How Common is Fibromyalgia in Patients with Hypothyroidism?

Abstract Background: Fibromyalgia (FM) is the most common cause of chronic generalized musculoskeletal pain and it is generally accompanied by the other nonspecific common symptoms. The etiology and the pathophysiology is still not clear but also there are some studies that show a relationship between FM and thyroid diseases. So, in this study we aimed to determine the frequency of FM in patients with hypothyroidism and the variables that may affect this frequency. Methods: This is a cross-sectional, single center and prospective study. A total of 180 patients -who were applied to internal medicine outpatient clinics- included in the study and the patients who described the generalized musculoskeletal pain were consulted to the physical medicine and rehabilitation outpatient clinics. We have evaluated demographic data, laboratory, presence of thyroid disease and FM, and Beck Depression Questionnaire (BDQ) and FM Impact Questionnaire (FIQ) for FM patients.Results: 39.4% (n = 71) of the patients had FM and 60.6% (n = 109) of them did not. There was a positive corelation between FIQ score and age at diagnosis and disease duration. As the age at diagnosis and duration of disease increased, the FIQ score increased by 37.3% and 25.7%, respectively. In addition, as BDQ increased, the FIQ score increased by 44.8%. Conclusion: Signs and symptoms of hypothyroidism is similar to signs and symptoms of FM, and approximately 40% of patients with hypothyroidism could have FM concomittantly. Therefore, all patients with hypothyroidism should also be examined for FM.

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The epidemiology of Moebius syndrome in Italy

Orphanet Journal of Rare Diseases ◽

10.1186/s13023-021-01808-2 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Arturo Carta ◽

Stefania Favilla ◽

Giacomo Calzetti ◽

Maria Cristina Casalini ◽

Pier Francesco Ferrari ◽

...

Keyword(s):

Demographic Data ◽

Geographical Area ◽

National Level ◽

Age At Diagnosis ◽

University Hospital ◽

Italian Population ◽

Moebius Syndrome ◽

Cross Sectional ◽

Geographical Regions ◽

Chi Square Analysis

Abstract Background The epidemiology of Moebius syndrome (MBS) is difficult to assess. In the present study, we investigated the epidemiology of MBS in a well-defined population within a precise geographical area. Materials and methods Our university hospital is the only national referral center for the diagnosis and treatment of MBS. Participants in this cross-sectional study were patients affected by MBS who had been periodically followed by our medical staff since 1998. Most of the patients were referred to our hospital by the Italian Association of Moebius Syndrome (AISMO). Demographic data necessary for study purposes were made available in the AISMO database, updated to April 2018. Subjects were assigned to geographical macroareas that are conventionally used in surveys and epidemiological investigations by the Italian National Institute of Statistics. The rates and prevalence of MBS cases were calculated on the basis of the last available survey of the Italian population. Each study parameter was then calculated with reference to the whole country and macroarea partition. The sex rate and the corresponding prevalence were calculated with respect to the weighted whole population and to the respective sex population. Chi-square analysis was adopted to investigate possible differences among geographical regions and/or sexes. A p value < 0.05 was considered statistically significant. Results One hundred and sixty-four out of 212 MBS patients fulfilled our inclusion criteria. All cases occurred in Caucasian patients and were sporadic. The median age at diagnosis was 3.6 years, ranging from 0 to 55 years; this range was significantly reduced to 0–5 years (median age at diagnosis: 2.2 years) in patients included after 2007. The calculated prevalence at birth was 0.06 cases per 10,000 live births, with an overall prevalence of 0.27/100,000, without any sex or geographical predominance. Conclusions The prevalence of MBS observed herein, rounded for possible underestimation, was 0.3/100,000 people, without any regional difference in the distribution of cases. Our data confirm the rarity of the disease on a national level.

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Soluble CD30 Levels in the Sera of Patients With Psoriasis in Myanmar

Journal of Psoriasis and Psoriatic Arthritis ◽

10.1177/2475530320930465 ◽

2020 ◽

Vol 5 (3) ◽

pp. 114-118

Author(s):

Myat Sanda Kyaw ◽

Hitoshi Tsuchihashi ◽

Hideoki Ogawa ◽

Shigaku Ikeda

Keyword(s):

