scholarly journals The Up-Regulation of CXCL12-CXCR4 Axis By Radiotherapy Could Accelerate Glioma Progression

2021 ◽  
Author(s):  
Yuichiro Tsuji ◽  
Naosuke Nonoguchi ◽  
Daisuke Okuzaki ◽  
Yusuke Wada ◽  
Daisuke Motooka ◽  
...  
Keyword(s):  
Survival Time ◽  
Brain Tissue ◽  
Left Hemisphere ◽  
Median Survival Time ◽  
Glioma Cell ◽  
Right Hemisphere ◽  
X Ray ◽  
The Right ◽  
The Brain ◽  
Cxcr4 Axis

Abstract Background: This study investigated whether the effect of changes in the microenvironment of parenchymal brain tissue caused by radiotherapy for malignant brain tumors affect the recurrence and progression of glioma. Methods: 3 months after the same 65-Gy irradiation had been applied to the right hemisphere. Irradiated Fisher rats were divided into three groups for in vitro assay as follows. IR/Ipsi-brain; the right-hemisphere tissue was used for experiments. IR/Contra-brain; the left-hemisphere tissue was used. Sham-IR/Brain; sham-irradiation was applied to the brain, and the right-hemisphere tissue was used. The effects of proteins extracted from the brains directly or indirectly affected by irradiation on the growth of F98 cells, the effect on tube formation, the influence on tumor biology, and the influence on cytokine production were investigated. Additionally, irradiated animals were divided into three groups for in vivo assay as follows. IR/Ipis-tumor; F98 cells (a glioma cell line) were transplanted to the right hemisphere. IR/Contra-tumor; F98 cells were transplanted to the left hemisphere. Sham-IR/Tumor; F98 cells were transplanted to the right hemisphere without irradiation. The median survival time of F98 transplanted rats was also examined. Results: X-ray irradiation promoted the secretion of cytokines such as TNFα, TGF-β1, VEGF-A, and CXCL12 from the irradiated brain. F98 glioma cells implanted in the irradiated brains showed significantly high proliferation and angiogenesis ability, and the post-irradiation F98 tumor-implanted rats showed a shorter median survival time compared to the Sham-irradiation group.Conclusions: These results indicate that the up-regulation of CXCL12-CXCR4 axis by radiotherapy could promote tumor proliferation. Radiation therapy is a standard treatment for malignant gliomas including glioblastoma multiforme, but the current study suggests that the microenvironment around the brain tissue in the chronic phase after exposure to X-ray radiation becomes suitable for glioma cell growth and invasion.

scholarly journals Chronic pathophysiological changes in the normal brain parenchyma caused by radiotherapy accelerate glioma progression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yuichiro Tsuji ◽  
Naosuke Nonoguchi ◽  
Daisuke Okuzaki ◽  
Yusuke Wada ◽  
Daisuke Motooka ◽  
...  
Keyword(s):  
Survival Time ◽  
Brain Tissue ◽  
Median Survival ◽  
Median Survival Time ◽  
Glioma Cell ◽  
Right Hemisphere ◽  
Glioma Cells ◽  
Chronic Phase ◽  
Normal Brain ◽  
X Ray

AbstractRadiation therapy is one of standard treatment for malignant glioma after surgery. The microenvironment after irradiation is considered not to be suitable for the survival of tumor cells (tumor bed effect). This study investigated whether the effect of changes in the microenvironment of parenchymal brain tissue caused by radiotherapy affect the recurrence and progression of glioma. 65-Gy irradiation had been applied to the right hemisphere of Fisher rats. After 3 months from irradiation, we extracted RNA and protein from the irradiated rat brain. To study effects of proteins extracted from the brains, we performed WST-8 assay and tube formation assay in vitro. Cytokine production were investigated for qPCR. Additionally, we transplanted glioma cell into the irradiated and sham animals and the median survival time of F98 transplanted rats was also examined in vivo. Immunohistochemical analyses and invasiveness of implanted tumor were evaluated. X-ray irradiation promoted the secretion of cytokines such as CXCL12, VEGF-A, TGF-β1 and TNFα from the irradiated brain. Proteins extracted from the irradiated brain promoted the proliferation and angiogenic activity of F98 glioma cells. Glioma cells implanted in the irradiated brains showed significantly high proliferation, angiogenesis and invasive ability, and the post-irradiation F98 tumor-implanted rats showed a shorter median survival time compared to the Sham-irradiation group. The current study suggests that the microenvironment around the brain tissue in the chronic phase after exposure to X-ray radiation becomes suitable for glioma cell growth and invasion.

