scholarly journals Associations of hysteroscopic features of chronic endometritis with pregnancy outcomes of in vitro fertilization: A retrospective study

2021 ◽  
Author(s):  
Hui Wang ◽  
Chang-hong Liu ◽  
Cui-fang Hao
Keyword(s):  
Retrospective Study ◽  
Embryo Transfer ◽  
Pregnancy Outcomes ◽  
Birth Rate ◽  
Standardized Patients ◽  
Miscarriage Rate ◽  
Fresh Embryo Transfer ◽  
Chronic Endometritis ◽  
The Impact

Abstract The impact of the hysteroscopic features of chronic endometritis (CE) on pregnancy outcomes is unclear. This study explored whether the morphological features of CE on hysteroscopy were associated with in vitro fertilization (IVF) pregnancy outcomes. This retrospective study was conducted at Yantai Yuhuangding Hospital from 01/2017 to 09/2018. Infertile women who underwent hysteroscopy before IVF were grouped according to CE. To decrease confounding, a group of standardized patients was selected from the women enrolled in this study to compare pregnancy outcomes between the CE and non-CE groups. The outcomes were clinical pregnancy rate (CPR), live birth rate (LBR), miscarriage rate, and premature birth rate. In this study, 3280 women underwent IVF, and 3179 of these patients underwent hysteroscopy. In standardized patients, significant differences were found between the CE and non-CE groups in CPR (54.3% vs. 65.6%, P=0.02) and LBR (45.7% vs. 58.3%, P=0.012). In patients who underwent fresh embryo transfer, CPR differed among groups (P=0.002) and was highest in the hemorrhagic spots group (61.7%). In patients who underwent frozen embryo transfer (FET), CPR was higher in the CE group than in the non-CE group (54.7% vs. 43.0%, P<0.001), highest in the hemorrhagic spots group (70.6%, P=0.002) and lowest in the hyperemia combined with micropolyps group (39.4%, P=0.022). The only factor independently associated with CPR was hysteroscopic features of CE (odds ratio: 1.47, 95% confidence interval: 1.21–1.80, P<0.001). Hysteroscopic features of CE are associated with adverse pregnancy outcomes after IVF.

scholarly journals Retrospective study of multiple factors imparting effect on pregnancy outcomes in an in-vitro-fertilization centre

2020 ◽  
Vol 9 (6) ◽  
pp. 2516
Author(s):  
Preksha T. Singh ◽  
Shreyans D. Singhvi ◽  
Utkarsh Kachhia ◽  
Trishala Punjabi ◽  
Shital Punjabi ◽  
...  
Keyword(s):  
Retrospective Study ◽  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Pregnancy Outcomes ◽  
Statistical Difference ◽  
P Value ◽  
Fresh Embryo Transfer ◽  
Vitro Fertilization ◽  
Multiple Factors

Background: Assisted reproductive technology (ART) cycles include in vitro fertilization of the sperm and ovum and transferring the embryo formed into the uterus of the patients. In ART cycles, there is still a shroud of doubt regarding the pregnancy outcomes of embryo transfer on day 3 versus the embryo transfers on day 5 as well the better pregnancy outcome with fresh versus frozen embryo transfer and the number of embryos transferred. This study is aimed to evaluate these factors and study the way to optimize methods to obtain highest pregnancy outcomes.Methods: A retrospective study was performed of 87 patients who had undergone embryo transfers during the duration of the study from an IVF centre in Ahmedabad. Multiple factors were studied and the clinical outcome was tabulated. The pregnancy outcomes were compared using the values of beta- hcg (human chorionic gonadotropin). The data was compiled and analyzed using Google spreadsheets. To find the statistical difference between different factors- the statistical method of Fischer’s exact test and p-value was used.Results: No statistical difference between day 3 and day 5 embryo transfer as well as between frozen and fresh embryo transfer were both. All of them were found equally efficacious, although 3 and 5 number of embryo transfers were found efficacious.Conclusions: In conclusion authors recommend a day 5 embryo transfer with 3 or 5 embryos which are best-quality frozen or fresh embryos to achieve maximum pregnancy outcomes.

