scholarly journals Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China

2020 ◽  
Author(s):  
Dongyan Cui ◽  
Yan Hou ◽  
Ling Feng ◽  
Guo Li ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Platelet Count ◽  
Gestational Age ◽  
Reference Interval ◽  
Reference Intervals ◽  
Capillary Blood ◽  
Full Term ◽  
Term Neonates ◽  
First Time ◽  
Early Phases

Abstract Background No consensus has been reached on reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of gender, gestational age and postnatal age on platelet parameters. Methods This study was implemented in 594 healthy full-term neonates from 12 to 84 hours of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th − 97.5th percentiles. Results Capillary reference interval for platelet count was (152–464) × 109/L. No significance was found between gender-divided reference intervals for platelet parameters. The values of platelet count changed significantly across gestational age and postnatal age. Reference intervals for other platelet parameters were affected by these factors to a different extent. Conclusions We established capillary blood reference intervals for platelet parameters in the early phases after birth of full-term neonates in China for the first time.

scholarly journals Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China

2020 ◽  
Author(s):  
Dongyan Cui ◽  
Yan Hou ◽  
Ling Feng ◽  
Guo Li ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Platelet Count ◽  
Gestational Age ◽  
Reference Interval ◽  
Reference Intervals ◽  
Capillary Blood ◽  
Full Term ◽  
Term Neonates ◽  
Prospective Investigation

Abstract Background: No consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of sex, gestational age and postnatal age on platelet parameters.Methods: This study was a prospective investigation and implemented in 594 healthy full-term neonates from 12 to 84 hours of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th –97.5th percentiles.Results: Capillary reference interval for platelet count was (152 - 464) ×109/L. No significance was found between sex-divided reference intervals for platelet parameters. The values of platelet count changed minimally across gestational age (37-41 weeks) and postnatal age (12-84 hours). Reference intervals for other platelet parameters were affected by these factors to a different extent.Conclusions: We established capillary blood reference intervals for platelet parameters in the first days after birth of full-term neonates in China.

scholarly journals Capillary blood reference intervals for platelet parameters in healthy full-term neonates in China

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Dongyan Cui ◽  
Yan Hou ◽  
Ling Feng ◽  
Guo Li ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Platelet Count ◽  
Gestational Age ◽  
Reference Interval ◽  
Reference Intervals ◽  
Capillary Blood ◽  
Full Term ◽  
Term Neonates ◽  
Prospective Investigation

Abstract Background No consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate influences of sex, gestational age and postnatal age on platelet parameters. Methods This study was a prospective investigation and implemented in 594 healthy full-term neonates from 12 to 84 h of age, using SYSMEX XN-9000 haematology automatic analyser by means of capillary blood. Reference intervals for platelet parameters were defined by an interval of 2.5th − 97.5th percentiles. Results Capillary reference interval for platelet count was (152–464) × 109/L. No significance was found between sex-divided reference intervals for platelet parameters. The values of platelet count changed minimally across gestational age (37–41 weeks) and postnatal age (12–84 h). Reference intervals for other platelet parameters were affected by these factors to a different extent. Conclusions We established capillary blood reference intervals for platelet parameters in the first days after birth of full-term neonates in China.

scholarly journals Reference intervals for hematology test parameters from apparently healthy individuals in southwest Ethiopia

2018 ◽  
Vol 6 ◽  
pp. 205031211880762 ◽  
Author(s):  
Lealem Gedefaw Bimerew ◽  
Tesfaye Demie ◽  
Kaleab Eskinder ◽  
Aklilu Getachew ◽  
Shiferaw Bekele ◽  
...  
Keyword(s):  
Platelet Count ◽  
Blood Cell ◽  
White Blood Cell ◽  
Red Blood Cell ◽  
Hematological Parameters ◽  
Age Groups ◽  
Reference Interval ◽  
Reference Intervals ◽  
Southwest Ethiopia ◽  
Apparently Healthy

Background: Clinical laboratory reference intervals are an important tool to identify abnormal laboratory test results. The generating of hematological parameters reference intervals for local population is very crucial to improve quality of health care, which otherwise may lead to unnecessary expenditure or denying care for the needy. There are no well-established reference intervals for hematological parameters in southwest Ethiopia. Objective: To generate hematological parameters reference intervals for apparently healthy individuals in southwest Ethiopia. Methods: A community-based cross-sectional study was conducted involving 883 individuals from March to May 2017. Four milliliter of blood sample was collected and transported to Jimma University Medical Center Laboratory for hematological analysis and screening tests. A hematological parameters were measured by Sysmex XS-500i hematology analyzer (Sysmex Corporation Kobe, Japan). The data were analyzed by SPSS version 20 statistical software. The non-parametric independent Kruskal–Wallis test and Wilcoxon rank-sum test (Mann–Whitney U test) were used to compare the parameters between age groups and genders. The 97.5 percentile and 2.5 percentile were the upper and lower reference limit for the population. Results: The reference interval of red blood cell, white blood cell, and platelet count in children were 4.99 × 1012/L (4.26–5.99 × 1012/L), 7.04 × 109/L (4.00–11.67 × 109/L), and 324.00 × 109/L (188.00–463.50 × 109/L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in adults was 5.19 × 1012/L (4.08–6.33 × 1012/L), 6.35 × 109/L (3.28–11.22 × 109/L), and 282.00 × 109/L (172.50–415.25 × 109/L), respectively. The reference interval of red blood cell, white blood cell, and platelet count in geriatrics were 5.02 × 1012/L (4.21–5.87 × 1012/L), 6.21 × 109/L (3.33–10.03 × 109/L), and 265.50 × 109/L (165.53–418.80 × 109/L), respectively. Most of the hematological parameters showed significant differences across all age groups. Conclusion: Most of the hematological parameters in this study showed differences from similar studies done in the country. This study provided population-specific hematological reference interval for southwest Ethiopians. Reference intervals should also be established in the other regions of the country.