Asymmetries of Sensory Functions (Spatial and Temporal Discrimination) in Normal Persons

1947 ◽  
Vol 93 (391) ◽  
pp. 318-332 ◽  
Author(s):  
H. H. Fleischhacker
Keyword(s):  
Left Hemisphere ◽  
Right Hemisphere ◽  
Temporal Discrimination ◽  
Mental Symptoms ◽  
The Right ◽  
The Brain ◽  
Sensory Functions

Commenting on the different symptoms produced by disturbances of the left hemisphere (aphasia, apraxia, etc.) and of the right (dreamy states, hallucinations, etc.), Hughlings Jackson on many occasions pointed out that there exists a “duality” of the brain; the anterior parts of the left hemisphere serving more controlled and objective purposes, the posterior parts of the right more subjective† and the anterior parts of the right serving more automatic purposes. Consequently, quoting Bastian and Rosenthal to support him, he tendered the suggestion that “mental” symptoms might be indicative of a disturbance particularly of the posterior parts of the right hemisphere (in right-handed people).

scholarly journals Artificial Intelligence to Analyze the Cortical Thickness Through Age

2021 ◽  
Vol 4 ◽  
Author(s):  
Sergio Ledesma ◽  
Mario-Alberto Ibarra-Manzano ◽  
Dora-Luz Almanza-Ojeda ◽  
Pascal Fallavollita ◽  
Jason Steffener
Keyword(s):  
Artificial Intelligence ◽  
Neural Networks ◽  
Artificial Neural Networks ◽  
Left Hemisphere ◽  
Cortical Thickness ◽  
Right Hemisphere ◽  
Unseen Data ◽  
Artificial Neural ◽  
The Right ◽  
The Brain

In this study, Artificial Intelligence was used to analyze a dataset containing the cortical thickness from 1,100 healthy individuals. This dataset had the cortical thickness from 31 regions in the left hemisphere of the brain as well as from 31 regions in the right hemisphere. Then, 62 artificial neural networks were trained and validated to estimate the number of neurons in the hidden layer. These neural networks were used to create a model for the cortical thickness through age for each region in the brain. Using the artificial neural networks and kernels with seven points, numerical differentiation was used to compute the derivative of the cortical thickness with respect to age. The derivative was computed to estimate the cortical thickness speed. Finally, color bands were created for each region in the brain to identify a positive derivative, that is, a part of life with an increase in cortical thickness. Likewise, the color bands were used to identify a negative derivative, that is, a lifetime period with a cortical thickness reduction. Regions of the brain with similar derivatives were organized and displayed in clusters. Computer simulations showed that some regions exhibit abrupt changes in cortical thickness at specific periods of life. The simulations also illustrated that some regions in the left hemisphere do not follow the pattern of the same region in the right hemisphere. Finally, it was concluded that each region in the brain must be dynamically modeled. One advantage of using artificial neural networks is that they can learn and model non-linear and complex relationships. Also, artificial neural networks are immune to noise in the samples and can handle unseen data. That is, the models based on artificial neural networks can predict the behavior of samples that were not used for training. Furthermore, several studies have shown that artificial neural networks are capable of deriving information from imprecise data. Because of these advantages, the results obtained in this study by the artificial neural networks provide valuable information to analyze and model the cortical thickness.

scholarly journals EEG Asymmetries in Depressive Female Adolescents with Different Kinds of Auto-Aggressive Behavior

Psychiatry ◽  
2020 ◽  
Vol 18 (3) ◽  
pp. 14-21
Author(s):  
E. V. Iznak ◽  
E. V. Damyanovich ◽  
N. S. Levchenko ◽  
I. V. Oleichik ◽  
A. F. Iznak
Keyword(s):  
Aggressive Behavior ◽  
Left Hemisphere ◽  
Right Hemisphere ◽  
Spectral Power ◽  
Quantitative Eeg ◽  
Female Adolescents ◽  
Self Injury ◽  
Increased Risk ◽  
The Right ◽  
The Brain