Analytical Study ◽

Disease Duration ◽

Th2 Cells ◽

Enzyme Linked Immunosorbent Assay ◽

Cross Sectional ◽

Soluble Cd30 ◽

Prolonged Duration ◽

Dominant Disease ◽

Duration Of Disease

Background: Although psoriasis is a Th1-dominant disease, certain investigations have also revealed the involvement of Th2 cells in the disease. Soluble CD30 (sCD30) is predominantly associated with various Th2 diseases. Therefore, the role of sCD30 in psoriasis requires further evaluation. Objectives: To evaluate the association between sCD30 and psoriasis. Methods: In this cross-sectional analytical study, the association between serum sCD30 levels and psoriasis was evaluated using enzyme-linked immunosorbent assay in sera obtained from patients with psoriasis. Results: The results indicated elevated sCD30 levels in 79 patients with psoriasis, and the levels were significantly higher in those with a prolonged duration of disease (duration > 10 years). Furthermore, there was a significant positive correlation between the duration of disease (years) and sCD30 (pg/mL) levels. These findings suggest that sCD30 is a useful marker for chronicity of psoriasis. Conclusion: Elevated sCD30 levels in psoriasis are associated with disease duration, and they may reflect the chronicity of psoriasis. Further research is required to determine the role of sCD30 in psoriasis.

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Olfactory threshold is impaired in early, active multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458511399798 ◽

2011 ◽

Vol 17 (8) ◽

pp. 964-969 ◽

Cited By ~ 51

Author(s):

A Lutterotti ◽

M Vedovello ◽

M Reindl ◽

R Ehling ◽

F DiPauli ◽

...

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Disease Duration ◽

Demographic Data ◽

Olfactory Function ◽

Olfactory Threshold ◽

Perception Threshold ◽

Cross Sectional ◽

Odour Perception

Background: Olfactory dysfunction has been reported in multiple sclerosis (MS). However, to date no data are available on different qualities of olfactory function, namely odour identification, odour discrimination and odour perception threshold. Objective: To assess different qualities of olfactory function in patients with MS and correlate these with demographic data, clinical data, depression, quality of life and cognitive functions. Methods: In this cross-sectional study, 50 patients with MS or clinically isolated syndrome and 30 healthy controls were included. Olfactory function was measured using the Sniffin’ Sticks test. Results: The scores for odour identification ( p = 0.001), odour perception threshold ( p = 0.037) and the combined score of odour identification, discrimination and perception threshold (TDI, p = 0.002) were significantly lower in MS. Hyposmia for identification ( p = 0.0017), threshold ( p = 0.017) and TDI score ( p = 0.0014) was more frequent in MS. Olfactory threshold was impaired in patients who were clinically active in the previous year ( p = 0.026) and in patients with a disease duration less than 2 years ( p = 0.0093). Identification score was negatively correlated with disease duration ( p = 0.0017). Olfactory function was not associated with disability, depression or quality of life. Conclusions: We report evidence for qualitatively distinct hyposmia in MS, with increased smell threshold in the early inflammatory phases of the disease and impaired identification with a more widespread chronic disease.

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Challenge and hope for parents who have cancer

International Journal of Science and Research Archive ◽

10.30574/ijsra.2021.3.1.0125 ◽

2021 ◽

Vol 3 (1) ◽

pp. 136-147

Author(s):

Yuko Akagawa ◽

Sachiko Makabe ◽

Tomoko Ito ◽

Yutaka Kimura ◽

Hideaki Andoh

Keyword(s):

Disease Duration ◽

Response Rate ◽

Demographic Data ◽

Current Status ◽

Stress Coping ◽

Parental Cancer ◽

Cross Sectional ◽

Coping Ability ◽

The Mean ◽

The Relationship

Parents who have cancer face particular problems in their relationships with children. This study aims to clarify 1) the current status of challenge/hope in parental cancer, 2) the factors related to challenge/hope, and 3) the relationship between challenge/hope and QOL/stress-coping ability. Cross-sectional national survey was conducted at designated cancer hospitals in Japan. Participants were undergoing cancer treatment and have children under 18 years old. The questionnaire included demographic data, QOL, ability to cope with stress, and challenge/hope. From 11 hospitals, 54 patients (response rate: 79.4%) participated. Majority of participants were female (72.2%) with the mean age of 39.3 ± 5.3 (SD). The total score was QOL (FACT-G: 50.4 ± 16.2), stress-coping ability (SOC: 46.7 ± 10.4). The main challenges were an inability to fulfill the parental role and children’s mental suffering due to loneliness. The main aspects of hope were the value of the children’s present self, being a parent, and strengthening family bonds. Gender and disease duration were significantly related with challenge/hope. Challenge was significantly related with QOL/stress-coping ability. Parents who have cancer derive hope from their relationship with their children, although they feel a gap between their ideal role/value as a parent and their current status.

