Clot formation of neonates tested by thromboelastography correlates with gestational age

2010 ◽  
Vol 103 (02) ◽  
pp. 344-350 ◽  
Author(s):  
Tzipi Strauss ◽  
Yael Levy-Shraga ◽  
Bruria Ravid ◽  
Irit Schushan-Eisen ◽  
Ayala Maayan-Metzger ◽  
...  
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Blood Clot ◽  
Full Term ◽  
Clot Formation ◽  
Clotting Time ◽  
Term Infants ◽  
Term Neonates ◽  
Pregnancy And Delivery ◽  
Clot Formation Time

SummaryEvaluation of clot formation in neonates is troublesome. Our aim was to investigate cord blood clot formation of pre-term versus full-term infants and adults, using rotating thromboelastogram (ROTEM®, Pentafarm, Munich, Germany). ROTEM was investigated in cord blood of 184 full-term and 47 pre-term infants. Measurements of the clotting time (CT), clot formation time (CFT) and maximal clot firmness (MCF) were obtained in order to asses reference values for this age group, and compare between full-term and pre-term neonates and compared to adult controls. For each infant demographic information and data regarding pregnancy and delivery were gathered. Infants were prospectively followed until discharge. CT and CFT were significantly shorter among pre-term and term infants as compared to adults [median CT: 185, 194, 293 seconds respectively, p≤0.001, CFT: 80, 76, 103 seconds respectively, p≤0.001). MCF was lower in pre-term and term as compared to adults (p≤0.001) with significantly lower values in pre-term as compared to full-term neonates (p=0.004). Clotting time and MCF correlated with gestational age (R=0.132, p=0.045, R= 0.259, p<0.001, respectively). No association was found between any ROTEM values and the occurrence of post-natal complications in infants of our study group. This is the first study assessing clot formation by ROTEM in pre-term infants. Clot formation parameters of term and premature infants correlated with gestational age. The predictive value of clot formation tests in neonates deserves further attention.

Neonatal Polycythemia: I. Early Diagnosis and Incidence Relating to Time of Sampling

PEDIATRICS ◽  
1984 ◽  
Vol 73 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Mordechai Shohat ◽  
Paul Merlob ◽  
Salomon H. Reisner
Keyword(s):  
Early Diagnosis ◽  
Cord Blood ◽  
Gestational Age ◽  
Linear Correlation ◽  
Blood Viscosity ◽  
Full Term ◽  
Peripheral Vein ◽  
Dynamic Changes ◽  
Term Infants ◽  
Appropriate For Gestational Age

The dynamic changes occurring in hematocrit and blood viscosity within the first 18 hours of life were studied in 50 full-term infants who were vaginally delivered and had weight appropriate for gestational age. In all cases, the cord was clamped within 30 seconds and cord blood was collected from the vein and artery. Subsequently, samples were taken from a peripheral vein at ages 15 minutes, and 2, 4, 6, and between 12 to 18 hours. Both the Hct and blood viscosity reach their peak at age 2 hours. The incidence of neonatal polycythemia varied greatly with age. Thus at the age of 2 hours, ten infants (20%) were polycythemic, whereas by age 6 hours only six (12%) of these infants were still polycythemic and by age 12 to 18 hours only one infant (2%) was polycythemic. A linear correlation was found between cord Hct levels and peripheral venous Hct levels by age 2 hours. None of the infants with cord blood Hct levels ≤56% had developed polycythemia, whereas ten of the 12 infants with cord Hct levels &gt;56% developed polycythemia. In this particular group of infants, cord blood Hct levels may be used for the screening of neonatal polycythemia.

scholarly journals Comparative clinical study of preterm and full-term newborn neonatal seizures

2006 ◽  
Vol 64 (1) ◽  
pp. 45-50 ◽  
Author(s):  
Manoel R.R. Holanda ◽  
Áurea N. de Melo
Keyword(s):  
Gestational Age ◽  
Full Term ◽  
Test Results ◽  
Neonatal Seizures ◽  
Term Infants ◽  
Term Neonates ◽  
Exact Test ◽  
Comparative Clinical Study ◽  
Clonic Seizures ◽  
A Prospective Study

OBJECTIVE: To compare the characteristics of neonatal seizures between preterm and full-term infants in intensive care unit. METHOD: A prospective study was developed with 104 high-risk newborn, 30 preterm and 74 full-term infants, with clinical seizures. The dependent variable was gestational age. Statistical analyses: Fisher's exact test, odds-ratio and Mann Witney U test. RESULTS: There were significant differences (p<0.05): i) premature neonates develop neonatal seizures later, probably related to the etiologies of the seizures; ii) etiologically, there is a predominance of peri-intraventricular hemorrhage in preterm and of asphyxia in full term neonates; iii) clonic seizures are most frequent in preterm and subtle seizures in full term neonates. CONCLUSION: Although the study had a clinical basis, it was possible to identify differences when the dependent variable was gestational age.

