Correlation of Fasting and Postprandial Glucose Levels with Glycosylated Hemoglobin in Diagnosis of Diabetes

Introduction: Diabetes Mellitus describes a group of metabolic disorders characterized by hyperglycemia. Uncontrolled glycemic state often leads to micro and macro vascular complications. Diabetes is the foremost cause of new blindness in adults. Constant screening of the diabetic profile through blood tests of the affected people and prompt actions to control them can help to improve the quality of life of these patients. The study was done to evaluate the correlation between fasting and postprandial plasma glucose levels with glycosylated hemoglobin for diagnosis of diabetes and to determine the prevalence of diabetes in different age groups with sex predilection. Methods: A descriptive cross sectional study was conducted and the data collection was carried out in the Department of Ophthalmic Pathology and Laboratory Medicine, Biratnagar Eye Hospital. Ethical approval was obtained from Institutional Review Committee of this hospital. All 275 patients who attended the laboratory from January 2019 to June 2019 for fasting plasma glucose, postprandial plasma glucose and glycosylated hemoglobin values estimation were included in this study. The data obtained were computed and analyzed using Statistical Package for the Social Sciences version 20.0 Results: A significant correlation between fasting plasma glucose, postprandial plasma glucose and glycosylated hemoglobin was observed in this study (p value <0.001). The correlation coefficient between fasting plasma glucose and glycosylated hemoglobin (r= 0.728) is stronger than the correlation coefficient between postprandial plasma glucose and glycosylated hemoglobin (r= 0.709). Conclusions: Fasting plasma glucose correlated better than postprandial plasma glucose with glycosylated hemoglobin.

Download Full-text

Relationship of Glycosylated Hemoglobin with Fasting and Postprandial Plasma Glucose in Nondiabetic, Pre-diabetic and Newly Diagnosed Diabetic Subjects

Bangladesh Medical Journal ◽

10.3329/bmj.v40i1.9961 ◽

1970 ◽

Vol 40 (1) ◽

pp. 37-38

Author(s):

M Saiedullah ◽

S Begum ◽

S Shermin ◽

MR Rahman ◽

MAH Khan

Keyword(s):

Correlation Coefficient ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

High Performance ◽

Glycosylated Hemoglobin ◽

Newly Diagnosed ◽

Postprandial Plasma Glucose ◽

Fasting Plasma ◽

Relationship Of ◽

The Relationship

Glycosylated hemoglobin (HbA1c) is considered as an index of glycemic status of previous 2 to 3 months. HbA1c in diabetic subjects is translated to average glucose (eAG) and well correlated to mean plasma glucose (MPG). This study was performed to assess the relationship of fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) with HbA1c in nondiabetic, pre-diabetic and newly diagnosed diabetic subjects. Seven hundred subjects of both sexes were included conveniently in this study. Fasting and 2 hours postprandial plasma glucose concentrations were measured by hexokinase method. HbA1c was measured by high performance liquid chromatyography (HPLC) based hemoglobin assay system. Subjects were classified into three groups according to WHO criteria. The correlation coefficient between FPG and HbA1c were 0.2495 (P<0.001), 0.2665 (P<0.001) and 0.8010 (P<0.001) in the nondiabetic, pre-diabetic and newly diagnosed diabetic subjects respectively. The correlation coefficient between PPG and HbA1c were -0.0661 (P>0.05), 0.2447 (P<0.01) and 0.7812 (P<0.001) in the nondiabetic, pre-diabetic and newly diagnosed diabetic subjects respectively. This study revealed that fasting plasma glucose had a modest higher relation with HbA1c than 2 hours postprandial plasma glucose in the newly diagnosed diabetic subjects. It can be concluded that evaluation of FPG may provide better outcome than PPG in the newly diagnosed never treated diabetic subjects. DOI: http://dx.doi.org/10.3329/bmj.v40i1.9961 BMJ 2011; 40(1): 37-38

Download Full-text

Randomized, Double-Blinded, Double-Dummy, Active-Controlled, and Multiple-Dose Clinical Study Comparing the Efficacy and Safety of Mulberry Twig (Ramulus Mori, Sangzhi) Alkaloid Tablet and Acarbose in Individuals with Type 2 Diabetes Mellitus

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/7121356 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Mengyi Li ◽

Xuemin Huang ◽

Hui Ye ◽

Yao Chen ◽

Jing Yu ◽

...

