Correlation Analysis of Mood State and Symptom Clusters in Patients With Stage-Ⅳ Lung Cancer During Immunotherapy

Abstract Purpose: To investigate the status of symptom clusters and mood states and analyze the correlation between them in patients with stage-IV lung cancer undergoing immunotherapy.Methods: Using a convenience sampling method, we selected 259 patients for analysis with stage-IV lung cancer who were admitted to the oncology department of a hospital for immunotherapy from February to December 2020. Three instruments were used: a general situation questionnaire, the Chinese version of the M. D. Anderson Symptom Inventory, and the Brief Profile of Mood State Short Form.Results: An exploratory factor analysis identified three main symptom clusters: the disturbance influence, general, and pain–fatigue related symptom clusters. The total score for mood state was (25.71 SD: ±8.32). The score of the depression dimension was the highest (3.30 ±1.85) in the negative mood state; the total score of mood state and the score of negative mood state at different latitudes were significantly positively correlated with the total score of symptom clusters (r = 0.420–0.529, p < 0.01).Conclusion: There are many symptom clusters in patients with lung cancer undergoing immunotherapy. The negative mood state is significant and changes along with changes in symptom clusters; moreover, there is high correlation between them. There should be more focus on the evaluation and management of symptom clusters of patients in nursing to improve the patients’ quality of life.

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Impact on parents of feeding young children with congenital or acquired cardiac disease

Cardiology in the Young ◽

10.1017/s1047951100008842 ◽

2000 ◽

Vol 10 (6) ◽

pp. 574-581 ◽

Cited By ~ 6

Author(s):

Christine Imms

Keyword(s):

Cardiac Disease ◽

Negative Impact ◽

Mood State ◽

Negative Mood ◽

Oral Feeding ◽

Social Emotional ◽

Negative Mood State ◽

Congenital Cardiac Disease ◽

Culturally Based ◽

Emerging Themes

AbstractFeeding an infant is an interactive process that facilitates social, emotional and culturally based skills. Children with congenital or acquired cardiac disease frequently require supportive regimes with regard to feeding so as to maintain weight, resulting in altered experiences for both the child and family. This study evaluated the practical, emotional and social ramifications for parents, of having a child with cardiac disease who also experienced difficulties with oral feeding. The study sampled three groups of parents who had children less than 3 years of age: those with cardiac disease who had difficulty in feeding, those with cardiac disease and no such difficulty, and those with no medical diagnosis. Parents completed a questionnaire about feeding, a time diary of activities involved in feeding, and Tuckman's Mood Thermometers, which measure anger and ‘poorness-of-mood’ associated with feeding the identified child. Parents of children with cardiac disease and a feeding difficulty reported a significantly more negative mood-state, and significantly longer time associated with feeding, than parents of children in the other two groups. Emerging themes from qualitative analysis of the data suggested that having a child with congenital cardiac disease producing difficulty in feeding had a strong negative impact on the whole family.

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Opportunistic bowel infection after corticosteroid dosage tapering in a stage IV lung cancer patient with tislelizumab‐related colitis

Thoracic Cancer ◽

10.1111/1759-7714.13401 ◽

2020 ◽

Vol 11 (6) ◽

pp. 1699-1702 ◽

Cited By ~ 1

Author(s):

Jun Ni ◽

Xiaotong Zhang ◽

Li Zhang

Keyword(s):

Lung Cancer ◽

Cancer Patient ◽

Lung Cancer Patient ◽

Stage Iv ◽

Corticosteroid Dosage ◽

Stage Iv Lung Cancer

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Torque Teno Virus load in lung cancer patients correlates with age but not with tumor stage

PLoS ONE ◽

10.1371/journal.pone.0252304 ◽

2021 ◽

Vol 16 (6) ◽

pp. e0252304

Author(s):

Dirk Stefani ◽

Balazs Hegedues ◽

Stephane Collaud ◽

Mohamed Zaatar ◽

Till Ploenes ◽

...

Keyword(s):

Lung Cancer ◽

Cancer Patients ◽

Early Stage ◽

Stage Iv ◽

Tumor Stage ◽

Plasma Dna ◽

Early Stage Lung Cancer ◽

Lung Cancer Patients ◽

Stage Iv Lung Cancer ◽

Stage Lung Cancer

Background Torque teno virus (TTV) is a ubiquitous non-pathogenic virus, which is suppressed in immunological healthy individuals but replicates in immune compromised patients. Thus, TTV load is a suitable biomarker for monitoring the immunosuppression also in lung transplant recipients. Since little is known about the changes of TTV load in lung cancer patients, we analyzed TTV plasma DNA levels in lung cancer patients and its perioperative changes after lung cancer surgery. Material and methods Patients with lung cancer and non-malignant nodules as control group were included prospectively. TTV DNA levels were measured by quantiative PCR using DNA isolated from patients plasma and correlated with routine circulating biomarkers and clinicopathological variables. Results 47 patients (early stage lung cancer n = 30, stage IV lung cancer n = 10, non-malignant nodules n = 7) were included. TTV DNA levels were not detected in seven patients (15%). There was no significant difference between the stage IV cases and the preoperative TTV plasma DNA levels in patients with early stage lung cancer or non-malignant nodules (p = 0.627). While gender, tumor stage and tumor histology showed no correlation with TTV load patients below 65 years of age had a significantly lower TTV load then older patients (p = 0.022). Regarding routine blood based biomarkers, LDH activity was significantly higher in patients with stage IV lung cancer (p = 0.043), however, TTV load showed no correlation with LDH activity, albumin, hemoglobin, CRP or WBC. Comparing the preoperative, postoperative and discharge day TTV load, no unequivocal pattern in the kinetics were. Conclusion Our study suggest that lung cancer has no stage dependent impact on TTV plasma DNA levels and confirms that elderly patients have a significantly higher TTV load. Furthermore, we found no uniform perioperative changes during early stage lung cancer resection on plasma TTV DNA levels.

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Dogs are more pessimistic if their owners use two or more aversive training methods

Scientific Reports ◽

10.1038/s41598-021-97743-0 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Rachel A. Casey ◽

Maria Naj-Oleari ◽

Sarah Campbell ◽

Michael Mendl ◽

Emily J. Blackwell

Keyword(s):

Positive Reinforcement ◽

Negative Reinforcement ◽

Mood State ◽

Negative Mood ◽

Domestic Dogs ◽

Matched Pair ◽

Training Methods ◽

Negative Mood State ◽

Judgement Bias ◽

Welfare Implications

AbstractDomestic dogs are trained using a range of different methods, broadly categorised as reward based (positive reinforcement/negative punishment) and aversive based (positive punishment/negative reinforcement). Previous research has suggested associations between use of positive punishment-based techniques and undesired behaviours, but there is little research investigating the relative welfare consequences of these different approaches. This study used a judgement bias task to compare the underlying mood state of dogs whose owners reported using two or more positive punishment/negative reinforcement based techniques, with those trained using only positive reinforcement/negative punishment in a matched pair study design. Dogs were trained to discriminate between rewarded and unrewarded locations equidistant from a start box, and mean latencies recorded. Their subsequent latency to intermediate ‘ambiguous’ locations was recorded as an indication of whether these were perceived as likely to contain food or not. Dogs trained using aversive methods were slower to all ambiguous locations. This difference was significant for latency to the middle (Wilcoxon Z = − 2.380, P = 0.017), and near positive (Wilcoxon Z = − 2.447, P = 0.014) locations, suggesting that dogs trained using coercive methods may have a more negative mood state, and hence that there are welfare implications of training dogs using such methods.

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