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ANALISIS HASIL PEMERIKSAAN FISIK DAN LABORATORIUM DEMAM BERDARAH DENGUE DERAJAT I DAN II DI RSUD H. SAHUDIN KUTACANE TAHUN 2021

Jurnal Maternitas Kebidanan ◽

10.34012/jumkep.v6i2.1969 ◽

2021 ◽

Vol 6 (2) ◽

pp. 73-83

Author(s):

Joharsah Joharsah ◽

Fika Lestari ◽

Purnama Sari Cane

Keyword(s):

Physical Examination ◽

Demographic Data ◽

Signs And Symptoms ◽

Oxygen Intake ◽

Normal Numbers ◽

Cross Sectional ◽

Dengue Disease ◽

Laboratory Results ◽

Physical Examinations ◽

Laboratory Examinations

Dengue fever is a severe fever that is often deadly, caused by a virus, characterized by capillary permeability, hemostasis abnormalities and in severe cases, shock syndrome loss of protein. The disease is divided into several degrees. To ensure patients suffer from DENGUE disease, it is necessary to perform physical and laboratory examinations such as hematology tests. This study aims to analyze the results of physical examinations and laboratories of DBD degrees I and II at H.Sahudin Kutacane Hospital. The study used descriptive methods with a Cross Sectional approach. Accidental sampling and the number of samples obtained is 20 respondents, among others, degrees I and II are 10 respondents. The data collection tool is carried out using observation sheets including demographic data, physical examination of DBD degrees I and II, and normal standard numbers and laboratory examination units of Amanah Kutacane Clinic. The results of research conducted from a physical examination of DBD degrees I and II show signs and symptoms of DENGUD disease that appear differently because in addition to the condition of a person's body response is different, It may also be because it has been given symptomatic and supportive treatment, while the laboratory results of DBD degrees I and II are only platelets whose value is low from normal numbers (150,000-450,000/μl) of 88,500/μl and 42,300/μl respectively and these laboratory results are affected by adequate fluid and oxygen intake and nutritious food intake so as to support proper administration of action/management

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The Epidemiology of Moebius Syndrome

10.21203/rs.3.rs-15457/v2 ◽

2020 ◽

Author(s):

arturo carta ◽

Stefania Favilla ◽

Giacomo Calzetti ◽

Maria Cristina Casalini ◽

Pier Francesco Ferrari ◽

...

Keyword(s):

Demographic Data ◽

Geographical Area ◽

Age At Diagnosis ◽

University Hospital ◽

P Value ◽

Italian Population ◽

Moebius Syndrome ◽

Cross Sectional ◽

Geographical Regions ◽

Chi Square Analysis

Abstract Background: The epidemiology of Moebius Syndrome (MBS) is actually difficult to assess. In the present study we investigated the epidemiology of MBS in a well-defined population over a precise geographical area. Materials and Methods: Our University Hospital is the only national referral Centre for the diagnosis and treatment of MBS. Participants to this cross sectional study are patients affected by MBS who have been periodically followed by our medical staff since 1998. Most of the patients were referred to our hospital by the Italian Association of Moebius Syndrome (AISMO). Demographic data necessary for our purposes were made available by AISMO database updated to April 2018. Subjects were assigned to the geographical macro- areas which are the ones conventionally used for surveys and epidemiological investigations by the Italian National Institute of Statistics. Rates and prevalence of the MBS cases were calculated referring to the last survey of the Italian population available. Every study parameter was then calculated by reference to the whole country and to macro-area partition. Gender rate and the corresponding prevalence were calculated with respect to the weighted whole population and to the respective gender population. Chi-square analysis was adopted to investigate possible differences among geographical regions and/or gender. A p value <0.05 was considered statistically significant. Results: One-hundred and sixty-four out of 212 MBS patients fulfilled our inclusion criteria. All cases were Caucasian and sporadic. The median age at diagnosis was 3.6 years, ranging from 0-55; this range was significantly reduced to 0-5 years (median age at diagnosis: 2.2 years) for patients included after 2007. The birth prevalence calculated was 0.06 cases per 10000 live births with an overall prevalence of 0.27/100000 without any gender or geographical predisposition. Conclusions: The rate of MBS prevalence herein observed, rounded for possible underestimation, is 0.3/100000 people without any regional difference in the distribution of the cases. Our data confirm on a national basis the rarity of the disease.