Keyword(s):

Type 2 Diabetes ◽

Clinical Trial ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Efficacy And Safety ◽

Postprandial Plasma Glucose ◽

Glucose Levels ◽

Fasting Plasma ◽

Significant Difference

Aims. To evaluate the efficacy and safety of mulberry twig alkaloid (SZ-A) tablet compared with acarbose in patients with type 2 diabetes.Methods. This clinical trial enrolled 38 patients who were randomized into two groups (SZ-A: 23; acarbose: 15) and were treated for 24 weeks. Patients and clinical trial staffs were masked to treatment assignment throughout the study. The primary outcome measures were glycated hemoglobin (HbA1c) and 1-hour and 2-hour postprandial and fasting plasma glucose levels from baseline to the end of treatment. Analysis included all patients who completed this study.Results. By the end of this study, HbA1c level in SZ-A group was decreased from baseline significantly (P<0.001). No significant difference was found when compared with acarbose group (P=0.652). Similarly, 1-hour and 2-hour postprandial plasma glucose levels in SZ-A group were decreased from baseline statistically (P<0.05), without any significant differences compared with acarbose group (P=0.748and 0.558, resp.). The fasting plasma glucose levels were not significantly changed in both groups. One of 23 patients in SZ-A group (4.76%) and 5 of 15 patients in acarbose group (33.33%) suffered from gastrointestinal adverse events.Conclusions. Compared with acarbose, SZ-A tablet was effective and safe in glycemic control in patients with type 2 diabetes.

Download Full-text

Trends in diabetes prevalence, awareness, treatment, control in Yangon, Myanmar between 2004-2014

European Journal of Public Health ◽

10.1093/eurpub/ckz185.446 ◽

2019 ◽

Vol 29 (Supplement_4) ◽

Author(s):

W P Aung ◽

E Bjertness ◽

H Stigum ◽

A S Htet ◽

M K Kjøllesdal

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Rural Areas ◽

Diabetes Prevalence ◽

World Health ◽

Treatment Rate ◽

Cross Sectional ◽

Glucose Levels ◽

Fasting Plasma ◽

And Control

Abstract Background In 2004, a survey in Yangon Region was conducted as the first STEP survey in Myanmar, which was repeated in 2014, assessing diabetes prevalence. Whether there have been any changes over time in the awareness, treatment and control status of diabetes is not known. The study aimed to assess changes in the prevalence, awareness, treatment and control of diabetes from 2004 to 2014, among adults in Yangon region. Methods The study was conducted in urban and rural areas of Yangon region, Myanmar, using two cross-sectional household based studies, in accordance with World Health Organization STEPS methodology. Men and women aged 25-74 years old participated in the studies (n = 4448 in 2004) and (n = 1372 in 2014). Logistic and linear regression were performed and outcome variables were diabetes and fasting plasma glucose. Results The overall age-standardized prevalence of diabetes were 8.3% (95% CI 6.5-10.6) in 2004 and 10.2% (7.6-13.6) in 2014 (p = 0.296). The diabetes prevalence increased from 2004 to 2014 only among participants aged ≥60 years, from 14.6% (11.7-18.1) to 31.9% (21.1-45.0) (p = 0.009). Awareness of having diabetes increased between 2004 and 2014 (44.3% (39.2, 49.6) to 69.4% (62.9-75.2)) (p < 0.001). Among participants who were aware of having diabetes, the proportion under treatment had increased between 2004 and 2014 from 55.1% (46.8-63.1) to 68.6% (61.5-74.8) (p = 0.015). There were no increase between 2004 and 2014 in the proportion of participants with controlled diabetes. After adjustments for age, sex and education, mean fasting plasma glucose levels in 2014 was 0.56 mmol/l (0.26-0.84) higher than in 2004. Conclusions The studies to monitor the development of diabetes prevalence in Myanmar are needed. Preventive measures to halt increases prevalence, to increase the detection rate of undiagnosed DM also treatment rate and to help people with diabetes to control their situation are needed. Key messages Mean plasma glucose levels were higher in 2014 than in 2004, but an increase in DM prevalence during this period was seen only among the oldest participants. The proportion of women being aware of having DM, as well as the proportion under treatment for most groups, had increased, however not the proportion under control.

Download Full-text

Correlation between urinary contents of some metals and fasting plasma glucose levels: A cross-sectional study in China

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2021.112976 ◽

2021 ◽

Vol 228 ◽

pp. 112976

Author(s):

Xiaoting Mo ◽

Jiansheng Cai ◽

Yinxia Lin ◽

Qiumei Liu ◽

Min Xu ◽

...

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Glucose Levels ◽

Fasting Plasma

Download Full-text

A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS

Pakistan Armed Forces Medical Journal ◽

10.51253/pafmj.v71i5.4918 ◽

2021 ◽

Vol 71 (5) ◽

pp. 1651-55

Author(s):

Shehar Bano Imran ◽

Shabnam Dildar ◽

Sadia Taj ◽

Afshan Khanum ◽

Qasim Ahmed

Keyword(s):

