The Associations Between Fasting Plasma Glucose Levels and Mortality of SFTS in Patients

Abstract Objective To identify the correlation between the level of at-admission fasting plasma glucose (FPG) with poor outcomes in hospitalized patients suffering from severe fever with thrombocytopenia syndrome (SFTS). Methods Between April 1 and December 1, 2020, the list of hospitalized patients affected with SFTS infection was provided by the Infectious Disease Department at First Affiliated Hospital of Anhui Medical University, followed by the collection of information I.e., gender, age, diabetic history and the level of FPG on admission. Results In this study, a total of 77 patients were included and were categorized into three groups (<5.6, 5.6–6.9, and ≥7.0 mmol/l) on the basis of their glucose level in the blood. The obtained results revealed that among three groups considerable variations were observed in leukocytes, FPG, D-Dimer, aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), fibrin degradation products (FDP), and interleukin (IL)-10 level. Correlation analysis indicated a linear negative correlation between PLT and FPG (r = −0.28, P = 0.01), however, a linear positive correlation was observed between AST, IL10, D-Dimer, and FDP levels and FPG (P-value < 0.05). Conclusions Elevated level of FPG has been correlated with hypercoagulability, inflammation, and lower PLT in SFTS patients. The measurement of FPG level can help in evaluating the inflammatory process, hypercoagulability, and prognosis of patients suffering from SFTS.

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Correlation of Fasting and Postprandial Glucose Levels with Glycosylated Hemoglobin in Diagnosis of Diabetes

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v17i1.31014 ◽

2021 ◽

Vol 17 (1) ◽

pp. 44-54

Author(s):

Prija Poudyal ◽

Kabina Shrestha ◽

Lily Rajbanshi ◽

Afaque Anwar

Keyword(s):

Correlation Coefficient ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Glycosylated Hemoglobin ◽

Vascular Complications ◽

P Value ◽

Cross Sectional ◽

Postprandial Plasma Glucose ◽

Glucose Levels ◽

Fasting Plasma

Introduction: Diabetes Mellitus describes a group of metabolic disorders characterized by hyperglycemia. Uncontrolled glycemic state often leads to micro and macro vascular complications. Diabetes is the foremost cause of new blindness in adults. Constant screening of the diabetic profile through blood tests of the affected people and prompt actions to control them can help to improve the quality of life of these patients. The study was done to evaluate the correlation between fasting and postprandial plasma glucose levels with glycosylated hemoglobin for diagnosis of diabetes and to determine the prevalence of diabetes in different age groups with sex predilection. Methods: A descriptive cross sectional study was conducted and the data collection was carried out in the Department of Ophthalmic Pathology and Laboratory Medicine, Biratnagar Eye Hospital. Ethical approval was obtained from Institutional Review Committee of this hospital. All 275 patients who attended the laboratory from January 2019 to June 2019 for fasting plasma glucose, postprandial plasma glucose and glycosylated hemoglobin values estimation were included in this study. The data obtained were computed and analyzed using Statistical Package for the Social Sciences version 20.0 Results: A significant correlation between fasting plasma glucose, postprandial plasma glucose and glycosylated hemoglobin was observed in this study (p value <0.001). The correlation coefficient between fasting plasma glucose and glycosylated hemoglobin (r= 0.728) is stronger than the correlation coefficient between postprandial plasma glucose and glycosylated hemoglobin (r= 0.709). Conclusions: Fasting plasma glucose correlated better than postprandial plasma glucose with glycosylated hemoglobin.

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