control study

Molecular Nutrition & Food Research ◽

10.1002/mnfr.201600500 ◽

2016 ◽

Vol 61 (3) ◽

pp. 1600500 ◽

Cited By ~ 15

Author(s):

Nitin Shivappa ◽

James R. Hébert ◽

Valentina Rosato ◽

Maurizio Montella ◽

Diego Serraino ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Italian Case ◽

Control Study

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Dietary inflammatory index and odds of breast cancer: A case–control study

Food Science & Nutrition ◽

10.1002/fsn3.2493 ◽

2021 ◽

Author(s):

Shatha S. Hammad ◽

Reema Mahmoud ◽

Nitin Shivappa ◽

James R. Hebert ◽

Lina Marie ◽

...

Keyword(s):

Breast Cancer ◽

Case Control Study ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Control Study

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Dietary Inflammatory Index and Risk of Breast Cancer Based on Hormone Receptor Status: A Case-Control Study in Korea

Nutrients ◽

10.3390/nu11081949 ◽

2019 ◽

Vol 11 (8) ◽

pp. 1949 ◽

Cited By ~ 5

Author(s):

Lee ◽

Quiambao ◽

Lee ◽

Ro ◽

Lee ◽

...

Keyword(s):

Breast Cancer ◽

Hormone Receptor ◽

Case Control Study ◽

Case Control ◽

Hormone Receptor Status ◽

Korean Women ◽

Dietary Inflammatory Index ◽

Receptor Status ◽

Inflammatory Index ◽

Control Study

Breast cancer is the most common cancer in women globally, and the risk of developing breast cancer is associated with inflammation. The present study aimed to examine the association between the Dietary Inflammatory Index (DII®) and breast cancer in Korean women and investigate whether the tumor’s hormone receptor status affects this association. In this case-control study, we enrolled 364 breast cancer patients and 364 age-matched controls. DII scores were calculated from dietary intake evaluated by a 106-item food frequency questionnaire. The DII score was significantly higher in cases than in controls. After adjusting for potential confounders, the odds ratio (OR) of breast cancer was higher in the highest DII tertile (OR = 3.68, 95% confidence interval (CI): 2.34–5.80, p for trend < 0.0001) than in the lowest tertile. We found that higher DII scores were related to an increased risk of breast cancer for estrogen receptor (ER)+/progesterone receptor (PR)+ tumors regardless of menopausal status (OR = 2.59, 95% CI: 1.37–4.88 in the highest DII category, p for trend = 0.01 for premenopausal women; OR = 11.00, 95% CI: 2.93–41.30 in the highest DII category, p for trend = 0.0004 for postmenopausal women), but not for ER−/PR− status. Our results suggested that the DII scores are positively associated with breast cancer risk in Korean women and that this relationship is more robust in ER+/PR+ tumors.

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