Features and prognosis of cytomegalovirus-associated biliary atresia: a retrospective study

2020 ◽  
Author(s):  
Zhe Wang ◽  
Xi-Si Guan ◽  
Yue Wu ◽  
Qiu-Ming He ◽  
Le Li ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Biliary Atresia ◽  
Statistical Significance ◽  
Underlying Mechanism ◽  
Gamma Glutamyl Transferase ◽  
Cmv Infection ◽  
Short Term ◽  
Term Outcome ◽  
Dna Test ◽  
Glutamyl Transferase

Abstract Purpose To investigate the relationship between cytomegalovirus (CMV) infection and biliary atresia (BA) onset, development and short-term prognosis after Kasai operation. Methods A retrospective study was conducted. BA Patients with obstructive jaundice and tested for CMV infection were included and grouped by CMV-IgM and CMV-DNA test results, between-group differences of preoperative blood tests and short-term prognosis indicators were investigated for the statistical significance. Results the CMV infection rate was higher in BA patients compared with non-BA jaundiced patients. Higher preoperative gamma-glutamyl transferase (GGT) level and lymphocyte percentage (Lym%) were significantly corelated with the CMV infection in BA patients. CMV(+) BA Patients had similar short-term outcome comparing with CMV(-) patients. IgM(+)DNA(+) group had highest GGT, total bilirubin (TBiL) and direct bilirubin (DBiL) level. IgM(-)DNA(+) group had the lowest GGT and the highest alkaline phosphatase (ALP) level. IgM(+)DNA(-) group had the highest bodyweight and lymphocyte percentage. The IgM (+)DNA (-) group had more patient achieved complete jaundice clearance than other groups. Conclusion CMV infection may associate to BA development and progression. Perioperative antivirus treatments may be necessary for improving outcome. Better elucidation of the underlying mechanism will require further investigation.

UP-03.134 Short-Term Outcome, Morbidity and Quality of Life of Artificial Urinary Sphincter: A Retrospective Study

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S387-S388
Author(s):  
L. Kluth ◽  
R. Dahlem ◽  
P. Reiss ◽  
B. Schoensee ◽  
J. Hansen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Retrospective Study ◽  
Artificial Urinary Sphincter ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Urinary Sphincter

scholarly journals Dynamic changes in liver function parameters in patients with coronavirus disease 2019: a multicentre, retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qing-Lei Zeng ◽  
Zu-Jiang Yu ◽  
Fanpu Ji ◽  
Guang-Ming Li ◽  
Guo-Fan Zhang ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Liver Disease ◽  
Liver Function ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Gamma Glutamyl Transferase ◽  
Dynamic Changes ◽  
Viral Shedding ◽  
Glutamyl Transferase ◽  
Multicentre Retrospective Study

Abstract Background Liver injuries have been reported in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the clinical role played by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methods In this multicentre, retrospective study, the parameters of liver function tests in COVID-19 inpatients were compared between various time-points in reference to SARS-CoV-2 shedding, and 3 to 7 days before the first detection of viral shedding was regarded as the reference baseline. Results In total, 70 COVID-19 inpatients were enrolled. Twenty-two (31.4%) patients had a self-medication history after illness. At baseline, 10 (14.3%), 7 (10%), 9 (12.9%), 2 (2.9%), 15 (21.4%), and 4 (5.7%) patients already had abnormal alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), albumin, and total bilirubin (TBIL) values, respectively. ALT and AST abnormal rates and levels did not show any significant dynamic changes during the full period of viral shedding (all p > 0.05). The GGT abnormal rate (p = 0.008) and level (p = 0.033) significantly increased on day 10 of viral shedding. Meanwhile, no simultaneous significant increases in abnormal ALP rates and levels were observed. TBIL abnormal rates and levels significantly increased on days 1 and 5 of viral shedding (all p < 0.05). Albumin abnormal decrease rates increased, and levels decreased consistently from baseline to SARS-CoV-2 clearance day (all p < 0.05). Thirteen (18.6%) patients had chronic liver disease, two of whom died. The ALT and AST abnormal rates and levels did not increase in patients with chronic liver disease during SARS-CoV-2 shedding. Conclusions SARS-CoV-2 does not directly lead to elevations in ALT and AST but may result in elevations in GGT and TBIL; albumin decreased extraordinarily even when SARS-CoV-2 shedding ended.

