The different structure-function correlation as measured by OCT and Octopus perimetry cluster analysis in intracranial tumor and glaucoma patients

Abstract BackgroundTo explore the correlation of visual field (VF) defect values and retinal nerve fiber layer (RNFL) thickness for the intracranial tumor and glaucoma patients. MethodsRetrospective analysis is performed for the intracranial and glaucoma patients, whose VF defect values measured with Octopus perimeter cluster analysis, and RNFL thickness and optic disk parameters measured with swept source OCT. The differences between VF and RNFL (included the data of optic disc) are calculated. The correlation between VF defect values and RNFL thickness are explored.Results43 eyes of 29 patients with the intracranial tumor and 39 eyes of 23 patients with the glaucoma are enrolled. Thickness of RNFL not only for the whole (360°), but also for the four quadrants are thinner in the glaucoma group than those of the intracranial tumor group (p<0.05). There is no significant difference of VF for those two groups. Stronger correlation for mean deviations (MD)s of VF ten clusters and RNFL thickness of OCT twelve sectors is found in the glaucoma patients, but few in the intracranial tumor patients. Logistic regression also shows the RNFL loss tending to the diagnosis of glaucoma, and the VF damage is inclined to the diagnosis of intracranial tumor.ConclusionsIntracranial tumor has a weak correlation between the RNFL thickness and Octopus VF MD, compared with that of glaucoma. OCT and Octopus VF might provide more helpful information for the antidiastole of intracranial tumor and glaucoma.

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The Effects of the Amount of Fluid Used in Epiduroscopic Laser Neural Discectomy Procedures on Intraocular Pressure and an Evaluation of the Ocular Findings

Pain Medicine ◽

10.1093/pm/pnz347 ◽

2020 ◽

Vol 21 (7) ◽

pp. 1357-1361

Author(s):

Serbülent Gökhan Beyaz ◽

Ali Metin Ülgen ◽

Burçin Çakir

Keyword(s):

Intraocular Pressure ◽

Macular Thickness ◽

Optic Disk ◽

Increased Intracranial Pressure ◽

Epidural Pressure ◽

Fiber Layer ◽

Hospital System ◽

Rnfl Thickness ◽

Ocular Findings ◽

Significant Difference

Abstract Introduction During epiduroscopic laser neural discectomy (ELNP) procedures, the amount of fluid used in the epidural area may cause increased intracranial pressure. This study aimed to investigate the effect of increased epidural pressure on intraocular pressure and other ocular findings due to the amount of fluid delivered to the epidural area and the rate of delivery of the fluid. Material and Methods After obtaining approval from the Ethics Committee of Sakarya University Faculty of Medicine, patients who underwent ELNP in the Department of Anesthesiology and Reanimation Department, Algology Clinic, between January 2017 and May 2017 were included in this retrospective study. To evaluate the ocular findings after the operation, measurements obtained using an optical coherence tomography device were retrieved from the patient files and evaluated. Results Data from the medical files of 52 patients from the hospital system were evaluated. There was no significant difference between preoperative and postoperative retinal nerve fiber layer (RNFL) thickness, mean central macular thickness, optic disk area, and vertical cup-to-disk ratio (P > 0.05). Conclusions Epiduroscopy procedures include intermittent or continuous infusion of saline into the epidural area. Currently, the volume of fluid that should be given to the epidural area in epiduroscopy procedures is very controversial. As a result of this study, we concluded that the amount of fluid used during ELNP, at 107.25 mL and 8.33 mL/min, had no effect on the intraocular pressure, optic disk diameter, macular thickness, or peripapillary RNFL thickness; thus, it was safe for ELNP.

