Quality Assessment of Clinical Trials Included in Cochrane Oral Health Systematic Reviews
Abstract Background: Risk of Bias (RoB) and other characteristics of randomised clinical trials included in Cochrane oral health systematic reviews were assessed.Methods: All the trials included in Cochrane oral health systematic reviews were identified and examined. The RoB was evaluated for all the included clinical trials according to the Cochrane review standards. The Overall Risk of Bias (ORoB) was defined in this study based on the criteria in Cochrane’s RoB tool-v2. Descriptive analyses were carried out to determine the frequency of each intended variable.Results: In a total of 2565 included studies, the majority (n=1600) had 50 or higher sample sizes. As for blinding, 907 studies were labelled as double-blind. Performance bias showed the highest rate of high risk (31.4%). Almost half of the studies had a high ORoB compared to 11.1% with low ORoB. The studies that used placebos had higher low ORoB (14.8% vs 10.7%). The double-blind studies had the highest low ORoB (23.6%). The studies with a cross-over design had the highest low ORoB (28.8%).Conclusion: The RoB of oral health studies in Cochrane reviews was deemed high. Special efforts may be required to improve conducting and reporting of trials in this area.