Studies on Reference Intervals for Platelet Counts in Three Cities in China and one in Japan

2002 ◽  
Vol 88 (07) ◽  
pp. 111-114 ◽  
Author(s):  
Changgeng Ruan ◽  
Yun Wu ◽  
Tokuhiro Okada ◽  
Shigemi Motoi ◽  
Tamiaki Kondo ◽  
...  
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Healthy Subjects ◽  
Hematological Parameters ◽  
Reference Interval ◽  
Reference Intervals ◽  
Sichuan Province ◽  
Jiangsu Province ◽  
Platelet Volume ◽  
Platelet Counts

SummaryHematological parameters including platelet counts, etc. were determined in 1,140 healthy subjects living in four cities: Suzhou (Jiangsu Province), Chengdu (Sichuan Province) and Harbin (Heilongjang Province) in China, and Kobe in Japan. Then, the reference intervals for platelet counts were calculated and compared. The reference interval for platelet count of subjects aged between 18 and 60 years was 60-259 × 109/L in Suzhou and 52–202 × 109/L in Chengdu, and subjects with platelet counts of 100 × 109/L or less accounted for about 30% of the subjects examined in these cities. The reference intervals in Harbin and Kobe were within the range of 150–350 × 109/L, and no subject having a platelets count of 100 × 109/L or less was detected. Mean platelet volume (MPV) determined concurrently was negatively correlated with platelet count, and the reference intervals for MPV in Chengdu and Suzhou were higher than those in Harbin and Kobe.

Hypoglycaemia and seizures in large-for-gestational-age (LGA) full-term neonates

2007 ◽  
Vol 95 (7) ◽  
pp. 874-876
Author(s):  
Floris Groenendaal ◽  
Patty M. Elferink-Stinkens ◽  
Keyword(s):  
Gestational Age ◽  
Full Term ◽  
Large For Gestational Age ◽  
Term Neonates

Clot formation of neonates tested by thromboelastography correlates with gestational age

2010 ◽  
Vol 103 (02) ◽  
pp. 344-350 ◽  
Author(s):  
Tzipi Strauss ◽  
Yael Levy-Shraga ◽  
Bruria Ravid ◽  
Irit Schushan-Eisen ◽  
Ayala Maayan-Metzger ◽  
...  
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Blood Clot ◽  
Full Term ◽  
Clot Formation ◽  
Clotting Time ◽  
Term Infants ◽  
Term Neonates ◽  
Pregnancy And Delivery ◽  
Clot Formation Time

SummaryEvaluation of clot formation in neonates is troublesome. Our aim was to investigate cord blood clot formation of pre-term versus full-term infants and adults, using rotating thromboelastogram (ROTEM®, Pentafarm, Munich, Germany). ROTEM was investigated in cord blood of 184 full-term and 47 pre-term infants. Measurements of the clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) were obtained in order to asses reference values for this age group, and compare between full-term and pre-term neonates and compared to adult controls. For each infant demographic information and data regarding pregnancy and delivery were gathered. Infants were prospectively followed until discharge. CT and CFT were significantly shorter among pre-term and term infants as compared to adults [median CT: 185, 194, 293 seconds respectively, p≤0.001, CFT: 80, 76, 103 seconds respectively, p≤0.001). MCF was lower in pre-term and term as compared to adults (p≤0.001) with significantly lower values in pre-term as compared to full-term neonates (p=0.004). Clotting time and MCF correlated with gestational age (R=0.132, p=0.045, R= 0.259, p<0.001, respectively). No association was found between any ROTEM values and the occurrence of post-natal complications in infants of our study group. This is the first study assessing clot formation by ROTEM in pre-term infants. Clot formation parameters of term and premature infants correlated with gestational age. The predictive value of clot formation tests in neonates deserves further attention.

scholarly journals Effect of early and delayed cord clamping on hemoglobin and hematocrit among full term neonates.