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Are Strokes Mostly Genetically Based or Acquired? Stenosis vs Hypoplasia of Vertebral Artery Anomalous as The Leading Cause of Stroke (Anatomical Study of VA Anomalies in Neck Three-Dimensional Computed Tomography Angiography)

10.21203/rs.3.rs-791684/v1 ◽

2021 ◽

Author(s):

Farzaneh Mohammadi ◽

Hussein Soleimantabar ◽

Fatemeh Mohamadi ◽

Sofia Sabouri

Keyword(s):

Vertebral Artery ◽

Demographic Data ◽

Three Dimensional ◽

Neck Region ◽

Anatomical Study ◽

Signs And Symptoms ◽

Cross Sectional Study ◽

Anomalous Origin ◽

Cross Sectional ◽

Imaging Center

Abstract Background A thorough understanding of the vertebral artery (VA) variations and course of the artery and its related branches could significantly enhance the efficacy and safety of interventions involving the neck and spine. Here, we aimed to investigate the incidence of various VA variations in individuals presenting with signs and symptoms of stroke with our neurology team. In this cross-sectional study, all patients referred to our specialized medical imaging center and underwent neck CT-angiography (CTA) were enrolled in this study for two years from September 2019 onward. Patients' information forms were obtained to collect demographic data. Results An experienced board-certified radiologist evaluated the CTA images, recording the characteristics of VA, regarding dominance and any possible anomalies. These included anomalous origin, anomalous route, anomalous branching, stenosis, hypoplasia, atresia, thrombosis, and dissection. A total of 125 patients (53.6% females; mean age, 60.7 (11–87)) were included. In the case of VA dominance, 66.4% of cases were co-dominant while 16.0% were right, and 12.8% were left dominant. Overall, males had more VA anomalies than females, 24.8% and 17.6%, respectively (in general, 42.4% of all participants) (p = 0.020). Among patients, 4.0% (n = 5) had an anomalous origin and anomalous branching was reported in 5 patients (4.0%). Among the variations, significant stenosis (18.4%) and hypoplasia (17.6%) were the most prevalent anomalies with the earliest one having the higher rate. While anomalous branching was reported in 5 patients (4.0%). Conclusions VA variations are relatively common and should be addressed during procedures involving the neck region and would allow surgeons to avoid life threatening injury.

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P031 Adherence with Methotrexate in Tunisian Juvenile Idiopathic Arthritis Patients

Rheumatology ◽

10.1093/rheumatology/keab722.023 ◽

2021 ◽

Vol 60 (Supplement_5) ◽

Author(s):

Hiba Bettaieb ◽

Wafa Triki ◽

Kaouther Maatallah ◽

Hanene Ferjani ◽

Dorra Ben Nessib ◽

...

Keyword(s):

Juvenile Idiopathic Arthritis ◽

Rheumatoid Factor ◽

Disease Duration ◽

Pediatric Population ◽

Demographic Data ◽

Disease Onset ◽

Weekly Dose ◽

Cross Sectional ◽

High Adherence ◽

The Mean

Abstract Background Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in the pediatric population. Methotrexate (MTX) has been considered as the cornerstone of treatment of poly and oligoarticular subtypes of JIA. However, this treatment is supposed to be for long term, which may involve an obstacle for adherence. The aims of the study were to evaluate adherence of Tunisian JIA patients to MTX and to identify factors associated with high adherence to MTX. Methods A cross-sectional study including patients with confirmed JIA diagnosis, according to the International League of Associations for Rheumatology (ILAR) criteria, was performed. Demographic data as well as disease characteristics were obtained from medical records. Laboratory markers including erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were collected. Adherence was measured, for patients under MTX for >3 months, using the 5-item Compliance Questionnaire Rheumatology (CQR5) (1). Patients were divided into two groups: group 1: High adherence (HA) for patients having a CQR5 ≥ 80% and group 2: low adherence (LA) for patients having CQR5 < 80%. A p inferior to 0.05 was considered statistically significant. Results The study included 29 patients (10 males and 19 females) with a mean age at disease onset of 9.1 ± 3.4 years. The mean disease duration was 61 ± 79 months [7–336]. JIA subtypes were in decreasing order of frequency as follows: enthesitis-related arthritis (n = 13), oligoarticular (n = 8), Polyarticular without rheumatoid factor (n = 4), Polyarticular with rheumatoid factor (n = 2), systemic (n = 1) and, psoriatic arthritis (n = 1). A biologic inflammatory syndrome was found in 48.3% (n = 14) of cases. The mean ESR and CRP were 20 mm/h ± 11.3 [3–98] and 5 ± 17.8 mg/l [0–56] respectively. Nineteen (65.5%) patients had coxitis. Overall, 55.17% of patients (n = 16) were treated with MTX with a mean weekly dose of 9.2 ± 3.2 mg [5–15]. MTX was orally administrated in all patients. NSAIDs and prednisone were prescribed in 51.7% (n = 15) and 17.2% (n = 5) of cases respectively. The MTX was associated with biological DMARDs in five patients (17.2%). It was about Etanercept in 4 patients and Tocilizumab in 1 patient. Mean CQR5 score was 70.8% ± 18 [25–100]. Only seven patients (43.8%) showed high adherence to MTX. The statistical study revealed no difference between HA and LA in term of gender (P = 0.84), age at disease onset (P = 0.39), disease duration (P = 0.9), prednisone use (P = 0.22), the occurrence of coxitis (P = 0.2), ESR (P = 0.83) and CRP (P = 0.033) rates. Conclusion In this study, less than one half of JIA patients were highly adherent to MTX according to CQR5. Low adherence should be considered before declaring MTX treatment failure.

