Alterations of Amygdala Volume and Functional Connectivity in Patients with Migraine Comorbid Depression

2021 ◽  
Author(s):  
Xin Chen ◽  
Wei Gui ◽  
Mei Dan Zu ◽  
Juan Zhang ◽  
Han Li Li ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Depression Scale ◽  
Episodic Migraine ◽  
Magnetic Resonance Images ◽  
Hamilton Depression Scale ◽  
Resting State Functional Connectivity ◽  
Dorsolateral Prefrontal ◽  
Brain Structure And Function ◽  
The Right ◽  
And Function

Abstract Objective: The comorbidity of migraine and depressive has been recognized, but the pathophysiology remains unknown. Here, we aimed to explore the structural change of amygdala(AMY) and abnormal function in the centromedial amygdala (CMA) among migraineurs with depression. Methods: High-resolution T1-weighted and functional magnetic resonance images were acquired from subjects of 22 migraine comorbid with depression(EMwD ), 22 episodic migraine (EM), 20 major depressive disorder (MDD), respectively, and 18 healthy controls(HC). Apply voxel-based morphometry (VBM ) and resting state functional connectivity (rsFC) to examing inter-group differences in brain structure and function. Results: The volume of bilateral AMY increased in EMwD and EM compared to HC. EMwD showed larger volume than MDD. And the volume of AMY showed positive correlation with duration of illness in patient groups. Compared with EM, EMwD exhibited decreased rsFC between the right CMA and left cerebellum, left dorsolateral prefrontal cortex (DLPFC) , left precuneus(PCC). In addition, rsFC between the left CMA and left DLPFC was negatively correlated with Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD). Conclusions: According to our findings, the larger volume of amygdala and the abnormal functional connectivity may help to determining the common symptoms in migraine with depression, and may be a treatment target for migraine and depression comorbidities.

scholarly journals Altered connectivity in the right inferior frontal gyrus associated with self-control in adolescents exhibiting problematic smartphone use: A fMRI study

2021 ◽  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Magnetic Resonance Images ◽  
Self Control ◽  
Parahippocampal Gyrus ◽  
Resting State Functional Connectivity ◽  
Problematic Smartphone Use ◽  
Smartphone Use ◽  
The Right

Abstract Background With the continued spread of smartphones and development of the internet, the potential negative effects arising from problematic smartphone use (PSU) in adolescents are being reported on an increasing basis. This study aimed to investigate whether altered resting-state functional connectivity (rsFC) is related to the psychological factors underlying PSU in adolescents. Methods Resting-state functional magnetic resonance images were acquired from 47 adolescents with PSU and 46 healthy control adolescents (the CON group). Seed-based functional connectivity analyses were then performed to compare the two groups with respect to rsFC in the right inferior frontal gyrus, associated with various forms of self-control, and rsFC in the left inferior frontal gyrus. Results Compared to the CON group, the PSU group exhibited a reduction in rsFC between the right inferior frontal gyrus and limbic areas, including the bilateral parahippocampal gyrus, the left amygdala, and the right hippocampus. In addition, a reduction in fronto-limbic rsFC was associated with the severity of PSU, the degree of self-control, and the amount of time the subjects used their smartphones. Conclusion Adolescents with PSU exhibited reduced levels of fronto-limbic functional connectivity; this mechanism is involved in salience attribution and self-control, attributes that are critical to the clinical manifestation of substance and behavioral addictions. Our data provide clear evidence for alterations in brain connectivity with respect to self-control in PSU.

scholarly journals The connectome predicts resting state functional connectivity across the Drosophila brain

2020 ◽  
Author(s):  
Maxwell H Turner ◽  
Kevin Mann ◽  
Thomas R. Clandinin
Keyword(s):  
Functional Connectivity ◽  
Large Scale ◽  
Neural Circuit ◽  
Brain Networks ◽  
Brain Regions ◽  
Central Complex ◽  
Resting State Functional Connectivity ◽  
Brain Structure And Function ◽  
And Function

Connectomic datasets have emerged as invaluable tools for understanding neural circuits in many systems. What constraints does the connectome place on information processing and routing in a large scale neural circuit? For mesoscale brain networks, the relationship between cell and synaptic level connectivity and brain function is not well understood. Here, we use data from the Drosophila connectome in conjunction with whole-brain in vivo imaging to relate structural and functional connectivity in the central brain. We find that functional connectivity is strongly associated with the strength of both direct and indirect anatomical pathways. We also show that some brain regions, including the mushroom body and central complex, show considerably higher functional connectivity to other brain regions than is predicted based on their direct anatomical connections. We find several key topological similarities between mesoscale brain networks in flies and mammals, revealing conserved principles relating brain structure and function.