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Determination of Referential Rates for Optical Coherence Tomography and Optical Coherence Tomography Angiography Flow Deficits in the Macular Choriocapillaris in Ophthalmologically Healthy Children

Medicina ◽

10.3390/medicina56050238 ◽

2020 ◽

Vol 56 (5) ◽

pp. 238

Author(s):

Viktorija Bakstytė ◽

Liveta Šniurevičiūtė ◽

Evelina Šimienė ◽

Justina Skruodytė ◽

Ingrida Janulevičienė

Keyword(s):

Optical Coherence Tomography ◽

Optical Coherence Tomography Angiography ◽

Healthy Children ◽

Optical Coherence ◽

Fiber Layer ◽

Swept Source ◽

Rnfl Thickness ◽

Swept Source Oct ◽

New Research

Background and Objectives: Despite the growing number of new research publications, normative references for children’s optical coherence tomography (OCT) parameters are still not completed. We chose to explore this topic because of the lack of normative parameters that is due to an improvement in different technologies and instruments. Our aim was to determine referential rates of retinal nerve fiber layer (RNFL) thickness and flow deficits (FD%) in the macular choriocapillaris (CC) in normal eyes of ophthalmologically healthy children. Materials and Methods: Ophthalmologically healthy 8- to 14-year-old individuals participated (n = 75) in this study. OCT images were taken using an swept-source-OCT (SS-OCT) instrument (DRI-OCT Triton, Topcon, Tokyo, Japan). The early treatment diabetic retinopathy study (EDTRS) grid (6 × 6 mm) divided the RNFL into the thickness maps. The FD% values of the CC were calculated on the 3 × 3-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), and the entire 2.5-mm circle (C2.5), and on the 6 x 6-mm scans in a 1-mm circle (C1), 1.5-mm rim (R1.5), the entire 2.5-mm circle (C2.5), 2.5-mm rim (R2.5), and 5-mm circle (C5). Results: Both scan quantifications of FD% in the C1, C2.5, and R1.5 sectors were similar, but the 6 × 6-mm scan measurements were statistically significantly smaller than the 3 × 3-mm ones. Significant moderate correlations were found between axial length (AxL) and FD% in the 6 × 6-mm scans, namely C1 (r = −0.347, p = 0.002), C2.5 (r = −0.337, p = 0.003), R1.5 (r = −0.328, p = 0.004), R2.5 (r = −0.306, p = 0.008), and C5 (r = −0.314, p = 0.006). Conclusions: The thinnest RNFL layers were on the temporal and nasal sides. FD% values in the C1, C2.5, and R1.5 sectors were similar between the 3 × 3-mm and 6 × 6-mm scans. The negative moderate correlations between AxL and FD% were found in all C1, C2.5, C5, R1.5, and R2.5 sectors of the 6 × 6-mm scans. Further prospective studies are needed to determine more accurate normative references for children’s OCT parameters.

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Ganglion cell complex scan in the early prediction of glaucoma

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v4i2.6538 ◽

2012 ◽

Vol 4 (2) ◽

pp. 236-241

Author(s):

S Ganekal

Keyword(s):

Ganglion Cell ◽

Cell Complex ◽

P Value ◽

Ganglion Cell Complex ◽

Automated Perimetry ◽

Standard Automated Perimetry ◽

Fiber Layer ◽

Color Code ◽

Rnfl Thickness ◽

Significant Difference

Objective: To compare the macular ganglion cell complex (GCC) with peripapillary retinal fiber layer (RNFL) thickness map in glaucoma suspects and patients. Subjects and methods: Forty participants (20 glaucoma suspects and 20 glaucoma patients) were enrolled. Macular GCC and RNFL thickness maps were performed in both eyes of each participant in the same visit. The sensitivity and specificity of a color code less than 5% (red or yellow) for glaucoma diagnosis were calculated. Standard Automated Perimetry was performed with the Octopus 3.1.1 Dynamic 24-2 program. Statistics: The statistical analysis was performed with the SPSS 10.1 (SPSS Inc. Chicago, IL, EUA). Results were expressed as mean ± standard deviation and a p value of 0.05 or less was considered significant. Results: Provide absolute numbers of these findings with their units of measurement. There was a statistically significant difference in average RNFL thickness (p=0.004), superior RNFL thickness (p=0.006), inferior RNFL thickness (p=0.0005) and average GCC (p=0.03) between the suspects and glaucoma patients. There was no difference in optic disc area (p=0.35) and vertical cup/disc ratio (p=0.234) in both groups. While 38% eyes had an abnormal GCC and 13% had an abnormal RNFL thickness in the glaucoma suspect group, 98% had an abnormal GCC and 90% had an abnormal RNFL thickness in the glaucoma group.Conclusion: The ability to diagnose glaucoma with macular GCC thickness is comparable to that with peripapillary RNFL thickness. Macular GCC thickness measurements may be a good alternative or a complementary measurement to RNFL thickness assessment in the clinical evaluation of glaucoma.DOI: http://dx.doi.org/10.3126/nepjoph.v4i2.6538 Nepal J Ophthalmol 2012; 4 (2): 236-241