Diabetes Mellitus ◽

Blood Pressure ◽

Plasma Glucose ◽

Fasting Plasma Glucose ◽

High Sensitivity ◽

P Value ◽

Cross Sectional ◽

Fasting Plasma ◽

Hs Crp ◽

Glycemic Markers

Objective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes. Study Design: Cross sectional study. Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019. Methodology: Consecutive patients aged 18-65 years coming for screening of diabetes mellitus (DM) were included. Blood sample for plasma glucose and glycated hemoglobin (HbA1c), high sensitivity CRP (hs-CRP) were analyzed. Results: Total 93 subjects were included, out of which 42 (45.2%) were males and 51 (54.8%) were females with the mean age of 48.3 ± 12 years and 42.6 ± 14 years respectively. Median concentration of hs-CRP in males and females was 0.7 (IQR1.2) mg/L and 0.6 (IQR1.4) mg/L (p-value=0.844) respectively. A significant positive correlation was observed between hs-CRP levels, HBA1c with r=0.205 (p=0.05) and fasting plasma glucose (FPG) with r=0.225 (p=0.03). However, no significant relationship was found between hs-CRP and age, BMI, waist circumference and systolic blood pressure (SBP) and diastolic blood pressure (DBP), cholesterol, LDL-cholesterol, triglycerides (TG), HDL-cholesterol. Conclusion: HbA1c and fasting plasma glucose is significantly associated with hs-CRP. This implies a significant relation between inflammation and glycemic markers. This leads to the conclusion that patients with diabetes and high hs-CRP need further evaluation, follow-up and therapy for inflammation compared to those with low hs-CRP.

Download Full-text

The Associations Between Fasting Plasma Glucose Levels and Mortality of SFTS in Patients

10.21203/rs.3.rs-228628/v1 ◽

2021 ◽

Author(s):

Yin Zhang ◽

Yu Zhang ◽

Yuanhong Xu ◽

Ying Huang

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Degradation Products ◽

Hospitalized Patients ◽

P Value ◽

Glucose Levels ◽

Fasting Plasma ◽

Poor Outcomes ◽

Factor Α ◽

D Dimer

Abstract Objective To identify the correlation between the level of at-admission fasting plasma glucose (FPG) with poor outcomes in hospitalized patients suffering from severe fever with thrombocytopenia syndrome (SFTS). Methods Between April 1 and December 1, 2020, the list of hospitalized patients affected with SFTS infection was provided by the Infectious Disease Department at First Affiliated Hospital of Anhui Medical University, followed by the collection of information I.e., gender, age, diabetic history and the level of FPG on admission. Results In this study, a total of 77 patients were included and were categorized into three groups (<5.6, 5.6–6.9, and ≥7.0 mmol/l) on the basis of their glucose level in the blood. The obtained results revealed that among three groups considerable variations were observed in leukocytes, FPG, D-Dimer, aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), fibrin degradation products (FDP), and interleukin (IL)-10 level. Correlation analysis indicated a linear negative correlation between PLT and FPG (r = −0.28, P = 0.01), however, a linear positive correlation was observed between AST, IL10, D-Dimer, and FDP levels and FPG (P-value < 0.05). Conclusions Elevated level of FPG has been correlated with hypercoagulability, inflammation, and lower PLT in SFTS patients. The measurement of FPG level can help in evaluating the inflammatory process, hypercoagulability, and prognosis of patients suffering from SFTS.

Download Full-text

Age- and sex-specific profiles of temporal fasting plasma glucose variability in a population undergoing routine health screening

BMC Public Health ◽

10.1186/s12889-021-10367-x ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Agyei Helena Lartey ◽

Xiaona Li ◽

Zhongqi Li ◽

Qun Zhang ◽

Jianming Wang

Keyword(s):

Plasma Glucose ◽

Fasting Plasma Glucose ◽

Chinese Population ◽

Age Groups ◽

Health Screening ◽

Health Examination ◽

Cross Sectional ◽

Fasting Plasma ◽

Percentage Difference ◽

Age And Sex

Abstract Background Fasting plasma glucose (FPG) variability is a significant predictor of mortality, especially in patients with poor glycemic control. This study aimed to explore the temporal age- and sex-specific profiles of temporal FPG variability in a Chinese population undergoing routine health screening and to guide the development of targeted public health interventions for the prevention and control of diabetes. Methods In this cross-sectional study, we used a general linear model to compare differences in temporal FPG values between sexes and across age groups in 101,886 Nanjing residents who underwent a routine physical health examination at the Health Management Center, the First Affiliated Hospital of Nanjing Medical University, in 2018. The variability of FPG as a function of time, age, and sex, independently and in combination, was analyzed. Results The participants included 57,455 (56.4%) males and 44,431 (43.6%) females, with a mean ± SD age of 42.8 ± 15.0 years. The average ± SD FPG level was 5.5 ± 1.1 mmol/L. The monthly variation contributed to 22% of the overall FPG variability. A significant main effect for the age group was observed (F = 7.39, P < 0.05), with an excellent fitting effect (Eta-squared =0.15). The variability of FPG showed sex differences in the percentage difference of the coefficient of variation, which was 34.1% higher in males than females. There were significant interaction effects for month*age*sex and day*age*sex. Conclusions Temporal variability in FPG is evident in the general Chinese population and is affected by both age and sex. To avoid complications associated with FPG variability, interventions should be directed at females and males at specific ages for optimal control of FPG variability and to reduce the risk of diabetes and cardiovascular events.

Download Full-text