scholarly journals Dose Effect of Caffeine Ingestion on Cardiac Parasympathetic Reactivation Following an Acute Bout of Anaerobic Performance Exercise in Recreational Athletes

2020 ◽  
Author(s):  
Amir Sarshin ◽  
Alireza Naderi ◽  
Carlos Janssen Gomes da Cruz ◽  
Foad Feizolahi ◽  
Scott C. Forbes ◽  
...  
Keyword(s):  
Anaerobic Exercise ◽  
Dose Effect ◽  
Secondary Outcome ◽  
Autonomic Reactivity ◽  
Double Blind ◽  
Caffeine Ingestion ◽  
Post Exercise ◽  
Recreational Athletes ◽  
Parasympathetic Reactivation ◽  
Post Exercise Recovery

Abstract Background: To examine the dose effects of caffeine ingestion on autonomic reactivation following anaerobic exercise. Methods: Recreationally active males (N=20; 24±2y) participated in a randomized, double-blind, placebo-controlled, crossover study where participants ingested: (1) Control (CON; no supplement), (2) a non-caffeinated placebo (PLA), (3) 3-mg∙kg-1 of caffeine (CAF3) or (4) 6-mg∙kg-1 of caffeine (CAF6) prior to a Wingate testing. Parasympathetic (lnRMSSD, primary outcome) and global HRV (lnSDNN, secondary outcome) were assessed at rest (i.e., pre-ingestion), 45-min post-ingestion, and 5-min and 35-min post-exercise recovery. We used a GLM to assess mean (95% CI) changes from pre-ingestion baseline.Results: Overall, we observed a significant trend for lnRMSSD and lnSDNN (both, p=0.001, ηp2=0.745). Forty-five minutes after treatment ingestion, we observed a significant increase in lnRMSSD for CAF3 (0.15ms, 95%CI, 0.07,0.24) and CAF6 (0.16ms, 95%CI, 0.06,0.25), both being significant (both, p<0.004) vs. CON (-0.02ms, 95%CI, -0.09,0.04). Five-minutes after exercise, all treatments demonstrated significant declines in lnRMSSD vs. baseline (all, p<0.001). After 35-min of recovery, lnRMSSD returned to a levels not significantly different than baseline for CAF3 (0.03ms, 95%CI, -0.05, 0.12) and CAF6 (-0.03ms, 95%CI, -0.17, 0.10), while PLA (-0.16ms, 95%CI, -0.25, -0.06) and CON (-0.17ms, 95%CI, -0.28, -0.07) treatments remained significantly depressed. A similar pattern was also observed for SDNNConclusion: Caffeine ingestion increases resting cardiac autonomic modulation and accelerates post-exercise autonomic recovery after a bout of anaerobic exercise test in recreationally active young men. However, no differences between caffeine doses on cardiac autonomic reactivity were observed.

scholarly journals The effects of varying doses of caffeine on cardiac parasympathetic reactivation following an acute bout of anaerobic exercise in recreational athletes

2020 ◽  
Author(s):  
Amir Sarshin ◽  
Alireza Naderi ◽  
Carlos Janssen Gomes da Cruz ◽  
Foad Feizolahi ◽  
Scott C. Forbes ◽  
...  
Keyword(s):  
Anaerobic Exercise ◽  
Secondary Outcome ◽  
Autonomic Reactivity ◽  
Double Blind ◽  
Caffeine Ingestion ◽  
Post Exercise ◽  
Acute Bout ◽  
Recreational Athletes ◽  
Parasympathetic Reactivation ◽  
Post Exercise Recovery

Abstract Background: To examine the effects of varying doses of caffeine on autonomic reactivation following anaerobic exercise. Methods: Recreationally active males (N=20; 24±2y) participated in a randomized, double-blind, placebo-controlled, crossover study where participants ingested: (1) Control (CON; no supplement), (2) a non-caffeinated placebo (PLA), (3) 3-mg∙kg-1 of caffeine (CAF3) or (4) 6-mg∙kg-1 of caffeine (CAF6) prior to Wingate testing. Parasympathetic (lnRMSSD, primary outcome) and global HRV (lnSDNN, secondary outcome) were assessed at rest (i.e., pre-ingestion), 45-min post-ingestion, and 5-min and 35-min post-exercise recovery. We used a GLM to assess mean (95% CI) changes from pre-ingestion baseline.Results: Overall, we observed a significant trend for lnRMSSD and lnSDNN (both, p=0.001, ηp2=0.745). Forty-five minutes after treatment ingestion, we observed a significant increase in lnRMSSD for CAF3 (0.15ms, 95%CI, 0.07,0.24) and CAF6 (0.16ms, 95%CI, 0.06,0.25), both being significant (both, p<0.004) vs. CON (-0.02ms, 95%CI, -0.09,0.04). Five-minutes after exercise, all treatments demonstrated significant declines in lnRMSSD vs. baseline (all, p<0.001). After 35-min of recovery, lnRMSSD returned to a levels not significantly different than baseline for CAF3 (0.03ms, 95%CI, -0.05, 0.12) and CAF6 (-0.03ms, 95%CI, -0.17, 0.10), while PLA (-0.16ms, 95%CI, -0.25, -0.06) and CON (-0.17ms, 95%CI, -0.28, -0.07) treatments remained significantly depressed. A similar pattern was also observed for SDNN.Conclusion: Caffeine ingestion increases resting cardiac autonomic modulation and accelerates post-exercise autonomic recovery after a bout of an anaerobic exercise test in recreationally active young men. However, no differences between caffeine doses on cardiac autonomic reactivity were observed.