scholarly journals Increased functional connectivity between the right temporo-parietal junction and the temporal poles in migraine without aura

2018 ◽  
Vol 1 ◽  
pp. 251581631880482 ◽  
Author(s):  
Marco Lisicki ◽  
Kevin D’Ostilio ◽  
Gianluca Coppola ◽  
Alain Maertens de Noordhout ◽  
Vincenzo Parisi ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Migraine Without Aura ◽  
Brain Structures ◽  
Episodic Migraine ◽  
Angular Gyrus ◽  
Healthy Controls ◽  
Resting State Functional Connectivity ◽  
Positive Interaction ◽  
The Right

Rather than a localized alteration, increased visual reactivity in migraine patients seems to result from a complex interaction between several brain structures, mostly involving the ventral attention network. The hub of this network is the right temporo-parietal junction. In this report, complementing our previous findings, we describe the differences in seed-to-voxel resting-state functional connectivity seeded in the right temporo-parietal junction (right angular gyrus) between migraine patients and healthy controls. Resting-state functional MRIs of episodic migraine without aura patients in the interictal period ( n = 19) and matched healthy controls ( n = 19) were analysed. With the seed placed in the right temporo-parietal junction (right angular gyrus), seed-to-voxel connectivity was compared between groups. Electrophysiological, voxel-based morphometry (both groups) and specific region of interest (ROI)-to-ROI functional connectivity (migraine patients) data have already been published. Migraine patients showed a higher positive interaction between the right temporo-parietal junction and both temporal poles and a higher negative interaction between this same region and bilateral areas of the visual cortex. On the basis of our results, and because of their established properties as multisensory integration hubs, it is likely that the right temporo-parietal junction and both temporal poles are involved in the altered processing of sensory stimulus commonly observed in migraine patients. Therefore, more attention should be paid to these regions for migraine research in the future.

Resting-state Functional Connectivity of the Right Temporoparietal Junction Relates to Belief Updating and Reorienting during Spatial Attention

2020 ◽  
Vol 32 (6) ◽  
pp. 1130-1141
Author(s):  
Anne-Sophie Käsbauer ◽  
Paola Mengotti ◽  
Gereon R. Fink ◽  
Simone Vossel
Keyword(s):  
Functional Connectivity ◽  
Cognitive Processing ◽  
Resting State ◽  
Prior Information ◽  
Dependent Manner ◽  
Resting State Functional Connectivity ◽  
Belief Updating ◽  
Temporoparietal Junction ◽  
Right Temporoparietal Junction ◽  
The Right

Although multiple studies characterized the resting-state functional connectivity (rsFC) of the right temporoparietal junction (rTPJ), little is known about the link between rTPJ rsFC and cognitive functions. Given a putative involvement of rTPJ in both reorienting of attention and the updating of probabilistic beliefs, this study characterized the relationship between rsFC of rTPJ with dorsal and ventral attention systems and these two cognitive processes. Twenty-three healthy young participants performed a modified location-cueing paradigm with true and false prior information about the percentage of cue validity to assess belief updating and attentional reorienting. Resting-state fMRI was recorded before and after the task. Seed-based correlation analysis was employed, and correlations of each behavioral parameter with rsFC before the task, as well as with changes in rsFC after the task, were assessed in an ROI-based approach. Weaker rsFC between rTPJ and right intraparietal sulcus before the task was associated with relatively faster updating of the belief that the cue will be valid after false prior information. Moreover, relatively faster belief updating, as well as faster reorienting, were related to an increase in the interhemispheric rsFC between rTPJ and left TPJ after the task. These findings are in line with task-based connectivity studies on related attentional functions and extend results from stroke patients demonstrating the importance of interhemispheric parietal interactions for behavioral performance. The present results not only highlight the essential role of parietal rsFC for attentional functions but also suggest that cognitive processing during a task changes connectivity patterns in a performance-dependent manner.

Anesthesia-induced Suppression of Human Dorsal Anterior Insula Responsivity at Loss of Volitional Behavioral Response

2016 ◽  
Vol 124 (4) ◽  
pp. 766-778 ◽  
Author(s):  
Catherine Elizabeth Warnaby ◽  
Marta Seretny ◽  
Roísín Ní Mhuircheartaigh ◽  
Richard Rogers ◽  
Saad Jbabdi ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Anterior Insula ◽  
Cortical Region ◽  
Dorsolateral Prefrontal ◽  
Behavioral Responsiveness ◽  
Insula Cortex ◽  
Evoked Activity ◽  
The Right ◽  
Conjunction Analysis ◽  
External Stimuli