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The Epidemiology of Moebius Syndrome in Italy

10.21203/rs.3.rs-15457/v3 ◽

2020 ◽

Author(s):

arturo carta ◽

Stefania Favilla ◽

Giacomo Calzetti ◽

Maria Cristina Casalini ◽

Pier Francesco Ferrari ◽

...

Keyword(s):

Demographic Data ◽

Geographical Area ◽

Age At Diagnosis ◽

University Hospital ◽

P Value ◽

Italian Population ◽

Moebius Syndrome ◽

Cross Sectional ◽

Geographical Regions ◽

Chi Square Analysis

Abstract Background: The epidemiology of Moebius Syndrome (MBS) is actually difficult to assess. In the present study we investigated the epidemiology of MBS in a well-defined population over a precise geographical area. Materials and Methods: Our University Hospital is the only national referral Centre for the diagnosis and treatment of MBS. Participants to this cross-sectional study are patients affected by MBS who have been periodically followed by our medical staff since 1998. Most of the patients were referred to our hospital by the Italian Association of Moebius Syndrome (AISMO). Demographic data necessary for our purposes were made available by AISMO database updated to April 2018. Subjects were assigned to the geographical macro- areas which are the ones conventionally used for surveys and epidemiological investigations by the Italian National Institute of Statistics. Rates and prevalence of the MBS cases were calculated referring to the last survey of the Italian population available. Every study parameter was then calculated by reference to the whole country and to macro-area partition. Gender rate and the corresponding prevalence were calculated with respect to the weighted whole population and to the respective gender population. Chi-square analysis was adopted to investigate possible differences among geographical regions and/or gender. A p value <0.05 was considered statistically significant. Results: One-hundred and sixty-four out of 212 MBS patients fulfilled our inclusion criteria. All cases were Caucasian and sporadic. The median age at diagnosis was 3.6 years, ranging from 0-55; this range was significantly reduced to 0-5 years (median age at diagnosis: 2.2 years) for patients included after 2007. The birth prevalence calculated was 0.06 cases per 10000 live births with an overall prevalence of 0.27/100000 without any gender or geographical predisposition. Conclusions: The rate of MBS prevalence herein observed, rounded for possible underestimation, is 0.3/100000 people without any regional difference in the distribution of the cases. Our data confirm on a national basis the rarity of the disease.

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Relationships between Pain, Function and Radiographic Findings in Osteoarthritis of the Knee: A Cross-Sectional Study

Arthritis ◽

10.1155/2012/984060 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 43

Author(s):

Duygu Cubukcu ◽

Ayse Sarsan ◽

Hakan Alkan

Keyword(s):

Knee Pain ◽

Disease Duration ◽

Osteoarthritis Of The Knee ◽

Womac Pain ◽

Cross Sectional ◽

Radiographic Findings ◽

Knee Oa ◽

Duration Of Disease ◽

Grading Scale ◽

The Mean

Objectives. The aim of this study was to investigate the relationships between pain, disability, and radiographic findings in patients with knee osteoarthritis (OA). Patients and Methods. A total of 114 patients with knee OA who attended the physical medicine and rehabilitation outpatient clinic were included in this study. The diagnosis was based on the American College of Rheumatology (ACR) criteria for knee OA. Age, duration of disease, and body mass index (BMI) of the patients were recorded. Radiographic features on the two-sided knee radiography were assessed with the Kellgren-Lawrence scale. The severity of knee pain, stiffness, and disability were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Results. The mean age of the patients was 56.98 (±8.28) years and the mean disease duration was 4.14 (±4.15) years. Kellgren-Lawrence grading scale and age or disease duration were positively and significantly associated, whereas none of the WOMAC subscores were found to be related with Kellgren-Lawrence grading scale (). On the other hand, WOMAC disability scores were significantly associated with WOMAC pain and WOMAC stiffness (). Conclusions. Knee pain, stiffness, and duration of disease may affect the level of disability in the patients with knee OA. Therefore treatment of knee OA could be planned according to the clinical features and functional status instead of radiological findings.

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