scholarly journals Positive results for patients with COVID-19 discharged form hospital in Chongqing, China

2020 ◽  
Author(s):  
Wang Deng ◽  
Tian-wen Guang ◽  
Mei Yang ◽  
Jian-rong Li ◽  
De-peng Jiang ◽  
...  
Keyword(s):  
Clinical Evidence ◽  
Medical Illness ◽  
Test Results ◽  
Rt Pcr ◽  
Pharyngeal Swab ◽  
Viral Nucleic Acid ◽  
Negative Results ◽  
Chronic Medical Illness ◽  
Positive Results

Abstract Background: Since December 2019, over 80,000 patients with coronavirus disease 2019 (COVID-19) have been confirmed in China. With the increasing number of recovered patients, more attention should be paid to the follow-up of these patients. Methods: In the study, 576 patients with COVID-19 discharged from hospital in Chongqing, China from January 24, 2020, to March 10, 2020 were evaluated by viral nucleic acid tests for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) to determine if they could be released from quarantine. Among the 576 patients, 61 patients (10.6%) had positive RT-PCR test results of SARS-CoV-2. We aimed to analyze the demographics, clinical characteristics and treatment of 61 patients.Results: These positive patients were characterized by older age, chronic medical illness and mild conditions. 38 (62.3%) patients who were asymptomatic without abnormalities on chest radiographs were found in the positive with COVID-19. Also, they showed positive results of stool or sputum specimens with negative results of nasal and pharyngeal swab specimens. The median duration of positive result of SARS-CoV-2 was varied from 3 days to 35 days in the patients discharged from hospital with no family member infection. Conclusions: Multi-site screening of SARS-CoV-2 including nasal and pharyngeal swabs, stool and sputum specimens could be considered to improve the diagnosis, treatment and infection control in patients with COVID-19. Our findings provide the important information and clinical evidence for the improved management of patients recovered from COVID-19

scholarly journals Positive results for patients with COVID-19 discharged form hospital in Chongqing, China

2020 ◽  
Author(s):  
Wang Deng ◽  
Tian-wen Guang ◽  
Mei Yang ◽  
Jian-rong Li ◽  
De-peng Jiang ◽  
...  
Keyword(s):  
Clinical Evidence ◽  
Medical Illness ◽  
Test Results ◽  
Rt Pcr ◽  
Pharyngeal Swab ◽  
Viral Nucleic Acid ◽  
Negative Results ◽  
Chronic Medical Illness ◽  
Positive Results

Abstract Background: Since December 2019, over 80,000 patients with coronavirus disease 2019 (COVID-19) have been confirmed in China. With the increasing number of recovered patients, more attention should be paid to the follow-up of these patients. Methods: In the study, 576 patients with COVID-19 discharged from hospital in Chongqing, China from January 24, 2020, to March 10, 2020 were evaluated by viral nucleic acid tests for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) to determine if they could be released from quarantine. Among the 576 patients, 61 patients (10.6%) had positive RT-PCR test results of SARS-CoV-2. We aimed to analyze the demographics, clinical characteristics and treatment of 61 patients.Results: These positive patients were characterized by older age, chronic medical illness and mild conditions. 38 (62.3%) patients who were asymptomatic without abnormalities on chest radiographs were found in the positive with COVID-19. Also, they showed positive results of stool or sputum specimens with negative results of nasal and pharyngeal swab specimens. The median duration of positive result of SARS-CoV-2 was varied from 3 days to 35 days in the patients discharged from hospital with no family member infection. Conclusions: Multi-site screening of SARS-CoV-2 including nasal and pharyngeal swabs, stool and sputum specimens could be considered to improve the diagnosis, treatment and infection control in patients with COVID-19. Our findings provide the important information and clinical evidence for the improved management of patients recovered from COVID-19

scholarly journals Positive results for patients with COVID-19 discharged form hospital in Chongqing, China

2020 ◽  
Author(s):  
Wang Deng ◽  
Tian-wen Guang ◽  
Mei Yang ◽  
Jian-rong Li ◽  
De-peng Jiang ◽  
...  
Keyword(s):  
Clinical Evidence ◽  
Throat Swab ◽  
Medical Illness ◽  
Sputum Specimen ◽  
Viral Nucleic Acid ◽  
Mild Conditions ◽  
Negative Results ◽  
Chronic Medical Illness ◽  
Positive Results