Reference ranges of thromboelastometry in healthy full-term and pre-term neonates

2017 ◽  
Vol 55 (10) ◽  
Author(s):  
Rozeta Sokou ◽  
Leontini Foudoulaki-Paparizos ◽  
Theodore Lytras ◽  
Aikaterini Konstantinidi ◽  
Martha Theodoraki ◽  
...  
Keyword(s):  
Reference Values ◽  
Full Term ◽  
Reference Ranges ◽  
Term Infants ◽  
Term Neonates ◽  
Blood Samples ◽  
Arterial Blood ◽  
Significant Difference ◽  
Peripheral Arterial ◽  
Clot Formation Time

AbstractBackground:Rotational thromboelastometry (ROTEM) is an attractive method for rapid evaluation of hemostasis in neonates. Currently, no reference values exist for ROTEM assays in full-term and pre-term neonates. Our aim was to establish reference ranges for standard extrinsically activated ROTEM assay (EXTEM) in arterial blood samples of healthy full-term and pre-term neonates.Methods:In the present study, EXTEM assay was performed in 198 full-term (≥37 weeks’ gestation) and 84 pre-term infants (<37 weeks’ gestation) using peripheral arterial whole blood samples.Results:Median values and reference ranges (2.5th and 97.5th percentiles) for the following main parameters of EXTEM assay were determined in full-term infants: clotting time (seconds), 41 (range, 25.9–78); clot formation time (seconds), 70 (range, 40–165.2); maximum clot firmness (mm), 66 (range, 41–84.1); lysis index at 60 min (LI60, %), 97 (range, 85–100). The only parameter with a statistically significant difference between full-term and pre-term neonates was LI60 (p=0.006). Furthermore, it was inversely correlated with gestational age (p=0.002) and birth weight (p=0.016) in pre-term neonates.Conclusions:In conclusion, an enhanced fibrinolytic activity in pre-term neonates was noted. For most EXTEM assay parameters, reference ranges obtained from arterial newborn blood samples were comparable with the respective values from studies using cord blood. Modified reagents, small size samples, timing of sampling, and different kind of samples might account for any discrepancies among similar studies. Reference values hereby provided can be used in future studies.

Cord Blood Alkaline Phosphatase as a predictor of Neonatal Jaundice in full term neonates

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Samah Esmail ◽  
Ali Abdo ◽  
Sherief Elgebaly ◽  
Marwa Mostafa
Keyword(s):  
Alkaline Phosphatase ◽  
Cord Blood ◽  
Neonatal Jaundice ◽  
Full Term ◽  
Term Neonates

Growth Hormone and Insulin-Like Growth Factor I Levels in Maternal Blood and the Cord Blood of Full-Term Infants

1989 ◽  
Vol 78 (s349) ◽  
pp. 145-145
Author(s):  
S. HATEMI ◽  
H.H. HATEMI ◽  
C. GULBABA ◽  
T. GULBABA ◽  
H. BOZKURT ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Cord Blood ◽  
Maternal Blood ◽  
Full Term ◽  
Insulin Like Growth Factor ◽  
Term Infants ◽  
Factor I ◽  
Growth Factor I

scholarly journals Newborn Screening for Severe Combined Immunodeficiency: Do Preterm Infants Require Special Consideration?

2021 ◽  
Vol 7 (3) ◽  
pp. 40
Author(s):  
Anne E. Atkins ◽  
Michael F. Cogley ◽  
Mei W. Baker
Keyword(s):  
Newborn Screening ◽  
Premature Infant ◽  
Gestational Age ◽  
Linear Regression Analysis ◽  
Severe Combined Immunodeficiency ◽  
Cell Receptor ◽  
Full Term ◽  
Combined Immunodeficiency ◽  
Term Infants ◽  
Preterm Newborns