scholarly journals The Impact of Laparoscopic Treated Endometrioma on the Live Birth Rate in IVF/ICSI Cycles Compared with Unexplained Infertility: A Prospective Randomized Study

2020 ◽  
Vol 8 (B) ◽  
pp. 160-165
Author(s):  
Snezhana Stojkovska ◽  
Gligor Dimitrov ◽  
Jane Stojkovski ◽  
Stefan Saltirovski ◽  
Makuli Hadzi-Lega
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Birth Rate ◽  
Randomized Study ◽  
Live Birth Rate ◽  
Unexplained Infertility ◽  
Fresh Embryo Transfer ◽  
Vitro Fertilization ◽  
The Impact

BACKGROUND: It is estimated that 30–70% of patients who undergo treatment for infertility are afflicted with endometriosis. AIM: The objectives of this study are to evaluate the impact of laparoscopic treated endometrioma compared to unexplained subfertility on the live birth rate in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). METHODS: This randomized prospective study included 120 women who contacted the department of IVF in the period from 2010 to 2015. Women were divided into two groups according to the findings obtained by laparoscopy. The treated endometrioma group (n = 60) with unilateral ovarian endometriomas and the non-endometriosis group (n = 60) with unexplained infertility undergoing the first cycle of IVF-embryo transfer (IVF-ET) were included in the study. In all participants, ICSI was used and all had fresh embryo transfer per cycle. The primary outcome was to live birth. RESULTS: Our results demonstrated that clinical pregnancy rates (p = 0.54) and live birth rate (p = 0.63) are similar. The preservation of a good ovarian response to stimulation by gonadotropins after laparoscopic ovarian cystectomy was presented. Laparoscopic cystectomy is followed by good IVF/ICSI outcome into the level expected in women with unexplained subfertility. CONCLUSION: Therefore, operative treatment is justified by not altering the live birth rate. Additional study is needed to be considered cystectomy before IVF as an effective approach for managing endometriosis-associated infertility.

scholarly journals Influence of surgical evacuation on pregnancy outcomes of subsequent embryo transfer cycle following miscarriage in an initial IVF cycle: a retrospective cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Junan Meng ◽  
Mengchen Zhu ◽  
Wenjuan Shen ◽  
Xiaomin Huang ◽  
Haixiang Sun ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Pregnancy Outcomes ◽  
Birth Rate ◽  
Endometrial Thickness ◽  
Live Birth Rate ◽  
First Trimester ◽  
Miscarriage Rate ◽  
Significant Difference ◽  
Surgical Evacuation

Abstract Background It is still uncertain whether surgical evacuation adversely affects subsequent embryo transfer. The present study aims to assess the influence of surgical evacuation on the pregnancy outcomes of subsequent embryo transfer cycle following first trimester miscarriage in an initial in vitro fertilization and embryo transfer (IVF-ET) cycle. Methods A total of 645 patients who underwent their first trimester miscarriage in an initial IVF cycle between January 2013 and May 2016 in Nanjing Drum Tower Hospital were enrolled. Surgical evacuation was performed when the products of conception were retained more than 8 h after medical evacuation. Characteristics and pregnancy outcomes were compared between surgical evacuation patients and no surgical evacuation patients. The pregnancy outcomes following surgical evacuation were further compared between patients with ≥ 8 mm or < 8 mm endometrial thickness (EMT), and with the different EMT changes. Results The EMT in the subsequent embryo transfer cycle of surgical evacuation group was much thinner when compared with that in the no surgical evacuation group (9.0 ± 1.6 mm vs. 9.4 ± 1.9 mm, P = 0.01). There was no significant difference in implantation rate, clinical pregnancy rate, live birth rate or miscarriage rate between surgical evacuation group and no surgical evacuation group (P > 0.05). The live birth rate was higher in EMT ≥ 8 mm group when compared to < 8 mm group in surgical evacuation patients (43.0% vs. 17.4%, P < 0.05). Conclusions There was no significant difference in the pregnancy outcomes of subsequent embryo transfer cycle between surgical evacuation patients and no surgical evacuation patients. Surgical evacuation led to the decrease of EMT, especially when the EMT < 8 mm was association with a lower live birth rate.