Abstract Background: Since December 2019,more than 80 thousand patients with coronavirus disease 2019 (COVID-19) has been confirmed in China. With the increasing number of recovered patients, more attention should be paid to the follow-up of patients. Methods: In the study, 576 patients with COVID-19 discharged from hospital in Chongqing, China from January 24, 2020, to March 10, 2020 were evaluated by viral nucleic acid tests for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) to determine if they could be released from quarantine. Among the 576 patients, 61 patients (10.6%) had positive results for SARS-CoV-2. We aimed to analyze the demographics, clinical characteristics and treatment of 61 patients.Results: These positive patients were characterized by older age, chronic medical illness and mild conditions. Asymptom and normalities on chest radiograph were found in most of the positive patients with COVID-19. Also, they showed positive results by stool or sputum specimen with negative results by nasal and throat swab. The median duration of positive result for SARS-CoV-2 was varied from 3 days to 35 days after hospital discharge with no family member infection.Conclusions: Multi-site screening of SARS-CoV-2 including nasal and throat swab, stool and sputum samples could be considered to improve the diagnosis, treatment and infection control in patients with COVID-19. Our findings provide the important information and clinical evidence for the improved management of patients recovered from COVID-19

scholarly journals Cushing’s Disease: The Relevance of a Combined Dexamethasone Desmopressin Test as a Component of Postoperative Hormonal Evaluation

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Przemysław Witek ◽  
Grzegorz Zieliński ◽  
Katarzyna Szamotulska
Keyword(s):  
Cushing’S Disease ◽  
Adrenal Function ◽  
Cushing's Disease ◽  
Test Results ◽  
Negative Results ◽  
Cortisol Levels ◽  
Hormonal Evaluation ◽  
Positive Results ◽  
Time Point

Background. The risk of Cushing’s disease (CD) recurring may persist for years, even after initially successful surgery.Objective. To prospectively assess the relevance of a combined dexamethasone desmopressin test (CDDT) as a component of postoperative hormonal evaluation, including the dynamics of ACTH and cortisol concentrations.Material and Methods. We included 28 patients after TSS for CD. Eighteen months after surgery the standard hormonal evaluation was performed, followed by a CDDT.Results. Fifteen patients (53.6%) were in remission whereas in 13 subjects (46.4%) hypercortisolemia was confirmed. Positive results of CDDT were observed in 12 noncured patients (92.3%) and in one subject in remission (6.7%). Negative results were obtained in 12 patients with remission (80%) and in one noncured patient (7.7%). With 2 patients in CD remission (13.3%) the test results were inconclusive. We confirmed a high compatibility between CDDT and standard hormonal assessment results (κ=0.846;P<0.001). Significant differences in ACTH and cortisol levels at each CDDT time point between the two studied subgroups were shown.Conclusions. A negative CDDT result can be regarded as one of the factors indicative of CD remission during follow-up. Additionally, CDDT can help distinguish persistent hypercortisolemia from naturally recurring adrenal function after TSS.

scholarly journals Positive results for patients with COVID-19 discharged from hospital in Chongqing, China

2020 ◽  
Author(s):  
Wang Deng ◽  
Tian-wen Guang ◽  
Mei Yang ◽  
Jian-rong Li ◽  
De-peng Jiang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Severe Acute Respiratory Syndrome ◽  
Hospital Discharge ◽  
Clinical Characteristics ◽  
Clinical Evidence ◽  
Viral Nucleic Acid ◽  
Positive Results ◽  
Nucleic Acid Tests ◽  
At Home

Abstract Since December 2019 , more than 80 thousand patients with coronavirus disease 2019 (COVID-19) has been confirmed in China. With the increasing number of recovered patients, more attention should be paid to the follow-up of patients. In the study, 576 patients with COVID-19 discharged from hospital in Chongqing, China from January 24, 2020, to March 10, 2020 were evaluated by viral nucleic acid tests for SARS-CoV-2 to determine if they could be released from quarantine at home. Among the 576 patients, 61 patients (10.6%) had positive results for severe acute respiratory syndrome coronavirus 2. We aimed to analyze the demographics, clinical characteristics and treatment of 61 patients. Criteria for hospital discharge or discontinuation of quarantine would be updated with the progress of clinical evidence and experience accumulation.

scholarly journals Clinical characteristics of 57 patients infected with COVID-19 in Baodi area of Tianjin, China

2020 ◽  
Author(s):  
Yingchao Zhang ◽  
Zhentao Lin ◽  
Lijing Wang ◽  
Shuxiang Shan
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Real Time ◽  
Clinical Characteristics ◽  
Laboratory Data ◽  
Chest Tightness ◽  
Rt Pcr ◽  
Pharyngeal Swab ◽  
Radiological Features ◽  
Negative Results ◽  
Positive Results

