scholarly journals One-pot, multi-component synthesis of novel 2-amino-[1,2,4]triazolo[1,5-a] pyrimidine-6-carboxamide derivatives as antiproliferative agents 

2021 ◽  
Author(s):  
Xian-Sen Huo ◽  
Yu-Feng Ma ◽  
Zhi-Ru Chen ◽  
Li-Li Yuan ◽  
Xiao-Lan Zheng ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Inhibition Activity ◽  
Cell Growth Inhibition ◽  
Cancer Cell Growth ◽  
One Pot ◽  
Antiproliferative Agents ◽  
Heterocyclization Reaction ◽  
Growth Inhibition Activity

Abstract A novel series of 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide derivatives has been achieved successfully via an efficient one-pot three-component Biginelli-like heterocyclization reaction between different benzaldehydes, 1H-1,2,4-triazole-3,5-diamine, and N-substituted acetoacetamides in the presence of p-toluenesulfonic acid as a catalyst. Moreover, the effects of different conditions on the reaction were well investigated. In addition, cancer cell growth inhibition activity for these target compounds was also explored, and analogue 5l demonstrated the most potent cytotoxic activity against different cancer cells. These finds indicat that 2-amino-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide core could be well worth further optimization as a potential scaffold for development of anticancer agents.

scholarly journals Antioxidant and Cancer Cell Growth Inhibition Activity of Five Different Varieties of Artemisia Cultivars in Korea

2012 ◽  
Vol 22 (6) ◽  
pp. 844-851 ◽  
Author(s):  
Ra-Jeong Kim ◽  
Min-Jung Kang ◽  
Cho-Rong Hwang ◽  
Woo-Jae Jung ◽  
Jung-Hye Shin
Keyword(s):  
Cell Growth ◽  
Growth Inhibition ◽  
Cancer Cell ◽  
Inhibition Activity ◽  
Cell Growth Inhibition ◽  
Cancer Cell Growth ◽  
Growth Inhibition Activity

scholarly journals Ethanol extract of mangosteen (Garcinia Mangostana Linn) peel effect in inhibiting the growth of human tongue cancer cells Supri’s Clone 1, invitro

2011 ◽  
Vol 23 (2) ◽  
Author(s):  
Edi Suanto ◽  
Roosje Rosita Oewen ◽  
Inne Suherna Sasmita ◽  
S. Supriatno ◽  
Unang Supratman
Keyword(s):  
Cell Growth ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Incubation Time ◽  
Tongue Cancer ◽  
Ethanol Extract ◽  
Cell Growth Inhibition ◽  
Cancer Cell Growth ◽  
Human Tongue ◽  
Mangosteen Peel

The incidence of tongue cancer in Indonesia reached 1.01% of all cancers and 42% of oral cavity cancer. Tongue cancer therapies including chemotherapy, radiotherapy, surgery, and all three combined therapy. Search for anti-cancer drugs currently switched on herbal plants, one of which is the mangosteen. Has the properties of mangosteen peel extract inhibited the growth of cancer cells. The purpose of the study, obtain IC50 of ethanol extract of mangosteen peel in inhibiting the growth of human tongue cancer cells SP-C1. Research carried out on 96 preparations of human tongue cancer SP-C1 were incubated with ethanol extract of mangosteen peel, preparations were classified in two groups of incubation time (24 hours and 48 hours) and each group will be given preferential treatment over 6 randomly different concentrations: 0 (control), 62.5 μg/mL, 125 μg/mL, 250 μg/mL, 500 μg/mL and 1000 μg/mL. Model experiments were 2 x 6 factorial experiment with eight replication for each cell. Test results with ANAVA, incubation (24 and 48 hour) SP-tongue cancer cells with various concentrations of C1 ethanol extract of mangosteen peel gives a highly significant, indicating differences cancer cell growth inhibition. Incubation time factor showed the long incubation effect on cancer cell growth inhibition. Furthermore, by Newman Keuls test, showed 500μg/mL concentrations of 24-hour incubation had the best effect. Conclusion of the study of ethanol extract of mangosteen peel could achieve with IC50 values of cell growth resistance 50.3% at a concentration of 500 μg/mL and an incubation time of 24 hours.

scholarly journals Biphenyl Derivatives from Garcinia Schomburgkiana and the Cytotoxicity of the Isolated Compounds

2013 ◽  
Vol 8 (9) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Chihiro Ito ◽  
Takuya Matsui ◽  
Eri Noda ◽  
Nijsiri Ruangrungsi ◽  
Masataka Itoigawa
Keyword(s):  
Phenolic Compounds ◽  
Cell Growth ◽  
Chemical Constituents ◽  
Leukemia Cell ◽  
Human Leukemia ◽  
Inhibition Activity ◽  
Cell Growth Inhibition ◽  
Isolation And Identification ◽  
Leukemia Cell Lines ◽  
Growth Inhibition Activity

Study of the chemical constituents of the stems of Garcinia schomburgkiana Pierre (Guttiferae), collected in Thailand, led to the isolation and identification of five known compounds and two new biphenyl derivatives, schomburgbiphenyl A (1) and B (2). Six phenolic compounds isolated from this plant were screened for their cell growth inhibition activity using several human leukemia cell lines. One compound, oblongifolin C (7), showed significant cytotoxic activity towards Jurkat, NALM6, K562 and HPB-ALL cells.

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