Abstract Background It has been postulated that a small cortical region could be responsible for the loss of behavioral responsiveness (LOBR) during general anesthesia. The authors hypothesize that any brain region demonstrating reduced activation to multisensory external stimuli around LOBR represents a key cortical gate underlying this transition. Furthermore, the authors hypothesize that this localized suppression is associated with breakdown in frontoparietal communication. Methods During both simultaneous electroencephalography and functional magnetic resonance imaging (FMRI) and electroencephalography data acquisition, 15 healthy volunteers experienced an ultraslow induction with propofol anesthesia while a paradigm of multisensory stimulation (i.e., auditory tones, words, and noxious pain stimuli) was presented. The authors performed separate analyses to identify changes in (1) stimulus-evoked activity, (2) functional connectivity, and (3) frontoparietal synchrony associated with LOBR. Results By using an FMRI conjunction analysis, the authors demonstrated that stimulus-evoked activity was suppressed in the right dorsal anterior insula cortex (dAIC) to all sensory modalities around LOBR. Furthermore, the authors found that the dAIC had reduced functional connectivity with the frontoparietal regions, specifically the dorsolateral prefrontal cortex and inferior parietal lobule, after LOBR. Finally, reductions in the electroencephalography power synchrony between electrodes located in these frontoparietal regions were observed in the same subjects after LOBR. Conclusions The authors conclude that the dAIC is a potential cortical gate responsible for LOBR. Suppression of dAIC activity around LOBR was associated with disruption in the frontoparietal networks that was measurable using both electroencephalography synchrony and FMRI connectivity analyses.

Clinical correlates of hypothalamic functional changes in migraine patients

Cephalalgia ◽  
2021 ◽  
pp. 033310242110466
Author(s):  
Roberta Messina ◽  
Maria A Rocca ◽  
Paola Valsasina ◽  
Paolo Misci ◽  
Massimo Filippi
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Visual Processing ◽  
Episodic Migraine ◽  
Resting State Functional Connectivity ◽  
Functional Interaction ◽  
Functional Changes ◽  
Lingual Gyrus ◽  
Headache Impact

Objective To elucidate the hypothalamic involvement in episodic migraine and investigate the association between hypothalamic resting state functional connectivity changes and migraine patients’ clinical characteristics and disease progression over the years. Methods Ninety-one patients with episodic migraine and 73 controls underwent interictal resting state functional magnetic resonance imaging. Twenty-three patients and controls were re-examined after a median of 4.5 years. Hypothalamic resting state functional connectivity changes were investigated using a seed-based correlation approach. Results At baseline, a decreased functional interaction between the hypothalamus and the parahippocampus, cerebellum, temporal, lingual and orbitofrontal gyrus was found in migraine patients versus controls. Increased resting state functional connectivity between the hypothalamus and bilateral orbitofrontal gyrus was demonstrated in migraine patients at follow-up versus baseline. Migraine patients also experienced decreased right hypothalamic resting state functional connectivity with ipsilateral lingual gyrus. A higher migraine attack frequency was associated with decreased hypothalamic-lingual gyrus resting state functional connectivity at baseline, while greater headache impact at follow-up correlated with decreased hypothalamic-orbitofrontal gyrus resting state functional connectivity at baseline. At follow-up, a lower frequency of migraine attacks was associated with higher hypothalamic-orbitofrontal gyrus resting state functional connectivity. Conclusions During the interictal phase, the hypothalamus modulates the activity of pain and visual processing areas in episodic migraine patients. The hypothalamic-cortical interplay changes dynamically over time according to patients’ clinical features.

scholarly journals Altered Long- and Short-Range Functional Connectivity in Patients with Betel Quid Dependence: A Resting-State Functional MRI Study

2016 ◽  
Vol 40 (6) ◽  
pp. 1626-1636 ◽  
Author(s):  
Tao Liu ◽  
Jianjun Li ◽  
Zhiqiang Zhang ◽  
Qiang Xu ◽  
Guangming Lu ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Long Range ◽  
Short Range ◽  
Anterior Cingulate ◽  
Betel Quid ◽  
Posterior Lobe ◽  
Functional Connectivity Density ◽  
Dorsolateral Prefrontal ◽  
The Right ◽  
Mri Study