Abstract BackgroundCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading worldwide.ObjectiveTo study the clinical characteristics of COVID-19, we included 57 real-time RT-PCR confirmed patients in Baodi area of Tianjin, China, admitted to hospital from 31 January 2020 and 22 February 2020.MethodsEpidemiological, demographic, clinical, and radiological features and laboratory data were analyzed. Patients were confirmed by real-time RT-PCR with pharyngeal swab and/or sputum samples. Some patients that presented positive results with sputum samples yielded negative results with multiple swab tests, suggesting sputum samples RT-PCR tests may be a more reliable means of positively diagnosing infected individuals.ResultsOf the 57 patients studied, three were mild and 54 were moderate in severity. None of the patients infected traveled to Wuhan indicating all studied cases were infected by human to human transmission. The most common symptoms at onset of illness were included fever (86%), cough (29.8%), myalgia or fatigue (14%), chest tightness (5.3%), sore throat (5.3%), and diarrhea (5.3%).ConclusionCompared with patients of COVID-19 in Wuhan, the symptoms of patients in Baodi area of Tianjin province are relatively mild.

Scoring System for the Diagnosis of COVID-19

2020 ◽  
Vol 13 (1) ◽  
pp. 413-414 ◽  
Author(s):  
Mohamed Farouk Allam
Keyword(s):  
Scoring System ◽  
Clinical Symptoms ◽  
False Negative ◽  
Nasopharyngeal Swab ◽  
Rt Pcr ◽  
Pcr Assay ◽  
Negative Results ◽  
False Negative Results ◽  
Symptoms And Signs

Due to the international spread of COVID-19, the difficulty of collecting nasopharyngeal swab specimen from all suspected patients, the costs of RT-PCR and CT, and the false negative results of RT-PCR assay in 41% of COVID-19 patients, a scoring system is needed to classify the suspected patients in order to determine the need for follow-up, home isolation, quarantine or the conduction of further investigations. A scoring system is proposed as a diagnostic tool for suspected patients. It includes Epidemiological Evidence of Exposure, Clinical Symptoms and Signs, and Investigations (if available). This scoring system is simple, could be calculated in a few minutes, and incorporates the main possible data/findings of any patient.

Rare Diseases, Common Problems: Recognition and Management

PEDIATRICS ◽  
1978 ◽  
Vol 62 (6) ◽  
pp. 1056-1060
Author(s):  
Neil A. Holtzman
Keyword(s):  
Johns Hopkins Hospital ◽  
Full Time ◽  
Test Results ◽  
Irreversible Damage ◽  
Negative Results ◽  
Initial Symptoms ◽  
Metabolic Conditions ◽  
Common Problems

Although a growing number of inherited metaboic diseases can be treated effectively, diagnosis often comes too late to benefit the patient. There are at least two ways, however, in which diagnosis can be made before irreversible damage occurs. First, physicians whose services are sought when a patient becomes ill could be attuned to the possibility of metabolic conditions. This is difficult when the initial symptoms, for example, vomiting or poor feeding, resemble those of common, self-limited illnesses, or when they suggest, as with respiratory distress, other categories of serious illness. Second, all infants could be screened for indicators of some of these conditions. Then the primary physician has a responsibility to determine the significance of both positive and negative results and to decide whether follow-up is needed. This study had three objectives: (1) to determine whether physicians are aware of the common problems with which inherited metabolic conditions often present; (2) to determine whether their management of common problems facilitates the early diagnosis of such conditions; and (3) to assess their evaluation of screening test results. METHODS Physicians who were participating in three continuing education programs were asked to answer, anonymously, several questions dealing with recognition and in management of geneticmetaboic diseases before they were given any instruction on the subject. The same questionnaire was distributed to the pediatric house staff at The Johns Hopkins Hospital. The tabulated results were discussed with the respondents collectively during hour-long conferences. RESULTS AND COMMENTS Classification of Respondents One hundred fifty-six physicians returned the questionnaire: 67 pediatricians (in practice, 56; full-time faculty, 6: unknown, 5), 30 general or family practitioners, and 59 pediatric house officers.

scholarly journals The Positive Predictive Value of Diagnostic Ultrasound for Occult Herniae

2006 ◽  
Vol 88 (2) ◽  
pp. 165-167 ◽  
Author(s):  
M Bradley ◽  
J Morgan ◽  
B Pentlow ◽  
A Roe
Keyword(s):  
Positive Predictive Value ◽  
Predictive Value ◽  
Diagnostic Tests ◽  
Diagnostic Ultrasound ◽  
Pain Clinic ◽  
Diagnostic Problem ◽  
Clinical Criteria ◽  
Negative Results ◽  
Positive Results