Background: non-suicidal self-injury (NSSI) in adolescence is a significant risk factor for suicide, and therefore, the search for neurobiological markers and predictors of risk for suicidal intentions and actions seems to be an urgent task. In particular, quantitative EEG parameters can be such predictors.Objective: to identify the features of EEG in female adolescents with endogenous depressive conditions, manifested only by NSSI without suicidal intentions, in comparison with the EEG of patients who had suicidal auto-aggressive behavior (SAB) in the structure of depression.Patients and methods: the study was conducted as a comparative clinical and neurophysiological. The study included 45 female patients aged 16–25 years with endogenous depressive conditions, divided into 2 subgroups: those who showed only NSSI (NSSI subgroup, 21 patients), or who had a history of SAB (SAB subgroup, 24 patients). Clinical-psychopathological, psychometric, neurophysiological and statistical methods were used.Results and its discussion: intergroup differences were revealed in relation to the ratio and hemispheric asymmetry of the EEG spectral power of narrow frequency sub-bands of the parietal-occipital alpha rhythm. In the SAB subgroup alpha-2 (9–11 Hz) rhythm spectral power is higher than in the NSSI subgroup, the focus of alpha-2 spectral power is located in the right hemisphere, and alpha-3 sub-band (11–13 Hz) spectral power is higher than of alpha-1 (8–9 Hz). In the NSSI subgroup, alpha-1 (8–9 Hz) sub-band spectral power are higher than of alpha-3 (11–13 Hz), and focuses of alpha-2 (9–11 Hz) and alpha-3 (11–13 Hz) rhythms are localized in the left hemisphere. The results are discussed in terms of functional specialization of the brain hemispheres in relation to the regulation of emotions and control of behavior.Conclusions: the spatial distribution of the EEG frequency components in the SAB subgroup reflects the greater activation of the brain left hemisphere that is more typical for the EEG of individuals with an increased risk of suicide. In the NSSI subgroup, the right hemisphere is relatively more activated that is more typical for EEG in depressive disorders.The results obtained allow the use of quantitative EEG data to clarify the degree of suicidal risk in depressed female adolescents with non-suicidal self-injury.

EFFECT OF AMINOTHIOL ANTIHyPOXANTS ON INTERHEMISPHERIC ASyMMETRy OF THE bRAIN

2012 ◽  
Vol 10 (1) ◽  
pp. 51-53
Author(s):  
Vladimir Vladimirovich Mihkeev ◽  
Vera Vasilievna Marysheva ◽  
Boris Nikolaevich Bogomolov ◽  
Lubov Vladislavovna Zhukova-Williams
Keyword(s):  
Left Hemisphere ◽  
Right Hemisphere ◽  
Acute Hypoxia ◽  
Life Time ◽  
Antihypoxic Activity ◽  
Interhemispheric Relations ◽  
Hypoxia With Hypercapnia ◽  
Antihypoxic Effect ◽  
The Right ◽  
The Brain

The effect of aminothiol antihipoxants amthizol and its analogue VM-606 on the resistance of the SHR mice males to an acute hypoxia with hypercapnia under conditions of isolated functioning of one of the hemispheres of the brain was studied. Antihypoxic agent amthizol 25 mg/kg increases life time of naïve mice by 46.2%. The drug acted on the sham-operated mice more slightly, increasing of their life only on 28.1% (p<0.01). Administration of amthizol under conditions of functioning of the right hemisphere significantly enhanced (+64.8%) the life time of mice. No antihypoxic effect was registered after administration of amthizol to mice with active left hemisphere: the result was the same as in mice without amthizol. Therefore, antihypoxic effect of amthizol was due to its action on the right (but not the left) hemisphere of the brain. VM-606 possessed more antihypoxic activity in comparison with amthizol. After unilateral cortical inactivation, VM-606 increased life time of mice both in active right and active left hemispheres, but in more degree in active right hemisphere. Thus, interhemispheric differences in resistance of mice to hypoxia with hypercapnia were diminished. Therefore, the differences between amthizol and VM-606 are the followings: amthizol inverts interhemispheric relations in hypoxia whereas VM-606 diminishes them.

UNBIASING THE BRAIN: THE EFFECTS OF MEDITATION UPON THE CEREBRAL HEMISPHERES

1983 ◽  
Vol 11 (1) ◽  
pp. 65-76 ◽  
Author(s):  
John Meissner ◽  
Michael Pirot
Keyword(s):  
Reaction Time ◽  
Left Hemisphere ◽  
Right Hemisphere ◽  
Transcendental Meditation ◽  
Hand Preference ◽  
Control Group ◽  
Control Groups ◽  
Clinical Method ◽  
The Right ◽  
The Brain

Twenty males with a strong right hand preference underwent 120 simple reaction time trials to a 500 hz auditory stimulus presented to right, left and both ears. Ten Transcendental Meditators served as their own controls in twenty minute meditation and relaxation conditions and were also compared to a ten Non-Meditator control group who relaxed only in two 20-minute conditions. The reaction time trials were administered after the conditions. When the ears were compared to each other a significant right-ear (left hemisphere) advantage (REA) occurred in all relaxation conditions of the Meditator and Non-Meditator control groups. However, no REA emerged after meditation conditions of the Meditator group. The Meditator group after meditation compared to their own baseline relaxation condition showed a significant suppression of reaction time latencies to stimulation delivered to the left hemisphere and a significant facilitation to stimulation delivered to the right hemisphere. The meaning of these findings suggest Transcendental Meditation is an attentional strategy that disrupts the usual biases of the brain which also has implications as a clinical method. A neuropsychological explanation of the results suggest a comprehensive theory of Transcendental Meditation.