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Age-Related Physiologic Thinning Rate of the Retinal Nerve Fiber Layer in Different Levels of Myopia

Journal of Ophthalmology ◽

10.1155/2020/1873581 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Daun Jeong ◽

Kyung Rim Sung ◽

Youn Hye Jo ◽

Sung-cheol Yun

Keyword(s):

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Refractive Error ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Significant Difference ◽

Thinning Rate ◽

Sd Oct ◽

Retinal Nerve Fiber

Purpose. To investigate the effect of refractive error on the physiologic thinning rate of the retinal nerve fiber layer (RNFL) in healthy eyes. Materials and Methods. This study analyzed 223 eyes of 141 healthy subjects followed for more than 5 years and underwent at least five serial spectral domain optical coherence tomography (SD-OCT) examinations. Longitudinal RNFL measurements were analyzed by linear mixed models incorporating follow-up duration, baseline RNFL thickness, spherical equivalent (SE), age, intraocular pressure, and visual field mean deviation. Thinning rates were classified according to SE into three groups: nonmyopic (NM; >0 D), mild-to-moderately myopic (MM; >–6 D and ≤0 D), and highly myopic (HM; ≤–6 D). Results. The overall slopes of change in RNFL thickness over time in the NM, MM, and HM groups were −0.305 ± 0.128, −0.294 ± 0.068, and −0.208 ± 0.097 μm/yr, respectively. Slopes of RNFL thickness changes in these groups were −0.514 ± 0.248, −0.520 ± 0.133, and −0.528 ± 0.188 μm/yr, in the superior quadrant; −0.084 ± 0.145, 0.107 ± 0.082, and −0.161 ± 0.112 μm/yr, in the temporal quadrant; −0.807 ± 0.242, −0.794 ± 0.130, and −0.727 ± 0.183 μm/yr, in the inferior quadrant; and 0.160 ± 0.157, 0.118 ± 0.084, and 0.429 ± 0.119 μm/yr, in the nasal quadrant. Overall and in all four quadrants, there was no significant difference in the rate of RNFL thickness change among the three groups. Conclusions. Refractive error did not affect the physiologic thinning rate of RNFL when assessed by SD OCT.

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T176. Examining Retinal Nerve Fiber Layer Thickness and Microvascular Abnormalities in Psychosis With Swept Source OCT and OCT-A

Biological Psychiatry ◽

10.1016/j.biopsych.2019.03.499 ◽

2019 ◽

Vol 85 (10) ◽

pp. S197-S198

Author(s):

Paulo Lizano ◽

Megan Kasetty ◽

Rebecca Zeng ◽

Jay Wang ◽

Daniel Diaz ◽

...

Keyword(s):

Nerve Fiber ◽

Layer Thickness ◽

Retinal Nerve Fiber Layer ◽

Fiber Layer ◽

Swept Source ◽

Nerve Fiber Layer ◽

Nerve Fiber Layer Thickness ◽

Swept Source Oct ◽

Retinal Nerve Fiber

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Choroidal Thickness and Structural Glaucoma Parameters in Glaucomatous, Preperimetric Glaucomatous, and Healthy Eyes using Swept-Source OCT

European Journal of Ophthalmology ◽

10.5301/ejo.5000926 ◽

2017 ◽

Vol 27 (5) ◽

pp. 548-554 ◽

Cited By ~ 5

Author(s):