2021 ◽  
Vol 28 (08) ◽  
pp. 1114-1119
Author(s):  
Saqib Aslam ◽  
◽  
Sadaf Minhas ◽  
Muhammad Azhar Farooq ◽  
Beenish Bashir Mughal ◽  
...  
Keyword(s):  
Birth Weight ◽  
Gestational Age ◽  
Full Term ◽  
P Value ◽  
Delayed Cord Clamping ◽  
Term Neonates ◽  
Cord Clamping ◽  
Significant Difference ◽  
Early Cord Clamping ◽  
The Mean

Objective: To compare the mean hemoglobin levels and frequency of polycythemia in full term neonates after early and delayed cord clamping. Study Design: Randomized Controlled Trial. Setting: KRL General Hospital Islamabad (Labor Room/ Neonatology). Periods: December 2017 to June 2018. Material & Methods: 190 full term neonates were selected and divided into 2 equal groups randomly: Early cord clamping group after delivery and late cord clamping group. Two hours after clamping the venous blood samples were taken for the hemoglobin and hematocrit levels. Mean and standard deviation were calculated for gestational age, birth weight, hemoglobin and hematocrit. Frequency and proportions were calculated for gender and polycythemia. Results: Mean gestational age of the mothers was 39.27 ± 1.50 weeks. Of 190 neonates, 91 (47.9%) were males, 99 (52.1%) were females. Mean birth weight was 3.64 ± 0.72 kg while mean Hb and HCT levels were 16.07 ± 2.30 g/dl and 63.26 ± 5.32% respectively. Keeping cut off value of 13.5 g/dl of Hb to label anemia or no, 35 (18.4%) neonates were anemic in this study. The polycythemia (HCT >65%) was present in 72 (37.9%) of neonates. There was no difference between groups in terms of gender, anemia, gestational age and birth weight (p values 0.663, 0.852, 0.700 and 0.491 respectively). The distribution of polycythemia was different among groups (p value 0.007). The mean hemoglobin level in group A was 15.52 ± 1.90 g/dl while in group B it was 16.62 ± 2.53 g/dl (p value 0.001). Mean Hb levels were statistically not different among some of the groups (gestational age <40 weeks, birth weight <4 kg) while HCT levels are significantly different among male group and category of birth weight >4 kg. Rest of the stratification groups showed significant difference. Conclusion: The delayed cord clamping in neonates results in increased mean hemoglobin and hematocrit levels with increased frequency of polycythemia as compared to early cord clamping.

Newborn: First Stool and Urine

1994 ◽  
Vol 15 (8) ◽  
pp. 319-320
Keyword(s):  
Intestinal Obstruction ◽  
Magnesium Sulfate ◽  
Imperforate Anus ◽  
Hirschsprung Disease ◽  
Well Being ◽  
Full Term ◽  
Maternal History ◽  
Term Neonates ◽  
First Time

Passage of the first stool and urine in full-term neonates within the first 24 hours of life usually is a sign of well-being. After birth, 60% of healthy full-term neonates "stool" for the first time by 8 hours of life, 91% by 16 hours, 98.5% by 24 hours, and virtually all by 48 hours. Delay in the passage of the first stool in term neonates may be associated with lower intestinal obstruction, that is, meconium plug syndrome, Hirschsprung disease, and imperforate anus. More generalized problems such as sepsis or hypothyroidism should be considered and the maternal history should be reviewed carefully for an unanticipated complication of magnesium sulfate administration or narcotic use.

scholarly journals Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis

2015 ◽  
Vol 43 (5) ◽  
Author(s):  
Joerg C. Schefold ◽  
Linn Porz ◽  
Barbara Uebe ◽  
Holger Poehlmann ◽  
Stephan von Haehling ◽  
...  
Keyword(s):  
Gestational Age ◽  
Human Leukocyte ◽  
Severe Infection ◽  
Full Term ◽  
Term Neonates ◽  
Observational Analysis ◽  
Leukocyte Antigen ◽  
Hla Dr ◽  
Leukocyte Counts ◽  
Antigen Presenting

AbstractThe risk of neonates for severe infection/sepsis is reciprocally proportional to gestational age and birth weight. As monocytes and dendritic cells (DC) are recognised key antigen-presenting immune cells, we aimed to elucidate whether neonatal age is associated with reduced expression of human-leukocyte antigen-DR (HLA-DR) antigens on subsets of monocytes and DCs.Forty-three consecutive neonates (20 male, mean gestational age 236.0±26.8 days; mean 1-min Apgar score 7.5±2.0) were included in a monocentric prospective observational analysis. Patients were grouped according to gestational age (n=15 full-term, n=28 pre-term defined as <33 weeks). Ten healthy adult volunteers were assessed also. Flow-cytometric assessment of HLA-DR expression was performed in subsets of peripheral blood myeloid and plasmacytoid DCs (MDC and PDC) and monocytes (CD14At birth, leukocyte counts were increased in full-term neonates. Monocyte counts were significantly increased in neonates when compared with adults (all P<0.05). A significant numerical increase of CD14We observed a markedly diminished HLA-DR expression on monocyte and DC subsets in pre-term and full-term neonates, which may contribute to impaired antimicrobial defence mechanisms in the early days of life.

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