INTRODUCTION The aim of this study is to ascertain the accuracy of diagnostic ultrasound in the assessment of the occult abdominal and groin herniae. The authors have previously demonstrated its efficacy in diagnosing the type of clinical groin herniae but occult herniae provide a further diagnostic problem. PATIENTS AND METHODS A total of 113 consecutive patients were referred prospectively for ultrasound examinations with clinically suspected occult herniae. All positive scans were offered surgery whilst the negative results were offered further imaging or other diagnostic tests depending on the clinical criteria. The end point for negative scans was based on 18-month follow-up or resolution of symptoms. RESULTS Overall, 59 scans showed positive results for herniae and 56 of these had surgery. In the other three patients, two refused an operation, and one had no hernia detected at operation. In the remaining 57 scans, ultrasound offered alternative soft tissue diagnoses in 23 patients and surgical/endoscopic diagnoses accounted for a further 8 patients. CONCLUSIONS Ultrasound offered a diagnosis for the symptomology in 82 patients (70.6%) of which 59 were herniae. The positive predictive value for hernia is 98.3%. Twenty-six patients with no diagnosis or confirmation of herniae on follow-up showed symptom resolution in 22 cases, and four patients were treated by the pain clinic.

scholarly journals Synchronous cytomegalovirus infection in a newly diagnosed ulcerative colitis patient

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Jin Yu Chieng ◽  
Yasotha Sugumaran ◽  
Sellymiah Adzman ◽  
Pan Yan
Keyword(s):  
Ulcerative Colitis ◽  
Medical Illness ◽  
C Reactive Protein ◽  
Colitis Patient ◽  
Intravenous Ganciclovir ◽  
Reactive Protein ◽  
Chronic Medical Illness ◽  
History Of ◽  
Cmv Colitis

A 61-year-old Punjabi female patient presented with six months history of mild abdominal discomfort with bloody diarrhea. She did not have underlying chronic medical illness; she neither took steroid nor immunosuppressant. She was found anemic, thrombocytosis, and elevated C-reactive protein. Colonoscopy showed moderate left sided colitis, with histopathology evidence of ulcerative colitis (UC) with cytomegalovirus (CMV) infection. Her serum anti-CMV IgM antibody was detected. She was treated with intravenous ganciclovir, together with 5-ASA and tapering dose of steroid. Anemia was corrected. Subsequent clinic reviews and follow up endoscopies showed dramatically improvement. CMV colitis should be considered for the patients presenting with moderate to severe UC. Early prescription of antiviral would be beneficial in the treatment of flare of UC.

scholarly journals SARS-CoV-2 re-positivity within the first 3 months of COVID-19 recovery; probable re-infection

2021 ◽  
Author(s):  
sara sadr ◽  
Melika Arab Bafrani ◽  
Alireza Abdollahi ◽  
SeyedAhmad SeyedAlinaghi ◽  
Esmaeil Mohammadnejad ◽  
...  
Keyword(s):  
Herd Immunity ◽  
Rt Pcr ◽  
Complete Protection ◽  
Genetic Sequencing ◽  
Serum Igg ◽  
Follow Up Studies ◽  
Positive Results

Objectives Possibility of reinfection with SARS-CoV-2 changes our view on herd immunity and vaccination, and can impact worldwide quarantine policies. We performed RT-PCR follow-up studies on recovered patients to assess possible development of reinfections and re-positivity. Method During a 6-month period, 202 PCR-confirmed recovering COVID-19 patients entered this study. Follow-up RT-PCR tests and symptoms assessment were performed one month after the initial Positive results. patients who tested negative were tested again one and three months later. The Serum IgG and IgM levels were measured in the last follow-up session. Results In the first two follow-up sessions, 82 patients continued their participation, of which four patients tasted positive. In the second follow-up 44 patients participated, three of whom tested positive. None of the patients who tested positive in the first and second follow-up session were symptomatic. In the last session, 32 patients were tested and four patients were positive, three of them were mildly symptomatic and all of them were positive for IgG. Conclusion A positive RT-PCR in a recovering patient may represent reinfection. While we did not have the resources to prove reinfection by genetic sequencing of the infective viruses, we believe presence of mild symptoms in the three patients who tested positive over 100 days after becoming asymptomatic, can be diagnosed as reinfection. The IgG may have abated the symptoms of the reinfection, without providing complete protection.

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