Handan Akil ◽

Mayss Al-Sheikh ◽

Khalil Ghasemi Falavarjani ◽

Brian Francis ◽

Vikas Chopra

Keyword(s):

Nerve Fiber ◽

Choroidal Thickness ◽

Wide Field ◽

Inner Plexiform Layer ◽

Fiber Layer ◽

Swept Source ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

The Mean ◽

Healthy Eyes

Purpose To evaluate choroidal thickness (CT) and its relationship with retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer thickness (GCIPLT) in glaucomatous, preperimetric glaucomatous, and healthy eyes using swept-source optical coherence tomography (SS-OCT). Methods Fifty eyes with primary open-angle glaucoma, 20 eyes with preperimetric glaucoma, and 20 age-matched healthy eyes were enrolled. Three-dimensional wide-field (12 × 9 mm) images were obtained using a SS-OCT instrument. Peripapillary CT and RNFL thickness, as well as macular CT and GCIPLT, were recorded. The correlation of the CT with nerve fiber layer and GCIPLT measurements was assessed. The association between CT and potential confounding variables including age, sex, axial length, intraocular pressure, and central corneal thickness was also examined. Results Mean peripapillary CTs were 111.7 ± 41.7, 127.7 ± 40.1, and 120.8 ± 35.4 μm in glaucomatous, preperimetric glaucomatous, and normal eyes, respectively. There was statistically significant but weak correlation for the mean RNFL and mean peripapillary CT in glaucomatous subjects (r = 0.341, p = 0.04). There was a significant correlation between RNFL thickness and peripapillary CT in 1, 2, 5, and 6 clock hours of glaucomatous eyes (r = 0.410, p = 0.005; r = 0.316, p = 0.03; r = 0.346, p = 0.02; r = 0.35, p = 0.04, respectively). Mean macular CT was 181.5 ± 70.5, 187.4 ± 65.5, and 185.4 ± 76.4 μm in glaucomatous, preperimetric glaucomatous, and healthy eyes, respectively (p = 0.7). There was no statistically significant correlation between the mean GCIPLT and mean macular CT in all subjects (p>0.05). Conclusions Choroidal thinning and its correlation with other parameters in patients with glaucoma should be further investigated with the proprietary software of SS-OCT.

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The Effect of LASIK Procedure on Peripapillary Retinal Nerve Fiber Layer and Macular Ganglion Cell-Inner Plexiform Layer Thickness in Myopic Eyes

BioMed Research International ◽

10.1155/2017/8923819 ◽

2017 ◽

Vol 2017 ◽

pp. 1-5 ◽

Cited By ~ 3

Author(s):

Maja Zivkovic ◽

Vesna Jaksic ◽

Athanassios Giarmoukakis ◽

Michael Grentzelos ◽

Marko Zlatanovic ◽

...

Keyword(s):

Ganglion Cell ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Plexiform Layer ◽

Inner Plexiform Layer ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Significant Difference ◽

Retinal Nerve Fiber

Purpose. To evaluate the effect of applied suction during microkeratome-assisted laser in situ keratomileusis (LASIK) procedure on peripapillary retinal nerve fiber layer (RNFL) thickness as well as macular ganglion cell-inner plexiform layer (GC-IPL) thickness. Methods. 89 patients (124 eyes) with established myopia range from −3.0 to −8.0 diopters and no associated ocular diseases were included in this study. RNFL and GC-IPL thickness measurements were performed by spectral domain optical coherence tomography (SD OCT) one day before LASIK and at 1 and 6 months postoperatively. Results. Mean RNFL thickness prior to LASIK was 93.86±12.17 μm while the first month and the sixth month postoperatively were 94.01±12.04 μm and 94.46±12.27 μm, respectively. Comparing results, there is no significant difference between baseline, one month, and six months postoperatively for mean RNFL (p>0.05). Mean GC-IPL thickness was 81.70±7.47 μm preoperatively with no significant difference during the follow-up period (82.03±7.69 μm versus 81.84±7.64 μm; p>0.05). Conclusion. RNFL and GC-IPL complex thickness remained unaffected following LASIK intervention.

