scholarly journals The genetic variants of LINC-PINT are related to head and neck squamous cell carcinoma susceptibility in Chinese population

2021 ◽  
Author(s):  
Jincai Xue ◽  
Fang Dong ◽  
Tianchang Wang ◽  
Qinjiang Liu ◽  
Jun Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Case Control Study ◽  
Neck Squamous Cell Carcinoma ◽  
Increased Risk ◽  
The Relationship ◽  
Control Study ◽  
Increased Susceptibility

Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is the most leading incident tumor worldwide. Genetic factors act crucial role in the HNSCC progression. Our study is intent to explore the correlation of LINC-PINT polymorphism with the risk of HNSCC in Chinese population.Methods: The case-control study (including 537 HNSCC cases and 533 controls) was performed to determine the relationship between LINC-PINT polymorphisms and HNSCC susceptibility. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to determine the associations.Results: The current study indicated that rs157916 and rs7781295 in the LINC-PINT gene have a strong significant correlation with HNSCC risk (OR 1.32, p = 0.042; OR 1.31, p = 0.016). Stratification analyses showed that rs157916 is related to the increased risk of HNSCC in age ≤ 46 years (OR 1.56, p = 0.029). Rs157916, rs16873842, rs7801029, and rs7781295 exhibited an enhanced risk of HNSCC in men (OR 1.82, p = 0.004; OR 1.61, p = 0.028; OR 1.53, p = 0.047; OR 1.62, p = 0.021). Besides, we found that rs16873842 significantly increased the risk of Nasopharyngeal SCC (OR 4.04, p = 0.015). Rs157916 (OR 1.39, p = 0.028) and rs7781295 (OR 1.30, p = 0.028) had a high susceptibility to Thyroid SCC.Conclusions: This research indicated that polymorphisms in the LINC-PINT gene are significantly associated with an increased susceptibility to HNSCC, which suggest that LINC-PINT polymorphisms have a significant role in prevention and diagnosis of HNSCC.

scholarly journals A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma

2009 ◽  
Vol 2 (8) ◽  
pp. 759-768 ◽  
Author(s):  
Caihua Liang ◽  
Michael D. McClean ◽  
Carmen Marsit ◽  
Brock Christensen ◽  
Edward Peters ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Case Control Study ◽  
Marijuana Use ◽  
Population Based ◽  
Case Control ◽  
Neck Squamous Cell Carcinoma ◽  
Control Study

Head and neck squamous cell carcinoma (HNSCC) in non-at risk patients: A case control study

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5583-5583
Author(s):  
F. Peyrade ◽  
E. Chamorey ◽  
H. Raybaud ◽  
O. Dassonville ◽  
R. J. Bensadoun ◽  
...  
Keyword(s):  
At Risk ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Case Control Study ◽  
Case Control ◽  
Neck Squamous Cell Carcinoma ◽  
Risk Patients ◽  
Control Study

Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: A case–control study

Oral Oncology ◽  
2007 ◽  
Vol 43 (4) ◽  
pp. 345-351 ◽  
Author(s):  
Kai-Ping Chang ◽  
Sheng-Po Hao ◽  
Chun-Ting Liu ◽  
Ming-Huei Cheng ◽  
Yu-Liang Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Case Control Study ◽  
Case Control ◽  
Neck Squamous Cell Carcinoma ◽  
Promoter Polymorphisms ◽  
Control Study

Head and neck squamous cell carcinoma (HNSCC) in non-at risk patients: A case control study

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5583-5583
Author(s):  
F. Peyrade ◽  
E. Chamorey ◽  
H. Raybaud ◽  
O. Dassonville ◽  
R. J. Bensadoun ◽  
...  
Keyword(s):  
At Risk ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Case Control Study ◽  
Case Control ◽  
Neck Squamous Cell Carcinoma ◽  
Risk Patients ◽  
Control Study

Patient Choice of Nonsurgical Treatment Contributes to Disparities in Head and Neck Squamous Cell Carcinoma

2018 ◽  
Vol 158 (6) ◽  
pp. 1057-1064 ◽  
Author(s):  
Harman S. Parhar ◽  
Donald W. Anderson ◽  
Arif S. Janjua ◽  
J. Scott Durham ◽  
Eitan Prisman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Patient Choice ◽  
Nonsurgical Treatment ◽  
Neck Squamous Cell Carcinoma ◽  
Primary Surgery ◽  
Increased Risk ◽  
Risk Of Cancer

Objectives There are well-established outcome disparities among different demographic groups with head and neck squamous cell carcinoma (HNSCC). We aimed to investigate the potential contribution of patient choice of nonsurgical treatment to these disparities by estimating the rate of this phenomenon, identifying its predictors, and estimating the effect on cancer-specific survival. Study Design Retrospective nationwide analysis. Settings Surveillance, Epidemiology, and End Results Database (2004-2014). Subjects and Methods Patients with HNSCC, who were recommended for primary surgery, were included. Multivariable logistic regression was used to identify demographic and clinical factors associated with patient choice of nonsurgical treatment, and Kaplan Meier/Cox regression was used to analyze survival. Results Of 114,506 patients with HNSCC, 58,816 (51.4%) were recommended for primary surgery, and of those, 1550 (2.7%) chose nonsurgical treatment. Those who chose nonsurgical treatment were more likely to be older (67.1 ± 12.6 vs 63.6 ± 13.1, P < .01), were of Black (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.28-1.74) or Asian (OR = 1.79; 95% CI, 1.46-2.20) ethnicity, were unmarried (OR married, 0.50; 95% CI, 0.44-0.58), had an advanced tumor, and had a hypopharyngeal or laryngeal primary. Choice of nonsurgical treatment imparted a 2.16-fold (95% CI, 2.02-2.30) increased risk of cancer-specific death. Conclusion Of the patients, 2.7% chose nonsurgical treatment despite a provider recommendation that impairs survival. Choice of nonsurgical treatment is associated with older age, having Black or Asian ethnicity, being unmarried, having an advanced stage tumor, and having a primary site in the hypopharynx or larynx. Knowledge of these disparities may help providers counsel patients and help patients make informed decisions.

Molecular Markers in Head and Neck Squamous Cell Carcinoma: Their Biological Function and Prognostic Significance

2001 ◽  
Vol 110 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Benjamin D. Smith ◽  
Bruce G. Haffty ◽  
Clarence T. Sasaki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Biological Function ◽  
Prognostic Significance ◽  
Growth Factor Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
Increased Risk

Head and neck squamous cell carcinoma affects more than 500,000 people worldwide each year. Despite optimal treatment with surgery, irradiation, and chemotherapy, disease recurrence and progression remains a common and challenging oncological problem. Recently, interest has developed in identifying novel molecular markers that allow identification of those patients at increased risk for locoregional recurrence and death. This article reviews several such molecular markers studied in head and neck cancer, including p53, angiogenesis-related markers, cyclin D1, and epidermal growth factor receptor. The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field.

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