scholarly journals The impact of atosiban on pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer: A meta-analysis

PLoS ONE ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. e0175501 ◽  
Author(s):  
Qian-Yi Huang ◽  
Min-Hua Rong ◽  
Ai-Hua Lan ◽  
Xiao-Miao Lin ◽  
Xing-Gu Lin ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Vitro Fertilization ◽  
The Impact

scholarly journals Impacts of Anti-dsDNA Antibody on In Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Jiao Fan ◽  
Yiping Zhong ◽  
Cuina Chen
Keyword(s):  
In Vitro Fertilization ◽  
Embryo Transfer ◽  
Hormone Replacement ◽  
Miscarriage Rate ◽  
Fresh Embryo Transfer ◽  
Vitro Fertilization ◽  
Dsdna Antibody ◽  
Frozen Thawed Embryo Transfer ◽  
Thawed Embryo Transfer

Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+/anti-dsDNA− group), and 121 women with negative ANA and anti-dsDNA (ANA−/anti-dsDNA− group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enrolled in the hormone replacement therapy frozen-thawed embryo transfer (HRT-TET) cycle. We compared basic characters and IVF outcomes among three groups in fresh embryo transfer and frozen-thawed embryo transfer cycle, respectively. The number of retrieved oocytes, available embryos, and high-quality embryos in the ANA+/anti-dsDNA+ group was lower than those in the other two groups in the fresh embryo transfer cycle. The rates of fertilization, implantation, and clinical pregnancy in the ANA+/anti-dsDNA+ group were the lowest, while the early miscarriage rate was the highest in the ANA+/anti-dsDNA+ group both in the fresh embryo transfer cycle and in the frozen-thawed embryo transfer cycle. Our data suggested that anti-dsDNA antibody may be the essential marker for defective oocytes or embryos in infertile women with any type of ANA.

scholarly journals The Impact of Preconception TSH on the Reproductive Outcomes of Infertile Women Undergoing the First Fresh D3 Embryo Transfer Cycle

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yuchao Zhang ◽  
Wenbin Wu ◽  
Yanli Liu ◽  
Yichun Guan ◽  
Xingling Wang ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Live Birth ◽  
Birth Rate ◽  
Live Birth Rate ◽  
Reproductive Outcomes ◽  
Miscarriage Rate ◽  
Infertile Women ◽  
The Impact ◽  
Serum Tsh ◽  
Tsh Levels

Purpose. To investigate the association between high-normal preconception TSH levels and reproductive outcomes in infertile women undergoing the first fresh D3 embryo transfer. Methods. This was a retrospective study. Euthyroid patients undergoing the first fresh D3 embryo transfer from January 2018 to May 2019 were initially included. The patients were divided into a low-TSH (0.27–2.5 mIU/L) group and a high-normal TSH (2.5–4.2 Miu) group. The reproductive outcomes were compared between the groups. Results. A total of 1786 women were ultimately included, in which 1008 of whom had serum TSH levels between 0.27 and 2.5 mIU/L and 778 of whom had serum TSH levels between 2.5 and 4.2 mIU/L. The patients were highly homogeneous in terms of general characteristics. High-normal TSH levels had no adverse impact on the clinical pregnancy rate, miscarriage rate, or live birth rate (respectively, aOR = 0.92, 1.30, and 0.88 and P  = 0.416, 0.163, and 0.219). No significant differences were observed in terms of gestational age, single live birth rates, and birth weight, or birth length. Conclusion. High-normal TSH levels did not significantly influence reproductive outcomes in infertile women undergoing the first fresh D3 embryo transfer. Further studies are needed to test whether the results might be applicable to a wider population.

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