The short-term outcome of modified laparoscopic Kasai portoenterostomy for biliary atresia

2020 ◽  
Author(s):  
Yi Ji ◽  
Kaiying Yang ◽  
Xuepeng Zhang ◽  
Shuguang Jin ◽  
Xiaoping Jiang ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Kasai Portoenterostomy ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome

Normal Gamma Glutamyl Transferase Levels at Presentation Predict Poor Outcome in Biliary Atresia

2020 ◽  
Vol 70 (3) ◽  
pp. 350-355 ◽  
Author(s):  
Sahana Shankar ◽  
Rishi Bolia ◽  
Hee Wei Foo ◽  
Colleen E D’Arcy ◽  
Natasha Hardikar ◽  
...  
Keyword(s):  
Biliary Atresia ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Poor Outcome ◽  
Glutamyl Transferase

scholarly journals Predictor factors for choledocholithiasis

2015 ◽  
Vol 28 (2) ◽  
pp. 109-112 ◽  
Author(s):  
Joana TOZATTI ◽  
André Luiz Parizi MELLO ◽  
Orli FRAZON
Keyword(s):  
Alkaline Phosphatase ◽  
Statistical Significance ◽  
Magnetic Resonance Cholangiopancreatography ◽  
High Specificity ◽  
Control Group ◽  
Interventional Treatment ◽  
Gamma Glutamyl Transferase ◽  
Imaging Studies ◽  
Laboratory Markers ◽  
Glutamyl Transferase

BACKGROUND: The choledocolithiasis has an incidence of 8-20% in patients with cholecystolithiasis. The preoperative diagnosis guides the interventional treatment on the bile duct AIM: To evaluate the sensitivity and specificity of the laboratory markers and imaging studies for choledocholithiasis preoperatively. METHODS: The study comprised 254 patients divided into two groups: the control group (207 patients), patients without choledocholithiasis intraoperatively and cases group (47 patients), that enrolled the patients with choledocholithiasis intra-operatively. Were evaluated the laboratory markers, image exams and intra-operative diagnostic aspects. RESULTS: The sample was homogeneous for age and gender. It was observed that 47% of the cases the patients did not show comorbidities. Hospitalization showes in cases group acute pancreatitis in12.8%, jaundice in 30%, fever in 30% and pain in the right hypochondrium in 95%. By comparing them, was observed that fever and jaundice were the signs and symptoms with statistical significance. Patients with choledocholithiasis had transaminases, alkaline phosphatase, gamma-glutamyl transferase and higher bilirubin with statistical significance (p<0.001). In regard to imaging studies, ultrasound was fairly accurate for cholelithiasis and choledocholithiasis (p<0.001). CONCLUSION: Changes in canalicular and transaminase enzymes are suggestive for preoperative choledocholithiasis; GGT showed better sensitivity and alkaline phosphatase greater specificity; ultrasonography and nuclear magnetic resonance cholangiopancreatography showed high specificity.

scholarly journals The short-term effect of vitamin D supplementation on the response to muscle and liver damages indices by exhaustive aerobic exercise in untrained men: a quasi-experimental study

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Vahid Parvizi Mastali ◽  
Rastegar Hoseini ◽  
Mohammad Azizi
Keyword(s):  
Vitamin D ◽  
Aerobic Exercise ◽  
Repeated Measures ◽  
Vitamin D Supplementation ◽  
T Test ◽  
Gamma Glutamyl Transferase ◽  
Fat Percentage ◽  
Short Term ◽  
Damage Indices ◽  
Glutamyl Transferase