Objective: Addiction is a chronic relapsing brain disease. Brain structural abnormalities may constitute an abnormal neural network that underlies the risk of drug dependence. We hypothesized that individuals with Betel Quid Dependence (BQD) have functional connectivity alterations that can be described by long- and short-range functional connectivity density(FCD) maps. Methods: We tested this hypothesis using functional magnetic resonance imaging (fMRI) data from subjects of the Han ethnic group in Hainan, China. Here, we examined BQD individuals (n = 33) and age-, sex-, and education-matched healthy controls (HCs) (n = 32) in a rs-fMRI study to observe FCD alterations associated with the severity of BQD. Results: Compared with HCs, long-range FCD was decreased in the right anterior cingulate cortex (ACC) and increased in the left cerebellum posterior lobe (CPL) and bilateral inferior parietal lobule (IPL) in the BQD group. Short-range FCD was reduced in the right ACC and left dorsolateral prefrontal cortex (dlPFC), and increased in the left CPL. The short-range FCD alteration in the right ACC displayed a negative correlation with the Betel Quid Dependence Scale (BQDS) (r=-0.432, P=0.012), and the long-range FCD alteration of left IPL showed a positive correlation with the duration of BQD(r=0.519, P=0.002) in BQD individuals. Conclusions: fMRI revealed differences in long- and short- range FCD in BQD individuals, and these alterations might be due to BQ chewing, BQ dependency, or risk factors for developing BQD.

scholarly journals Aberrant Frontostriatal Connectivity in Negative Symptoms of Schizophrenia

2018 ◽  
Vol 45 (5) ◽  
pp. 1051-1059 ◽  
Author(s):  
Dinesh K Shukla ◽  
Joshua John Chiappelli ◽  
Hemalatha Sampath ◽  
Peter Kochunov ◽  
Stephanie M Hare ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Negative Symptom ◽  
Negative Symptoms ◽  
Imaging Study ◽  
Anterior Cingulate ◽  
Functional Magnetic Resonance ◽  
Resting State Functional Connectivity ◽  
Symptom Scale ◽  
Distinct Component ◽  
The Right

AbstractNegative symptoms represent a distinct component of psychopathology in schizophrenia (SCZ) and are a stable construct over time. Although impaired frontostriatal connectivity has been frequently described in SCZ, its link with negative symptoms has not been carefully studied. We tested the hypothesis that frontostriatal connectivity at rest may be associated with the severity of negative symptoms in SCZ. Resting state functional connectivity (rsFC) data from 95 mostly medicated patients with SCZ and 139 healthy controls (HCs) were acquired. Negative symptoms were assessed using the Brief Negative Symptom Scale. The study analyzed voxel-wise rsFC between 9 frontal “seed regions” and the entire striatum, with the intention to reduce potential biases introduced by predefining any single frontal or striatal region. SCZ showed significantly reduced rsFC between the striatum and the right medial and lateral orbitofrontal cortex (OFC), lateral prefrontal cortex, and rostral anterior cingulate cortex compared with HCs. Further, rsFC between the striatum and the right medial OFC was significantly associated with negative symptom severity. The involved striatal regions were primarily at the ventral putamen. Our results support reduced frontostriatal functional connectivity in SCZ and implicate striatal connectivity with the right medial OFC in negative symptoms. This task-independent resting functional magnetic resonance imaging study showed that medial OFC–striatum functional connectivity is reduced in SCZ and associated with severity of negative symptoms. This finding supports a significant association between frontostriatal connectivity and negative symptoms and thus may provide a potential circuitry-level biomarker to study the neurobiological mechanisms of negative symptoms.

scholarly journals Resting State Functional Connectivity Predicts Future Changes in Sedentary Behavior

2021 ◽  
Author(s):  
Timothy P. Morris ◽  
Aaron Kucyi ◽  
Sheeba Arnold Anteraper ◽  
Maiya Rachel Geddes ◽  
Alfonso Nieto-Castañon ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Exercise Intervention ◽  
Supplementary Motor Area ◽  
Anterior Insula ◽  
Motor Area ◽  
Anterior Cingulate ◽  
Sedentary Behaviors ◽  
Resting State Functional Connectivity ◽  
The Right

AbstractInformation about a person’s available energy resources is integrated in daily behavioral choices that weigh motor costs against expected rewards. It has been posited that humans have an innate attraction towards effort minimization and that executive control is required to overcome this prepotent disposition. With sedentary behaviors increasing at the cost of millions of dollars spent in health care and productivity losses due to physical inactivity-related deaths, understanding the predictors of sedentary behaviors will improve future intervention development and precision medicine approaches. In 64 healthy older adults participating in a 6-month aerobic exercise intervention, we use neuroimaging (resting state functional connectivity), baseline measures of executive function and accelerometer measures of time spent sedentary to predict future changes in objectively measured time spent sedentary in daily life. Using cross-validation and bootstrap resampling, our results demonstrate that functional connectivity between 1) the anterior cingulate cortex and the supplementary motor area and 2) the right anterior insula and the left temporoparietal/temporooccipital junction, predict changes in time spent sedentary, whereas baseline cognitive, behavioral and demographic measures do not. Previous research has shown activation in and between the anterior cingulate and supplementary motor area as well as in the right anterior insula during effort avoidance and tasks that integrate motor costs and reward benefits in effort-based decision making. Our results add important knowledge toward understanding mechanistic associations underlying complex sedentary behaviors.

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