scholarly journals Processing of metaphors in transcortical motor aphasia

2008 ◽  
Vol 2 (4) ◽  
pp. 339-348 ◽  
Author(s):  
Renata Mancopes ◽  
Fernanda Schultz
Keyword(s):  
Left Hemisphere ◽  
Right Hemisphere ◽  
Great Emphasis ◽  
Clinical Aspects ◽  
Metaphor Comprehension ◽  
Motor Aphasia ◽  
The Right ◽  
Left Hemisphere Stroke ◽  
Comprehension Tests ◽  
The Brain

Abstract Great emphasis has been placed on the right hemisphere, due to its possible selective contribution, in the processing of metaphorical statements. Objectives: To describe the processing of metaphors in the case of a patient with transcortical motor aphasia, using specific tests for patients with encephalic injuries of the right hemisphere, and to contribute to the discussion on the inter-hemispheric relationships associated with this function. Methods: A 54 year-old man with transcortical motor aphasia was evaluated three years after a left hemisphere stroke. The tasks of comprehension of metaphors were based on the subtest Metaphor Comprehension Task of the Montreal Evaluation of Communications Scale (MEC). Two metaphor comprehension tests were applied, in 45-minute sessions with a 48 hour interval between each. Test 1 involved comprehension of the metaphors according to the options offered, and Test 2 the comprehension of metaphors measured by response time and visual field. Results: Although the right hemisphere was not affected by the stroke in this case, difficulties were observed in the processing of metaphors. Conclusions: This study suggests that the left hemisphere participates in the processing of figurative meanings. The adaptability of the brain can also re-accommodate the uninjured areas of the brain, causing the dynamic of the brain to be modified. As a result, deducing cerebral functions based on clinical data can be problematic. The value of this study is that it can contribute to clinical aspects of language rehabilitation.

Effect of Short Lateralized Signals on Arousal versus Activation on Tasks Requiring Visuospatial or Elementary Semantic Stimulus Processing

1988 ◽  
Vol 67 (3) ◽  
pp. 783-788 ◽  
Author(s):  
Bert De Brabander
Keyword(s):  
Information Processing ◽  
Left Hemisphere ◽  
Right Hemisphere ◽  
Self Regulation ◽  
Indirect Evidence ◽  
Supplementary Information ◽  
Processing Load ◽  
Basic Hypothesis ◽  
The Right ◽  
The Brain

The results of the experiment offer indirect evidence for the basic hypothesis that the brain self-regulates its own arousal and activation as a function of the intensity and type of ongoing cortical activity. When subjects perform a task which can be assumed to be primarily attended to by the right hemisphere, the result of a supplementary information-processing load seems to be increased arousal. On a task primarily attended to by the left hemisphere, the consequence is increased activation. The evidence is indirect because no measurements have been made of the neurological events and processes which are assumed to intervene in this self-regulation process. Although indirect, the evidence may help to formulate more precise psychological hypotheses about the factors controlling the putative effort system which, according to Pribram and McGuinness in 1975, coordinates the arousal and activation of cerebral processes.

scholarly journals The role of neurotransmitter systems separate the hemispheres of the brain in action the new antiepileptic compounds AGB-31

2013 ◽  
Vol 11 (2) ◽  
pp. 31-35
Author(s):  
Oleg Aleksandrovich Yarosh
Keyword(s):  
Nitric Oxide ◽  
Left Hemisphere ◽  
Glutamic Acid Decarboxylase ◽  
Right Hemisphere ◽  
Reduced Glutathione ◽  
Acid Decarboxylase ◽  
Decarboxylase Activity ◽  
The Right ◽  
The Brain

Compound AGB-31, a monocarbamate derivative, is shown to possess a high antiepileptic activity. The mechanisms of antiepileptic action are connected with significant increase in glutamic acid decarboxylase activity in the left hemisphere of the brain, with trend of the glutamate content decrease in the left hemisphere and the tendency to increase GABA in both hemispheres. AGB-31 significantly (more than 3-fold) increases syntase nitric oxide activity in the left hemisphere and has a tendency to reduce the NO content in both hemispheres. AGB-31 significantly (by 63.4%), reduced glutathione peroxydase activity in the right hemisphere without changing it in the left, with a tendency to increase the activity of glutathione reductase in both hemispheres.

Right Hemisphere Strokes

2016 ◽  
Vol 1 (2) ◽  
pp. 63-65 ◽  
Author(s):  
Margaret Lehman Blake
Keyword(s):  
Medical Treatment ◽  
Left Hemisphere ◽  
Right Hemisphere ◽  
Stroke Severity ◽  
The Right ◽  
The Brain

Although strokes occur about as often on the right as on the left side of the brain, much more attention is given to left hemisphere (LH) strokes, which results in biases in stroke severity assessments and medical treatment.

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