scholarly journals Effect of topiramate on eating behaviours in Prader-Willi syndrome: TOPRADER double-blind randomised placebo-controlled study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Angèle Consoli ◽  
Sophie Çabal Berthoumieu ◽  
Marie Raffin ◽  
Denise Thuilleaux ◽  
Christine Poitou ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Primary Outcome ◽  
Dose Effect ◽  
Secondary Outcome ◽  
Controlled Study ◽  
Prader Willi Syndrome ◽  
Eating Behaviours ◽  
Behavioural Disorders ◽  
Double Blind ◽  
Effect Relationship

Abstract Prader–Willi Syndrome (PWS) is a rare genetic syndrome leading to severe behavioural disorders and mild cognitive impairment. The objective of this double-blind randomised placebo-controlled trial was to study the efficacy and tolerance of topiramate on behavioural disorders in patients with PWS. Participants (aged 12–45 years) had genetically confirmed PWS and severe irritability/impulsivity, eating disorders and/or obesity, and skin picking. Thirty-two participants received a placebo (PBO), and 30 participants received topiramate (TOP) (50–200 mg/day) for 8 weeks. The primary outcome was the rate of responders using the Clinical Global Impression-Improvement (CGI-I) scale. The secondary outcome measures included the Aberrant Behaviour Checklist, the Dykens Hyperphagia Questionnaire (DHK), the Self-Injurious Behaviour Scale (SIBS) and the body mass index (BMI). We found no significant difference in the primary outcome (the CGI-I): 9 (30%) patients were very much or much improved in the TOP group compared to 7 (22.6%) patients in the PBO group. However, the DHK behaviour and severity scores improved significantly more over time in patients treated with topiramate versus those receiving a placebo, with a significant dose–effect relationship. DHK scores were also significantly associated with genetic subtypes and hospitalisation status. The effects of topiramate on eating behaviours remained significant after adjusting for genetic subtype and hospitalisation. Topiramate had therefore a significant effect on eating disorders, with a dose–effect relationship. Given the burden of eating disorders in PWS, we believe that topiramate may become the first psychotropic option within the global care of obesity in individuals with PWS.

scholarly journals Effect of Carbohydrate Intake during Recovery from Eccentric Exercise on Interleukin-6 and Muscle-Damage Markers

2007 ◽  
Vol 17 (6) ◽  
pp. 507-520 ◽  
Author(s):  
Mary P. Miles ◽  
Sherri D. Pearson ◽  
Jan M. Andring ◽  
Jessy R. Kidd ◽  
Stella L. Volpe
Keyword(s):  
Muscle Damage ◽  
Muscle Soreness ◽  
Force Production ◽  
Double Blind ◽  
Post Exercise ◽  
Carbohydrate Supplementation ◽  
Reactive Protein ◽  
Arm Circumference ◽  
Post Exercise Recovery ◽  
Glycogen Stores

The purpose of this investigation was to determine whether carbohydrate supplementation during the frst 2 d post exercise recovery influenced the inflammation (IL-6, C-reactive protein [CRP], and cortisol) and muscle-damage responses. Eight participants performed a high-force eccentric elbow-fexion exercise to induce muscle soreness and inflammation and then consumed carbohydrate (0.25 g·kg−1·h−1) or an equal volume of placebo during hours 0–12 and 24–36 post exercise in a double-blind, crossover protocol. Muscle soreness; mid brachial arm circumference; blood glucose, IL-6, CRP, cortisol, and creatine-kinase (CK) activity; and maximal force production were measured pre exercise and 4, 8, 12, 24, 48, and 120 h post exercise. Plasma IL-6 increased, F(5) = 5.27, P < 0.05, 8 h post exercise, with no difference between carbohydrate and placebo conditions. Changes in muscle soreness, arm circumference, strength, and serum CK activity were consistent with small amounts of muscle damage and did not differ between conditions. The authors conclude that carbohydrate supplementation during recovery from soreness-inducing exercise does not influence the delayed IL-6 response temporally linked to inflammation or indications of muscle damage. Thus, increased carbohydrate consumption at levels consistent with recommendations for replenishing glycogen stores does not impair or promote the immune and muscle responses.