Abstract Background Exercise-induced muscle damage typically caused by unaccustomed exercise results in pain, soreness, inflammation, and muscle and liver damages. Antioxidant supplementation might be a useful approach to reduce myocytes and hepatocytes damages. Therefore, the present study was conducted to investigate the effect of short-term vitamin D (Vit D) supplementation on the response to muscle and liver damages indices by Exhaustive Aerobic Exercise (EAE) in untrained men. Methods In this clinical trial, 24 untrained men were randomly divided into experimental (Exp; n = 12) and control (C; n = 12) groups. Exp received 2000 IU of Vit D daily for six weeks (42 days), while C daily received a lactose placebo with the same color, shape, and warmth percentage. Two bouts of EAE were performed on a treadmill before and after six weeks of supplementation. Anthropometric characteristics (Bodyweight (BW), height, Body Fat Percentage (BFP), Body Mass Index (BMI), waist to hip ratio (WHR)) were measured at the Pre 1 and Pre 2. Blood samples were taken to measure the Creatine Kinase (CK), Lactate Dehydrogenase (LDH), Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Gamma-Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), and Vit D levels at four stages: Pre 1 (before the first EE session), Post 1 (after the first EE session), Pre 2 (before the second EE session), and Post 2 (after the second EE session). The data were analyzed using repeated-measures ANOVA, Bonferroni's post hoc test, independent t test, and dependent t-test at the significant level of P < 0.05 using SPSS version 26. Results The results show significant differences between Exp and C in alterations of BW (P = 0.039), BMI (P = 0.025), BFP (P = 0.043), and WHR (P = 0.035). The results showed that EAE increased muscle and liver damage indices and Vit D (P < 0.05). Compared with C, the results of the independent t-test showed significantly lower ALT (P = 0.001; P = 0.001), AST (P = 0.011; P = 0.001), GGT (P = 0.018; P = 0.001), and ALP (P = 0.001; P = 0.001); while significantly higher Vit D (P = 0.001, P = 0.001) in the Exp in both Pre 2 and Post 2; receptivity. The independent t test showed significantly lower ALT (P = 0.001; P = 0.001), AST (P = 0.011; P = 0.001), GGT (P = 0.018; P = 0.001), and ALP (P = 0.001; P = 0.001) and considerably greater Vit D (P = 0.001, P = 0.001) in the Exp in both Pre 2 and Post 2 compared to C. The results of an independent t test showed that LDH and CK levels in the Exp were significantly lower than those in the Post 2 (P = 0.001). Conclusions Short-term Vit D supplementation could prevent myocytes and hepatocytes damage induced by EAE.

scholarly journals Development and validation of bile acid profile-based scoring system for identification of biliary atresia: a prospective study

2020 ◽  
Author(s):  
Dongying Zhao ◽  
Kejun Zhou ◽  
Yan Chen ◽  
Wei Xie ◽  
Yongjun Zhang
Keyword(s):  
Bile Acid ◽  
Prospective Study ◽  
Biliary Atresia ◽  
Scoring System ◽  
Validation Cohort ◽  
Gamma Glutamyl Transferase ◽  
Derivation Cohort ◽  
Significant Difference ◽  
Glutamyl Transferase ◽  
A Prospective Study

Abstract Background: Early distinguishing biliary atresia from other causes of infantile cholestasis remains a major challenge. We aimed to develop and validate a scoring system based on bile acid for identification of biliary atresia. Methods: In a prospective study, a total of 141 infants with cholestasis were enrolled in two sets (derivation cohort, n=66; validation cohort, n=75) from 2014 to 2018. Variables with significant difference between biliary atresia and non-biliary atresia infants were selected in the derivation cohort. Then, a scoring system including those variables was designed and validated. Results: Among 66 patients in the derivation cohort, 34 (51.5%) had biliary atresia. A scoring system was proposed with the following variables: glycochenodeoxycholic acid/chenodeoxycholic acid, clay stool, and gamma-glutamyl transferase. The total score ranged from 0 to 41, and a cutoff value of 15 identified biliary atresia with an area under receiver operating characteristic curve of 0.87 (95% confidence interval, 0.77–0.94), sensitivity of 85.3%, and specificity of 81.3% in the derivation cohort; these values were also confirmed in a validation cohort with a sensitivity of 90.0% and specificity of 80.0%. Conclusions: The proposed simple scoring system had good diagnostic accuracy for estimating the risk of biliary atresia in infants with cholestasis.

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