The Wisconsin Newborn Screening (NBS) Program began screening for severe combined immunodeficiency (SCID) in 2008, using real-time PCR to quantitate T-cell receptor excision circles (TRECs) in DNA isolated from dried blood NBS specimens. Prompted by the observation that there were disproportionately more screening-positive cases in premature infants, we performed a study to assess whether there is a difference in TRECs between full-term and preterm newborns. Based on de-identified SCID data from 1 January to 30 June 2008, we evaluated the TRECs from 2510 preterm newborns (gestational age, 23–36 weeks) whose specimens were collected ≤72 h after birth. The TRECs from 5020 full-term newborns were included as controls. The relationship between TRECs and gestational age in weeks was estimated using linear regression analysis. The estimated increase in TRECs for every additional week of gestation is 9.60%. The 95% confidence interval is 8.95% to 10.25% (p ≤ 0.0001). Our data suggest that TRECs increase at a steady rate as gestational age increases. These results provide rationale for Wisconsin’s existing premature infant screening procedure of recommending repeat NBS following an SCID screening positive in a premature infant instead of the flow cytometry confirmatory testing for SCID screening positives in full-term infants.

scholarly journals Visual function and fine-motor control in small-for-gestational age infants

2004 ◽  
Vol 62 (4) ◽  
pp. 955-962 ◽  
Author(s):  
Heloisa G.R.G. Gagliardo ◽  
Vanda M.G. Gonçalves ◽  
Maria Cecilia M.P. Lima ◽  
Maria de Fatima de C. Francozo ◽  
Abimael Aranha Netto
Keyword(s):  
Motor Control ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Visual Function ◽  
Infant Development ◽  
Full Term ◽  
Fine Motor ◽  
Genetic Syndromes ◽  
Fine Motor Control ◽  
Term Infants

OBJECTIVE: To compare visual function and fine-motor control of full-term infants small-for-gestational age (SGA) and appropriate for gestational age (AGA), in the first three months. METHOD: We evaluated prospectively 31 infants in the 1st month; 33 in the 2nd and 34 infants in the 3rd month, categorized as full-term; birth weight less than 10th percentile for SGA and 25th to 90th percentile for the AGA group. Genetic syndromes, infections, multiple congenital malformations were excluded. The Bayley Scales of Infant Development-II were used, especially items related to visual function and to fine-motor control outcomes. RESULTS: The Motor Index Score (IS) was significantly lower in the SGA group in the 2nd month. The items "attempts to bring hands to mouth", in the 1st month and "reaches for suspended ring", in the 3rd month showed higher frequency in the SGA group. CONCLUSION: The Motor IS was lower in the 2nd month and items of fine-motor control in the 1st month and in the 3rd month showed higher frequency in the SGA group.

scholarly journals External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Malia SQ Murphy ◽  
Steven Hawken ◽  
Wei Cheng ◽  
Lindsay A Wilson ◽  
Monica Lamoureux ◽  
...  
Keyword(s):  
Cord Blood ◽  
Gestational Age ◽  
Age Estimation ◽  
External Validation ◽  
Population Level ◽  
Average Deviation ◽  
Term Infants ◽  
Data Set ◽  
Heel Prick ◽  
Gestational Age Estimation

This study sought to evaluate the performance of metabolic gestational age estimation models developed in Ontario, Canada in infants born in Bangladesh. Cord and heel prick blood spots were collected in Bangladesh and analyzed at a newborn screening facility in Ottawa, Canada. Algorithm-derived estimates of gestational age and preterm birth were compared to ultrasound-validated estimates. 1036 cord blood and 487 heel prick samples were collected from 1069 unique newborns. The majority of samples (93.2% of heel prick and 89.9% of cord blood) were collected from term infants. When applied to heel prick data, algorithms correctly estimated gestational age to within an average deviation of 1 week overall (root mean square error = 1.07 weeks). Metabolic gestational age estimation provides accurate population-level estimates of gestational age in this data set. Models were effective on data obtained from both heel prick and cord blood, the latter being a more feasible option in low-resource settings.

Alveolar Macrophages in Perinatal Infants

PEDIATRICS ◽  
1984 ◽  
Vol 74 (2) ◽  
pp. 221-223 ◽  
Author(s):  
Elizabeth Alenghat ◽  
John R. Esterly
Keyword(s):  
Gestational Age ◽  
Alveolar Macrophages ◽  
Full Term ◽  
Postnatal Life ◽  
Term Infants ◽  
Pulmonary Lesions ◽  
Neonatal Lung

The presence of alveolar macrophages in the neonatal lung at the time of autopsy is correlated with the presence of pulmonary lesions and with the duration of postnatal life. Alveolar macrophages were noted at 20 weeks of gestation in infants with congenital pneumonia, but were not present in most full-term infants who were stillborn. They were found in nearly all infants who survived for 48 hours irrespective of pulmonary lesions or gestational age.

Sign in / Sign up

Export Citation Format

Share Document