Dose Effect of Caffeine on Testosterone and Cortisol Responses to Resistance Exercise

2008 ◽  
Vol 18 (2) ◽  
pp. 131-141 ◽  
Author(s):  
C. Martyn Beaven ◽  
Will G. Hopkins ◽  
Kier T. Hansen ◽  
Matthew R. Wood ◽  
John B. Cronin ◽  
...  
Keyword(s):  
Resistance Exercise ◽  
Random Order ◽  
Acute Effect ◽  
Rugby League ◽  
Dose Effect ◽  
Exercise Session ◽  
Dependent Manner ◽  
Double Blind ◽  
Caffeine Ingestion ◽  
Testosterone Concentration

Introduction:Interest in the use of caffeine as an ergogenic aid has increased since the International Olympic Committee lifted the partial ban on its use. Caffeine has beneficial effects on various aspects of athletic performance, but its effects on training have been neglected.Purpose:To investigate the acute effect of caffeine on the exercise-associated increases in testosterone and cortisol in a double-blind crossover study.Methods:Twenty-four professional rugby-league players ingested caffeine doses of 0, 200, 400, and 800 mg in random order 1 hr before a resistance-exercise session. Saliva was sampled at the time of caffeine ingestion, at 15-min intervals throughout each session, and 15 and 30 min after the session. Data were log-transformed to estimate percent effects with mixed modeling, and effects were standardized to assess magnitudes.Results:Testosterone concentration showed a small increase of 15% (90% confidence limits, ± 19%) during exercise. Caffeine raised this concentration in a dose-dependent manner by a further small 21% (± 24%) at the highest dose. The 800-mg dose also produced a moderate 52% (± 44%) increase in cortisol. The effect of caffeine on the testosterone:cortisol ratio was a small decline (14%; ± 21%).Conclusion:Caffeine has some potential to benefit training outcomes via the anabolic effects of the increase in testosterone concentration, but this benefit might be counteracted by the opposing catabolic effects of the increase in cortisol and resultant decline in the testosterone:cortisol ratio.

scholarly journals The Effects of Aerobic Capacity Level on Biochemical Changes in Response to Anaerobic Exercise and During Post-Exercise Recovery in Football Players

2020 ◽  
Vol 3 (9) ◽  
pp. 160-168
Author(s):  
Moulongo Jean Georges Andre ◽  
Moussoki Jean Martin ◽  
Moussouami Simplice Innoncent ◽  
Makosso-Vheiye Georges ◽  
Packa Tchissambou Bernard ◽  
...  
Keyword(s):  
Aerobic Capacity ◽  
Biochemical Changes ◽  
Anaerobic Exercise ◽  
Football Players ◽  
Exercise Recovery ◽  
Post Exercise ◽  
Capacity Level ◽  
Post Exercise Recovery

Physiological and Cognitive Responses to Caffeine during Repeated, High-Intensity Exercise

2006 ◽  
Vol 16 (5) ◽  
pp. 528-544 ◽  
Author(s):  
Melissa J. Crowe ◽  
Anthony S. Leicht ◽  
Warwick L. Spinks
Keyword(s):  
Peak Power ◽  
Exercise Bout ◽  
Plasma Potassium ◽  
Blood Parameters ◽  
Anaerobic Exercise ◽  
Cognitive Responses ◽  
Double Blind ◽  
Caffeine Ingestion ◽  
Time To Peak ◽  
Positive Effects

This study investigated the effects of caffeine on repeated, anaerobic exercise using a double-blind, randomized, crossover design. Seventeen subjects (five female) underwent cognitive (reaction time, number recall) and blood (glucose, potassium, catecholamines, lactate) testing before and after consuming caffeine (6 mg/kg), placebo, or nothing (control). An exercise test (two 60 s maximal cycling bouts) was conducted 90 min after caffeine/placebo consumption. Plasma caffeine concentrations significantly increased after caffeine ingestion, however, there were no positive effects on cognitive or blood parameters except a significant decrease in plasma potassium concentrations at rest. Potentially negative effects of caffeine included significantly higher blood lactate compared to control and significantly slower time to peak power in exercise bout 2 compared to control and placebo. Caffeine had no significant effect on peak power, work output, RPE, or peak heart rate. In conclusion, caffeine had no ergogenic effect on repeated, maximal cycling bouts and may be detrimental to anaerobic performance.

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