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Comparative analysis of two optical biometry devices: high wavelength swept source OCT versus partial coherence interferometry

International Ophthalmology ◽

10.1007/s10792-021-02036-0 ◽

2021 ◽

Author(s):

Eszter Szalai ◽

Adrienne Csutak

Keyword(s):

Anterior Chamber Depth ◽

Partial Coherence ◽

Anterior Surface ◽

Swept Source ◽

Partial Coherence Interferometry ◽

Significant Difference ◽

Swept Source Oct ◽

Iol Power ◽

The Difference ◽

High Wavelength

Abstract Purpose To study the reproducibility of measurements performed with a recently developed multimodal high resolution swept source optical coherence tomography (SSOCT) and to make comparisons with a partial coherence interferometry (PCI) biometer. Methods One hundred and fifty-two eyes of 152 subjects were involved in this study with a mean age of 65.71 ± 13.86 years (26–85 years). Anterior surface keratometry (K), anterior chamber depth (ACD), white-to-white (WTW) and axial length (AL) values were recorded by the SSOCT (ANTERION, Heidelberg Engineering Ltd, Germany) and PCI (IOLMaster 500, version 5.5, Carl Zeiss Meditec, Germany). Intraocular lens (IOL) power was calculated based on ANTERION and IOLMaster keratometry values by using five traditional vergence formulas. Results Anterior surface simulated keratometry values did not differ significantly between the IOLMaster and ANTERION (P > 0.05). AL measurements were successful in 95% of the cases both with the SSOCT and PCI. No significant difference was disclosed between the two instruments (P = 0.229). For WTW measurements, a significant difference was observed between the two optical biometers (P < 0.0001). The difference between PCI and SSOCT in IOL powers was statistically significant for SRK/T, Hoffer and Holladay formulas (P < 0.001). Conclusion Our results implicated an overall good reproducibility of anterior keratometry, AL, ACD and WTW measurements for IOLMaster and ANTERION. The discrepancies between their measurements resulted in significant difference in the calculated IOL power for SRK/T, Hoffer and Holladay formulas, but not for Haigis formula.

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Ability of Swept-Source Optical Coherence Tomography to Detect Retinal and Choroidal Changes in Patients with Multiple Sclerosis

Journal of Ophthalmology ◽

10.1155/2018/7361212 ◽

2018 ◽

Vol 2018 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Elena Garcia-Martin ◽

Laura Jarauta ◽

Elisa Vilades ◽

Jose Ramon Ara ◽

Jesus Martin ◽

...

Keyword(s):

Multiple Sclerosis ◽

Optical Coherence Tomography ◽

Choroidal Thickness ◽

Optical Coherence ◽

Retinal Ganglion ◽

Fiber Layer ◽

Swept Source ◽

Rnfl Thickness ◽

Depth Analysis ◽

Retinal Thinning

Purpose. To evaluate the ability of new swept-source (SS) optical coherence tomography (OCT) technology to detect changes in retinal and choroidal thickness in patients with multiple sclerosis (MS). Methods. A total of 101 healthy and 97 MS eyes underwent retinal and choroidal assessment using SS Triton OCT (Topcon). Macular thickness and peripapillary data (retinal, ganglion cell layer (GCL+, GCL++) and retinal nerve fiber layer (RNFL) thickness) were analyzed, including choroidal thickness evaluation. Results. Significant macular thinning was observed in all ETDRS areas (p<0.001) in MS patients. Peripapillary retinal, RNFL, and GCL ++ thickness showed a significant reduction in patients in all sectors (p<0.001) except in the nasal quadrant/sector (p>0.05). GCL+ measurements were found to be reduced in the nasal (p=0.003), inferonasal (p=0.045), and temporal (p=0.001) sectors and total thickness (p<0.001). Choroidal thickness was reduced in the outer macular ring in MS patients compared with controls (p=0.038). Conclusion. New swept-source technology for OCT devices detects retinal thinning in MS patients, providing increased depth analysis of the choroid in these patients. MS patients present reduced retinal and choroidal thickness in the macular area and reduced peripapillary retinal, RNFL, and GCL thickness.

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